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Ongoing clinical trials for Hirschsprung's disease: Actively recruiting


Hirschsprung's disease

Study title:

Endoscopic mucosal resection for the diagnosis of A-Ganglionosis, a controlled prospective trial (EDGE Trial)

Description of study:

The purpose of this study is to learn about a possible new way to diagnose Hirschsprung’s disease. Currently, Hirschsprung’s disease can sometimes be diagnosed by rectal suction biopsy. This procedure uses a suction device to remove a small sample of tissue from the rectum, and involves little or no anesthesia. This type of biopsy usually happens during a colonoscopy, which is a routine examination of the intestine.

Basic eligibility criteria:

The population of patients who are offered rectal suction biopsy will be eligible to participate.  It is this population of patients that will stand to benefit if EMR improves the diagnostic yield.  Children under the age of 10 will not be able to participate as EMR requires the use of a small caliber adult gastroscope, and younger children would be too small for scope placement. 

Principal Investigator:

Braden Kuo, MD


Shahar Castel; 617-726-0196

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