Photo of Carlos  Fernandez-del Castillo, MD

Carlos Fernandez-del Castillo, MD

  • Clinical Co-director; GI Cancer Center
  • Director, Pancreas and Biliary Surgery Program


Accepting New Patients


Dr. Fernandez-del Castillo is a gastrointestinal surgeon specialized in pancreatic and biliary diseases.


General & Gastrointestinal Surgery


Centers & Specialties

Cancer Center

Digestive Healthcare Center

Clinical Interests
  • Pancreatic disease
  • Pancreatobiliary surgery
  • Gastrointestinal surgery
  • Pancreatic cancer
  • Pancreatic cystic tumors
  • Pancreatitis (acute and chronic)
  • Pancreatic and hepatobiliary surgery
Medical Education
  • MD, Universidad Autonoma De Mexico
  • Residency, Instituto Nacional de la Nutricion
  • Fellowship, Massachusetts General Hospital
Foreign Languages
  • Spanish
  • Boston: Massachusetts General Hospital
  • Revere: MGH Revere HealthCare Center
  • Waltham: Mass General Waltham
Insurances Accepted
  • Aetna Health Inc.
  • AllWays Health (NHP) - ACD
  • AllWays Health (NHP) - PBO
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • BMC HealthNet Mass Health MCO/ACO
  • Cigna (PAL #'s)
  • Commonwealth Care Alliance
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Harvard Pilgrim Health Plan - SSN
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • Maine Community Health Options (MCHO)
  • MassHealth
  • Medicare
  • Medicare - ACD
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • OSW - Vermont
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Railroad Medicare - ACD
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
  • Well Sense Pediatrics

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Provider Gender


Dr. Carlos Fernandez-del Castillo is a gastrointestinal surgeon specialized in pancreatic and biliary diseases.

Dr. Fernandez-del Castillo is the director of the pancreas and biliary surgery program and clinical co-director of the GI cancer center at the MGH, as well as professor of surgery at Harvard Medical School. He is a widely recognized expert in pancreatic and biliary surgery, and has authored over 250 publications on pancreatic cancer, cystic tumors of the pancreas, Intraductal papillary mucinous neoplasms (IPMN), neuroendocrine pancreatic tumors, acute and chronic pancreatitis. He serves in the editorial board many journals, including Annals of Surgery, and Surgery.

Research & Publications

Research Summary

Dr. Fernandez-del Castillo has laboratory and clinical research focused on pathogenesis of acute pancreatitis, models of pancreatic cancer, molecular genetics of pancreatic cancer and cystic neoplasms of the pancreas, and neuroendocrine tumors.


View my most recent publications at PubMed

Select Publications:

  • Phase I Study of Preoperative Short-Course Chemoradiation with Proton Beam Therapy and Capecitabine for Resectable Pancreatic Ductal Adenocarcinoma of the Head. Hong TS, Ryan DP, Blaszkowsky LS, Mamon HJ, Kwak EL, Mino-Kenudson M, Adams J, Yeap B, Winrich B, Delaney TF, Fernandez-Del Castillo C. Int J Radiat Oncol Biol Phys. 2010 Apr 24.
  • Invasive intraductal papillary mucinous carcinomas of the pancreas: predictors of survival and the role of lymph node ratio. Partelli S, Fernandez-Del Castillo C, Bassi C, Mantovani W, Thayer SP, Crippa S, Ferrone CR, Falconi M, Pederzoli P, Warshaw AL, Salvia R. Ann Surg. 2010 Mar;251(3):477-82.
  • New metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinoma. Maduekwe UN, Lauwers GY, Fernandez-Del-Castillo C, Berger DL, Ferguson CM, Rattner DW, Yoon SS.  Ann Surg Oncol. 2010 May;17(5):1267-77. Epub 2010 Jan 23.
  • Pancreatic cysts: preoperative diagnosis and clinical management. Pitman MB, Lewandrowski K, Shen J, Sahani D, Brugge W, Fernandez-del Castillo C. Cancer Cytopathol. 2010 Feb 25;118(1):1-13. Review.
  • Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia. Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Alsina J, Fernández-Del Castillo C, Warshaw AL, Thayer SP. Gastroenterology. 2010 Mar;138(3):1166-77. Epub 2009 Dec 21.

News & Events

  • Mass General Surgeons Named to Boston Magazine's 2019 Top Doctors List

    45 doctors from Massachusetts General Hospital’s Department of Surgery included in Boston magazine's 2019 Top Doctors list.

  • New Radiology and Endoscopy Techniques Are Improving Treatment of Pancreatic and Biliary Disorders

    Patients seeking care for pancreatic and biliary system disorders at Massachusetts General Hospital’s Digestive Healthcare Center receive the latest in diagnostic and therapeutic treatments from a collaborative team of experts, including gastroenterologists, interventional endoscopists, pathologists, medical oncologists, surgeons, radiation oncologists, and radiation therapists.

  • Honoring an MGH legacy

    Andrew L. Warshaw, MD, who stepped down as chief of Surgery earlier this year, continues to be acknowledged for his contributions to the field, particularly pancreatic surgery.

  • One patient at a time

    During the fifth annual physician recognition dinner hosted Nov. 12 by the Massachusetts General Physicians Organization (MGPO), nearly 600 physicians and guests gathered to celebrate the past, present and future of MGH’s clinical contributions and to honor the memory of the late cardiologist Brian A. McGovern, MD, with the presentation of three awards in his name.

  • In General awards and honors

    MGH Hotline 06.26.09 In General awards and honors


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