Explore This Research Lab

Overview

The Cardiac MR PET CT Program is a combined radiology/cardiology clinical research program at the Massachusetts General Hospital Corrigan Minehan Heart Center and Harvard Medical School. The Program is a thriving multimodality multidisciplinary hub for patient-oriented research focused on the translation and implementation of innovative advanced cardiovascular PET, MR, and CT imaging methods including imaging of coronary atherosclerosis, myocardial structure and function, inflammation, and adipose tissues. The program has an excellent publication, funding, and mentoring record.

The program is led by Dr. Udo Hoffmann (Director) and brings together a broad group of collaborators from cardiology and radiology with the following interests:

  • The development and validation of imaging biomarkers of cardiovascular disease.
  • The use of imaging biomarkers in clinical trials.
  • The development and use of imaging technologies to improve patient care.

The program has led, and is leading, pioneer studies with coronary CTA, vascular inflammation and MR. Highlighted studies include large multicenter comparative effectiveness trials of cardiac CT in patients with acute (ROMICAT II) and stable (PROMISE) coronary syndromes, incidental coronary atherosclerosis and the effect of statins in HIV (REPRIEVE CT Sub-study), imaging in primary prevention in the Framingham Heart Study, the effect of methotrexate on vascular inflammation with PET in HIV (CIRT PET sub-study) and statins, myocardial fibrosis and function after anthracyclines using MR (STOP-CA).

A key component of the Program is teaching and the Program supports an embedded T32 training program in cardiovascular imaging which provides extensive high quality mentoring for MD’s and PhD's.

Research Projects

Comparative Effectiveness and Resource Utilization

Randomized controlled trials to determine the effectiveness of cardiovascular imaging on health outcomes and processes of care.

Therapeutic Efficacy

Randomized controlled trials of novel therapies among patients at increased risk of heart disease including those getting chemotherapy or living with HIV.

Mechanisms of Cardiovascular Disease

Multi-modal, multi-tissue imaging to derive unique insights into pathobiological mechanisms contributing to cardiovascular disease.

Epidemiology of Cardiovascular Disease

Including baseline exposures, genetic determinants, cardiometabolic imaging phenotyping and outcomes.

Computational Innovations

Innovations in imaging computation, including 3D visualization, computational fluid dynamics, and machine learning.

Careers & Training 

T32 postdoctoral fellowship (only for US citizens or permanent residents)

Postdoctoral fellowship (open to US or international MDs and PhDs)

Predoctoral Fellowship (Pre-med or medical students):

For further information please contact:

Roxanne Wilkins
Cardiac MR PET CT Fellowship Program
Massachusetts General Hospital
165 Cambridge St, Suite 400
Boston, MA 02114
Email: rwilkins1@mgh.harvard.edu
Phone: 617-643-0239