Udo Hoffmann, MD, MPH

Director, Cardiac MR PET CT Program, MGH
Division Chief, Cardiovascular Imaging
Professor of Radiology, HMS

Email:   uhoffmann@mgh.harvard.edu


  • BS, General Liberal Arts Studies, Humboldt College; Leipzig, Germany
  • MD, Medical School, University of Leipzig; Leipzig, Germany
  • MPH, 2006, Harvard School of Public Heath


Dr. Hoffmann went to medical school in Leipzig, Germany and completed radiology residency in Vienna, Austria. In 2001, Dr. Hoffmann joined the MGH for a fellowship in cardiovascular imaging and since 2011 is the Chief of Cardiovascular Imaging, the Director of the Cardiac MR PET CT Program.

Dr. Hoffmann is a Professor of Radiology at Harvard Medical School and leads a multidisciplinary group focused on utilizing advanced imaging to improve prevention, diagnosis, and treatment of disease. Dr. Hoffmann is the Director of an NHLBI T32 program in Cardiac Imaging and has trained more than 100 researchers and clinicians. He has lead hallmark clinical trials in cardiovascular imaging such as ROMICAT I and II, PROMISE, and REPRIEVE and leads CT imaging in the Framingham Heart Study. He has published >400 peer reviewed publications and is an Associate Editor for Circulation Cardiovascular Imaging, the Co-Chair of the Imaging Oversight Committee of the Framingham Heart Study, and a member of multiple national initiatives, guideline committees, and task forces for the major cardiology and radiological societies.

Key Interests

  • Population Imaging - Value of multi-organ phenotyping for cardiovascular risk for risk stratification in the community
  • Imaging to Improve Efficiency of Management of Patients with acute and stable chest pain syndromes
  • Biomarkers of inflammation and injury and imaging to decipher the pathophysiology of CAD and the effects of treatments
  • Imaging of high risk plaque

Key Papers

  • Hoffmann U, Truong QA, Schoenfeld DA, and ROMICAT-II Investigators. Coronary CT angiography versus standard evaluation in acute chest pain. N Engl J Med. 2012 Jul 26; 367(4): 299-308.
  • Puchner S, Liu T, Mayrhofer T, Truong QA, Lee H, Fleg J, Nagurney JT, Udelson J, Hoffmann U, Ferencik M. High-Risk Plaque Detected on Coronary CT Angiography Predicts Acute Coronary Syndromes Independent of Significant Stenosis in Acute Chest Pain: Results From the ROMICAT-II Trial. J Am Coll Cardiol. 2014; 64(7):684-692.
  • Pursnani A, Massaro JM, D'Agostino RB Sr, O'Donnell CJ, Hoffmann U. Guideline-Based Statin Eligibility, Coronary Artery Calcification, and Cardiovascular Events. JAMA. 2015 Jul 14;314(2): 134-41.
  • Ahmed W, Schlett CL, Uthamalingam S, Truong QA, Koenig W, Rogers IS, Blankstein R, Nagurney JT, Tawakol A, Januzzi JL, Hoffmann U. Single Resting hsTnT Level Predicts Abnormal Myocardial Stress Test in Acute Chest Pain Patients With Normal Initial Standard Troponin. JACC Cardiovasc Imaging. 2013 Jan;6(1):72-82.
  • Douglas PS, Hoffmann U, Patel MR, and PROMISE Investigators. Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med. 2015 Apr 2; 372(14): 1291-300.



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