In large study populations to assess the screening performance of breast tomosynthesis in clinical settings, breast tomosynthesis plus digital mammography compared to digital mammography alone was consistently associated with:

  • a decrease in recall rates 
    • Skaane et al: 15% decrease
    • Rose et al: from 8.7% to 5.5%
    • Haas et al: from 12.0% to 8.4%
    • Friedewald et al: 15% decrease
  • an increase in cancer detection rates, especially invasive cancers
    • Friedewald et al: 5.4 compared to 4.2 per 1000 screenings (28% increase) for cancer detection and 4.1 compared to 2.9 per 1000 screenings (41% increase) for invasive cancer detection
    • Skaane et al: 8.0 compared to 6.1 per 1000 screenings (27% increase)
    • Rose et al: 5.4 compared to 4.0 per 1000 screenings 
    • Haas et al: 5.7 compared to 5.2 per 1000 (not statistically significant)


Friedwald et al. Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography. JAMA. 2014;311(24):2499-2507.

Skaane et al. Comparison of digital mammography alone and digital mammography plus tomosynthesis in a population-based screening program. Radiology. 2013 Apr; 267(1):47-56.

Rose et al. Implementation of breast tomosynthesis in a routine screening practice: an observational study. AJR Am J Roentgenol. 2013 Jun; 200(6):1401-8.

Haas et al. Comparison of tomosynthesis plus digital mammography and digital mammography alone for breast cancer screening. Radiology. 2013 Dec; 269(3):694-700.

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