The research mission of the Division of Gastroenterology is to advance the understanding, diagnosis, treatment and prevention of diseases of the digestive tract, liver and pancreas.Discoveries into the underlying mechanisms of gastrointestinal diseases and new treatment approaches are facilitated by a large research base within Massachusetts General Hospital and the NIH-funded Center for the Study of Inflammatory Bowel Disease.
My research focuses on understanding the epidemiology of inflammatory bowel diseases, identifying predictors of natural history of disease, and defining high-risk subgroups. The overarching goal of my research is to work towards improving our understanding of the pathogenesis of these diseases, and developing a personalized medicine approach to the management of IBD.
Our research is focused on traditional, molecular, and genetic epidemiology of digestive diseases, including colorectal cancer, inflammatory bowel disease, and gastrointestinal bleeding.
Elucidating the genetic events in gastrointestinal tumorigenesis
Research on hepatitis C persistence and pathogenesis, HCV pathogenesis and HCV and HIV co-infection.
Our research focuses on understanding the pathogenesis of non-alcoholic fatty liver disease.
My lab is focused on understanding the complex interaction between the immune system and cancer, especially on the balance between protective antitumor immunity and immunotherapy toxicities.
Molecular mechanisms of intestinal epithelial growth and differentiation; cell cycle regulation and colon carcinogenesis; thyroid hormone regulation of gut development
We are interested in how “epigenetic” mechanisms such as histone modifying enzymes and non-coding RNA regulate inflammation and antiviral immunity.
Our research efforts include trials of new drugs to combat obesity, and studies examining the genetic and physical factors affecting appetite and fat metabolism.
The laboratory is focused upon clinical and translational research in GI motility and visceral pain syndromes such as GERD, gastroparesis, constipation and irritable bowel syndrome.
Understanding the human immune response against viruses, with a focus on T cell responses targeting human hepatotropic viruses (hepatitis C virus (HCV), hepatitis B Virus (HBV), HCV/HIV co-infection). Establishing the groundwork for rational design of antiviral vaccines and immunotherapies.
Understanding how long noncoding RNAs regulate embryonic stem cell differentiation and liver fibrosis
Dr. Daniel S. Pratt
Database and registry for primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), and cholangiocarcinoma.
Genetic analysis of signal transduction pathways that determine host cell responses to microbes and cancer
The Division is currently directing more than 30 clinical trials that seek to improve the treatment and diagnosis of a wide range of gastrointestinal conditions.
This NIH-funded center brings together investigators with expertise in key areas integral to study of Inflammatory Bowel Disease.