Overview

The Massachusetts General Hospital's Clinical and Translational Epidemiology Unit (CTEU) is a research unit within the Department of Medicine’s Mongan Institute. The mission of the CTEU is to advance epidemiologic investigation for the translation of discoveries into effective clinical interventions.

The CTEU utilizes, develops, and optimizes cutting edge epidemiologic methods to discover and characterize determinants of human health, develop novel preventive and therapeutic interventions, and elucidate molecular biomarkers for the development of precision medicine strategies. Approaches include the analysis of traditional epidemiologic exposures, as well as novel genetic, biochemical, metabolomic, proteomic, and microbial biomarkers.


Group Members

Faculty

Andrew T. Chan, MD, MPH

Dr. Andrew T. Chan is a Professor of Medicine at Harvard Medical School, Professor in the Department of Immunology and Infectious Disease at Harvard T.H. Chan School of Public Health, Chief of the Clinical and Translational Epidemiology Unit, and Program Director of Gastroenterology fellowship at Mass General. He also co-leads the Cancer Epidemiology Program at the Dana-Farber Harvard Cancer Center.

He aims to advance epidemiologic investigation for the translation of discoveries into effective clinical interventions. His current focus is on chronic digestive diseases, including gastrointestinal cancer (colorectal, esophageal, pancreatic), inflammatory bowel disease, diverticulitis, and gastrointestinal bleeding. His group utilizes molecular approaches encompassing genetic, metabolomic, proteomic, and biochemical platforms applied to populations ranging from large cohort studies to small biomarker-driven clinical trials. He also has an active program studying the oral and gut microbiome as a determinant and mediator of chronic disease.

Dr. Chan earned his MD from Harvard Medical School and a MPH from Harvard T.H. Chan School of Public Health. He completed his internal medicine residency, chief residency, and gastroenterology fellowship at Mass General. He is the Stuart and Suzanne Steele MGH Research Scholar. He was awarded the 2016 Martin Prize for Clinical Research by the MGH Executive Committee on Research and is an Elected Fellow of the American Society of Clinical Investigation. His group is supported by several grants from the National Institutes of Health, the National Cancer Institute, and several foundations.

Ashwin Ananthakrishnan, MD, MPH

Dr. Ashwin Ananthakrishnan is the Director of the Mass General Crohn’s and Colitis Center. He completed his medical school training at JIPMER in India and subsequently obtained his Masters in Public Health degree at the Johns Hopkins University Bloomberg School of Public Health. After completing his GI fellowship at the Medical College of Wisconsin, he joined the faculty at Mass General where he is involved in clinical care, research, and teaching. In addition to his clinical expertise in the management of patients with complex inflammatory bowel disease (IBD), he has been involved in NIH-funded investigations using large prospective cohorts to define for the first time an important role for factors such as diet, vitamin D, stress, and sleep and determine how they may be altered to prevent disease or improve the course of established IBD. He is also conducting studies aimed to understand how an individual¹s genetics and composition of their intestinal microbiome may predispose them to developing IBD, and how they can be used to determine which treatments may be of greatest benefit in each patient. He has published over 180 manuscripts, has co-authored a textbook in IBD, and serves on multiple Editorial Boards of major GI journals.

Jennifer Chen, MD

Instructor in Medicine, Harvard Medical School

Kathleen Corey, MD, MPH

Kathleen E Corey, MD, MPH, MMSc, is an Assistant Professor of Medicine at Harvard Medical School and Director of the Mass General Fatty Liver Clinic in the Mass General Gastrointestinal Unit.

Dr. Corey's clinical interests include all areas of hepatology including non-alcoholic fatty liver disease (NAFLD), viral hepatitis including hepatitis B, C and D infection, autoimmune hepatitis, cholestatic liver disease including primary biliary cirrhosis and primary sclerosing cholangitis. In addition, Dr. Corey treats patients with hereditary forms of liver disease including hemochromatosis and alpha-1-antitrypsin disease. Dr. Corey is also a transplant hepatologist and evaluates patients in need of liver transplantation and cares for patients after liver transplant. Dr. Corey also performs endoscopies including diagnostic and therapeutic upper endoscopy and colonoscopy.

Dr. Corey's research focuses on non-alcoholic fatty liver disease and the development of non-invasive biomarkers for the diagnosis and monitoring of NAFLD.  Dr. Corey has lectured regionally and nationally on NAFLD.

Manish Gala, MD

Dr. Gala is an attending gastroenterologist at Massachusetts General Hospital and an Instructor of Medicine at Harvard Medical School. His interests include hereditary colon cancer syndrome, molecular pathogenesis of colorectal cancer, and colorectal adenoma. Dr. Gala earned his MD at Harvard Medical School. He completed his training in internal medicine at Stanford University before completing gastroenterology fellowship at Mass General.

Jennifer Ho, MD

Dr. Ho is a cardiologist in the Heart Failure and Transplantation section of the Massachusetts General Hospital Cardiology Division and Assistant Professor of Medicine at Harvard Medical School. She sees patients with advanced heart failure.

Dr. Ho is a faculty member of the Cardiovascular Research Center, and also maintains an affiliation with the Framingham Heart Study. Her laboratory is focused on clinical and translational patient-oriented investigations to understand mechanisms driving heart failure and cardiometabolic disease, with a particular focus on heart failure with preserved ejection fraction. She is a recipient of the MGH Claflin Distinguished Scholar Award (2017), an MGH Hassenfeld Scholar Award (2016), and multiple NIH grants to support her research laboratory.

Amit Joshi, MBBS, PhD

Dr. Amit Joshi is an Investigator in the Clinical and Translational Epidemiology Unit in Massachusetts General Hospital, and an Instructor in Medicine at Harvard Medical School. He is a molecular epidemiologist by training, with a background in clinical medicine.

His research interests include studying the risk of breast, prostate and colorectal cancers, and gastrointestinal diseases, using high-dimensional genomic  data. To study these outcomes, he has conducted genome-wide association studies (GWAS) and studies of gene-gene and gene-environment interactions on the relative and absolute risk scales. He is also currently involved in studying gut microbial and metabolomic risk factors of symptomatic gallbladder disease and cholecystectomy outcomes.

Dr. Joshi earned his MBBS from B.J. Medical College, Ahmedabad, India. He holds a MS in Molecular Epidemiology prior to obtaining a PhD in Molecular Epidemiology from University of Southern California.

Hamed Khalili, MD, MPH

Dr. Khalili is a gastroenterologist specialized in inflammatory bowel disease (IBD) at Mass General and an Assistant Professor of Medicine at Harvard Medical School.

His interests include clinical and translational research in the field of IBD. He aims to better understand the environmental risk factors, particularly dietary, reproductive, and lifestyle factors, for the development IBD. He has been involved in NIH-funded research to study the complex interplay between common genetic risk loci and gut microbial environment on risk and progression of IBD.

Dr. Khalili earned his MD and completed his training in internal medicine at University of Texas Southwestern Medical Center. Before joining the faculty at MGH, he completed Gastroenterology and Advanced IBD fellowship at Mass General and obtained an MPH from Harvard T.H. Chan School of Public Health.

Jay Luther, MD

Jay Luther, MD attended Cornell University for undergraduate studies and SUNY at Syracuse for medical school. He then attended the University of Michigan for Internal Medicine Residency, during which time he was awarded an NIH research fellowship. Jay also completed his gastroenterology and hepatology fellowship at the Mass General. Jay grew up in Buffalo, NY and remains an avid Sabres and Bills fan.

Alisa Manning, PhD

Dr. Manning is an Instructor of Medicine at Harvard Medical School, an Associated Scientist at Program in Medical and Population Genetics at Broad Institute, and an Assistant Investigator at Clinical Translational Epidemiology Unit at Mass General.

Dr. Manning is a statistical geneticits with an established focus on glycemic traits and a recent focus on integrative analyses of whole genome sequence data. She has been exploring the link between genetic associations and phenotype refinement since 2005. Her Lab studies the molecular and mechanistic basis of insulin resistance and obesity and is known for developing statistical strategies for translational epidemiology using whole genome sequence association studies, physiological and molecular studies in humans and integrative analytics, with the overarching goal to understand the relationship between Genes, Environment and Disease and to foster a stimulating and interdisciplinary research environment with local and international collaborators on a range of projects.

Dr. Manning earned her PhD from Boston University.

Anne Marie McCarthy, PhD

Instructor in Medicine, Harvard Medical School

Mingyang Song, MD, ScD

Dr. Mingyang Song is an Instructor of Medicine at Massachusetts General Hospital. His research focuses on the role of diet and lifestyle factors, in conjunction with the host immune system and gut microbiome, in colorectal cancer prevention and survivorship. He has extensive research experience in nutritional, genetic, and molecular epidemiology. He is particularly interested in integrating large-scale population studies with biomarker-based randomized controlled trials to identify novel nutrition- and gut microbiota-targeted strategies for cancer prevention and treatment.

Currently, he is the Assistant Director for the MICRObiome Among Nurses (MICRO-N) Study, a large prospective microbiome study of 25,000 women in the Nurses’ Health Study II. He is also a member of the Cancer Epidemiology and Gastrointestinal Malignancies Programs at Dana-Farber / Harvard Cancer Center.

Kyle Staller, MD, MPH

Kyle D. Staller, MD, MPH is an instructor in medicine at Harvard Medical School and a member of the Center for Neurointestinal Health and the Clinical and Translational Epidemiology Unit at Mass General. He is interested in disorders of gastrointestinal motility and neurogastroenterology.

Dr. Staller's clinical interests are focused on treating patients with gastrointestinal motility and functional disorders. In his practice he cares for patients with conditions including achalasia, chronic constipation, fecal incontinence, gastroesophageal reflux disease (GERD), gastroparesis, irritable bowel syndrome, and swallowing disorders. He also interprets gastrointestinal motility studies including esophageal manometry, pH studies, anorectal manometry, and wireless motility capsules. Dr. Staller also performs endoscopies including diagnostic and therapeutic upper endoscopies and colonoscopies as well as Bravo pH probe placements and pneumatic dilations for achalasia.

Erica Warner, ScD, MPH

Dr. Warner is an Assistant Professor in the Department Medicine at Harvard Medical School and an Assistant Investigator at Massachusetts General Hospital where she conducts epidemiological research on cancer. She is also Research Associate at Harvard T.H. Chan School of Public Health in the Department of Epidemiology. She is a member of the Dana-Farber Harvard Cancer Center in the Cancer Epidemiology and Risk and Health Disparities Programs.  Dr. Warner is a cancer epidemiologist, studying how lifestyle, behavioral and genetic factors affect risk of cancer, particularly aggressive subtypes.  She also examines factors that lead to more aggressive subtypes of cancer and higher risk of cancer mortality in minority populations.  Dr. Warner’s work appears in leading public health, medical, oncology, and epidemiology journals. Dr. Warner’s recent work has been funded by the National Institutes of Health, the Robert Wood Johnson Foundation, the Aetna Foundation and the Alliance for Clinical Trials in Oncology. Dr. Warner has a bachelor's degree from Duke University and a master's in public health degree (MPH) from Yale School of Public Health. Dr. Warner completed her doctorate and the Alonzo Smythe Yerby Postdoctoral Fellowship, both in Epidemiology, at the Harvard T.H. Chan School of Public Health.

Research Fellows

  • David Drew, PhD

    Dr. Drew is a Research Fellow at Harvard Medical School and Massachusetts General Hospital within the CTEU and the Division of Gastroenterology.

    His long-term research has focused on the prevention of gastrointestinal disorders, primarily GI cancers, through chemoprevention, lifestyle modification, or enhanced endoscopic screening methods. Recently, this interest has been focused on the molecular mechanisms, particularly those influenced by the gut microbiome, driving gastrointestinal disease and cancer, and the mechanisms by which pharmacologic agents, such as aspirin, prevent or contribute to the development of GI disorders. Broadly, his training has provided him strong foundations in basic and translational research, the gut microbiome, colorectal carcinogenesis, precision prevention, epidemiology/biostatistics, and cancer genetics.

    Dr. Drew earned a PhD in Biomedical Science from the University of Connecticut and also holds a B.S. in Biochemistry/Biophysics from Rensselaer Polytechnic Institute.

  • Xiosheng He, MD, PhD

    Dr. He is a colorectal surgeon from China. His research focus is on colorectal inflammation and carcinogenesis. He joins the CTEU at Mass General in 2017 as a research fellow. His current project includes dietary fiber and risk of colorectal adenoma.

  • Manol Jovani, MD, MPH

    Dr. Jovani is a Research Fellow in the Clinical and Translational Epidemiology Unit, Division of Gastroenterology, at the Massachusetts General Hospital and Harvard Medical School.

    His research projects include identification of risk factors for Barrett’s esophagus, identification of risk factors for diverticulitis, identification of early biomarkers of cancer incidence and cancer-related death, novel technologies for the identification of gastrointestinal malignancies, and quality improvement in colonoscopy.

    Dr. Jovani earned an MD from the University of Bologna (Italy), specialized in Gastroenterology in Milan (Italy), and obtained an MPH from the Harvard T.H.Chan School of Public Health.

  • Paul Lochhead, MBChB, PhD

    Paul trained as a gastroenterologist in the UK and subsequently completed advanced clinical training in inflammatory bowel diseases at Massachusetts General Hospital. During his doctoral studies in the UK, Paul spent a year as a Knox Memorial Fellow at the Dana-Farber Cancer Institute where he worked on the molecular pathology and epidemiology of colorectal cancer survival. Paul joined the CTEU as a research fellow in 2015 and has been involved in a number of gastrointestinal epidemiologic studies involving the Harvard prospective cohorts. Paul’s current research interests include investigating the role of medication, lifestyle and environmental factors in the development and progression of IBD. Paul is supported by a career development award from the Crohn’s and Colitis Foundation.

  • Wenjie Ma, MBBS, ScD

    Wenjie joined the CTEU in 2017 with extensive training and research experience in nutritional, genetic, and molecular epidemiology. Her research interests include understanding the etiology and developing intervention strategies for colorectal cancer, diverticulitis, and cardiovascular diseases and examining the role of gut microbiome in inflammation and diseases. Wenjie earned her ScD in Epidemiology from Harvard T.H. Chan School of Public Health. Before coming to the US, she graduated from Peking University in 2012 with a Bachelor’s degree in Medicine.

  • Long Nguyen, MD, MS

    Dr. Nguyen is a Clinical and Research Fellow in Gastroenterology & Hepatology and physician at the Massachusetts General Hospital.

    His research focuses on the influence of dietary patterns, medication usage, and other lifestyle exposures on the gut microbiome in inflammatory bowel disease and colorectal cancer.

    Dr. Nguyen earned an M.D. from the Stanford University School of Medicine and also holds an M.S. in Epidemiology & Clinical Research from Stanford University.


Medical Residents

  • Raaj Mehta, MD

    Dr. Mehta is a Stanbury Service resident in Internal Medicine at the Massachussetts General Hospital. His research interests lie at the intersection of epidemiology, microbiology, and immunology. He received an AB from Princeton University and an MD from Harvard University. He was a Fulbright scholar to Ecuador from 2010 to 2011 and a Howard Hughes Medical Institute Medical Research Fellow from 2014 to 2015. He plans to be an academic gastroenterologist.


Research Coordinators

  • Dylan Christopher Zerjav

    Dylan joined the CTEU at Mass General in June 2017. He graduated from Johns Hopkins University with a BS in Chemical & Biomolecular Engineering. He works as a research coordinator on several clinical trials focusing on gastrointestinal chemoprevention.

  • Jennifer Mackinnon Krems

    Jennifer joined the Clinical and Translational Epidemiology Unit at Mass General in June 2018. She graduated from Amherst College in 2018 with a BA in Economics. She works as a clinical research coordinator on several clinical trials studying GI cancer prevention and detection.

Programmer

  • Elaine Coughlan-Gifford

Administrative Assistant

  • Julie Wusenich


Alumni

Yin Cao, ScD

Dr. Cao is currently an Assistant Professor of Surgery at Washington University School of Medicine in St. Louis and Siteman Cancer Center. She has extensive training and research experience in genetic, molecular, and nutritional epidemiology, and was an Instructor in Medicine in the Clinical and Translational Epidemiology Unit at Massachusetts General Hospital and Harvard Medical School (2015-2017). She is a cancer epidemiologist focusing on risk prediction, screening and early detection, and chemoprevention of gastrointestinal malignancies. Her current research areas include the etiology of young-onset colorectal cancer, the biological basis for colorectal cancer disparity, the role of microbiome and host immunity in carcinogenesis, and the development of precision aspirin chemoprevention guidelines. She will utilize -omic technologies, informatics tools, and methods in decision and implementation sciences, to develop personalized cancer prevention and control strategies.

Dr. Cao earned a ScD in Epidemiology from Harvard T.H. Chan School of Public Health in 2013. Prior to that, she obtained her MPH degree from Columbia University.


Research Projects

Epidemiology of colorectal adenoma and cancer

We are leading several studies in the prevention of colorectal adenoma and cancer using chemopreventative drugs and lifestyle interventions. We are also focused on genetic and biochemical markers that may be used to stratify risk of colorectal cancer for individuals, as well as predict responsiveness to various interventions.

Biomarker trial of aspirin in colorectal neoplasia

We conducting ASPIRED, an NCI-funded, randomized, clinical trial of aspirin among patients with a history of colorectal adenoma in relation to several cancer-specific biomarkers. The ultimate goal is to understand the mechanistic basis by which aspirin reduces the risk of colorectal cancer.

Epidemiology of the oral and gut microbiome

We have completed several prospective collections of the oral and gut microbiome to examine key questions regarding the stability of the microbiome over time, dietary and lifestyle determinants of the microbiome, and the association of the microbiome in relation to risk of several chronic diseases, including colorectal and other cancers. We collaborate closely with leading immunologists, computational biologists, microbiologists, and biostatisticians in this field..

Genomic landscape of interval cancers

We are using state-of-the art genome sequencing techniques to identify molecular markers of colorectal cancers which evade traditional endoscopic detection.

Genetic epidemiology of colorectal cancer

We are members of a national consortium of epidemiological studies of colorectal cancer which have assembled to conduct a large scale genome wide association study of colorectal cancer. The primary focus is to investigate the interaction between known environmental risk factors for colorectal cancer and genetic risk loci, as well as the interaction between germline genetic risk factors and colorectal cancers defined by molecular subtypes.

Survival in colorectal cancer

We co-lead, with the Fred Hutchinson Cancer Research Center, the International Survival Analysis in Colorectal Cancer Consortium, an international collaboration of investigators which is conducting studies in genetic and lifestyle factors associated with survival among patients with colorectal cancer.

Epidemiology of gastrointestinal bleeding

We focus on lifestyle risk factors for gastrointestinal bleeding, including intake of medications such as aspirin and NSAIDs in relation to genetic and biomarker risk factors.

Epidemiology of inflammatory bowel disease

We are examining lifestyle and dietary factors and risk of incident Crohn’s disease and ulcerative colitis. Based on this work, we will ultimately examine how these factors interact with known genetic risk loci for Crohn’s and ulcerative colitis.

Epidemiology of diverticulitis

We are studying the association of diet and lifestyle with risk of incident diverticulitis as well as recurrent diverticulitis. We are also examining the role of biochemical markers in relation to risk of incident and recurrent disease.

Molecular imaging of colorectal neoplasia

In collaboration with biotechnology firms, we are leading an NCI-sponsored clinical trial to translate novel near infrared activatable agents that selectively target tumor-specific cathepsin proteases. We are interested in using these agents with fluorescent imaging endoscopy to enhance the detection of gastrointestinal neoplasia.


Publications

2018

  1. Nguyen LH, Lochhead P, Joshi AD, Cao Y, Ma W, Khalili H, Rimm EB, Rexrode KB, Chan AT. No significant association between proton pump inhibitor use and risk of stroke after adjustment for lifestyle factors and indication. Gastroenterol. 154(5): 1290-1297.e1.
  2. Nguyen LH, Liu PH, Zheng X, Keum N, Zong X, Li X, Wu K, Fuchs CS, Ogino S, Ng K, Willett WC, Chan AT*, Giovannucci EL*, Cao Y*. Sedentary Behaviors, TV Viewing Time, and Risk of Young-Onset Colorectal Cancer. JNCI Cancer Spectr. in press.
  3. Jovani M, Ma Wenjie, Joshi A, Liu PL, Nguyen LH, Cao Y, Tam I, Wu K, Giovannucci EL, Chan AT, Strate LS. Menopausal Hormone Therapy and Risk of Diverticulitis. American Journal of Gastroenterology. 2018; in press
  4. Ma W, Song M, Kværner AS, Prescott J, Chan A, Giovannucci E, Zhang X. Sex-Specific Association between Family History of Diabetes and Risk of Colorectal Cancer: Two Prospective Cohort Studies. Cancer prevention research (Philadelphia, Pa.). 2018; 11(9):535-544.
  5. Ma W, Jovani M, Liu PH, Nguyen LH, Cao Y, Tam I, Wu K, Giovannucci EL, Strate LL, Chan AT. Association Between Obesity and Weight Change and Risk of Diverticulitis in Women. Gastroenterology. 2018; 155(1):58-66.e4. NIHMSID: NIHMS957397
  6. Ma W, Chan AT. Does Subclinical Inflammation Play a Role in the Pathogenesis of Diverticulosis? Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2018; 16(6):817-818.
  7. Heianza Y, Sun D, Ma W, Zheng Y, Champagne CM, Bray GA, Sacks FM, Qi L. Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial. International journal of obesity (2005). 2018; 42(9):1565-1573. NIHMSID: NIHMS921908
  8. Zheng Y, Xu M, Heianza Y, Ma W, Wang T, Sun D, Albert CM, Hu FB, Rexrode KM, Manson JE, Qi L. Gallstone disease and increased risk of mortality: Two large prospective studies in US men and women. Journal of gastroenterology and hepatology. 2018
  9. Ma W, Heianza Y, Huang T, Wang T, Sun D, Zheng Y, Hu FB, Rexrode KM, Manson JE, Qi L. Dietary glutamine, glutamate and mortality: two large prospective studies in US men and women. International journal of epidemiology. 2018; 47(1):311-320.
  10. Wang T, Heianza Y, Sun D, Huang T, Ma W, Rimm EB, Manson JE, Hu FB, Willett WC, Qi L. Improving adherence to healthy dietary patterns, genetic risk, and long term weight gain: gene-diet interaction analysis in two prospective cohort studies. BMJ (Clinical research ed.). 2018; 360:j5644.
  11. Song M, Vogelstein B, Giovannucci EL, Willett WC, Tomasetti C. Cancer prevention: Molecular and epidemiologic consensus. Science. 2018 Sep 28;361(6409):1317-1318. doi: 10.1126/science.aau3830. PubMed PMID: 30262488.
  12. Kosumi K, Hamada T, Koh H, Borowsky J, Bullman S, Twombly TS, Nevo D, Masugi Y, Liu L, da Silva A, Chen Y, Du C, Gu M, Li C, Li W, Liu H, Shi Y, Mima K, Song M, Nosho K, Nowak JA, Nishihara R, Baba H, Zhang X, Wu K, Wang M, Huttenhower C, Garrett WS, Meyerson ML, Lennerz JK, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Ogino S. The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome. Am J Pathol. 2018 Sep 19. pii: S0002-9440(18)30364-X. doi: 10.1016/j.ajpath.2018.08.015. [Epub ahead of print] PubMed PMID: 30243655.
  13. Hamada T, Zhang X, Mima K, Bullman S, Sukawa Y, Nowak JA, Kosumi K, Masugi Y, Twombly TS, Cao Y, Song M, Liu L, da Silva A, Shi Y, Gu M, Li W, Koh H, Nosho K, Inamura K, Keum N, Wu K, Meyerhardt JA, Kostic AD, Huttenhower C, Garrett W, Meyerson M, Giovannucci EL, Chan AT, Fuchs CS, Nishihara R, Giannakis M, Ogino S. Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status. Cancer Immunol Res. 2018 Sep 18. pii: canimm.0174.2018. doi: 10.1158/2326-6066.CIR-18-0174. [Epub ahead of print] PubMed PMID: 30228205.
  14. Hamada T, Liu L, Nowak JA, Mima K, Cao Y, Ng K, Twombly TS, Song M, Jung S, Dou R, Masugi Y, Kosumi K, Shi Y, da Silva A, Gu M, Li W, Keum N, Wu K, Nosho K, Inamura K, Meyerhardt JA, Nevo D, Wang M, Giannakis M, Chan AT, Giovannucci EL, Fuchs CS, Nishihara R, Zhang X, Ogino S. Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour. Eur J Cancer. 2018 Sep 12;103:98-107. doi: 10.1016/j.ejca.2018.07.130. [Epub ahead of print] PubMed PMID: 30219720.
  15. Dai JY, Peters U, Wang X, Kocarnik J, Chang-Claude J, Slattery ML, Chan A, Lemire M, Berndt SI, Casey G, Song M, Jenkins MA, Brenner H, Thrift AP, White E, Hsu L. Diagnostics of Pleiotropy in Mendelian Randomization Studies: Global and Individual Tests for Direct Effects. Am J Epidemiol. 2018 Sep 5. doi: 10.1093/aje/kwy177. [Epub ahead of print] PubMed PMID: 30188971.
  16. Kværner AS, Hang D, Giovannucci EL, Willett WC, Chan AT, Song M. Trajectories of body fatness from age 5 to 60 y and plasma biomarker concentrations of the insulin-insulin-like growth factor system. Am J Clin Nutr. 2018 Aug 1;108(2):388-397. doi: 10.1093/ajcn/nqy103. PubMed PMID: 30101328.
  17. Song M, Chan AT. The Potential Role of Exercise and Nutrition in Harnessing the Immune System to Improve Colorectal Cancer Survival. Gastroenterology. 2018 Sep;155(3):596-600. doi: 10.1053/j.gastro.2018.07.038. Epub 2018 Aug 1. Review. PubMed PMID: 30076837.
  18. Van Blarigan EL, Ou FS, Niedzwiecki D, Zhang S, Fuchs CS, Saltz L, Mayer RJ, Venook A, Ogino S, Song M, Benson A, Hantel A, Atkins JN, Giovannucci EL, Meyerhardt JA. Dietary Fat Intake after Colon Cancer Diagnosis in Relation to Cancer Recurrence and Survival: CALGB 89803 (Alliance). Cancer Epidemiol Biomarkers Prev. 2018 Oct;27(10):1227-1230. doi: 10.1158/1055-9965.EPI-18-0487. Epub 2018 Jul 23. PubMed PMID: 30038051; PubMed Central PMCID: PMC6170705.
  19. Song M, Chan AT. Environmental Factors, Gut Microbiota, and Colorectal Cancer Prevention. Clin Gastroenterol Hepatol. 2018 Jul 18. pii: S1542-3565(18)30712-2. doi: 10.1016/j.cgh.2018.07.012. [Epub ahead of print] Review. PubMed PMID: 30031175.
  20. Hamada T, Soong TR, Masugi Y, Kosumi K, Nowak JA, da Silva A, Mu XJ, Twombly TS, Koh H, Yang J, Song M, Liu L, Gu M, Shi Y, Nosho K, Morikawa T, Inamura K, Shukla SA, Wu CJ, Garraway LA, Zhang X, Wu K, Meyerhardt JA, Chan AT, Glickman JN, Rodig SJ, Freeman GJ, Fuchs CS, Nishihara R, Giannakis M, Ogino S. TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas. Oncoimmunology. 2018 Mar 19;7(7):e1442999. doi: 10.1080/2162402X.2018.1442999. eCollection 2018. PubMed PMID: 29900052; PubMed Central PMCID: PMC5993482.
  21. Neumeyer S, Banbury BL, Arndt V, Berndt SI, Bezieau S, Bien SA, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Casey G, Chan AT, Chanock SJ, Dai JY, Gallinger S, Giovannucci EL, Giles GG, Grady WM, Hampe J, Hoffmeister M, Hopper JL, Hsu L, Jenkins MA, Joshi A, Larsson SC, Le Marchand L, Lindblom A, Moreno V, Lemire M, Li L, Lin Y, Offit K, Newcomb PA, Pharaoh PD, Potter JD, Qi L, Rennert G, Schafmayer C, Schoen RE, Slattery ML, Song M, Ulrich CM, Win AK, White E, Wolk A, Woods MO, Wu AH, Gruber SB, Brenner H, Peters U, Chang-Claude J. Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer. Br J Cancer. 2018 Jun;118(12):1639-1647. doi: 10.1038/s41416-018-0108-8. Epub 2018 May 24. PubMed PMID: 29795306; PubMed Central PMCID: PMC6008474.
  22. Staller K, Song M, Grodstein F, Whitehead WE, Matthews CA, Kuo B, Chan AT. Increased Long-term Dietary Fiber Intake Is Associated With a Decreased Risk of Fecal Incontinence in Older Women. Gastroenterology. 2018 Sep;155(3):661-667.e1. doi: 10.1053/j.gastro.2018.05.021. Epub 2018 Jun 11. PubMed PMID: 29758215.
  23. Juan J, Huang H, Jiang X, Ardisson Korat AV, Song M, Sun Q, Willett WC, Jensen MK, Kraft P. Joint effects of fatty acid desaturase 1 polymorphisms and dietary polyunsaturated fatty acid intake on circulating fatty acid proportions. Am J Clin Nutr. 2018 May 1;107(5):826-833. doi: 10.1093/ajcn/nqy025. PubMed PMID: 29722844.
  24. Liu L, Tabung FK, Zhang X, Nowak JA, Qian ZR, Hamada T, Nevo D, Bullman S, Mima K, Kosumi K, da Silva A, Song M, Cao Y, Twombly TS, Shi Y, Liu H, Gu M, Koh H, Li W, Du C, Chen Y, Li C, Li W, Mehta RS, Wu K, Wang M, Kostic AD, Giannakis M, Garrett WS, Hutthenhower C, Chan AT, Fuchs CS, Nishihara R, Ogino S, Giovannucci EL. Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1622-1631.e3. doi: 10.1016/j.cgh.2018.04.030. Epub 2018 Apr 24. PubMed PMID: 29702299; PubMed Central PMCID: PMC6151288.
  25. He X, Wu K, Ogino S, Giovannucci EL, Chan AT, Song M. Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas. Gastroenterology. 2018 Aug;155(2):355-373.e18. doi: 10.1053/j.gastro.2018.04.019. Epub 2018 Apr 24. PubMed PMID: 29702117; PubMed Central PMCID: PMC6067965.
  26. Hang D, Nan H, Kværner AS, De Vivo I, Chan AT, Hu Z, Shen H, Giovannucci E, Song M. Longitudinal associations of lifetime adiposity with leukocyte telomere length and mitochondrial DNA copy number. Eur J Epidemiol. 2018 May;33(5):485-495. doi: 10.1007/s10654-018-0382-z. Epub 2018 Apr 4. PubMed PMID: 29619669.
  27. Song M, Giovannucci E. Substitution analysis in nutritional epidemiology: proceed with caution. Eur J Epidemiol. 2018 Feb;33(2):137-140. doi: 10.1007/s10654-018-0371-2. PubMed PMID: 29478107.
  28. Ogino S, Nowak JA, Hamada T, Phipps AI, Peters U, Milner DA Jr, Giovannucci EL, Nishihara R, Giannakis M, Garrett WS, Song M. Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine. Gut. 2018 Jun;67(6):1168-1180. doi: 10.1136/gutjnl-2017-315537. Epub 2018 Feb 6. Review. PubMed PMID: 29437869; PubMed Central PMCID: PMC5943183.
  29. Van Blarigan EL, Fuchs CS, Niedzwiecki D, Ye X, Zhang S, Song M, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Atienza D, Messino M, Kindler H, Venook A, Ogino S, Giovannucci EL, Meyerhardt JA. Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance). Cancer Epidemiol Biomarkers Prev. 2018 Apr;27(4):438-445. doi: 10.1158/1055-9965.EPI-17-0689. Epub 2018 Jan 22. PubMed PMID: 29358223; PubMed Central PMCID: PMC5939380.
  30. Mehta RS, Abu-Ali GS, Drew DA, Lloyd-Price J, Subramanian A, Lochhead P, Joshi AD, Ivey KL, Khalili H, Brown GT, DuLong C, Song M, Nguyen LH, Mallick H, Rimm EB, Izard J, Huttenhower C, Chan AT. Stability of the human faecal microbiome in a cohort of adult men. Nat Microbiol. 2018 Mar;3(3):347-355. doi: 10.1038/s41564-017-0096-0. Epub 2018 Jan 15. PubMed PMID: 29335554; PubMed Central PMCID: PMC6016839.
  31. Liu L, Nevo D, Nishihara R, Cao Y, Song M, Twombly TS, Chan AT, Giovannucci EL, VanderWeele TJ, Wang M, Ogino S. Utility of inverse probability weighting in molecular pathological epidemiology. Eur J Epidemiol. 2018 Apr;33(4):381-392. doi: 10.1007/s10654-017-0346-8. Epub 2017 Dec 20. PubMed PMID: 29264788; PubMed Central PMCID: PMC5948129.
  32. Song M, Zheng Y, Qi L, Hu FB, Chan AT, Giovannucci EL. Longitudinal Analysis of Genetic Susceptibility and BMI Throughout Adult Life. Diabetes. 2018 Feb;67(2):248-255. doi: 10.2337/db17-1156. Epub 2017 Dec 6. PubMed PMID: 29212779; PubMed Central PMCID: PMC5780056.
  33. Song M, Zheng Y, Qi L, Hu FB, Chan AT, Giovannucci EL. Associations between genetic variants associated with body mass index and trajectories of body fatness across the life course: a longitudinal analysis. Int J Epidemiol. 2018 Apr 1;47(2):506-515. doi: 10.1093/ije/dyx255. PubMed PMID: 29211904; PubMed Central PMCID: PMC5913610.
  34. Graff RE, Ahearn TU, Pettersson A, Ebot EM, Gerke T, Penney KL, Wilson KM, Markt SC, Pernar CH, Gonzalez-Feliciano AG, Song M, Lis RT, Schmidt DR, Vander Heiden MG, Fiorentino M, Giovannucci EL, Loda M, Mucci LA. Height, Obesity, and the Risk of TMPRSS2:ERG-Defined Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2018 Feb;27(2):193-200. doi: 10.1158/1055-9965.EPI-17-0547. Epub 2017 Nov 22. PubMed PMID: 29167279; PubMed Central PMCID: PMC5809280.
  35. Hu Y, Ding M, Yuan C, Wu K, Smith-Warner SA, Hu FB, Chan AT, Meyerhardt JA, Ogino S, Fuchs CS, Giovannucci EL, Song M. Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality. Gastroenterology. 2018 Mar;154(4):916-926.e9. doi: 10.1053/j.gastro.2017.11.010. Epub 2017 Nov 20. PubMed PMID: 29158191; PubMed Central PMCID: PMC5847429.
  36. Song M, Wu K, Meyerhardt JA, Ogino S, Wang M, Fuchs CS, Giovannucci EL, Chan AT. Fiber Intake and Survival After Colorectal Cancer Diagnosis. JAMA Oncol. 2018 Jan 1;4(1):71-79. doi: 10.1001/jamaoncol.2017.3684. PubMed PMID: 29098294; PubMed Central PMCID: PMC5776713.
  37. Ma Y, Yang W, Song M, Smith-Warner SA, Yang J, Li Y, Ma W, Hu Y, Ogino S, Hu FB, Wen D, Chan AT, Giovannucci EL, Zhang X. Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts. Br J Cancer. 2018 Nov 7. doi: 10.1038/s41416-018-0314-4. [Epub ahead of print]
  38. Chun KA, Kocarnik JM, Hardikar SS, Robinson JR, Berndt SI, Chan AT, Figueiredo JC, Lindor NM, Song M, Schoen RE, Hayes RB, Potter JD, Nassir R, Bézieau S, Le Marchand L, Slattery ML, White E, Peters U, Newcomb PA. Leptin gene variants and colorectal cancer risk: Sex-specific associations. PLoS One. 2018 Oct 31;13(10):e0206519. doi: 10.1371/journal.pone.0206519. eCollection 2018.
  39. Hamada T, Nowak JA, Masugi Y, Drew DA, Song M, Cao Y, Kosumi K, Mima K, Twombly TS, Liu L, Shi Y, da Silva A, Gu M, Li W, Nosho K, Keum N, Giannakis M, Meyerhardt JA, Wu K, Wang M, Chan AT, Giovannucci EL, Fuchs CS, Nishihara R, Zhang X, Ogino S. Smoking and Risk of Colorectal Cancer Sub-Classified by Tumor-Infiltrating T Cells. J Natl Cancer Inst. 2018 Oct 11. doi: 10.1093/jnci/djy137. [Epub ahead of print]
  40. Wirth J, Song M, Fung TT, Joshi AD, Tabung FK, Chan AT, Weikert C, Leitzmann M, Willett WC, Giovannucci E, Wu K. Diet-quality scores and the risk of symptomatic gallstone disease: a prospective cohort study of male US health professionals. Int J Epidemiol. 2018 Oct 11. doi: 10.1093/ije/dyy210. [Epub ahead of print]
  41. Mak WW, Tong AC, Yip SY, Lui WW, Chio FH, Chan AT, Wong CC. Efficacy and Moderation of Mobile App-Based Programs for Mindfulness-Based Training, Self-Compassion Training, and Cognitive Behavioral Psychoeducation on Mental Health: Randomized Controlled Noninferiority Trial. JMIR Ment Health. 2018 Oct 11;5(4):e60. doi: 10.2196/mental.8597.
  42. Petimar J, Smith-Warner SA, Fung TT, Rosner B, Chan AT, Hu FB, Giovannucci EL, Tabung FK. Recommendation-based dietary indexes and risk of colorectal cancer in the Nurses' Health Study and Health Professionals Follow-up Study. Am J Clin Nutr. 2018 Oct 4. doi: 10.1093/ajcn/nqy171. [Epub ahead of print]
  43. Simon TG, Ma Y, Ludvigsson JF, Chong DQ, Giovannucci EL, Fuchs CS, Meyerhardt JA, Corey KE, Chung RT, Zhang X, Chan AT. Association Between Aspirin Use and Risk of Hepatocellular Carcinoma. JAMA Oncol. 2018 Oct 4. doi: 10.1001/jamaoncol.2018.4154. [Epub ahead of print]
  44. Ma S, Ogino S, Parsana P, Nishihara R, Qian Z, Shen J, Mima K, Masugi Y, Cao Y, Nowak JA, Shima K, Hoshida Y, Giovannucci EL, Gala MK, Chan AT, Fuchs CS, Parmigiani G, Huttenhower C, Waldron L. Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis. Genome Biol. 2018 Sep 25;19(1):142. doi: 10.1186/s13059-018-1511-4.
  45. Kosumi K, Hamada T, Koh H, Borowsky J, Bullman S, Twombly TS, Nevo D, Masugi Y, Liu L, da Silva A, Chen Y, Du C, Gu M, Li C, Li W, Liu H, Shi Y, Mima K, Song M, Nosho K, Nowak JA, Nishihara R, Baba H, Zhang X, Wu K, Wang M, Huttenhower C, Garrett WS, Meyerson ML, Lennerz JK, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Ogino S. The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome. Am J Pathol. 2018 Sep 20. pii: S0002-9440(18)30364-X. doi: 10.1016/j.ajpath.2018.08.015. [Epub ahead of print]
  46. Hamada T, Zhang X, Mima K, Bullman S, Sukawa Y, Nowak JA, Kosumi K, Masugi Y, Twombly TS, Cao Y, Song M, Liu L, da Silva A, Shi Y, Gu M, Li W, Koh H, Nosho K, Inamura K, Keum N, Wu K, Meyerhardt JA, Kostic AD, Huttenhower C, Garrett WS, Meyerson M, Giovannucci EL, Chan AT, Fuchs CS, Nishihara R, Giannakis M, Ogino S. Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status. Cancer Immunol Res. 2018 Nov;6(11):1327-1336. doi: 10.1158/2326-6066.CIR-18-0174. Epub 2018 Sep 18.
  47. Hamada T, Liu L, Nowak JA, Mima K, Cao Y, Ng K, Twombly TS, Song M, Jung S, Dou R, Masugi Y, Kosumi K, Shi Y, da Silva A, Gu M, Li W, Keum N, Wu K, Nosho K, Inamura K, Meyerhardt JA, Nevo D, Wang M, Giannakis M, Chan AT, Giovannucci EL, Fuchs CS, Nishihara R, Zhang X, Ogino S. Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour. Eur J Cancer. 2018 Nov;103:98-107. doi: 10.1016/j.ejca.2018.07.130. Epub 2018 Sep 13.
  48. Liu PH, Lebwohl B, Burke KE, Ivey KL, Ananthakrishnan AN, Lochhead P, Olen O, Ludvigsson JF, Richter JM, Chan ATKhalili H. Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study. Am J Gastroenterol. 2018 Sep 4. doi: 10.1038/s41395-018-0267-5. [Epub ahead of print]
  49. Petrick JL, Thistle JE, Zeleniuch-Jacquotte A, Zhang X, Wactawski-Wende J, Van Dyke AL, Stampfer MJ, Sinha R, Sesso HD, Schairer C, Rosenberg L, Rohan TE, Robien K, Purdue MP, Poynter JN, Palmer JR, Newton CC, Linet MS, Liao LM, Lee IM, Koshiol J, Kitahara CM, Hofmann JN, Graubard BI, Giovannucci E, Gaziano JM, Gapstur SM, Freedman ND, Chong DQ, Chan AT, Buring JE, Beane Freeman LE, Campbell PT, McGlynn KA. Body Mass Index, Diabetes and Intrahepatic Cholangiocarcinoma Risk: The Liver Cancer Pooling Project and Meta-analysis. Am J Gastroenterol. 2018 Oct;113(10):1494-1505. doi: 10.1038/s41395-018-0207-4. Epub 2018 Sep 3.
  50. Burke KE, Ananthakrishnan AN, Lochhead P, Po-Hong Liu S, Olen O, Ludvigsson JF, Richter JM, Tworoger SS, Chan AT, Khalili H. Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis-Results From the Nurses' Health Study. Gastroenterology. 2018 Aug 23. pii: S0016-5085(18)34894-7. doi: 10.1053/j.gastro.2018.08.029. [Epub ahead of print]
  51. Kværner AS, Hang D, Giovannucci EL, Willett WC, Chan AT, Song M. Trajectories of body fatness from age 5 to 60 y and plasma biomarker concentrations of the insulin-insulin-like growth factor system. Am J Clin Nutr. 2018 Aug 1;108(2):388-397. doi: 10.1093/ajcn/nqy103.
  52. Zong G, Lebwohl B, Hu FB, Sampson L, Dougherty LW, Willett WC, Chan AT, Sun Q. Gluten intake and risk of type 2 diabetes in three large prospective cohort studies of US men and women. Diabetologia. 2018 Oct;61(10):2164-2173. doi: 10.1007/s00125-018-4697-9. Epub 2018 Aug 3.
  53. Wang X, Chan AT, Slattery ML, Chang-Claude J, Potter JD, Gallinger S, Caan B, Lampe JW, Newcomb PA, Zubair N, Hsu L, Schoen RE, Hoffmeister M, Brenner H, Le Marchand L, Peters U, White E. Influence of Smoking, Body Mass Index, and Other Factors on the Preventive Effect of Nonsteroidal Anti-Inflammatory Drugs on Colorectal Cancer Risk. Cancer Res. 2018 Aug 15;78(16):4790-4799. doi: 10.1158/0008-5472.CAN-18-0326. Epub 2018 Jun 19.
  54. Wang X1,2, Chan AT3,4, Slattery ML5, Chang-Claude J6, Potter JD7,2,8, Gallinger S9,10, Caan B11, Lampe JW7,2, Newcomb PA7,2, Zubair N2, Hsu L2, Schoen RE12, Hoffmeister M13, Brenner H13,14,15, Le Marchand L16, Peters U7,2, White E7,2. Influence of Smoking, Body Mass Index, and Other Factors on the Preventive Effect of Nonsteroidal Anti-Inflammatory Drugs on Colorectal Cancer Risk. Cancer Res. 2018 Aug 15;78(16):4790-4799. doi: 10.1158/0008-5472.CAN-18-0326. Epub 2018 Jun 19.
  55. Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL, Berndt SI, Bezieau S, Bien S, Bloomer A, Boehm J, Boutron-Ruault MC, Brenner H, Brezina S, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castelao JE, Chan AT, et al. Novel Common Genetic Susceptibility Loci for Colorectal Cancer. J Natl Cancer Inst. 2018 Jun 16. doi: 10.1093/jnci/djy099. [Epub ahead of print]
  56. Rebbeck TR, Burns-White K, Chan AT, Emmons K, Freedman M, Hunter DJ, Kraft P, Laden F, Mucci L, Parmigiani G, Schrag D, Syngal S, Tamimi RM, Viswanath K, Yurgelun MB, Garber JE. Precision Prevention and Early Detection of Cancer: Fundamental Principles. Cancer Discov. 2018 Jul;8(7):803-811. doi: 10.1158/2159-8290.CD-17-1415. Epub 2018 Jun 15.
  57. Hamada T, Soong TR, Masugi Y, Kosumi K, Nowak JA, da Silva A, Mu XJ, Twombly TS, Koh H, Yang J, Song M, Liu L, Gu M, Shi Y, Nosho K, Morikawa T, Inamura K, Shukla SA, Wu CJ, Garraway LA, Zhang X, Wu K, Meyerhardt JA, Chan AT, Glickman JN, Rodig SJ, Freeman GJ, Fuchs CS, Nishihara R, Giannakis M, Ogino S. TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas. Oncoimmunology. 2018 Mar 19;7(7):e1442999. doi: 10.1080/2162402X.2018.1442999. eCollection 2018.
  58. Kim CH, Tworoger SS, Stampfer MJ, Dillon ST, Gu X, Sawyer SJ, Chan AT, Libermann TA, Eliassen AH. Stability and reproducibility of proteomic profiles measured with an aptamer-based platform. Sci Rep. 2018 May 30;8(1):8382. doi: 10.1038/s41598-018-26640-w.
  59. Khalili H, Chan SSM, Lochhead P, Ananthakrishnan AN, Hart AR, Chan AT. The role of diet in the aetiopathogenesis of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):525-535. doi: 10.1038/s41575-018-0022-9. Review.
  60. Khalili H, Hakansson N, Chan SS, Ludvigsson JF, Olen O, Chan AT, Hart AR, Wolk A. No Association Between Consumption of Sweetened Beverages and Risk of Later-Onset Crohn's Disease or Ulcerative Colitis. Clin Gastroenterol Hepatol. 2018 May 8. pii: S1542-3565(18)30465-8. doi: 10.1016/j.cgh.2018.04.059. [Epub ahead of print]
  61. Chong DQ, Banbury BL, Phipps AI, Hua X, Kocarnik J, Peters U, Berndt SI, Huang WY, Potter JD, Slattery ML, White E, Campbell PT, Harrison T, Newcomb PA, Chan AT. Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies. Cancer Med. 2018 May;7(5):2192-2199. doi: 10.1002/cam4.1470. Epub 2018 Mar 26.
  62. Hang D, Nan H, Kværner AS, De Vivo I, Chan AT, Hu Z, Shen H, Giovannucci E, Song M. Longitudinal associations of lifetime adiposity with leukocyte telomere length and mitochondrial DNA copy number. Eur J Epidemiol. 2018 May;33(5):485-495. doi: 10.1007/s10654-018-0382-z. Epub 2018 Apr 4.
  63. Simon TG, King LY, Chong DQ, Nguyen LH, Ma Y, VoPham T, Giovannucci EL, Fuchs CS, Meyerhardt JA, Corey KE, Khalili H, Chung RT, Zhang X, Chan AT. Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies. Hepatology. 2018 May;67(5):1797-1806. doi: 10.1002/hep.29660. Epub 2018 Mar 26.
  64. Burke KE, Ananthakrishnan AN, Lochhead P, Olen O, Ludvigsson JF, Richter JM, Chan AT, Khalili H. Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. J Crohns Colitis. 2018 Apr 27;12(5):559-567. doi: 10.1093/ecco-jcc/jjy005.
  65. Petrick JL, Campbell PT, Koshiol J, Thistle JE, Andreotti G, Beane-Freeman LE, Buring JE, Chan AT, Chong DQ, Doody MM, Gapstur SM, Gaziano JM, Giovannucci E, Graubard BI, Lee IM, Liao LM, Linet MS, Palmer JR, Poynter JN, Purdue MP, Robien K, Rosenberg L, Schairer C, Sesso HD, Sinha R, Stampfer MJ, Stefanick M, Wactawski-Wende J, Zhang X, Zeleniuch-Jacquotte A, Freedman ND, McGlynn KA. Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project. Br J Cancer. 2018 Apr;118(7):1005-1012. doi: 10.1038/s41416-018-0007-z. Epub 2018 Mar 9.
  66. Khalaf N, Yuan C, Hamada T, Cao Y, Babic A, Morales-Oyarvide V, Kraft P, Ng K, Giovannucci E, Ogino S, Stampfer M, Cochrane BB, Manson JE, Clish CB, Chan AT, Fuchs CS, Wolpin BM. Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies. Gastroenterology. 2018 Apr;154(5):1380-1390.e5. doi: 10.1053/j.gastro.2017.12.001. Epub 2017 Dec 8.
  67. Cao Y, Wu K, Mehta R, Drew DA, Song M, Lochhead P, Nguyen LH, Izard J, Fuchs CS, Garrett WS, Huttenhower C, Ogino S, Giovannucci EL, Chan AT. Long-term use of antibiotics and risk of colorectal adenoma. Gut. 2018 Apr;67(4):672-678. doi: 10.1136/gutjnl-2016-313413. Epub 2017 Apr 4.
  68. Van Dyke AL, Langhamer MS, Zhu B, Pfeiffer RM, Albanes D, Andreotti G, Beane Freeman LE, Chan AT, Freedman ND, Gapstur SM, Giles GG, Grodstein F, Liao LM, Luo J, Milne RL, Monroe KR, Neuhouser ML, Poynter JN, Purdue MP, Robien K, Schairer C, Sinha R, Weinstein S, Zhang X, Petrick JL, McGlynn KA, Campbell PT, Koshiol J. Family History of Cancer and Risk of Biliary Tract Cancers: Results from the Biliary Tract Cancers Pooling Project. Cancer Epidemiol Biomarkers Prev. 2018 Mar;27(3):348-351. doi: 10.1158/1055-9965.EPI-17-1003. Epub 2018 Jan 16.
  69. Chan AT, Moayyedi P. Signature Celebration of Gastroenterology, Colorectal Cancer. Gastroenterology. 2018 Mar;154(4):767-770. doi: 10.1053/j.gastro.2017.11.029. Epub 2017 Nov 24.
  70. Hu Y, Ding M, Yuan C, Wu K, Smith-Warner SA, Hu FB, Chan AT, Meyerhardt JA, Ogino S, Fuchs CS, Giovannucci EL, Song M. Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality. Gastroenterology. 2018 Mar;154(4):916-926.e9. doi: 10.1053/j.gastro.2017.11.010. Epub 2017 Nov 20.
  71. Cao Y, Strate LL, Keeley BR, Tam I, Wu K, Giovannucci EL, Chan AT. Meat intake and risk of diverticulitis among men. Gut. 2018 Mar;67(3):466-472. doi: 10.1136/gutjnl-2016-313082. Epub 2017 Jan 9.
  72. Abu-Ali GS, Mehta RS, Lloyd-Price J, Mallick H, Branck T, Ivey KL, Drew DA, DuLong C, Rimm E, Izard J, Chan AT, Huttenhower C. Metatranscriptome of human faecal microbial communities in a cohort of adult men. Nat Microbiol. 2018 Mar;3(3):356-366. doi: 10.1038/s41564-017-0084-4. Epub 2018 Jan 15.

2017

  1. Jovani MCao Y, Feskanich D, Drew DA, Hur C, Chan AT, et al. Aspirin Use is Associated With Lower Risk of Barrett’s Esophagus in Women. Clinical and Translational Gastroenterology. 2017;8(12):e131-. doi:10.1038/ctg.2017.57.
  2. Israelsen M, Krag A, Allegretti AS, Jovani M, Goldin AH, Winter RW, Gluud LL.  Terlipressin versus other vasoactive drugs for hepatorenal syndrome. Cochrane Database Syst Rev. 2017 Sep 27;9:CD011532. doi: 10.1002/14651858.CD011532.pub2. Review. PubMed PMID: 28953318.
  3. Allegretti AS, Israelsen M, Krag A, Jovani M, Goldin AH, Shulman AR, Winter RW, Gluud LL. Terlipressin versus placebo or no intervention for people with cirrhosis and hepatorenal syndrome. The Cochrane Library, 2017. DOI: 10.1002/14651858.CD005162.pub4
  4. Moris M, Raimondo M, Woodward TA, Skinner VJ, Arcidiacono PG, Petrone MC, De Angelis C, Manfrè S, Carrara S, Jovani M, Fusaroli P, Wallace MB. International Intraductal Papillary Mucinous Neoplasms Registry: Long-Term Results Based on the New Guidelines. Pancreas. 2017 Mar;46(3):306-310. doi: 10.1097/MPA.0000000000000750. PubMed PMID: 28099263.
  5. Nguyen LH,Lochhead P,Joshi AD,Cao Y, Ma W,Khalili H, Rimm EB, Rexrode KM,Chan AT. No Significant Association Between Proton Pump Inhibitor Use and Risk of Stroke After Adjustment for Lifestyle Factors and Indication.Gastroenterology.2017 Dec 18. pii: S0016-5085(17)36710-0. doi: 10.1053/j.gastro.2017.12.006.
  6. Simon TG, King LY, Chong DQ,Nguyen L, Ma Y, VoPham T, Giovannucci EL, Fuchs CS, Meyerhardt JA, Corey KE,Khalili H, Chung RT, Zhang X,Chan AT. Diabetes, Metabolic Comorbidities and Risk of Hepatocellular Carcinoma: Results from Two Prospective Cohort Studies.Hepatology. 2017 Nov 20. doi: 10.1002/hep.29660.
  7. Liu PH,Cao Y, Keeley BR, Tam I, Wu K, Strate LL, Giovannucci EL,Chan AT. Adherence to a Healthy Lifestyle is Associated With a Lower Risk of Diverticulitis among Men.Am J Gastroenterol.2017 Dec;112(12):1868-1876. doi: 10.1038/ajg.2017.398.
  8. Song M, Wu K, Meyerhardt JA, Ogino S, Wang M, Fuchs CS, Giovannucci EL, Chan AT. Fiber Intake and Survival After Colorectal Cancer Diagnosis. JAMA Oncol. 2018 Jan 1;4(1):71-79. doi: 10.1001/jamaoncol.2017.3684.
  9. Ananthakrishnan AN,Khalili H,Song M, Higuchi LM,Lochhead P, Richter JM,Chan AT. Genetic Polymorphisms in Fatty Acid Metabolism Modify the Association Between Dietary n3: n6 Intake and Risk of Ulcerative Colitis: A Prospective Cohort Study.Inflamm Bowel Dis.2017 Nov;23(11):1898-1904. doi: 10.1097/MIB.0000000000001236.
  10. Lochhead P, Hagan K,Joshi AD,Khalili H,Nguyen LH, Grodstein F,Chan AT. Association Between Proton Pump Inhibitor Use and Cognitive Function in Women.Gastroenterology.2017 Oct;153(4):971-979.e4. doi: 10.1053/j.gastro.2017.06.061.
  11. Khalili H, de Silva PS,Ananthakrishnan AN,Lochhead P, Joshi A, Garber JJ, Richter JR, Sauk J,Chan AT. Dietary Iron and Heme Iron Consumption, Genetic Susceptibility, and Risk of Crohn's Disease and Ulcerative Colitis.Inflamm Bowel Dis.2017 Jul;23(7):1088-1095. doi: 10.1097/MIB.0000000000001161.
  12. Lebwohl B,Cao Y, Zong G, Hu FB, Green PHR, Neugut AI, Rimm EB, Sampson L, Dougherty LW, Giovannucci E, Willett WC, Sun Q,Chan AT. Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study.BMJ. 2017 May 2;357:j1892. doi: 10.1136/bmj.j1892.
  13. Cao Y, Wu K,Mehta R,Drew DA,Song M,Lochhead P,Nguyen LH, Izard J, Fuchs CS, Garrett WS, Huttenhower C, Ogino S, Giovannucci EL,Chan AT. Long-term use of antibiotics and risk of colorectal adenoma.Gut.2017 Apr 4. pii: gutjnl-2016-313413. doi: 10.1136/gutjnl-2016-313413.
  14. Mehta RS,Song M, Nishihara R,Drew DA, Wu K, Qian ZR, Fung TT, Hamada T, Masugi Y, da Silva A, Shi Y, Li W, Gu M, Willett WC, Fuchs CS, Giovannucci EL, Ogino S,Chan AT. Dietary Patterns and Risk of Colorectal Cancer: Analysis by Tumor Location and Molecular Subtypes.Gastroenterology.2017 Jun;152(8):1944-1953.e1. doi: 10.1053/j.gastro.2017.02.015.
  15. Strate LL, Keeley BR,Cao Y, Wu K, Giovannucci EL,Chan AT. Western Dietary Pattern Increases, and Prudent Dietary Pattern Decreases, Risk of Incident Diverticulitis in a Prospective Cohort Study.Gastroenterology.2017 Apr;152(5):1023-1030.e2. doi: 10.1053/j.gastro.2016.12.038.
  16. Warner ET, Carapinha R, Weber GM, Hill EV, Reede JY. Gender Differences in Receipt of National Institutes of Health R01 Grants Among Junior Faculty at an Academic Medical Center: The Role of Connectivity, Rank, and Research Productivity.J Womens Health (Larchmt). 2017 Oct;26(10):1086-1093. doi: 10.1089/jwh.2016.6102.
  17. Drew DA, Nishihara R,Lochhead P, Kuchiba A, Qian ZR, Mima K, Nosho K, Wu K, Wang M, Giovannucci E, Fuchs CS,Chan AT, Ogino S. A Prospective Study of Smoking and Risk of Synchronous Colorectal Cancers.Am J Gastroenterol.2017 Mar. doi: 10.1038/ajg.2016.589.
  18. Drew DA,Chin SM,Gilpin KK,Parziale M,Pond E,Schuck MM,Stewart K, Flagg M, Rawlings CA, Backman V, Carolan PJ, Chung DC, Colizzo FP 3rd, Freedman M,Gala M, Garber JJ, Huttenhower C, Kedrin D,Khalili H, Kwon DS, Markowitz SD, Milne GL, Nishioka NS, Richter JM, Roy HK,Staller K, Wang M,Chan AT. ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial.Trials. 2017 Feb 1;18(1):50. doi: 10.1186/s13063-016-1744-z.
  19. Spring L, Marshall M,Warner ET. Mammography decision-making: Trends, predictors and effects of provider communication in the Health Information National Trends Survey 2011-2014.Cancer.2017 Feb 1. doi: 10.1002/cncr.30378
  20. Mehta RS, Nishihara R,Cao Y,Song M, Mima K, Qian ZR, Nowak JA, Kosumi K, Hamada T, Masugi Y, Bullman S,Drew DA, Kostic AD, Fung TT, Garrett WS, Huttenhower C, Wu K, Meyerhardt JA, Zhang X, Willett WC, Giovannucci EL, Fuchs CS,Chan AT, Ogino S. Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium Nucleatum in Tumor Tissue.JAMA Oncol. 2017 Jan 26. doi: 10.1001/jamaoncol.2016.6374.
  21. Cao Y, Strate LL, Keeley BR, Wu K, Giovannucci EL,Chan AT. Meat consumption and risk of incident diverticulitis.Gut.2017 Jan 9. doi: 10.1136/gutjnl-2016-313082
  22. Chu JN, Choi J, Tramontano A, Morse C, Forcione D, Nishioka NS, Abrams JA, Rubenstein JH, Kong CY, Inadomi JM,Hur C. Surgical vs Endoscopic Management of T1 Esophageal Adenocarcinoma: A Modeling Decision Analysis.Clin Gastroenterol Hepatol. 2017 Nov 24. pii: S1542-3565(17)31249-1. doi: 10.1016/j.cgh.2017.10.024.
  23. Kabrhel C, Ali A, Choi JG,Hur C. Systemic Thrombolysis, Catheter-Directed Thrombolysis, and Anticoagulation for Intermediate-risk Pulmonary Embolism: A Simulation Modeling Analysis.Acad Emerg Med. 2017 Oct;24(10):1235-1243. doi: 10.1111/acem.13242.
  24. Lubitz C, Ali A, Zhan T, Heberle C, White C, Ito Y, Miyauchi A, Gazelle GS, Kong CY,Hur C. The thyroid cancer policy model: A mathematical simulation model of papillary thyroid carcinoma in The U.S. population.PLoS One. 2017 May 8;12(5):e0177068. doi: 10.1371/journal.pone.0177068.
  25. Tramontano AC, Sheehan DF, Yeh JM, Kong CY, Dowling EC, Rubenstein JH, Abrams JA, Inadomi JM, Schrag D,Hur C. The Impact of a Prior Diagnosis of Barrett's Esophagus on Esophageal Adenocarcinoma Survival.Am J Gastroenterol.2017 Aug;112(8):1256-1264. doi: 10.1038/ajg.2017.82.
  26. Heberle CR, Omidvari AH, Ali A, Kroep S, Kong CY, Inadomi JM, Rubenstein JH, Tramontano AC, Dowling EC, Hazelton WD, Luebeck EG, Lansdorp-Vogelaar I,Hur C. Cost Effectiveness of Screening Patients With Gastroesophageal Reflux Disease for Barrett's Esophagus With a Minimally Invasive Cell Sampling Device.Clin Gastroenterol Hepatol. 2017 Sep;15(9):1397-1404.e7. doi: 10.1016/j.cgh.2017.02.017.
  27. Kroep S, Heberle CR, Curtius K, Kong CY, Lansdorp-Vogelaar I, Ali A, Wolf WA, Shaheen NJ, Spechler SJ, Rubenstein JH, Nishioka NS, Meltzer SJ, Hazelton WD, van Ballegooijen M, Tramontano AC, Gazelle GS, Luebeck EG, Inadomi JM,Hur C. Radiofrequency Ablation of Barrett's Esophagus Reduces Esophageal Adenocarcinoma Incidence and Mortality in a Comparative Modeling Analysis.Clin Gastroenterol Hepatol. 2017 Sep;15(9):1471-1474. doi: 10.1016/j.cgh.2016.12.034.
  28. Klebanoff MJ,Corey KE, Chhatwal J, Kaplan LM, Chung RT,Hur C. Bariatric surgery for nonalcoholic steatohepatitis: A clinical and cost-effectiveness analysis.Hepatology. 2017 Apr;65(4):1156-1164. doi: 10.1002/hep.28958
  29. Borren NZ, Conway G, Garber JJ,Khalili H, Budree S, Mallick H, Yajnik V, Xavier RJ,Ananthakrishnan AN. Difference in clinical course, genetics, and the microbiome between familial and sporadic inflammatory bowel diseases.J Crohns Colitis. 2017 Nov 14. doi: 10.1093/ecco-jcc/jjx154.
  30. Gupta A, Agarwal R,Ananthakrishnan AN. "Weekend Effect" in Patients With Upper Gastrointestinal Hemorrhage: A Systematic Review and Meta-analysis.Am J Gastroenterol.2018 Jan;113(1):13-21. doi: 10.1038/ajg.2017.430.
  31. Borren NZ, Conway G, Tan W, Andrews E, Garber JJ, Yajnik V,Ananthakrishnan AN. Distance to Specialist Care and Disease Outcomes in Inflammatory Bowel Disease.Inflamm Bowel Dis.2017 Jul;23(7):1234-1239. doi: 10.1097/MIB.0000000000001133.
  32. Ananthakrishnan AN, Luo C, Yajnik V,Khalili H, Garber JJ, Stevens BW, Cleland T, Xavier RJ. Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases.Cell Host Microbe. 2017 May 10;21(5):603-610.e3. doi: 10.1016/j.chom.2017.04.010
  33. Borren NZ, Ghadermarzi S, Hutfless S,Ananthakrishnan AN. The emergence of Clostridium difficile infection in Asia: A systematic review and meta-analysis of incidence and impact.PLoS One. 2017 May 2;12(5):e0176797. doi: 10.1371/journal.pone.0176797.
  34. Burke KE, Boumitri C,Ananthakrishnan AN. Modifiable Environmental Factors in Inflammatory Bowel Disease.Curr Gastroenterol Rep. 2017 May;19(5):21. doi: 10.1007/s11894-017-0562-0.
  35. Ananthakrishnan AN, Donaldson T, Lasch K, Yajnik V. Management of Inflammatory Bowel Disease in the Elderly Patient: Challenges and Opportunities.Inflamm Bowel Dis.2017 Jun;23(6):882-893. doi: 10.1097/MIB.0000000000001099.
  36. Velonias G, Conway G, Andrews E, Garber JJ,Khalili H, Yajnik V,Ananthakrishnan AN. Older Age- and Health-related Quality of Life in Inflammatory Bowel Diseases.Inflamm Bowel Dis.2017 Feb;23(2):283-288. doi: 10.1097/MIB.0000000000001008.
  37. Staller K, Barshop K, Kuo B,Ananthakrishnan AN. Depression but Not Symptom Severity is Associated With Work and School Absenteeism in Refractory Chronic Constipation.J Clin Gastroenterol. 2017 Jan 5. doi: 10.1097/MCG.0000000000000782.
  38. Rice MS, Tworoger SS, Hankinson SE, Tamimi RM, Eliassen AH, Willett WC, Colditz G, Rosner B. Breast cancer risk prediction: an update to the Rosner-Colditz breast cancer incidence model.Breast Cancer Res Treat. 2017 Nov;166(1):227-240. doi: 10.1007/s10549-017-4391-5.
  39. Rice MS, Rosner BA, Tamimi RM. Percent mammographic density prediction: development of a model in the nurses' health studies.Cancer Causes Control. 2017 Jul;28(7):677-684. doi: 10.1007/s10552-017-0898-7.
  40. Staller K, Barshop K,Ananthakrishnan AN, Kuo B. Number of retained radiopaque markers on a colonic transit study does not correlate with symptom severity or quality of life in chronic constipation.Neurogastroenterol Motil. 2017 Dec 18. doi: 10.1111/nmo.13269.
  41. Barshop K,Staller K. Eluxadoline in irritable bowel syndrome with diarrhea: rationale, evidence and place in therapy.Ther Adv Chronic Dis. 2017 Nov;8(11):153-160. doi: 10.1177/2040622317714389.
  42. Koyfman S, Swartz K, Goldstein AM,Staller K. Laparoscopic-Assisted Percutaneous Endoscopic Cecostomy (LAPEC) in Children and Young Adults. J Gastrointest Surg. 2017 Apr;21(4):676-683. doi: 10.1007/s11605-016-3353-2
  43. Zakari M, Nee J, Hirsch W, Kuo B, Lembo A,Staller K. Gender differences in chronic constipation on anorectal motility.Neurogastroenterol Motil. 2017 Apr;29(4). doi: 10.1111/nmo.12980.

2016 

  1. Huang T, Tworoger SS, Hecht JL,Rice MS, Sood AK, Kubzansky LD, Poole EM. Association of ovarian tumor β2-adrenergic receptor status with ovarian cancer risk factors and survival. Cancer Epidemiol Biomarkers Prev. 2016 Dec;25(12):1587-1594
  2. Warner ET, Hu R, Collins LC, Beck AH, Schnitt S, Rosner BA, Eliassen AH, Michels KB, Willett WC, Tamimi RM. Height and body size in childhood, adolescence and young adulthood and breast cancer risk according to molecular subtype in the Nurses’ Health Studies.Cancer Prev Res (Phila). 2016 Sep;9(9):732-8. doi: 10.1158/1940-6207.CAPR-16-0085.
  3. Rice MS, Eliassen AH, Hankinson SE, Lenart EB, Willett WC, Tamimi RM. Breast Cancer Research in the Nurses' Health Studies: Exposures Across the Life Course. Am J Public Health. 2016 Sep;106(9):1592-8.
  4. Song M, Giovannucci E. Preventable incidence and mortality of carcinoma associated with lifestyle factors among white adults in the United States.JAMA Oncol. 2016 Sep 1;2(9):1154-61. doi: 10.1001/jamaoncol.2016.0843.
  5. Rice MS, Bertrand KA, VanderWeele TJ, Rosner BA, Liao X, Adami H, Tamimi RM. Mammographic density and breast cancer risk: a mediation analysis. Breast Cancer Res. 2016 Sep 21;18(1):94
  6. Eliassen AH,Warner ET, Rosner BA, Collins LC, Beck AH, Quintana LM, Tamimi RM, Hankinson SE. Plasma 25-hydroxyvitamin D and risk of breast cancer in women followed over 20 years.Cancer Res. 2016 Aug 16. pii: canres.0353.2016.
  7. Cao Y, Nishihara R, Wu K, Wang M, Ogino S, Willett WC, Spiegelman D, Fuchs, CS, Giovannucci EL,Chan AT. Population-wide impact of long-term use of aspirin and the risk of cancer.JAMA Oncol. 2016;2(6):762-769. doi:10.1001/jamaoncol.2015.6396
  8. Partridge AH, Hughes ME,Warner ET, Ottesen RA, Wong YN, Edge SB, Theriault RL, Blayney DW, Niland JC, Winer EP, Weeks JC. Tamimi RM. Subtype-dependent relationship between young age at diagnosis and breast cancer survival.J Clin Oncol. 2016 Aug 1. pii: JCO658013.
  9. Cao Yand Giovannucci EL. Alcohol as a risk factor for cancer.Seminars in Oncology Nursing. 2016 Aug;32(3):325-31.
  10. Cao Yand Giovannucci EL. Obesity and prostate cancer. Obesity and Cancer in Recent Results in Cancer Research, edited by Katharina Nimptsch and Tobias Pischon.Springer. 2016. 208:137-153.
  11. Cao Y*, Nishihara R*, Qian ZR*,Song M*et al.and Giovannucci EL*, Fuchs CS*,Chan AT*, Ogino S*. Regular aspirin use associates with lower risk of colorectal cancers with low numbers of tumor-infiltrating lymphocytes.Gastroenterology. 2016 Jul 27. doi: 10.1053/j.gastro.2016.07.030. (*co-first/senior author)
  12. Warner ET, Ballman KV, Strand C, Boughey JC, Buzdar AU, Carey LA, Sikov WM, Partridge AH. Impact of race, ethnicity and BMI on achievement of pathologic complete response following neoadjuvant chemotherapy for breast cancer: a pooled analysis of four prospective Alliance clinical trials (a151426).Breast Cancer Res Treat. 2016 Aug;159(1):109-18. doi: 10.1007/s10549-016-3918-5. Epub 2016 Jul 22.

2015

  1. Gala MK, Austin T, Ogino S,Chan AT. TFF2-CXCR4 Axis is associated with BRAF V600E colon cancer. Cancer Prev Res. 2015 Apr 21. PMCID: PMC4490961.
  2. Song M, Nishihara R, Wu K, Qian ZR, Kim SA, Sukawa Y, Mima K, Inamura K, Masuda A, Yang J, Fuchs CS, Giovannucci EL, Ogino S,Chan AT. Marine n-3 polyunsaturated fatty acids and risk of colorectal cancer according to microsatellite instability. J Natl Cancer Inst. 2015 Mar 25; 107(4). PMCID: PMC4402363.
  3. Nan H, Hutter CM, Lin Y, Jacobs EJ, Ulrich CM, White E, Baron JA, Berndt SI, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G, Chang-Claude J, Chanock SJ, Cotterchio M, Duggan D, Figueiredo JC, Fuchs CS, Giovannucci EL, Gong J, Haile RW, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hudson TJ, Jenkins MA, Jiao S, Lindor NM, Lemire M, Le Marchand L, Newcomb PA, Ogino S, Pflugeisen BM, Potter JD, Qu C, Rosse SA, Rudolph A, Schoen RE, Schumacher FR, Seminara D, Slattery ML, Thibodeau SN, Thomas F, Thornquist M, Warnick GS, Zanke BW, Gauderman WJ, Peters U, Hsu L,Chan AT. Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. JAMA. 2015 Mar 17. PMCID: PMC4382867
  4. Mehta RS, Chong DQ,Song M, Meyerhardt JA, Ng K, Nishihara R, Qian Z, Morikawa T, Wu K, Giovannucci EL, Fuchs CS, Ogino S,Chan AT. Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality. Gastroenterology. 2015;149(3):614-622. doi:10.1053/j.gastro.2015.05.038.
  5. Maguire LH,Song M, Strate LL, Giovannucci EL,Chan AT. Association of geographic and seasonal variation with diverticulitis admissions. JAMA Surg. 2015 Jan; 150(1) 74-7.

2014

  1. King LY, Johnson KB, Zheng H, Wei L, Gudewicz T, Hoshida Y,
  2. Corey KE, Ajayi T, Ufere N, Baumert TF,Chan AT, Tanabe KK, Fuchs BC, Chung RT. Host genetics predict clinical deterioration in HCV-related cirrhosis. PLoS One. 2014 Dec 12;9(12):e114747. doi: 10.1371/journal.pone.0114747. eCollection 2014. PMCID: PMC4264769.
  3. Franzosa EA, Morgan XC, Segata N, Waldron L, Reyes J, Earl AM, Giannoukos G, Boylan MR, Ciulla D, Gevers D, Izard J, Garrett WS,Chan AT, Huttenhower C. Relating the metatranscriptome and metagenome of the human gut. Proc Natl Acad Sci USA. 2014 May 19. PMCID: PMC4050606.
  4. Bezawada N,Song M, Wu K,Mehta RS, Milne G, Fuchs CS, Giovannucci EL,Chan AT. Urinary prostaglandin metabolites (PGE-M) are associated with risk of colorectal adenomas and chemopreventive response to anti-inflammatory drugs. Cancer Prev Res. 2014 May 13. PMCID: PMC4085181.
  5. Fink S, Yamauchi, M, Nishihara R, Jung S, Kuchiba A, Wu K, Cho E, Giovannucci E, Fuchs C, Ogino S, Markowitz SD,Chan AT. Aspirin and the risk of colorectal cancer in relation to expression of 15-Hydroxyprostaglandin dehydrogenase expression. Sci Transl Med 2014 Apr 23; 6(233). PMCID:PMC4030641.
  6. Konijeti GG, Shrime MG,Ananthakrishnan AN,Chan AT. Cost-effectiveness analysis of chromoendoscopy for colorectal cancer surveillance in patients with ulcerative colitis. Gastrointest Endosc. 2014 Mar; 79(3): 455-65. PMCID: PMC4116277.
  7. Boylan, MR,Khalili H, Huang ES, Michaud DS, Izard J, Joshipura KJ,Chan AT. A prospective study of periodontal disease and risk of gastric and duodenal ulcer in male health professionals. Clin Transl Gastroenterol. 2014;5:e49. PMCID: PMC3940834.
  8. Mehta RS, Bezawada N, Wu K, Garcia-Albeniz X, Morikawa T, Fuchs CS, Ogino S, Giovannucci E,Chan AT. A prospective study of macrophage inhibitory cytokine-1 and risk of colorectal cancer. J Natl Cancer Inst. 2014 Feb 24. [Epub ahead of print]. PMID: 24565956. PMCID: PMC3982884.

2013 

  1. Nan H, Morikawa T, Suuriniemi M, Imamura Y, Werner L, Kuchiba A, Yamauchi M, Hunter DJ, Kraft P, Giovannucci EL, Fuchs CS, Ogino S, Freedman ML,Chan AT. Aspirin use, 8q24 single nucleotide polymorphism rs6983267 and colorectal cancer according to CTNNB1 alterations. J Natl Cancer Inst 2013 Dec 18; 105(24): 1852-61. PMCID: PMC3866156.
  2. Maguire LH,Song M, Strate LE, Giovannucci EL,Chan AT. Higher serum levels of vitamin D are associated with reduced risk of diverticulitis. Clin Gastro Hepatol 2013. PMCID: PMC3840074.
  3. Khalili H,Ananthakrishnan AN, Konijeti GG, Liao X, Higuchi LM, Fuchs CS, Spiegelman D, Richter JM, Korzenik JR,Chan AT. Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses’ Health Study cohorts. BMJ. 2013 Nov 14. PMCID: PMC3935281.
  4. Hiraki LT, Qu C, Hutter CM, Baron J, Berndt SI, Bezieau S, Brenner H, Caan BJ, Casey G, Chang-Claude J, Chanock SJ, Conti DV, Duggan D, Fuchs CS, Gallinger S, Giovannucci EL, Harrison TA, Hayes RB, Hazra A, Henderson B, Hoffmeister M, Hopper JL, Hudson TJ, Jenkins MA, Küry S, Le Marchand L, Lemire M, Ma J, Manson JE, Nan H, Newcomb PA, Ng K, Potter JD, Schoen RE, Schumacher F, Seminara D, Slattery ML, Wactawski-Wende J, White E, Wu K, Zanke BW, Kraft P, Peters U,Chan AT. Genetic predictors of circulating vitamin 25-Hydroxyvitamin D and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2013. PMCID: PMC3818310.
  5. Nishihara R, Wu K,Lochhead P, Morikawa T, Liao X, Qian ZR, Inamura K, Kim SA, Kuchiba A, Yamauchi M, Imamura Y, Willett WC, Rosner BR, Fuchs CS, Giovannucci E, Ogino S,Chan AT. Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med 2013 Sept 19; 369(12):1095-105. PMCID: PMC3840160.
  6. Nishihara R,Lochhead P, Kuchiba A, Jung S, Yamauchi M, Liao X, Imamura Y, Qian ZR, Morikawa T, Wang M, Spiegelman D, Cho E, Giovannucci E, Fuchs CS,Chan AT*, Ogino S* (co-senior authors). Aspirin use and risk of colorectal cancer according to BRAF mutation status. JAMA. 2013. 309(24): 2563-71. PMCID: PMC3743040
  7. Ananthakrishnan AN,Khalili H, Konijeti GG, Higuchi LM, de Silva P, Korzenik JR, Fuchs CS, Willett WC, Richter JM,Chan AT. A prospective study of long-term intake of dietary fiber and risk of Crohn’s disease and ulcerative colitis. Gastroenterology. 2013 Aug 1. PMCID: PMC3805714.
  8. ,Khalili H, Konijeti GG, Higuchi LM, de Silva P, Fuchs CS, Willett WC, Richter JM,Chan AT. Long-term intake of dietary fat and risk of ulcerative colitis and Crohn’s disease. Gut. 2013 Jul 4. PMCID: PMC3915038.
  9. Forman JP, Scott JB, Ng K, Drake BF, Suarez EG, Hayden DL, Bennett GG, Chandler PD, Hollis BW, Emmons KM, Giovannucci EL, Fuchs CS,Chan AT. Effect of vitamin D supplementation in blacks. Hypertension. 2013 Apr;61(4):779-85. PMCID: PMC3775458.

2012 

  1. Khalili H, Higuchi LM,Ananthakrishnan AN, Manson JE, Feskanich D, Richter JM, Fuchs CS,Chan AT. Hormone therapy increases risk of ulcerative colitis but not Crohn's disease. Gastroenterology. 2012 Nov. 143(5); 33(32): 8026-33. PMCID:PMC3480540
  2. Liao X,Lochhead, P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Imamura Y, Qian Z, Baba Y, Shima K;, Meyerhardt JA, Giovannucci E, Fuchs CS;Chan AT*, Ogino S* (co-senior authors) . Aspirin use, PIK3CA mutation, and colorectal cancer survival. N Engl J Med 2012 Oct 25;367(17):1596-606. PMCID: PMC3532946
  3. Phipps AI, Newcomb PA*, Garcia-Albeniz X, Hutter CM, White E, Fuchs CS, Hazra A, Ogino S, Nan H, Ma J, Campbell PT, Figueiredo JC, Peters U,Chan AT. Association between colorectal cancer susceptibility loci and survival time following diagnosis with colorectal cancer. Gastroenterology 2012 July. 143(1): 51-54. PMCID: PMC3579620.
  4. Khalili H, Huang ES, Ogino S, Fuchs CS,Chan AT. A prospective study of bisphosphonate use and risk of colorectal cancer. J Clin Oncology. 2012 May 29. PMCID: PMC3434982.
  5. Khalili H, Huang ES, Jacobson BC, Camargo CA, Feskanich D,Chan AT. Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective study. BMJ 2012; 344: e372. PMCID: PMC3269660.
  6. Ananthakrishan AN,Khalili H, Higuchi LM, Bao Y, Korzenik JR, Giovannucci EL, Richter JM, Fuchs CS,Chan AT. Higher predicted vitamin D status is associated with reduced risk of Crohn’s disease. Gastroenterology 2012; 142(3): 482-9. PMCID: PMC3367959.
  7. Ananthakrishan AN, Higuchi LM, Huang ES,Khalili H, Richter JM, Fuchs CS,Chan AT. Aspirin, nonsteroidal anti-inflammatory drugs, and risk for Crohn disease and ulcerative colitis: a cohort study. Ann Internal Med 2012; 156 (5): 350-59. PMCID: PMC3369539.
  8. Khalili H, Higuchi L,Ananthakrishnan AN, Feskanich D, Richter JR, Fuchs CS,Chan AT. Oral contraceptives, reproductive factors and risk of inflammatory bowel disease. Gut 2012 May 22. PMCID: PMC3465475.
  9. Khalili H, Huang ES,Ananthakrishnan AN, Higuchi L, Richter JM, Fuchs CS,Chan AT. Geographical variation and the risk of inflammatory bowel disease among U.S. women. Gut 2012 Jan 11. PMCID: PMC3418414.

2011 

  1. Chan AT, Ogino S, Giovannucci EL, Fuchs CS. Inflammatory markers are associated with risk of colorectal cancer and chemopreventative response to anti-inflammatory drugs. Gastroenterology. 2011. 140(3): 799-808. PMCID: PMC3049858.
  2. Huang ES, Strate LL, Ho WH, Lee SS,Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. Am J Med. 2011. 124(5): 426-33. PMCID: PMC3086018.
  3. Strate LL, Liu YL, Huang ES, Giovannucci EL,Chan AT. Use of aspirin and nonsteroidal anti-inflammatory drugs increases risk of diverticulitis and diverticular bleeding. Gastroenterology. 2011; 140: 1427-1433. PMCID: PMC3081980.
  4. Chan AT, Sima CS, Zauber AG, Ridker PM, Hawk ET, Bertagnolli MM. C-reactive protein and risk of colorectal adenoma according to celecoxib treatment. Cancer Prev Res. 2011. 4(8): 1-9. PMCID: PMC3151679.

Publications prior to 2011

  1. Chan AT, Baba Y, Shima K, Nosho K, Chung DC, Hung KE, Mahmood U, Madden K, Poss K, Ranieri A, Shue D, Kucherlapati R, Fuchs CS, Ogino S. Cathepsin B expression and survival in colon cancer: Implications for molecular detection of neoplasia. Cancer Epidemiol Biomarkers Prev. 2010. 19 (11): 2777-85. PMCID: PMC2976771.
  2. Huang ES, Strate LL, Ho WH, Lee SS,Chan AT. A prospective study of aspirin use and the risk of gastrointestinal bleeding in men. PLOS One. 2010 Dec 29; 5(12): e15721. PMCID: PMC3012090
  3. Chan AT, Zauber AG, Hsu M, Breazna A, Hunter DJ, Rosenstein RB, Eagle CJ, Hawk ET, Bertagnolli MM. Cytochrome P450 2C9 Variants Influence Response to Celecoxib for Prevention of Colorectal Adenoma. Gastroenterology. 2009;136(7):2127-36. PMCID: PMC2693443.
  4. Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA. 2009;302(6):649-58. PMCID: PMC2848289.
  5. Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Wu K, Fuchs CS. Aspirin dose and duration of use and risk of colorectal cancer in men. Gastroenterology. 2008;134(1):21-8. NIHMSID: NIHMS38884.
  6. Chan AT, Manson JE, Feskanich D, Stampfer MJ, Colditz GA, Fuchs CS. Long-term aspirin use and mortality in women. Arch Intern Med. 2007;167(6):562-72.
  7. Chan AT, Ogino S, Fuchs CS. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med. 2007;356(21):2131-42.
  8. Cho E, Willett WC, Colditz GA, Fuchs CS, Wu K,Chan AT, Zeisel SH, Giovannucci EL. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst. 2007;99(16):1224-31. PMCID: PMC2441932.
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