A new health and economic model clearly shows why it’s imperative that food manufacturers reduce the amount of added sugar in their products.
Department of Medicine
Xia Lab: Yin Xia, PhD
Explore This Research Lab
We are interested in the role of repulsive guidance molecule (RGM) family members including RGMa, RGMb (Dragon) and RGMc (hemojuvelin) in various aspects of mammalian physiology and development. RGMs have been recently identified by us to be the first co-receptors for bone morphogenetic protein (BMP) signaling. The mechanisms by which RGMs regulate BMP signaling are being studied.
Hereditary hemochromatosis (HH) is a genetic disorder characterized by high levels of iron absorption from the diet, leding to iron overload. HH is linked to mutations in several genes, namely HFE, TFR2 (encoding transferrin receptor 2), HFE2 (encoding hemojuvelin/RGMc), or HAMP (encoding hepcidin). A small peptide secreted by the liver, hepcidin is an important regulator of body iron stores. Our studies have shown that hemojuvelin-mediated BMP signaling increases hepcidin expression both in-vitro and in-vivo. The precise combinations of BMP ligands and receptors used by hemojuvelin are being dissected using both in-vivo studies and in-vitro transfected liver cells.
RGMb (Dragon) is highly expressed in the ovary and kidney. Our Dragon knockout mice show defects in ovarian follicle development and kidney branching morphogenesis. The role of Dragon in ovarian function and in kidney development and function is being investigated.
- Xia Y, Sidis Y, Mukherjee A, Samad T, Brenner G, Woolf C, Lin HY, and Schneyer A. Localization and action of Dragon (RGMb), a novel BMP co-receptor, throughout the reproductive axis. Endocrinology. 2005. 146: 3614-3621.
- Xia Y, Yu P, Sidis Y, Schneyer A, Bloch KD, and Lin HY. Repulsive guidance molecule (RGMa) alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. Journal of Biological Chemistry. 2007. 282: 18129-18140.
- Xia Y, Babitt JL, and Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008. 111: 5195-5204.
- Andriopoulos B Jr*, Corradini E*, Xia Y*, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietragelo A, Vukicevic S, Lin HY, and Babitt JL. BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nature Genetics. 2009. 41: 482-487. (*co-first author)
- Aug | 13 | 2021
In this interview, Kerry Reynolds, MD chats with Meghan Sise, MD, director of onconephrology at Mass General Hospital, to learn more about how immune checkpoint inhibitor (ICI) therapy affects kidney function.
- Press Release
- Jul | 8 | 2021
Las puntuaciones de riesgo genético podrían mejorar la identificación clínica de los pacientes con mayor riesgo de infarto
Un equipo descubrió recientemente que la aplicación de la PRS puede identificar a los pacientes de riesgo que actualmente no se identifican mediante las evaluaciones clínicas estándar.
- Press Release
- Jun | 7 | 2021
Automated emails and letters that provide personalized feedback related to cafeteria purchases at work may help employees make healthier food choices.
- Staff Story
- Nov | 17 | 2020
Winfred W. Williams, MD, has been named a deputy editor of The New England Journal of Medicine. Williams, who is associate chief of the Division of Nephrology, becomes the first African American to serve in that role.
- Press Release
- Sep | 2 | 2020
Mass General study demonstrates that kidneys infected with hepatitis C can be safely transplanted into healthy recipients
Mass General study demonstrates that kidneys infected with hepatitis C can be safely transplanted into healthy recipients.
About the Nephrology Division
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.