Obesity, Metabolism and Nutrition Institute (OMNI)
The Obesity, Metabolism and Nutrition Institute (OMNI) at Massachusetts General Hospital is a multidisciplinary research and education center that investigates obesity and its complications, as well as the molecular, cellular and physiological regulation of energy balance and metabolic function.
The faculty and staff at the Obesity, Metabolism and Nutrition Institute (OMNI) are leaders within their field and work together to provide educational training on obesity and advance innovation within obesity medicine.
Lee Kaplan, MD, PhD
Lee M. Kaplan, MD, PhD, graduated from Harvard University and received his medical degree and doctorate in molecular biology from the Albert Einstein College of Medicine at Yeshiva University. He completed an internship and residency in internal medicine and a fellowship in gastroenterology at Mass General and Harvard Medical School and a fellowship in genetics at Brigham and Women’s Hospital.
He is director of the fellowship program in Obesity Medicine and Nutrition at Mass General, director of the Blackburn Course in Obesity Medicine at Harvard Medical School and chairman emeritus of the Campaign to End Obesity. He currently serves as chair of the Obesity, Metabolism and Nutrition Section of the American Gastroenterological Association (AGA), chair of the Bariatric Surgery Section and chair of the Clinical Committee of the Obesity Society.
Dr. Kaplan’s research is focused on the physiological and molecular mechanisms of gastrointestinal regulation of energy balance and metabolic function, and his group has pioneered the development and use of rodent models for weight loss surgery and gastrointestinal devices to explore these mechanisms. He is the author of more than 150 scientific and medical papers, including in The New England Journal of Medicine, Nature, Nature Genetics, Nature Medicine, Science Translational Medicine, the Proceedings of the National Academy of Sciences, the Journal of Clinical Investigation, Gastroenterology and the American Journal of Human Genetics.
Jill Carmody, PhD
Jill Carmody, PhD, is an Instructor in Medicine at Mass General and Harvard Medical School conducting research at the Obesity, Metabolism and Nutrition Institute. She received her doctorate in Nutritional and Metabolic Biology in 2010 from the Institute of Human Nutrition at Columbia University. Dr. Carmody’s current research examines the physiological mechanisms underlying the profound weight loss and diabetes resolution that is observed after gastric bypass surgery.
Ida Hatoum, ScD
Ida Hatoum, ScD, is a postdoctoral fellow at Mass General and Harvard Medical School conducting research at the Obesity, Metabolism and Nutrition Institute. As a doctoral student at Harvard School of Public Health, Dr. Hatoum was the inaugural recipient of the Pritzker Fellowship for Obesity Research. Upon graduating from the departments of Nutrition and Epidemiology in 2009, she joined the Obesity, Metabolism and Nutrition Institute and completed a postdoctoral Masters of Medical Science at Harvard Medical School in Computational Bioinformatics. Dr. Hatoum seeks to use computational approaches such as genomics and transcriptomics to understand the mechanisms underlying the development of human obesity and its related conditions, and to use that understanding to facilitate the development of more effective preventive treatment strategies for obesity.
Sriram Machineni, MD
Sriram Machineni, MD, is an obesity medicine specialist at the Mass General Weight Center and serves on the faculty of the Mass General Obesity Metabolism and Nutrition Institute. Dr. Machineni is the assistant director of the Blackburn Course in Obesity Medicine at Harvard Medical School and the co-director of the Obesity Medicine Board Review Course. He is fellowship-trained in obesity medicine at Mass General, board-certified in internal medicine and a 2012 Diplomate of the American Board of Obesity Medicine.
Dr. Machineni specializes in treatment of obesity and its accompanying complications and has extensive expertise in obesity pharmacotherapy. His research focuses on the mechanisms of energy regulation after weight loss surgery to help develop new therapies for obesity. His teaching interests include the development of new tools and approaches for the treatment of obesity in the primary care setting, and he leads a program to educate primary care practitioners at Mass General on the use of a staged approach to the management of obesity.
Dorothy Pazin, PhD
Dorothy Pazin, PhD, is the research program manager for the Obesity, Metabolism and Nutrition Institute at Mass General. After completing a doctorate in genetics and genomics at Boston University School of Medicine, Dr. Pazin worked as a post-doctoral fellow at the Harvard School of Dental Medicine. She serves as both the administrative director and the scientific director of the Obesity, Metabolism and Nutrition Institute.
M. Agostina Santoro, PhD
M. Agostina Santoro, PhD, is a postdoctoral fellow at Massachusetts General Hospital and Harvard Medical School, conducting research at the Obesity, Metabolism and Nutrition Institute. She received her doctorate in Cell and Molecular Physiology in 2015 from the University of North Carolina at Chapel Hill.
Dr. Santoro’s current research uses mouse models and ‘-omics’ technologies to identify key molecular mechanisms underlying weight loss and improvement of glucose homeostasis.