- the Epidemiology of Diabetes Interventions and Complications (EDIC) study, which demonstrated the primacy of intensive metabolic control in preventing the development of complications in Type 1 diabetes
- theDiabetes Prevention Program (DPP)which established the means of preventing Type 2 diabetes
- the LookAHEAD study which is examining the means of preventing heart disease in Type 2 diabetes
- the Immune Tolerance Network Study which is investigating islet transplantation as a treatment of Type 1 diabetes.
In the aggregate, these trials and other Diabetes Center studies are studying more than 1000 subjects at the Mass General.
Other current Center studies are investigating:
- the treatment of Type 2 diabetes in adolescents
- new techniques for islet transplantation
- the immune basis of Type 1 diabetes, cardiovascular disease prevention
- the genetics of Type 2 diabetes
- means of optimizing the care of Type 2 diabetes by primary care practitioners.
Epidemiologic studies in collaboration with the Framingham Heart Study, Baltimore Longitudinal Study of Aging, and Nurses and Physicians Health Studies explore the risk factors of diabetes and its complications and in particular the relationship between glycemia and heart disease.
The current annual budget (>90% from NIH) is approximately $2.5 million per year.
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