Bastepe Lab

Endocrine Unit: Bastepe Laboratory

The Bastepe Lab strives to improve clinical management of endocrine and musculoskeletal disorders through fundamental research that involves genetics and molecular and cell biology.


The Bastepe Lab investigates the pathophysiology of human disorders caused by alterations in G protein signaling and GPCR actions. We are primarily interested in endocrine and musculoskeletal diseases.

Using molecular genetics and a wide range of in vitro and in vivo technologies, our studies currently focus on the GNAS complex locus, an imprinted gene giving rise to the alpha-subunit of the stimulatory G protein (Gsα) and multiple other monoallelically expressed transcripts and proteins, such as XLαs. 

Group Members

  • Murat Bastepe, MD, PhD, FACMG
  • Qing He, PhD
  • Anara Karaca, MD
  • Julia Matthias, Student Intern
  • Lauren Shumate, Research Technician

Research Projects

Our research projects are detailed here.


Publications can be found here.


Contact Us

Endocrine Unit Research Laboratories

Thier Building

50 Blossom Street Boston, MA 02114
  • Near Public Transit
  • Accessible
  • Phone: 617-726-3967
  • Fax: 617-726-7543


  • 9:00 am-4:30 pm

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