Explore This Lab

Overview

The Luster Laboratory focuses on understanding the role of chemokines and lipid chemoattractants and their receptors in controlling the trafficking of leukocytes in vivo. Gene-targeted and transgenic mouse strains have been developed to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of inflammatory, autoimmune, allergic and infectious diseases. System biology approaches are being utilized to understand how multiple chemoattractant pathways are integrated in vivo for the fine control of leukocyte trafficking. In vivo multiphoton microscopy is being utilized to interrogate the function of chemokines in controlling the migratory and interactive behavior of T cells and dendritic cells in lymph nodes and peripheral tissue. We also study the regulation of chemokine production in vivo since this is a critical determinant of their role in a given biological response. We have a particular interest in the role of innate immune receptors, such as toll-like receptors, in regulating chemokine production in vivo. We are also interested in structure-function relationships of chemokines and their receptors as well as the molecular mechanism of chemokine signal transduction, as these are important questions relevant to chemotaxis and immune cell trafficking in health and disease. Finally, chemokines and chemoattractant receptors are interrogated in human diseases to determine chemokine systems relevant for disease pathogenesis.

Research Projects

Research Positions

If you are interested in applying for a postdoctoral position, or are a Harvard PhD student interested in a laboratory rotation, please e-mail your CV (for student and postdoctoral) and reference letters (for postdoctoral) to aluster@mgh.harvard.edu.


Lab Members

Principal Investigator

Andrew D. Luster, MD, PhD
Chief, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital
Director, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital
E. Alexandria and Michael N. Altman Chair in Immunology, Massachusetts General Hospital
Persis, Cyrus and Marlow B. Harrison Professor of Medicine, Harvard Medical School

Research Team

Assistant Professor

  • Ahmad Sedaghat, MD, PhD

Instructors

  • Melvyn Chow, PhD
  • Maud Deruaz, PhD
  • Lucas Faustino, PhD
  • Jason Griffith, MD, PhD
  • Mo Ling, MD
  • Yoshi Miyabe, MD, PhD
  • Rod Rahimi, MD, PhD

Postdoctoral Fellows

  • Laura Bricio Moreno, PhD
  • Chie Miyabe, MD, PhD
  • Mazen Nasrallah, MD
  • Aleksandra Ozga, PhD

Graduate Student

  • Jeff Lian

Senior Laboratory Manager

  • Carol P. Leary

Technicians

  • Keshav Nepal
  • Rachel Servis

Publications

Click here to view a list of publications from this investigator.