The Medical Practice Evaluation Center (MPEC) became a formalized interdivisional center within the Department of Medicine at Massachusetts General Hospital in 2011, housing faculty and staff from the Divisions of General Internal Medicine and Infectious Diseases.

The multidisciplinary MPEC team, led by Kenneth Freedberg, MD, MSc, and Rochelle Walensky, MD, MPH, is internationally recognized in the evaluation of clinical outcomes, costs, and cost-effectiveness for preventing, managing, and treating HIV/AIDS as well as other diseases.

Many of the research activities at MPEC utilize the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) model. With NIH funding since 1994, researchers at Mass General have used this Monte Carlo simulation model to evaluate the cost-effectiveness of national and multinational strategies for combating HIV/AIDS.

The model, first developed in response to the outbreak of the HIV/AIDS epidemic in the United States, has grown over time in both scope, geography, and application to provide comprehensive analyses for prospective treatment strategies of HIV/AIDS, as well as AIDS-related complications, including tuberculosis and other infections. The Center has recently expanded its focus into acute and chronic disease areas beyond HIV.

The MPEC team collaborates with research teams in Botswana, Brazil, Côte d’Ivoire, France, India, Mozambique, Nigeria, Portugal, South Africa, Spain, Uganda, and Zimbabwe, as well as investigators from across the United States.

Research from the MPEC team has been published in several leading medical journals, including the Journal of the American Medical Association, the New England Journal of Medicine, and AIDS.

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