Nephrology Research

Explore our current research projects in the Massachusetts General Hospital Division of Nephrology or search open clinical trials and medical research studies.

Research Labs

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  • Arnaout Laboratory

    The M. Amin Arnaout laboratory is interested in elucidating the molecular basis of human disease and in using this information to guide development of new and safer therapies. We utilize state-of-the-art technologies, including genetics, genomics, biochemistry, cell biology, structural and computational biology and animal models of disease.

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  • Babitt Laboratory

    Jodie Babitt, MD

    The Jodie L. Babitt Lab is focused on elucidating the molecular and cellular mechanisms involved in iron homeostasis

  • Bouley Laboratory

    Richard Bouley, PhD

    The Richard Bouley Laboratory is studying the role of vasopressin receptor type 2 in the pathophysiology of diseases associated with water reabsorption dysregulation.

  • Breton Laboratory

    Sylvie Breton, PhD

    The Sylvie Breton laboratory studies the regulation of epithelial cells in the urogenital tract with an emphasis on the kidney and epididymis. Our main areas of interest include: acute kidney injury, chronic kidney disease, male infertility, cystic fibrosis, acid/base homeostasis.

  • Brown Laboratory

    Dennis Brown, PhD

    The Dennis Brown Laboratory uses cell biological and imaging techniques to understand mechanisms and physiological signals that regulate the distribution of important proteins in the kidney that regulate urine concentration and systemic acid base balance. We are especially interested in the pathophysiology of vasopressin activated water channels (aquaporins), and in proton pump (V-ATPase) function.

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  • Da Silva Laboratory

    Nicolas Da Silva, PhD

    The Nicolas Da Silva Laboratory focuses on interactions between the immune system and the male reproductive tract, specifically on the importance of macrophages and dendritic cells during sperm maturation and storage.

  • Drummond Laboratory

    Iain Drummond, PhD

    The Iain Drummond Laboratory studies kidney organogenesis using the zebrafish to explore conserved molecular mechanisms underlying vertebrate kidney cell differentiation, morphogenesis, ciliogenesis, and regeneration.

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  • Endocrine/Nephrology Unit: Rhee Laboratory

    Eugene Rhee, MD

    The Eugene Rhee Laboratory is interested in several aspects of renal metabolism, with the goal to understand how alterations in energy metabolism contribute to kidney disease pathogenesis and its complications and to discover metabolite markers of CKD and its progression.

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  • Lim Lab: Kenneth Lim, MD, PhD

    Kenneth Lim

    Our mission is to be an incubator for advanced therapeutics and a strategic launching pad for next-generation enterprises. Our primary R&D platform focuses on therapeutic strategies for accelerated cardiovascular disease in chronic kidney disease (CKD) and other age-associated conditions. We integrate multidisciplinary approaches at the interface of translational and clinical research for improved patient care.

  • Lin Laboratory

    Herbert Lin, MD, PhD

    The Herbert Lin Laboratory studies the role of the TGF-beta/BMP signaling pathways in health and disease.

  • Lu Laboratory

    Hua Lu, MD, PhD

    The main focus in the Hua Lu Laboratory is to study the mechanism of the trafficking of a water channel protein, AQP2.

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  • Paunescu Laboratory

    Teodor Paunescu, PhD

    The Teodor Paunescu Laboratory studies proton secretion in the kidney and the olfactory epithelium, and its relevance for maintaining body acid-base balance, the sense of smell, and nutrition.

  • Program in Membrane Biology

    Program in Membrane Biology

    The MGH Program in Membrane Biology brings together a diverse group of investigators with a common interest in understanding how physiological signals regulate tissue and organ function at the cellular level.

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  • Sever Laboratory

    Sanja Sever, PhD

    The Sanja Sever Laboratory's research focuses on podocyte structure and function, the large regulatory GTPase dynamin, as well as the intersection of these two areas.

  • Soberman Laboratory

    Roy Soberman, MD

    The overall focus of the Roy Soberman Laboratory is to understand signal integration and macromolecular organization in cells of the immune system, and how these processes are linked to control the amplification of the immune response.

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  • Thadhani Laboratory

    Ravi Thadhani, MD, MPH

    The Ravi Thadhani Laboratory's research efforts are divided into two main areas: Pregnancy and Dialysis. Pregnancy related studies have centered on human studies supporting basic science collaborations in the area of angiogenic factors and preeclampsia. In dialysis, we have conducted studies examining the effect of vitamin D in the survival of chronic hemodialysis patients.

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  • Williams Laboratory

    Winfred Williams, MD

    The Winfred Williams Laboratory studies the genetic basis of chronic allograft nephropathy.

  • Wojciechowski Laboratory

    David Wojciechowski, DO

    The David Wojciechowski Laboratory's clinical research is focused on the prevention and treatment of viral infection post-kidney transplant, improving access to transplantation, and the evaluation of immunosuppressive regimens focusing on novel agents and drug combinations in order to maximize patient and graft outcomes and minimize toxicity.

Clinical Trials

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