Latest News

October 3, 2022: Healey & AMG Center announces top line results in ALS platform trial with CMN-Au8
The HEALEY ALS Platform Trial led by the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH) today announced topline results from Regimen C evaluating CMN-Au8, developed by Clene Nanomedicine, Inc. 
Read the release here.

September 30, 2022: Sean M. Healey & AMG Center for ALS awarded NINDS UO1 Grant to support Expanded Access for Trehalose (SLS-005)
The Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital has been awarded a grant from the National Institute of Neurological Disorders and Stroke (NINDS) to conduct an intermediate size Expanded Access Protocol (EAP) in Amyotrophic Lateral Sclerosis (ALS). The grant is supported by the ACT for ALS (Accelerating Access to Critical Therapies for ALS Act). 
 Read more here.

September 29, 2022: Healey & AMG Center announces results from the HEALEY ALS Platform Trial with verdiperstat
The HEALEY ALS Platform Trial led by the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH) today announced topline results from Regimen B evaluating verdiperstat, developed by Biohaven Pharmaceutical Holding Company, Ltd. 
Read the release here.

All Healey Center News     Sign up for ALS Link

Patient & Community Webinar Series

We are committed to an ongoing dialogue about the HEALEY ALS Platform Trial with the entire ALS patient community.

We will continue to share enrollment updates as well as new ideas and opportunities. Our team will be available to answer all questions that the community might have about this groundbreaking trial.

In addition to occasional comprehensive updates and our Mechanism of Action & Science series, we host weekly informal Q&A sessions. The idea of weekly interactive sessions came from our Patient Advisory Committee and we absolutely love the opportunity to connect with all who might be interested on a frequent basis. Please join us as often as you would like!

To submit questions prior to the webinars please email healeyalsplatform@mgh.harvard.edu

Upcoming Webinars

Join us Thursdays at 5:00 pm Eastern Time for weekly updates on trial progress and answers to audience questions.

  • Thursday, November 24th: Cancelled for Holiday 
  • Thursday, December 1st, 5:00 pm EST: Weekly Q&A with guest speaker Catherine Douthwright PhD, CCRP from UMass Worcester- Click here to register 
  •  Thursday, December 8th, 5:00 pm EST: Weekly Q&A - Click here to register 

Register for weekly webinars

Webinar Recordings

Science & Mechanism of Action Series

March 10, 2022: Trehalose Mechanism of Action & Science
Sabrina Paganoni, MD, PhD scientists from Seelos Therapeutics, and regimen co-leads Merit Cudkowicz, MD, MSc and Shafeeq Ladha, MD presented the rationale and science behind trehalose, the investigational product being studied in Regimen E of the HEALEY ALS Platform Trial, and answered questions from the audience.
Watch recording | Download slides (PDF)

February 25, 2021: Zilucoplan Mechanism of Action & Science
Merit Cudkowicz, MD, MSc, research scientists from UCB and regimen co-leads Sabrina Paganoni, MD, PhD and Christina Fournier, MD presented the rationale and science behind zilucoplan, the investigational product tested in regimen A of the HEALEY ALS Platform Trial, and answered questions from the audience.
Watch recording | Download slides (PDF)

February 18, 2021: Verdiperstat Mechanism of Action & Science
Merit Cudkowicz, MD, MSc, research scientists from Biohaven Pharmaceuticals and regimen co-leads, Jinsy Andrews, MD, MSc and Suma Babu, MD, MPH, MBBS presented the rationale and science behind verdiperstat, the investigational product being tested in regimen B of the HEALEY ALS Platform Trial, and answered questions from the audience.
Watch recording | Download slides (PDF)

February 4, 2021: CNM-Au8 Mechanism of Action & Science
Merit Cudkowicz, MD, MSc, Sabrina Paganoni, MD, PhD, research scientists from Clene Nanomedicine and regimen co-leads James Berry, MD, MPH and Nicholas Maragakis, MD presented the rationale and science behind CNM-Au8, the investigational product being tested in regimen C of the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

January 21, 2021: Pridopidine Mechanism of Action & Science
Merit Cudkowicz, MD, MSc, Sabrina Paganoni, MD, PhD, research scientists from Prilenia Therapeutics and regimen co-leads Jeremy Shefner, MD, PhD and Björn Oskarsson, MD, FAAN presented the rationale and science behind pridopidine, the investigational product being tested in regimen D of the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

Weekly & Monthly Updates

November 17, 2022: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. The presentation reviewed resources to learn more about the currently enrolling Regimen E and provided a look forward at plans for Expanded Access in 2023.
Watch recording | Download slides (PDF)

November 10, 2022: Weekly Q&A
Merit Cudkowicz, MD, MSc and Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

October 27, 2022: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. The presentation reviewed key aspects of the trial design and provided an update about the status of current regimens, a recap of recent research news, and a look forward at plans for 2023.  
Watch recording | Download slides (PDF)

October 20, 2022: Weekly Q&A with guest speaker Amanda Peltier MD, MS
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Amanda Peltier MD, MS , Site Investigator at Vanderbilt University in TN, to hear about her experience working in ALS research.
Watch recording | Download slides (PDF)

October 13, 2022: Weekly Q&A 
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. The presentation provided an overview of Platform Trial progress to date and a look forward at plans for the addition of new regimens and grant-funded Expanded Access in 2023.
Watch recording | Download slides (PDF)

October 6, 2022: Weekly Q&A featuring discussion of Regimen C/CNM-Au8 results
Merit Cudkowicz, MD, MSc and Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by the co-lead investigators for Regimen C and representatives from Clene Nanomedicine, Inc. to discuss the trial results for CNM-Au8.
Watch recording 

September 29, 2022: Weekly Q&A featuring discussion of Regimen B/Verdiperstat results
Merit Cudkowicz, MD, MSc and Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by the co-lead investigators for Regimen B and representatives from Biohaven Pharmaceuticals to discuss the trial results for Verdiperstat. 
Watch recording 

September 22, 2022: Weekly Q&A with guest speakers Meghan Hall and Mariah Connolly
Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speakers Meghan Hall, BS, CCRA, CCRP and Mariah Connolly, BS, CCRA to discuss the role of Site Monitors in the Platform Trial. 
Watch recording | Download slides (PDF)

September 15, 2022: Weekly Q&A with guest speaker Tawfiq Al-Lahham, MD 

Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Tawfiq Al-Lahham, MD, Site Investigator at UPMC in Pennsylvania.
Watch recording | Download slides (PDF)

September 8, 2022: Weekly Q&A

Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. 
Watch recording | Download slides (PDF)

September 1, 2022: Weekly Q&A with guest host James Berry MD, MPH

James Berry MD, MPH of Mass General Hospital presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. The webinar featured a special discussion about exploratory endpoints and biomarkers. 
Watch recording | Download slides (PDF)

August 25, 2022: Weekly Q&A with Guest Speaker Hani Kushlaf, MD, FAAN 
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Hani Kushlaf, MD, FAAN, Site Investigator at the University of Cincinnati in Ohio. 
Watch recording | Download slides (PDF)

August 11, 2022: Weekly Q&A 
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.  
Watch recording | Download slides (PDF)

July 28, 2022: Weekly Q&A with guest biostatistician Lori Chibnik, PhD, MPH
The Patient Navigation team presented this week’s updates on the HEALEY ALS Platform Trial and welcomed return guest speaker Lori Chibnik, PhD, MPH. Dr. Chibnik led a discussion about the use of placebos in clinical trials and answered questions from the audience. 
Watch recording | Download slides (PDF)

July 21, 2022: Weekly Q&A with guest speaker Allison Bulat
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Allison Bulat, Co-Chair of the NEALS Patient Education and Advocacy Committee, to learn about opportunities for patient advocacy in clinical research. 
Watch recording | Download slides (PDF)

July 14, 2022: Weekly Q&A with guest speaker Eufrosina Young, MD
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Dr. Eufrosina Young, Platform Trial Site Investigator, SUNY Upstate, to learn about her role in the trial
Watch recording | Download slides (PDF)

July 7, 2022 Weekly Q&A with guest speaker James Berry MD, MPH
Sabrina Paganoni, MD, PhD presented this week's updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker James Berry, MD, MPH for a special discussion about biomarkers. 
Watch recording | Download slides (PDF)

June 30, 2022: Weekly Q&A with guest speaker Gale Kittle, RN, MPH

Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Gale Kittle, RN, MPH, Director of Outcome Measurements Training, to learn about her role in the trial.
Watch recording | Download slides (PDF)

June 23, 2022: Weekly Q&A with guest speaker Jackie Whitesell, MD

Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Jackie Whitesell, MD, Site Investigator at Saint Alphonsus Regional Medical Center in Boise, ID.
Watch recording | Download slides (PDF)

June 16, 2022: Weekly Q&A featuring Bruce Rosenblum, EAP Patient Advisory Committee Member
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Bruce Rosenblum, who currently serves as a member of the Patient Advisory Committee for the Platform Trial's companion Expanded Access Program (EAP).
Watch recording | Download slides (PDF)

June 9, 2022: Weekly Q&A featuring Hospital for Special Care, CT
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speakers Honora Dalamagas, RN, MSN, CNS, and Natalie Cartwright, MS, from the Hospital for Special Care in New Britain, CT.
Watch recording | Download slides (PDF)

June 2, 2022: Weekly Q&A with guest speaker Daniel Hevert, BS
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by Daniel Hevert, BS to discuss his perspective working as a Lead Clinical Research Coordinator on the trial.
Watch recording | Download slides (PDF)

May 26, 2022: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 19, 2022: Weekly Q&A with guest speaker Nadia Sethi, DDS
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by Nadia Sethi, DDS to discuss her perspective as a member of our Patient Advisory Committee.
Watch recording | Download slides (PDF)

May 12, 2022: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 5, 2022: Weekly Q&A with guest speaker Peter Foss
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Peter Foss, President of ALS Finding a Cure.
Watch recording | Download slides (PDF)

April 28, 2022: Weekly Q&A with guest speaker Kelly G. Gwathmey, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Kelly G. Gwathmey MD, Site Investigator at Virginia Commonwealth University in Richmond, VA.
Watch recording | Download slides (PDF)

April 14, 2022: Weekly Q&A with guest speaker Kuldip Dave, PhD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Kuldip Dave, PhD, Vice President of Research at the ALS Association.
Watch recording | Download slides (PDF)

March 31, 2022: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We shared new online resources about Expanded Access and discussed recent events in the field of ALS research.
Watch recording | Download slides (PDF)

March 24, 2022: Weekly Q&A with guest speaker Jaimin Shah, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Jaimin Shah MD, Site Investigator at the Mayo Clinic in Jacksonville, FL.
Watch recording | Download slides (PDF)

March 17, 2022: Weekly Q&A with guest speaker Edward J. Kasarskis, MD, PhD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Edward J. Kasarskis, MD, PhD, Site Investigator at the University of Kentucky in Lexington, KY, who discussed his research on FUS familial ALS and the importance of nutrition in ALS.
Watch recording | Download slides (PDF)

March 10, 2022: Trehalose Mechanism of Action & Science
Sabrina Paganoni, MD, PhD scientists from Seelos Therapeutics, and regimen co-leads Merit Cudkowicz, MD, MSc and Shafeeq Ladha, MD presented the rationale and science behind trehalose, the investigational product being studied in Regimen E of the HEALEY ALS Platform Trial, and answered questions from the audience.
Watch recording | Download slides (PDF)

March 3, 2022: Weekly Q&A with guest speaker Andrea Swenson, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Andrea Swenson, MD, Site Investigator at the University of Iowa in Iowa City, IA.
Watch recording | Download slides (PDF)

February 24, 2022: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

February 17, 2022: Weekly Q&A with Guest Speaker Jim Caress, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Jim Caress, MD, Site Investigator at Wake Forest University in NC.
Watch recording | Download slides (PDF)

February 10, 2022: Weekly Q&A with Guest Speaker Ximena Arcila-Londono, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial, shared estimated timelines for study results, and answered questions from the audience. We were joined by guest speaker Ximena Arcila-Londono, MD, Site Investigator at Henry Ford Hospital in Detroit, MI.
Watch recording | Download slides (PDF)

February 3, 2022: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

January 27, 2022: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

January 20, 2022: Weekly Q&A with guest speaker Senda Ajroud-Driss, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Senda Ajroud-Driss, MD, Site Investigator at Northwestern University in Chicago, IL.
Watch recording | Download slides (PDF)

January 13, 2022: Weekly Q&A with guest speaker Sharon Hesterlee, PhD

Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. We were joined by guest speaker Sharon Hesterlee, PhD, Chief Research Officer of the Muscular Dystrophy Association (MDA), to discuss the MDA's commitment to advancing ALS research.
Watch recording | Download slides (PDF)

January 6, 2022: Weekly Q&A 

Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

December 16, 2021:
Weekly Q&A and discussion of biostatistics with guest Lori Chibnik, PhD, MPH
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial. She was joined by guest speaker Lori Chibnik, PhD, MPH to discuss biostatistics and answer questions from the audience.
Watch recording | Download slides (PDF)

December 9, 2021: Weekly Q&A with guest speaker Nicholas Olney, MD

Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial, joined by guest speaker Nicholas Olney, MD, Platform Trial Site Investigator at the Providence ALS Center in Oregon, to discuss his experience working on the trial and answer questions from the audience.
Watch recording | Download slides (PDF)

December 2, 2021: Weekly Q&A with guest speaker Neil Thakur, PhD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial. She was joined by guest speaker Neil Thakur, PhD, Chief Mission Officer of The ALS Association, to discuss the research pipeline and answer questions from the audience.
Watch recording | Download slides (PDF)

November 18, 2021: Weekly Q&A with guest speaker James Berry, MD, MPH
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial. They were joined by guest speaker James Berry, MD, MPH to discuss biomarkers and answer questions from the audience.
Watch recording | Download slides (PDF)

November 4, 2021: Weekly Q&A, Update from Clene Nanomedicine Inc., and Discussion of Biostatistics
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial. They were joined by guest speakers Robert Glanzman, MD, FAAN, and Michael Hotchkin of Clene Nanomedicine Inc., along with James Berry, MD, MPH and Nicholas Maragakis, MD, co-lead investigators for Regimen C of the Platform Trial. Lori Chibnik, PhD, MPH presented the role of biostatistics in clinical trials and answered questions from the audience.
Watch recording | Download slides (PDF)

October 28, 2021: Weekly Q&A with Guest Speaker Megan Miller, PhD from I AM ALS
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience. They were joined by guest speaker Megan Miller, PhD, Director of Science and Policy at I AM ALS, to discuss the Expanded Access Protocol Program (EAP).
Watch recording | Download slides (PDF)

October 21, 2021: Weekly Q&A with Guest Speaker Xiaowei (Bill) Su, MD, PhD from Penn State Health
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker Xiaowei (Bill) Su, MD, PhD from Penn State Health, and answered questions from the audience.
Watch recording | Download slides (PDF)

October 14, 2021: Weekly Q&A with Guest Speaker David Walk, MD, FAAN from the University of Minnesota
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker, David Walk, MD, FAAN from the University of Minnesota and answered questions from the audience.
Watch recording | Download slides (PDF)

September 30, 2021: Weekly Q&A with Guest Speaker Irfan Qureshi, MD from Biohaven Pharmaceuticals
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Irfan Qureshi, MD from Biohaven Pharmaceuticals.
Watch recording | Download slides (PDF)

September 23, 2021: Weekly Q&A with Guest Speaker Speaker Namita Goyal
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Namita Goyal, MD from the University of California, Irvine.
Watch recording | Download slides (PDF)

September 9, 2021: Weekly Q&A with Guest Speaker Jennifer DiMartino
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Jennifer DiMartino, Executive Director of ALS ONE.
Watch recording | Download slides (PDF)

September 2, 2021: Weekly Q&A with Guest Speaker Terry Heiman-Patterson, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker, Terry Heiman-Patterson, MD, from Temple University.
Watch recording | Download slides (PDF)

August 26, 2021: Weekly Q&A with Guest Speaker Niraja Suresh, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker, Niraja Suresh, MD, from the University of South Florida .
Watch recording | Download slides (PDF)

August 19, 2021: Weekly Q&A with guest speaker Laura Foster, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker, Laura Foster, MD, from the University of Colorado, Anschutz.
Watch recording | Download slides (PDF)

August 12, 2021: Weekly Q&A with guest speaker, Michael Weiss, MD, FAAN
Merit Cudkowicz, MD, MSc and Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker, Michael Weiss, MD, FAAN from the University of Washington.
Watch recording | Download slides (PDF)

August 5, 2021: Weekly Q&A
Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

July 29, 2021: Weekly Q&A with guest speaker Hristelina Ilieva, MD, PhD 
James Berry MD, MPH presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Hristelina Ilieva, MD, PhD from Thomas Jefferson University.
Watch recording | Download slides (PDF)

July 22, 2021: Weekly Q&A with guest speaker Richard Bedlack, MD, PhD, MS
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker Richard Bedlack, MD, PhD, MS from Duke University.
Watch recording | Download slides (PDF)

July 15, 2021: Weekly Q&A with guest speaker Shafeeq Ladha, MD
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial. They were joined by special guest Shafeeq Ladha, MD of the Barrow Neurological Institute.
Watch recording | Download slides (PDF)

July 8, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

July 1, 2021: Weekly Q&A with guest speaker Jeffrey Rosenfeld, PhD, MD, FAAN
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Jeffrey Rosenfeld, PhD, MD, FAAN of Loma Linda University.
Watch recording | Download slides (PDF)

June 24, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

June 17, 2021: Weekly Q&A with guest speaker Lauren Elman, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Lauren Elman, MD from the University of Pennsylvania.
Watch recording | Download slides (PDF)

June 10, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

June 3, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 27, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 20, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 13, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 6, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

April 29, 2021: Weekly Q&A with guest speaker Eduardo Locatelli, MD
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Eduardo Locatelli, MD from Holy Cross Hospital.
Watch recording | Download slides (PDF)

April 22, 2021: Weekly Q&A with guest speaker Daragh Heitzman, MD, FAAN
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience, with guest speaker Daragh Heitzman, MD, FAAN of Texas Neurology.
Watch recording | Download slides (PDF)

April 15, 2021: Weekly Q&A with guest speaker Adam Quick, MD
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker Adam Quick, MD, from The Ohio State University Wexner Medical Center and answered questions from the audience.
Watch recording | Download slides (PDF)

April 8, 2021: Weekly Q&A with guest speaker Jeremey Shefner, MD, PhD
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial, discussed voice app biomarkers with guest speaker Jeremey Shefner, MD, PhD and answered questions from the audience.
Watch recording | Download slides (PDF)

April 1, 2021: Weekly Q&A with guest speaker James Berry, MD, MPH
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial, discussed biomarkers with guest speaker James Berry, MD, MPH and answered questions from the audience.
Watch recording | Download slides (PDF)

March 25, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

March 18, 2021: Weekly Q&A

Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.

Watch recording | Download slides (PDF)

March 11, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

March 4, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience
Watch recording | Download slides (PDF)

February 11, 2021: Weekly Q&A

Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

January 28, 2021: Weekly Q&A
Merit Cudkowicz, MD, MSc and Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial, discussed the trial design, and answered questions from the audience.
Watch recording | Download slides (PDF)

January 14, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week's updates on the HEALEY ALS Platform Trial, discussed the Expanded Access Protocol (EAP) program, and answered questions from the audience.
Watch recording | Download slides (PDF)

January 7, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week's updates on the HEALEY ALS Platform Trial, discussed the Expanded Access Protocol (EAP) program, and answered questions from the audience.
Watch recording | Download slides (PDF)

December 17, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial, discussed open label extension and COVID impact, and answered questions from the audience.
Watch recording | Download slides (PDF)

December 10, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week's updates on the HEALEY ALS Platform Trial, discussed the enrollment process and study visits, and answered questions from the audience.
Watch recording | Download slides (PDF)

December 3, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week's updates on the HEALEY ALS Platform Trial and the Expanded Access Protocol (EAP) program, discussed the relationship between clinical research trials for ALS and clinical care, and answered questions from the audience.
Watch recording | Download slides (PDF)

November 30, 2020: Monthly Update with guest speaker Jen DiMartino 
Merit Cudkowicz, MD, MSc, principal investigator, and Sabrina Paganoni, MD, co-principal investigator of the HEALEY ALS Platform Trial, provided an update on the progress of the HEALEY ALS Platform Trial. They were joined by Jen DiMartino of ALS One.
Watch recording | Download slides (PDF)

November 19, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

November 12, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

November 5, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

October 29, 2020: Monthly Update with guest speakers Troy Green and Peter Foss
Merit Cudkowicz, MD, MSc, principal investigator, and Sabrina Paganoni, MD, co-principal investigator of the HEALEY ALS Platform Trial, provided an update on the progress of the HEALEY ALS Platform Trial. They were joined by Troy Green from Tackle ALS and Peter Foss from ALS Finding a Cure.
Watch recording | Download slides (PDF)

October 22, 2020: Weekly Q&A
Enrollment updates, trial sites, and patient questions.
Watch recording | Download slides (PDF)

October 21, 2020: ALS/MND Alliance Clinical Trial Design Webinar
Merit Cudkowicz, MD, MSc joined researchers from Europe and Scotland to discuss new research and clinical trial models, how they will change the landscape going forward and their practical implications for patients and researchers.
Watch recording

October 15, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD covers newly active trial sites, patient navigator service, and patient questions about the HEALEY ALS Platform Trial.
Watch recording | Download slides (PDF)

October 13, 2020: CTTI Master Protocol Development Webinar for Researchers
Marianne Chase, the Senior Director Clinical Trial Operations at Mass General's Neurological Clinical Research Institute, joined representatives from the FDA, Janssen R&D and Edgewise Therapeutics to discuss the design of master protocol clinical trials, which allow researchers to answer multiple scientific questions within a single trial. Watch recording.

October 8, 2020: Weekly Q&A with guest speaker Sandy Morris
Mass General researchers Merit Cudkowicz, MD, MSc and Sabrina Paganoni, MD, PhD are joined by Sandy Morris of I AM ALS.
Watch recording | Download slides (PDF)

September 29, 2020, 2020: Monthly Update with guest speaker Kuldip Dave, PhD
Merit Cudkowicz, MD, MSc, principal investigator, and Sabrina Paganoni, MD, co-principal investigator of the HEALEY ALS Platform Trial, provided an update on the progress of the HEALEY ALS Platform Trial. They were joined by Kuldip Dave, PhD, of the ALS Association.
Watch recording | Download slides (PDF)

August 27, 2020, 2020: Monthly Update with guest speaker Taner Dagdelen

Sabrina Paganoni, MD, co-principal investigator of the HEALEY ALS Platform Trial, joined Taner Dagdelen, co-founder and CEO of Unite Genomics, for a webinar on August 27 to discuss the latest updates on the trial.
Watch recording

Watch Our Launch Video

Pre-Launch Updates

July 7, 2020: Status Update
Healey Center faculty provide update on the status of the HEALEY ALS Platform Trial.
Watch recording.

April 8, 2020: Update and Message from Reagan Healey
We hosted a webinar on April 8th, 2020 to discuss the state of planning for the HEALEY ALS Platform Trial, featuring panelist Reagan Healey, who brought a message for us and for ALS patients and caregivers everywhere:

"I am really glad we could update you today and let you know of our neverending commitment you and your families. I am in New York and every night this month at 7 pm the city erupts with cheering, drum pounding and clapping to thank our Healthcare professionals and all frontline workers during this Corona Crisis. It can be heard as a low rumble if you’re inside and then a thunderous chorus when you open a window. But I am going to let you in on a secret: I scream and cheer for you all and for my brother Sean. And I want you to know that Sean and the Healey Center are and will continue to be the strongest voices on your behalf. We will put an end to the ALS crisis." – Regan Healey

Watch recording.

March 25, 2020: COVID Updates
As you all are, we too are closely monitoring the impact of COVID-19 on the HEALEY ALS Platform Trial timelines and operations.  The bottom line is this: we are committed to beginning the trial as soon and as safely as we can.

January 22, 2020: Sean M. Healey & AMG Center for ALS at Mass General receives “May Proceed” notice for three drugs in first ALS platform trial
The Sean M. Healey & AMG Center for ALS at Mass General has received approval from the U.S. Food and Drug Administration (FDA) to proceed with administering three proposed drug regimens in the HEALEY ALS Platform Trial – the first trial of its kind for amyotrophic lateral sclerosis (ALS)

Merit Cudkowicz, MD, MSc, Director of the Healey Center for ALS, discusses the impact of the “May Proceed” notice from the FDA for three drugs in first ALS platform trial

January 14, 2020: ALS Association makes multi-year commitment to HEALEY ALS Platform Trial
The ALS Association announced a $3 million commitment to the first platform trial for ALS, taking place at the Sean M. Healey & AMG Center for ALS at Mass General in collaboration with the Barrow Neurological Institute and the Northeast ALS Consortium (NEALS).

September 18, 2019: Sean M. Healey & AMG Center for ALS at Mass General launches first ALS Platform Trial with 5 promising drugs
The Sean M. Healey & AMG Center at Massachusetts General Hospital will launch the first platform trial for amyotrophic lateral sclerosis (ALS) to accelerate the development of effective and breakthrough treatments for people with ALS.