Departments, Centers, & Programs:
165 Cambridge Street
Boston, MA 02114-2783
- MD, SUNY at Stony Brook School of Medicine
- PhD, SUNY at Stony Brook School of Medicine
- Residency, Yale-New Haven Hospital
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Neurology, American Board of Psychiatry and Neurology
Accepted Insurance Plans
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
The Dystonia Center also serves as a gateway for those patients who are interested in participating in research. I am the Principal Investigator of the Clinical Core of an NIH-funded P50 grant, Molecular Etiology of Early Onset Torsion Dystonia. The P50 supports: (1) systematic clinical evaluation at each visit, as part of a longitudinal study of the natural history of dystonia; (2) genetic research regarding the role of single nucleotide polymorphisms in the Tor1A gene in the development of focal dystonias; (3) collection of families with dystonia, obtaining both DNA and systematic clinical examination data, to help identify as yet unidentified dystonia causing genes and (4) fMRI studies to evaluate white matter microstructure in those with focal dystonia. The genetic studies are part of an on-going collaboration with Dr. Laurie Ozelius at Mount Sinai School of Medicine, who has NIH funding for this research. The fMRI studies are part of an on-going collaboration with Dr. Anne Blood, of the Department of Psychiatry at MGH, who has NIH funding for this research.
Sharma N, and Richman, E. (2005) Parkinson's Disease and the Family, Harvard University Press.
Blood, AJ, et al. (2006) White matter abnormalities in dystonia normalize after botulinum toxin treatment. NeuroReport 17:1251-1255.
Shields DC, et al. (2007) Pallidal Stimulation for Dystonia in Pantothenate-Kinase Associated Neurodegeneration. Neurology. 34:442-445.
Sharma N (2008) Parkinson's disease. Greenwood Press.
Timmermann L, et al. (2010) Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulation. Brain 133:701-12.
Sharma N, et al. (2010) Genetic evidence for an association of the TOR1A locus with segmental/focal dystonia. Mov Disord 25:2183-2187.
Sharma N, et al. (2011) Mutation in 5 upstream region of GCH1 gene causes familial dopa-responsive dystonia. Mov Disord In press.