Photo of Sydney Samuel Cash, MD, PhD

Sydney Samuel Cash, MD, PhD


Accepting New Patients




Clinical Interests
  • Epilepsy
Medical Education
  • MD, PhD, Columbia University College of Physicians and Surgeons
  • Residency, Brigham and Women's Hospital
Board Certifications
  • Neurology
  • Boston: Massachusetts General Hospital
Existing Patients
Patient Gateway
Insurances Accepted
  • Aetna Health Inc.
  • AllWays Health (NHP) - ACD
  • AllWays Health (NHP) - PBO
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • BMC HealthNet Mass Health MCO/ACO
  • Cigna (PAL #'s)
  • Commonwealth Care Alliance
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • OSW - Vermont
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Railroad Medicare - ACD
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
  • Well Sense Pediatrics

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Provider Gender


Sydney S. Cash, MD, PhD, received his MD and PhD degrees from Columbia University College of Physicians and Surgeons, completed his Neurology residency and was a Chief Resident at MGH and BWH. Dr. Cash is on the Neurology staff at MGH, and is an Assistant Professor in Neurology at Harvard Medical School. Dr. Cash is a specialist in epilepsy with research expertise in cortical microphysiology, including research with the investigating the mechanisms of diseases such as epilepsy and ways of interfacing with the brain for improving the lives of people with seizures, paralysis and other neurological difficulties.

Research & Publications

Research Summary

View my most recent research

The focus of Dr. Cash's lab is on trying to understand how the brain works under both normal and pathological conditions with an ultimate goal of developing techniques for diagnosing and treating some of the most devastating diseases. We are particularly focused on using approaches which extract information at multiple scales and then combine them into a more complete and meaningful understanding of brain physiology. We feel this multi-scalar, multi-modal approach is particularly powerful for understanding the human brain because of its complexity and architecture which is, by nature, multi-scalar.

We employ non-invasive measures of brain activity (MEG, EEG, fMRI) and structure (MRI) to get a holistic view of the brain.  We also use very specialized methods of recording directly from either human or rodent cortex including techniques to record the activity of single human neurons while patients are awake (microelectrode recordings) and optogenetic methods to control individual neurons.  Our projects are focused on understanding four core, but overlapping, areas:

1. Normal cognition

2. The physiology and importance of sleep and dreaming

3. The basic physiology of cortical and subcortical oscillations

4. Controlling seizures

Long-range goals include the development of new methods for identifying seizure areas, predicting seizures and then stopping them. We are also using these techniques to move toward new ways of interacting directly with the human nervous system for diagnosis and repair or replacement (neuroprosthetics and brain-computer interfaces) of damaged nervous system tissue.

Cortical Physiology Laboratory at Mass General.


View my most recent publications at PubMed

View selected publications from Dr. Cash on the following sites:

News & Events

  • NeuroBlast e-Newsletter

    NeuroBlast: the newsletter of translational neuroscience and clinical care advances in neurology, neurosurgery, and neuroscience from Massachusetts General Hospital.

  • 2013 MGH Research Scholars

    ESTABLISHED IN 2011 by ECOR and the MGH Research Advisory Council, the MGH Research Scholars program provides five years of unrestricted funding to give innovative investigators the flexibility to pursue projects that may lead in unexpected directions. Supported by philanthropic gifts, the program expanded from the first group of five recipients to eight scholars in 2012.

  • Advanced technology reveals activity of single neurons during seizures

    The first study to examine the activity of hundreds of individual human brain cells during seizures has found that seizures begin with extremely diverse neuronal activity, contrary to the classic view that they are characterized by massively synchronized activity.



Neurology Associates
15 Parkman Street
Boston, MA 02114-3117
Phone: 617-726-3311
Fax: 617-726-9250

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