15 Parkman Street
Boston, MA 02114-3117
- MD, University of Chicago Pritzker School of Medicine
- Residency, Massachusetts General Hospital
American Board Certifications
- Neurology, American Board of Psychiatry and Neurology
Accepted Insurance Plans
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Dr. Rosas and her team have focused primarily on the development of biomarkers for use in the study of neurodegenerative diseases, to better characterize progression, to better understand genotype/phenotype correlations, and to apply novel neuroimaging approaches in clinical trials with the overall aim of making them more efficient. We have begun to develop models that may explain clinically heterogeneous phenotypes and variability in disease progression. The current models for both disease prediction and prediction of disease progression are insensitive and inaccurate. We are planning to expand our efforts to include multi-modal and multi-spectral imaging approaches that promise both more precise measurements and made provide novel and important information on the neural underpinnings of HD and their clinical consequences.
Rosas HD, Zaleta AK, Lee SY, Pappu V, Salat DH, Hersch SM (2008) Complexity and heterogeneity: The role of the cortex in the clinical expression of HDN Brain Apr 131: 1057-68.
Rosas HD, LeeSY, Bender AC, Zaleta AK, Vange lM, Yu P, Fisch lB, Pappu V, Onorato C, Cha JH,Salat DH,Hersch S. Altered white matter microstructure in the corpus callosum in Huntingto's disease: implications for cortical disconnection. (2010) NeuroImage.49; 2995-3.
SalatDH, ChenJJ, vander Kouwe AJ, GreveDN, FischlB, Rosas HD.Hippocampal degeneration is associated with temporal and limbic gray/white matter tissue contrast in Alzheimer's disease.(2011)NeuroImage; 54,1795-802.
Rosas HD, Reuter M, Doros G, LeeS Y, TriggsTT, MalarickK ,Fischl B,Salat DH, Hersch SM. A Tale of Two Factors: What better determines rate of progression in HD, age or CAG repeat(2010) Movement Disorders.