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I am a clinician-scientist with medical training in Neurocritical Care and analytical training in population genetics. I use these two skill-sets synergistically; employing the techniques of genetics and systems biology to probe the pathogenesis of devastating neurologic diseases, with the ultimate aim of identifying novel treatments to improve outcome. Managing severe injuries in an intensive care environment requires a team of motivated and skilled physicians and allied staff, and I have a strong administrative interest in quality improvement and systematic care delivery in Acute Stroke and Neurocritical Care.
My clinical and research training began as a medical student at Northwestern University, during which time I received a summer research grant from the Buehler Center on Aging. Later, at the conclusion of my residency, I was granted a research fellowship from the American Heart Association/Bugher Foundation Centers for Stroke Prevention Research. I then undertook a two-year clinical fellowship in Neurocritical Care at MGH. At the completion of my clinical training in 2012, I was awarded a Clinical Research Training Fellowship (CRTF) from the American Brain Foundation, which provided additional protected time as a junior faculty member to continue my research into common and rare genetic variants in ischemic stroke and intracerebral hemorrhage. The preliminary results I compiled during my CRTF formed the basis of my K23 application to the NINDS, which was funded by the NIH and began in April of 2014.
My investigative expertise is in medical genetics. My leading interests are the role of common and rare genetic variants in the pathogenesis of intracerebral hemorrhage, and the utility of polygenic risk profiling in the clinical care of complex human disease. My collaborations through the Center for Genomic Medicine and the Broad Institute have played a central role in the cultivation of these interests.
The Anderson laboratory espouses the mission of the MGH Center for Genomic Medicine as it applies to ischemic stroke and intracerebral hemorrhage (ICH). We employ translational and computational techniques to understand how genetic associations can teach us about the pathogenic mechanisms of stroke, and how we can apply genetic associations to guide therapeutic and diagnostic approaches at the bedside. Members of the Anderson lab use population genetics approaches to the study of cerebrovascular disease, with special emphasis on pathway-based and translational genomic techniques that clarify the causal biological mechanisms through which associated genetic variants exert their influence on disease risk and outcome.
Programs within the lab include: 1) Leveraging genetic tools to understand how risk factors influence the development of cerebrovascular disease, 2) Determining the causal mechanisms through which common and rare genetic variants lead to ICH, and 3) Developing precision genomic medicine tools for stratification of genetic risk in individuals at risk for ischemic stroke. Because genetic analyses require both clinical characteristics as well as genotypic information, members of the lab cultivate expertise in multiple clinical, imaging, and computational domains. Fellows, coordinators, and students in the lab devote their efforts to projects across these disciplines, including clinical contact with stroke survivors for determination of outcomes, ascertainment of qualitative and quantitative imaging phenotypes for genetic and epidemiologic studies, and application of advanced bioinformatic tools for interpretation and analysis of genetic and genomic data. All of these enterprises serve the common goal of improving our understanding of cerebrovascular disease, so that we may develop new approaches to reduce the burden of stroke in the patients we serve.
View my most recent publications at PubMed
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