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In 2021, the Mass General Neurology faculty published more than 1,500 papers in journals like Neurology, Stroke, Nature, the New England Journal of Medicine and JAMA Neurology. Our research efforts advance our mission to rapidly discover new treatments to reduce and eliminate the devastating impact of neurological disorders.

Toward personalized medicine in connectomic deep brain stimulation.
Hollunder B, Rajamani N, Siddiqi SH, Finke C, Kühn AA, Mayberg HS, Fox MD, Neudorfer C, Horn A. Prog Neurobiol. 2021 Dec 24:102211. doi: 10.1016/j.pneurobio.2021.102211.


Associations Between Stroke Localization and Delirium: A Systematic Review and Meta-Analysis.
Rhee JY, Colman MA, Mendu M, Shah SJ, Fox MD, Rost NS, Kimchi EY. J Stroke Cerebrovasc Dis. 2021 Dec 23;31(3):106270. doi: 10.1016/j.jstrokecerebrovasdis.2021.106270.


Adaptive Platform Trials to Transform ALS Therapy Development.
Paganoni S, Berry JD, Quintana M, Macklin E, Saville BR, Detry MA, Chase M, Sherman A, Yu H, Drake K, Andrews J, Shefner J, Chibnik L, Vestrucci M, Cudkowicz ME; HEALEY ALS Platform Trial Study Group. Ann Neurol. 2021 Dec 21. doi: 10.1002/ana.26285.


Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex.
Perosa V, Oltmer J, Munting LP, Freeze WM, Auger CA, Scherlek AA, van der Kouwe AJ, Iglesias JE, Atzeni A, Bacskai BJ, Viswanathan A, Frosch MP, Greenberg SM, van Veluw SJ. Acta Neuropathol. 2021 Dec 20. doi: 10.1007/s00401-021-02393-1.


ER proteins decipher the tubulin code to regulate organelle distribution
Zheng P, Obara CJ, Szczesna E, Nixon-Abell J, Mahalingan KK, Roll-Mecak A, Lippincott-Schwartz J, Blackstone C. Nature. 2021 Dec 15. doi:10.1038/s41586-021-04204-9


Selective retinal ganglion cell loss and optic neuropathy in a humanized mouse model of familial dysautonomia.
Chekuri A, Logan EM, Krauson AJ, Salani M, Ackerman S, Kirchner EG, Bolduc JM, Wang X, Dietrich P, Dragatsis I, Vandenberghe LH, Slaugenhaupt SA, Morini E. Hum Mol Genet. 2021 Dec 15:ddab359. doi: 10.1093/hmg/ddab359.


ER proteins decipher the tubulin code to regulate organelle distribution.
Zheng P, Obara CJ, Szczesna E, Nixon-Abell J, Mahalingan KK, Roll-Mecak A, Lippincott-Schwartz J, Blackstone C. Nature. 2021 Dec 15. doi: 10.1038/s41586-021-04204-9.


Treatment of myelin oligodendrocyte glycoprotein antibody associated disease with subcutaneous immune globulin.
Sotirchos ES, Vasileiou ES, Salky R, Huda S, Mariotto S, Chen JJ, Levy M. Mult Scler Relat Disord. 2021 Dec 13;57:103462. doi: 10.1016/j.msard.2021.103462


A Randomized Placebo-Controlled Phase 3 Study of Mesenchymal stem cells induced to secrete high levels of neurotrophic factors in Amyotrophic Lateral Sclerosis.
Cudkowicz ME, Lindborg SR, Goyal NA, Miller RG, Burford MJ, Berry JD, Nicholson KA, Mozaffar T, Katz JS, Jenkins LJ, Baloh RH, Lewis RA, Staff N, Owegi MA, Berry DA, Gothelf Y, Levy YS, Aricha R, Kern RZ, Windebank AJ, Brown RH Jr. Muscle Nerve. 2021 Dec 10. doi: 10.1002/mus.27472.


Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage.
Morini E, Gao D, Logan EM, Salani M, Krauson AJ, Chekuri A, Chen YT, Ragavendran A, Chakravarty P, Erdin S, Stortchevoi A, Svejstrup JQ, Talkowski ME, Slaugenhaupt SA. J Genet Genomics. 2021 Dec 9:S1673-8527(21)00364-7. doi: 10.1016/j.jgg.2021.11.011.


Transcranial magnetic stimulation to assess motor neurophysiology after acute stroke in the United States: Feasibility, lessons learned, and values for future research.
Kuo YL, Lin DJ, Vora I, DiCarlo JA, Edwards DJ, Kimberley TJ. Brain Stimul. 2021 Dec 7:S1935-861X(21)00836-6. doi: 10.1016/j.brs.2021.12.001.


Bow Hunter's Syndrome.
Regenhardt RW, Kozberg MG, Dmytriw AA, Vranic JE, Stapleton CJ, Silverman SB, Patel AB. Stroke. 2021 Dec 6:STROKEAHA121037253. doi: 10.1161/STROKEAHA.121.037253.


Effects of low-frequency repetitive transcranial magnetic stimulation in adductor laryngeal dystonia: a safety, feasibility, and pilot study.
Prudente CN, Chen M, Stipancic KL, Marks KL, Samargia-Grivette S, Goding GS, Green JR, Kimberley TJ. Exp Brain Res. 2021 Dec 2. doi: 10.1007/s00221-021-06277-4.


Molybdenum Cofactor Deficiency.
Misko A, Mahtani K, Abbott J, Schwarz G, Atwal P. 2021 Dec 2. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Mirzaa GM, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2021.


Safety and efficacy of teriflunomide in paediatric multiple sclerosis (TERIKIDS): a multicentre, double-blind, phase 3, randomised, placebo-controlled trial.
Chitnis T, Banwell B, Kappos L, Arnold DL, Gücüyener K, Deiva K, Skripchenko N, Cui LY, Saubadu S, Hu W, Benamor M, Le-Halpere A, Truffinet P, Tardieu M; TERIKIDS Investigators. Lancet Neurol. 2021 Dec;20(12):1001-1011. doi: 10.1016/S1474-4422(21)00364-1.


Dementia caregivers identify challenges and facilitators to attending health care visits.
Gately ME, Muccini S, McLaren JE, Moo LR. Alzheimers Dement. 2021 Dec;17 Suppl 8:e051842. doi: 10.1002/alz.051842.


Care processes related to clinical detection of Alzheimer's disease in the U.S. Veterans Affairs Health Care System. Miller DR, Jasuja G, Davila HW, Palnati M, Shao Q, Dinesh D, McDannold S, Zhang Q, Monfared AAT, Xia W, Palacios N, Moo LR. Alzheimers Dement. 2021 Dec;17 Suppl 8:e054149. doi: 10.1002/alz.054149.


Cumulative Risk of Immigration Prison Conditions on Health Outcomes Among Detained Immigrants in California.
Saadi A, Patler C, De Trinidad Young ME. J Racial Ethn Health Disparities. 2021 Nov 29:1-15. doi: 10.1007/s40615-021-01187-1.


Cumulative Concussion and Odds of Stroke in Former National Football League Players.
Brett BL, Kerr ZY, Aggarwal NT, Chandran A, Mannix R, Walton S, DeFreese JD, Echemendia RJ, Guskiewicz KM, McCrea MA, Meehan WP 3rd. Stroke. 2021 Nov 29:STROKEAHA121035607. doi: 10.1161/STROKEAHA.121.035607.


A review of neurotoxicities associated with immunotherapy and a framework for evaluation.
Burton LB, Eskian M, Guidon AC, Reynolds KL. Neurooncol Adv. 2021 Nov 27;3(Suppl 5):v108-v120. doi: 10.1093/noajnl/vdab107.


StimFit-A Data-Driven Algorithm for Automated Deep Brain Stimulation Programming.
Roediger J, Dembek TA, Wenzel G, Butenko K, Kühn AA, Horn A. Mov Disord. 2021 Nov 27. doi: 10.1002/mds.28878.


Mapping the subcortical connectivity of the human default mode network.
Li J, Curley WH, Guerin B, Dougherty DD, Dalca AV, Fischl B, Horn A, Edlow BL. Neuroimage. 2021 Nov 25:118758. doi: 10.1016/j.neuroimage.2021.118758.


Interactions Between Kidney Function and Cerebrovascular Disease: Vessel Pathology That Fires Together Wires Together.
Marini S, Georgakis MK, Anderson CD. Front Neurol. 2021 Nov 24;12:785273. doi: 10.3389/fneur.2021.785273.


It is time to move to alternative clinical trial designs: Reconsidering the holy grail of trial methodology.
Yeh EA, Giovannoni G, Hawkes CH, Lechner-Scott J, Levy M. Mult Scler Relat Disord. 2021 Nov;56:103426. doi: 10.1016/j.msard.2021.103426. Epub 2021 Nov 23.


Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson's disease enrolled in PPMI.
Huh YE, Park H, Chiang MSR, Tuncali I, Liu G, Locascio JJ, Shirvan J, Hutten SJ, Rotunno MS, Viel C, Shihabuddin LS, Wang B, Sardi SP, Scherzer CR. NPJ Parkinsons Dis. 2021 Nov 22;7(1):102. doi: 10.1038/s41531-021-00241-3.


The Perivascular Space Race: Understanding Their Role in Brain Clearance.
van Veluw SJ, Perosa V. Neurology. 2021 Nov 22:10.1212/WNL.0000000000013105. doi: 10.1212/WNL.0000000000013105.


Using electronic health data to explore effectiveness of ICU EEG and anti-seizure treatment.
Amerineni R, Sun H, Lee H, Hsu J, Patorno E, Westover MB, Zafar SF. Ann Clin Transl Neurol. 2021 Nov 21. doi: 10.1002/acn3.51478.


Presenilin/γ-secretase activity is located in acidic compartments of live neurons.
Maesako M, Houser MC, Turchyna Y, Wolfe MS, Berezovska O. J Neurosci. 2021 Nov 19:JN-RM-1698-21. doi: 10.1523/JNEUROSCI.1698-21.2021.


An MRI Method for Parcellating the Human Striatum into Matrix and Striosome Compartments In Vivo.
Waugh JL, Hassan A, Kuster JK, Levenstein JM, Warfield SK, Makris N, Brüggeman N, Sharma N, Breiter HC, Blood AJ. Neuroimage. 2021 Nov 17:118714. doi: 10.1016/j.neuroimage.2021.118714.


Patient-reported outcomes associated with transition to secondary progressive multiple sclerosis.
Healy BC, Zurawski J, Chitnis T, Weiner HL, Glanz BI. Qual Life Res. 2021 Nov 16. doi: 10.1007/s11136-021-03034-6.


Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid.
Petrozziello T, Amaral AC, Dujardin S, Farhan SMK, Chan J, Trombetta BA, Kivisäkk P, Mills AN, Bordt EA, Kim SE, Dooley PM, Commins C, Connors TR, Oakley DH, Ghosal A, Gomez-Isla T, Hyman BT, Arnold SE, Spires-Jones T, Cudkowicz ME, Berry JD, Sadri-Vakili G. Brain Pathol. 2021 Nov 14:e13035. doi: 10.1111/bpa.13035.


Case Study 1: A 55-Year-Old Woman With Progressive Cognitive, Perceptual, and Motor Impairments.
McGinnis SM, Stern AM, Woods JK, Torre M, Feany MB, Miller MB, Silbersweig DA, Gale SA, Daffner KR. J Neuropsychiatry Clin Neurosci. 2021 Nov 12:appineuropsych21040114. doi: 10.1176/appi.neuropsych.21040114.


Case 34-2021: A 38-Year-Old Man with Altered Mental Status and New Onset of Seizures.
Cole AJ, Slutzman JE, Ryan ET, Lev MH, Eng G. N Engl J Med. 2021 Nov 11;385(20):1894-1902. doi: 10.1056/NEJMcpc2027080. PMID: 34758256


Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.
Petrozziello T, Bordt EA, Mills AN, Kim SE, Sapp E, Devlin BA, Obeng-Marnu AA, Farhan SMK, Amaral AC, Dujardin S, Dooley PM, Henstridge C, Oakley DH, Neueder A, Hyman BT, Spires-Jones TL, Bilbo SD, Vakili K, Cudkowicz ME, Berry JD, DiFiglia M, Silva MC, Haggarty SJ, Sadri-Vakili G. Mol Neurobiol. 2021 Nov 10. doi: 10.1007/s12035-021-02557-w.


Circadian rhythms in neurodegenerative disorders.
Nassan M, Videnovic A. Nat Rev Neurol. 2021 Nov 10. doi: 10.1038/s41582-021-00577-7.


Linking the Paul Coverdell National Acute Stroke Program to commercial claims to establish a framework for real-world longitudinal stroke research.
Patorno E, Schneeweiss S, George MG, Tong X, Franklin JM, Pawar A, Mogun H, Moura LMVR, Schwamm LH. Stroke Vasc Neurol. 2021 Nov 8:svn-2021-001134. doi: 10.1136/svn-2021-001134.


Determinants of intracranial aneurysm retreatment following embolization with a single flow-diverting stent.
Vranic JE, Harker P, Stapleton CJ, Regenhardt RW, Dmytriw AA, Alotaibi NM, Gupta R, Leslie-Mazwi TM, Koch MJ, Raymond SB, Mascitelli JR, Patterson TT, Seinfeld J, White A, Case D, Roark C, Gandhi CD, Al-Mufti F, Cooper J, Patel AB. Neuroradiol J. 2021 Nov 7:19714009211049086. doi: 10.1177/19714009211049086.


Neuron, control thyself !
Rubin DB, Paulk AC. Brain. 2021 Nov 7:awab413. doi: 10.1093/brain/awab413.


One EEG, one read - A manifesto towards reducing interrater variability among experts.
Nascimento FA, Jing J, Beniczky S, Benbadis SR, Gavvala JR, Yacubian EMT, Wiebe S, Rampp S, van Putten MJAM, Tripathi M, Cook MJ, Kaplan PW, Tatum WO, Trinka E, Cole AJ, Westover MB. Clin Neurophysiol. 2021 Nov 5;133:68-70. doi: 10.1016/j.clinph.2021.10.007.


Cases of Neuroinfectious Disease Highlighting Frontotemporal Neurocircuitry in Cognitive and Affective Processing.
Kritzer MD, Buch K, Mukerji SS, Biffi A, Chemali Z. Prim Care Companion CNS Disord. 2021 Nov 4;23(6):20cr02894. doi: 10.4088/PCC.20cr02894.


Global white matter structural integrity mediates the effect of age on ischemic stroke outcomes.
Etherton MR, Schirmer MD, Zotin MCZ, Rist PM, Boulouis G, Lauer A, Wu O, Rost NS. Int J Stroke. 2021 Nov 3:17474930211055906. doi: 10.1177/17474930211055906.


Symmetric CTA Collaterals Identify Patients with Slow-progressing Stroke Likely to Benefit from Late Thrombectomy.
Regenhardt RW, González RG, He J, Lev MH, Singhal AB. Radiology. 2021 Nov 2:210455. doi: 10.1148/radiol.2021210455.


Efficacy of Fluoxetine for Post-Ischemic Stroke Depression in Tanzania.
Rice DR, Okeng'o K, Massawe E, Ismail S, Mworia NA, Chiwanga F, Kapina B, Wasserman M, Mateen FJ. J Stroke Cerebrovasc Dis. 2021 Nov 2;31(1):106181. doi: 10.1016/j.jstrokecerebrovasdis.2021.106181.


Expanding Access to Specialty Care Using Video-Telehealth: The Case for Functional Neurological Disorder.
Perez DL. J Acad Consult Liaison Psychiatry. 2021 Nov-Dec;62(6):667-668. doi: 10.1016/j.jaclp.2021.07.002.


Preserving brain health after intracerebral haemorrhage.
Rosand J. Lancet Neurol. 2021 Nov;20(11):879-880. doi: 10.1016/S1474-4422(21)00339-2.


Advances in Neurocardiology: Focus on Atrial Fibrillation.
Sposato LA, Gurol ME. Stroke. 2021 Nov;52(11):3696-3699. doi: 10.1161/STROKEAHA.121.033970


Autonomic, Endocrine, and Inflammation Profiles in Functional Neurological Disorder: A Systematic Review and Meta-Analysis.
Paredes-Echeverri S, Maggio J, Bègue I, Pick S, Nicholson TR, Perez DL. J Neuropsychiatry Clin Neurosci. 2021 Oct 29:appineuropsych21010025. doi: 10.1176/appi.neuropsych.21010025.


Developing a Dual Residency Program in Psychiatry and Neurology in an Area of Regional Conflict: The University of Hargeisa-Harvard Medical School-Boston University Experience.
Chemali Z, Henderson DC, Fricchione G. J Neuropsychiatry Clin Neurosci. 2021 Oct 29:appineuropsych21010003. doi: 10.1176/appi.neuropsych.21010003.


VGF as a biomarker and therapeutic target in neurodegenerative and psychiatric diseases.
Quinn JP, Kandigian SE, Trombetta BA, Arnold SE, Carlyle BC. Brain Commun. 2021 Oct 27;3(4):fcab261. doi: 10.1093/braincomms/fcab261.


Neurofibromatoses.
Jordan JT, Plotkin SR. Hematol Oncol Clin North Am. 2021 Oct 27:S0889-8588(21)00113-1. doi: 10.1016/j.hoc.2021.08.010.


Language Decline Characterizes Amnestic Mild Cognitive Impairment Independent of Cognitive Decline.
Sherman JC, Henderson CR Jr, Flynn S, Gair JW, Lust B. J Speech Lang Hear Res. 2021 Oct 26:1-21. doi: 10.1044/2021_JSLHR-20-00503.


Differential diagnosis of Multiple sclerosis.
Cavanagh JJ, Levy M. Presse Med. 2021 Oct 26:104092. doi: 10.1016/j.lpm.2021.104092.


A framework of social determinants of health for delirium tailored to older adults.
Arias F, Alegria M, Kind AJ, Jones RN, Travison TG, Marcantonio ER, Schmitt EM, Fong TG, Inouye SK. J Am Geriatr Soc. 2021 Oct 25. doi: 10.1111/jgs.17465.


Predicting neurological outcome in comatose patients after cardiac arrest with multiscale deep neural networks.
Zheng WL, Amorim E, Jing J, Ge W, Hong S, Wu O, Ghassemi M, Lee JW, Sivaraju A, Pang T, Herman ST, Gaspard N, Ruijter BJ, Sun J, Tjepkema-Cloostermans MC, Hofmeijer J, van Putten MJAM, Westover MB. Resuscitation. 2021 Oct 24;169:86-94. doi: 10.1016/j.resuscitation.2021.10.034.


Abnormally weak functional connections get stronger in chronic stroke patients who benefit from naming therapy.
Johnson JP, Meier EL, Pan Y, Kiran S. Brain Lang. 2021 Oct 22;223:105042. doi: 10.1016/j.bandl.2021.105042.


Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke Interventions.
Kuohn LR, Herman AL, Soto AL, Brown SC, Gilmore EJ, Hirsch LJ, Matouk CC, Sheth KN, Kim JA. J Stroke Cerebrovasc Dis. 2021 Oct 20;31(1):106155. doi: 10.1016/j.jstrokecerebrovasdis.2021.106155.


Re-CHARGE-AF: Recalibration of the CHARGE-AF Model for Atrial Fibrillation Risk Prediction in Patients With Acute Stroke.
Ashburner JM, Wang X, Li X, Khurshid S, Ko D, Trisini Lipsanopoulos A, Lee PR, Carmichael T, Turner AC, Jackson C, Ellinor PT, Benjamin EJ, Atlas SJ, Singer DE, Trinquart L, Lubitz SA, Anderson CD. J Am Heart Assoc. 2021 Oct 20:e022363. doi: 10.1161/JAHA.121.022363.


Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting.
Sahni V, Itoh Y, Shnider SJ, Macklis JD. Cell Rep. 2021 Oct 19;37(3):109842. doi: 10.1016/j.celrep.2021.109842.


Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting.
Sahni V, Shnider SJ, Jabaudon D, Song JHT, Itoh Y, Greig LC, Macklis JD. Cell Rep. 2021 Oct 19;37(3):109843. doi: 10.1016/j.celrep.2021.109843.


Dystonia-specific mutations in THAP1 alter transcription of genes associated with neurodevelopment and myelin.
Domingo A, Yadav R, Shah S, Hendriks WT, Erdin S, Gao D, O'Keefe K, Currall B, Gusella JF, Sharma N, Ozelius LJ, Ehrlich ME, Talkowski ME, Bragg DC. Am J Hum Genet. 2021 Oct 15:S0002-9297(21)00353-0. doi: 10.1016/j.ajhg.2021.09.017.


ALSUntangled #63: ketogenic diets.
Bedlack R, Barkhaus PE, Barnes B, Beauchamp M, Bertorini T, Bromberg MB, Carter GT, Chaudry V, Cudkowicz M, Jackson C, Levitsky G, Lund I, McDermott C, Novella S, Olby N, Ostrow L, Pattee GL, Heiman-Patterson T, Ratner D, Salmon K, Steves S, Terrelonge M, Wicks P, Wills AM. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Oct 14:1-5. doi: 10.1080/21678421.2021.1990346.


Frequency and Prognostic Significance of Clinical Fluctuations Before Hospital Arrival in Stroke.
Romano JG, Gardener H, Smith EE, Campo-Bustillo I, Khan Y, Tai S, Riley N, Sacco RL, Khatri P, Alger HM, Mac Grory B, Gulati D, Sangha NS, Olds KE, Benesch CG, Kelly AG, Brehaut SS, Kansara AC, Schwamm LH; MaRISS Investigators. Stroke. 2021 Oct 14:STROKEAHA121034124. doi: 10.1161/STROKEAHA.121.034124.


Long-Term Recovery from Disordered Consciousness Associated with COVID-19.
Fischer D, Edlow BL. Neurocrit Care. 2021 Oct 12:1-3. doi: 10.1007/s12028-021-01367-1.


Sociodemographic and clinical factors associated with depression, anxiety, and general mental health in people with multiple sclerosis during the COVID-19 pandemic. Uhr L, Rice DR, Mateen FJ. Mult Scler Relat Disord. 2021 Oct 11;56:103327. doi: 10.1016/j.msard.2021.103327.


On the dynamic and even reversible nature of Leigh syndrome: Lessons from human imaging and mouse models.
Walker MA, Miranda M, Allred A, Mootha VK. Curr Opin Neurobiol. 2021 Oct 13;72:80-90. doi: 10.1016/j.conb.2021.09.006.


Altered adipokine levels are associated with dimethyl fumarate treatment in multiple sclerosis patients.
Baharnoori M, Wilson R, Saxena S, Gonzalez CT, Sotiropoulos MG, Keyhanian K, Healy BC, Chitnis T. Mult Scler Relat Disord. 2021 Oct 4;56:103311. doi: 10.1016/j.msard.2021.103311.


Early Rehabilitation for Patients with Disorders of Consciousness after Severe COVID-19.
Edlow BL. Neurocrit Care. 2021 Oct 6:1-3. doi: 10.1007/s12028-021-01361-7.


Tracking the Migration of Injectable Microdevices in the Rodent Brain Using a 9.4T Magnetic Resonance Imaging Scanner.
Khalifa A, Weigand-Whittier J, Farrar CT, Cash S. Front Neurosci. 2021 Oct 5;15:738589. doi: 10.3389/fnins.2021.738589.


Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patients.
Normandin E, Holroyd KB, Collens SI, Shaw BM, Siddle KJ, Adams G, Rudy M, Solomon IH, Anahtar MN, Lemieux JE, Trombetta BA, Kivisakk P, Arnold SE, Rapalino O, Piantadosi AL, Sen P, Rosenberg ES, Branda J, Sabeti PC, Mukerji SS. J Neurol Sci. 2021 Oct 4;430:120023. doi: 10.1016/j.jns.2021.120023.


Diagnosing Level of Consciousness: The Limits of the Glasgow Coma Scale Total Score.
Bodien Y, Barra A, Temkin N, Barber J, Foreman B, Vassar M, Robertson CS, Taylor SR, Markowitz AJ, Manley GT, Giacino J, Edlow BL. J Neurotrauma. 2021 Oct 4. doi: 10.1089/neu.2021.0199.


Central Nervous System Complications Among Oncology Patients.
Winter SF, Jo J, Schiff D, Dietrich J. Hematol Oncol Clin North Am. 2021 Oct 2:S0889-8588(21)00108-8. doi: 10.1016/j.hoc.2021.08.005.


Greater Neural Differentiation in the Ventral Visual Cortex Is Associated with Youthful Memory in Superaging.
Katsumi Y, Andreano JM, Barrett LF, Dickerson BC, Touroutoglou A. Cereb Cortex. 2021 Oct 1;31(11):5275-5287. doi: 10.1093/cercor/bhab157.


Seizures, Status Epilepticus, and Continuous EEG in the Intensive Care Unit.
Rosenthal ES. Continuum (Minneap Minn). 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012.


Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome as Syndromes of Cerebrovascular Dysregulation.
Singhal AB. Continuum (Minneap Minn). 2021 Oct 1;27(5):1301-1320. doi: 10.1212/CON.0000000000001037.


Editorial: Vestibular Contributions to Health and Disease, Volume II-Dedicated to Bernard Cohen.
Lewis RF, Strupp M. Front Neurol. 2021 Oct 1;12:760822. doi: 10.3389/fneur.2021.760822. eCollection 2021.


Changes in Virtual and In-Person Health Care Utilization in a Large Health System During the COVID-19 Pandemic.
Zachrison KS, Yan Z, Schwamm LH. JAMA Netw Open. 2021 Oct 1;4(10):e2129973. doi: 10.1001/jamanetworkopen.2021.29973.


When Should Neuroendovascular Care for Patients With Acute Stroke Be Palliative?
Young MJ, Regenhardt RW, Sokol LL, Leslie-Mazwi TM. AMA J Ethics. 2021 Oct 1;23(10):E783-793. doi: 10.1001/amajethics.2021.783.


Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial.
Cudkowicz M, Genge A, Maragakis N, Petri S, van den Berg L, Aho VV, Sarapohja T, Kuoppamäki M, Garratt C, Al-Chalabi A; REFALS investigators. Lancet Neurol. 2021 Oct;20(10):821-831. doi: 10.1016/S1474-4422(21)00242-8.


Barriers and Facilitators to Implementation of Health System Interventions Aiming to Welcome and Protect Immigrant Patients: a Qualitative Study. Saadi A, Sanchez Molina U, Franco-Vasquez A, Inkelas M, Ryan GW. J Gen Intern Med. 2021 Oct;36(10):3071-3079. doi: 10.1007/s11606-021-06788-4.


Evaluation and Management of Delirium.
Ryan SL, Kimchi EY. Semin Neurol. 2021 Oct;41(5):572-587. doi: 10.1055/s-0041-1733791. Epub 2021 Oct 7.


Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease.
Papp KV, Samaroo A, Chou HC, Buckley R, Schneider OR, Hsieh S, Soberanes D, Quiroz Y, Properzi M, Schultz A, García-Magariño I, Marshall GA, Burke JG, Kumar R, Snyder N, Johnson K, Rentz DM, Sperling RA, Amariglio RE. Alzheimers Dement (Amst). 2021 Sep 30;13(1):e12243. doi: 10.1002/dad2.12243.


Cerebral Small Vessel Disease and Depression Among Intracerebral Hemorrhage Survivors.
Castello JP, Pasi M, Kubiszewski P, Abramson JR, Charidimou A, Kourkoulis C, DiPucchio Z, Schwab K, Anderson CD, Gurol ME, Greenberg SM, Rosand J, Viswanathan A, Biffi A. Stroke. 2021 Sep 30:STROKEAHA121035488. doi: 10.1161/STROKEAHA.121.035488.


Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults
Rodriguez-Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz AP, Properzi MJ, Scott MR, Amariglio R, Papp KV, Marshall GA, Fortea J, Johnson KA, Sperling RA, Vannini P. Mol Psychiatry. 2021 Sep 29. doi: 10.1038/s41380-021-01290-z.


Evolving phenotypes of non-hospitalized patients that indicate long COVID.
Estiri H, Strasser ZH, Brat GA, Semenov YR; Consortium for Characterization of COVID-19 by EHR (4CE), Patel CJ, Murphy SN. BMC Med. 2021 Sep 27;19(1):249. doi: 10.1186/s12916-021-02115-0.


Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S).
van Sleuwen M, Sun H, Eckhardt C, Neelagiri A, Tesh RA, Westmeijer M, Paixao L, Rajan S, Velpula Krishnamurthy P, Sikka P, Leone MJ, Panneerselvam E, Quadri SA, Akeju O, Kimchi EY, Westover MB. Crit Care Med. 2021 Sep 24. doi: 10.1097/CCM.0000000000005224.


Shedding Light on the Causes and Characteristics of Stroke in Lebanon: A Systematic Review of Literature.
Gifford A, Biffi A, Gelaye B, Chemali Z. J Geriatr Psychiatry Neurol. 2021 Sep 23:8919887211044753. doi: 10.1177/08919887211044753.


In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline.
Jacobs HIL, Becker JA, Kwong K, Engels-Domínguez N, Prokopiou PC, Papp KV, Properzi M, Hampton OL, d'Oleire Uquillas F, Sanchez JS, Rentz DM, El Fakhri G, Normandin MD, Price JC, Bennett DA, Sperling RA, Johnson KA. Sci Transl Med. 2021 Sep 22;13(612):eabj2511. doi: 10.1126/scitranslmed.abj2511


Epilepsy stigma in the Republic of Guinea and its socioeconomic and clinical associations: A cross-sectional analysis.
Rice DR, Cisse FA, Djibo Hamani AB, Tassiou NR, Sakadi F, Bah AK, Othon GC, Conde ML, Diawara K, Traoré M, Doumbouya I, Koudaye C, Mateen FJ; Guinea Epilepsy Project. Epilepsy Res. 2021 Sep 21;177:106770. doi: 10.1016/j.eplepsyres.2021.106770.


Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial.
de Havenon A, Anadani M, Prabhakaran S, Wong KH, Yaghi S, Rost N. J Am Heart Assoc. 2021 Sep 21;10(18):e022206. doi: 10.1161/JAHA.121.022206.


Reemergence of the language network during recovery from severe traumatic brain injury: A pilot functional MRI study.
Coffey BJ, Threlkeld ZD, Foulkes AS, Bodien YG, Edlow BL. Brain Inj. 2021 Sep 21:1-11. doi: 10.1080/02699052.2021.1972455.


Chronic Relapsing Inflammatory Optic Neuropathy (CRION).
Mukharesh L, Douglas VP, Chwalisz BK. Curr Opin Ophthalmol. 2021 Sep 20. doi: 10.1097/ICU.0000000000000804.


A Research Domain Criteria Approach to Gambling Disorder and Behavioral Addictions: Decision-Making, Response Inhibition, and the Role of Cannabidiol.
Pallanti S, Marras A, Makris N. Front Psychiatry. 2021 Sep 17;12:634418. doi: 10.3389/fpsyt.2021.634418.


Investigating Language and Domain-General Processing in Neurotypicals and Individuals With Aphasia - A Functional Near-Infrared Spectroscopy Pilot Study.
Gilmore N, Yücel MA, Li X, Boas DA, Kiran S. Front Hum Neurosci. 2021 Sep 17;15:728151. doi: 10.3389/fnhum.2021.728151. eCollection 2021.


Association between Hypothyroidism Onset and Alzheimer Disease Onset in Adults with Down Syndrome.
Lai F, Mercaldo ND, Wang CM, Hersch MS, Hersch GG, Rosas HD. Brain Sci. 2021 Sep 16;11(9):1223. doi: 10.3390/brainsci11091223.


Family Perspectives on Clinical Research for Pediatric Multiple Sclerosis: Enhancing Equity.
Mandel LA, O'Donnell E, Canenguez K, Castro-Mendoza PB, Lotze T, Waubant E, Weinstock-Guttmann B, Chitnis T. J Patient Exp. 2021 Sep 15;8:23743735211039319. doi: 10.1177/23743735211039319.


Treatment of Primary CNS Lymphoma: Maximizing Clinical Benefit, Minimizing Neurotoxicity.
Song KW, Batchelor T. Curr Oncol Rep. 2021 Sep 15;23(11):132. doi: 10.1007/s11912-021-01116-9.


Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial. Parkinson Study Group SURE-PD3 Investigators, Schwarzschild MA, Ascherio A, Casaceli C, Curhan GC, Fitzgerald R, Kamp C, Lungu C, Macklin EA, Marek K, Mozaffarian D, Oakes D, Rudolph A, Shoulson I, Videnovic A, Scott B, Gauger L, Aldred J, Bixby M, Ciccarello J, Gunzler SA, Henchcliffe C, Brodsky M, Keith K, Hauser RA, Goetz C, LeDoux MS, Hinson V, Kumar R, Espay AJ, Jimenez-Shahed J, Hunter C, Christine C, Daley A, Leehey M, de Marcaida JA, Friedman JH, Hung A, Bwala G, Litvan I, Simon DK, Simuni T, Poon C, Schiess MC, Chou K, Park A, Bhatti D, Peterson C, Criswell SR, Rosenthal L, Durphy J, Shill HA, Mehta SH, Ahmed A, Deik AF, Fang JY, Stover N, Zhang L, Dewey RB Jr, Gerald A, Boyd JT, Houston E, Suski V, Mosovsky S, Cloud L, Shah BB, Saint-Hilaire M, James R, Zauber SE, Reich S, Shprecher D, Pahwa R, Langhammer A, LaFaver K, LeWitt PA, Kaminski P, Goudreau J, Russell D, Houghton DJ, Laroche A, Thomas K, McGraw M, Mari Z, Serrano C, Blindauer K, Rabin M, Kurlan R, Morgan JC, Soileau M, Ainslie M, Bodis-Wollner I, Schneider RB, Waters C, Ratel AS, Beck CA, Bolger P, Callahan KF, Crotty GF, Klements D, Kostrzebski M, McMahon GM, Pothier L, Waikar SS, Lang A, Mestre T. JAMA. 2021 Sep 14;326(10):926-939. doi: 10.1001/jama.2021.10207.


A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia.
Henderson SK, Dev SI, Ezzo R, Quimby M, Wong B, Brickhouse M, Hochberg D, Touroutoglou A, Dickerson BC, Cordella C, Collins JA. Brain Commun. 2021 Sep 14;3(4):fcab210. doi: 10.1093/braincomms/fcab210.


Diazepam induced sleep spindle increase correlates with cognitive recovery in a child with epileptic encephalopathy. Stoyell SM, Baxter BS, McLaren J, Kwon H, Chinappen DM, Ostrowski L, Zhu L, Grieco JA, Kramer MA, Morgan AK, Emerton BC, Manoach DS, Chu CJ. BMC Neurol. 2021 Sep 14;21(1):355. doi: 10.1186/s12883-021-02376-5.


Radiomic signature of DWI-FLAIR mismatch in large vessel occlusion stroke.
Regenhardt RW, Bretzner M, Zanon Zotin MC, Bonkhoff AK, Etherton MR, Hong S, Das AS, Alotaibi NM, Vranic JE, Dmytriw AA, Stapleton CJ, Patel AB, Kuchcinski G, Rost NS, Leslie-Mazwi TM. J Neuroimaging. 2021 Sep 10. doi: 10.1111/jon.12928.


Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke.
Hong S, Giese AK, Schirmer MD, Bonkhoff AK, Bretzner M, Rist P, Dalca AV, Regenhardt RW, Etherton MR, Donahue KL, Nardin M, Mocking SJT, McIntosh EC, Attia J, Benavente OR, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Roquer J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah CL, Rolfs A, Ropele S, Rosand J, Rundek T, Sacco RL, Schmidt R, Enzinger C, Sharma P, Slowik A, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Zand R, McArdle PF, Worrall BB, Wu O, Jern C, Lindgren AG, Maguire J, Tomppo L, Golland P, Rost NS; MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium. Front Neurol. 2021 Sep 10;12:700616. doi: 10.3389/fneur.2021.700616. eCollection 2021.


A Longitudinal Analysis of Early Lesion Growth in Presymptomatic Patients with Cerebral Adrenoleukodystrophy.
Mallack EJ, Askin G, van de Stadt S, Caruso PA, Musolino PL, Engelen M, Niogi SN, Eichler FS. AJNR Am J Neuroradiol. 2021 Sep 9. doi: 10.3174/ajnr.A7250.


Intracerebral hemorrhage and small vessel disease.
Li Q, Wang ZJ, Viswanathan A. Chin Med J (Engl). 2021 Sep 9. doi: 10.1097/CM9.0000000000001620.


A Primer on EEG Spectrograms.
Ng MC, Jing J, Westover MB. J Clin Neurophysiol. 2021 Sep 8. doi: 10.1097/WNP.0000000000000736.


Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds.
Fernandes AR, Dujardin S, Maté de Gérando A, Hyman BT, Frosch MP. J Neuropathol Exp Neurol. 2021 Sep 8:nlab087. doi: 10.1093/jnen/nlab087.


Association of External Ventricular Drain Wean Strategy with Shunt Placement and Length of Stay in Subarachnoid Hemorrhage: A Prospective Multicenter Study.
Chung DY, Thompson BB, Kumar MA, Mahta A, Rao SS, Lai JH, Tadevosyan A, Kessler K, Locascio JJ, Patel AB, Mohamed W, Olson DM, John S, Rordorf GA. Neurocrit Care. 2021 Sep 8. doi: 10.1007/s12028-021-01343-9.


The Utility of Quantitative EEG in Detecting Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.
Baang HY, Chen HY, Herman AL, Gilmore EJ, Hirsch LJ, Sheth KN, Petersen NH, Zafar SF, Rosenthal ES, Westover MB, Kim JA. J Clin Neurophysiol. 2021 Sep 8. doi: 10.1097/WNP.0000000000000754.


Decoding the Spectrogram Rainbow.
Ng MC, Westover MB. J Clin Neurophysiol. 2021 Sep 8. doi: 10.1097/WNP.0000000000000741.


Adalimumab for CNS sarcoidosis: single-center experience and literature review.
Hutto SK, Kyle K, Cavanagh JJ, Reda H, Venna N. J Neurol. 2021 Sep 6. doi: 10.1007/s00415-021-10793-2.


Neurologic complications in patients with lymphoid cancer.
Nayak L, Batchelor TT. Blood. 2021 Sep 3:blood.2019003690. doi: 10.1182/blood.2019003690.


Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells.
Sadegh C, Ebina W, Arvanites AC, Davidow LS, Rubin LL, Macklis JD. PLoS One. 2021 Sep 2;16(9):e0254113. doi: 10.1371/journal.pone.0254113.


Increasing Representation of Women as Editors in Medical Journals.
Jacobs EA, Ganguli I, Inouye SK. JAMA Netw Open. 2021 Sep 1;4(9):e2123364. doi: 10.1001/jamanetworkopen.2021.23364.


The Urgent Need for Rigorous Studies of Telehealth for Older Adults Who Are Homebound.
Moo LR, Schwartz AW. JAMA Netw Open. 2021 Sep 1;4(9):e2113451. doi: 10.1001/jamanetworkopen.2021.13451.


High-Resolution Ultrasound in the Diagnosis and Surgical Management of Ulnar Neuropathy at the Elbow.
Limbekar NS, Soong MC, Vytopil MM, Blanchet DT, Paci GM, Ho DT. Orthopedics. 2021 Sep-Oct;44(5):285-288. doi: 10.3928/01477447-20210819-06


From REM to orexin: clinical progress in narcolepsy - was it worth the wait? was it worth the "weight?".
Sassower KC. Arq Neuropsiquiatr. 2021 Sep;79(9):757-758. doi: 10.1590/0004-282X-anp-2021-E009.


Neutralizing antibody evasion and transduction with purified extracellular vesicle-enveloped AAV vectors.
Cheng M, Dietz L, Gong Y, Eichler F, Nammour J, Ng C, Grimm D, Maguire CA. Hum Gene Ther. 2021 Aug 27. doi: 10.1089/hum.2021.122.


Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalitis Following COVID-19: Systematic Review and Meta-synthesis.
Manzano GS, McEntire CRS, Martinez-Lage M, Mateen FJ, Hutto SK. Neurol Neuroimmunol Neuroinflamm. 2021 Aug 27;8(6):e1080. doi: 10.1212/NXI.0000000000001080.


Targeting lipid droplets for autophagic degradation by ATTEC.
Fu Y, Lu B. Autophagy. 2021 Aug 26:1-3. doi: 10.1080/15548627.2021.1967616.


In vitro ictogenesis is stochastic at the single neuron level.
Lau LA, Staley KJ, Lillis KP. Brain. 2021 Aug 25:awab312. doi: 10.1093/brain/awab312.


EXPRESS: Idiopathic Primary Intraventricular Hemorrhage and Cerebral Small Vessel Disease. Das AS, Regenhardt RW, Gokcal E, Horn MJ, Daoud N, Schwab KM, Rost NS, Viswanathan A, Kimberly WT, Goldstein JN, Biffi A, Schwamm L, Rosand J, Greenberg SM, Gurol ME. Int J Stroke. 2021 Aug 24:17474930211043663. doi: 10.1177/17474930211043663.


High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.
Cheng C, Reis SA, Adams ET, Fass DM, Angus SP, Stuhlmiller TJ, Richardson J, Olafson H, Wang ET, Patnaik D, Beauchamp RL, Feldman DA, Silva MC, Sur M, Johnson GL, Ramesh V, Miller BL, Temple S, Kosik KS, Dickerson BC, Haggarty SJ. Sci Rep. 2021 Aug 23;11(1):17029. doi: 10.1038/s41598-021-96227-5.


Deep learning assisted quantitative assessment of histopathological markers of Alzheimer's disease and cerebral amyloid angiopathy.
Perosa V, Scherlek AA, Kozberg MG, Smith L, Westerling-Bui T, Auger CA, Vasylechko S, Greenberg SM, van Veluw SJ. Acta Neuropathol Commun. 2021 Aug 21;9(1):141. doi: 10.1186/s40478-021-01235-1.


Vesicle trafficking and pathways to neurodegeneration.
Blackstone C, Elwood F, Plun-Favreau H, Lewis PA. Mol Neurodegener. 2021 Aug 21;16(1):56. doi: 10.1186/s13024-021-00480-1.


B-Cell Targeted Treatments for Neuromyelitis Optica Spectrum Disorder: A Focus on CD19 and CD20.
Levy M, Mealy MA. Immunotargets Ther. 2021 Aug 20;10:325-331. doi: 10.2147/ITT.S255722. eCollection 2021.


Acquired Brain Injury in Adults: A Review of Pathophysiology, Recovery, and Rehabilitation.
Gilmore N, Katz DI, Kiran S. Perspect ASHA Spec Interest Groups. 2021 Aug;6(4):714-727. doi: 10.1044/2021_persp-21-00013. Epub 2021 Aug 20.


Treating epilepsy in forcibly displaced persons: timely, necessary, affordable.
Mateen FJ. Nat Rev Neurol. 2021 Aug 19. doi: 10.1038/s41582-021-00548-y.


Sleep apnea and respiratory anomaly detection from a wearable band and oxygen saturation.
Ganglberger W, Bucklin AA, Tesh RA, Da Silva Cardoso M, Sun H, Leone MJ, Paixao L, Panneerselvam E, Ye EM, Thompson BT, Akeju O, Kuller D, Thomas RJ, Westover MB. Sleep Breath. 2021 Aug 18. doi: 10.1007/s11325-021-02465-2.


Clinical Correlation Between Vertical Gaze Palsy and Midbrain Volume in Progressive Supranuclear Palsy.
Buch KA, Bouffard MA, Kardon RH, Wills AA, Privitera CM, Sharma M, Wray SH. J Neuroophthalmol. 2021 Aug 17. doi: 10.1097/WNO.0000000000001393.


Stroke Genetics: Turning Discoveries into Clinical Applications.
Dichgans M, Beaufort N, Debette S, Anderson CD. Stroke. 2021 Aug 17:STROKEAHA121032616. doi: 10.1161/STROKEAHA.121.032616.


The development and implementation of teleneuropsychology in an academic lifespan neuropsychology center: Lessons learned from the COVID-19 pandemic.
Pulsifer MB, Grieco JA, Burstein SM, Parsons MW, Gardner MM, Sherman JC. J Clin Exp Neuropsychol. 2021 Aug 13:1-12. doi: 10.1080/13803395.2021.1963683.


Retrospective Analysis of Safety and Outcomes of Rituximab for Myasthenia Gravis in Patients ≥ 65 Years Old.
Doughty CT, Suh J, David WS, Amato AA, Guidon AC. Muscle Nerve. 2021 Aug 11. doi: 10.1002/mus.27393.


Automated olfactory bulb segmentation on high resolutional T2-weighted MRI.
Estrada S, Lu R, Diers K, Zeng W, Ehses P, Stöcker T, Breteler MMB, Reuter M. Neuroimage. 2021 Aug 10;242:118464. doi: 10.1016/j.neuroimage.2021.118464.


Electronic pill bottles to monitor and promote medication adherence for people with multiple sclerosis: A randomized, virtual clinical trial.
Rice DR, Kaplan TB, Hotan GC, Vogel AC, Matiello M, Gillani RL, Hutto SK, Ham AS, Klawiter EC, George IC, Galetta K, Mateen FJ. J Neurol Sci. 2021 Aug 8;428:117612. doi: 10.1016/j.jns.2021.117612.


Preliminary Neurocognitive Results Post Hypoglossal Nerve Stimulation in Patients With Down Syndrome.
Grieco JA, Hartnick CJ, Skotko BG, Yu PK, Pulsifer MB. Laryngoscope. 2021 Aug 7. doi: 10.1002/lary.29808.


National Trends in Telestroke Utilization in a US Commercial Platform Prior to the COVID-19 Pandemic.
Zachrison KS, Sharma R, Wang Y, Mehrotra A, Schwamm LH. J Stroke Cerebrovasc Dis. 2021 Aug 7;30(10):106035. doi: 10.1016/j.jstrokecerebrovasdis.2021.106035.


Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions.
Pereira JD, DuBreuil DM, Devlin AC, Held A, Sapir Y, Berezovski E, Hawrot J, Dorfman K, Chander V, Wainger BJ. Nat Commun. 2021 Aug 6;12(1):4744. doi: 10.1038/s41467-021-24776-4.


De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells.
Fukuda A, Hazelbaker DZ, Motosugi N, Hao J, Limone F, Beccard A, Mazzucato P, Messana A, Okada C, San Juan IG, Qian M, Umezawa A, Akutsu H, Barrett LE, Eggan K. Stem Cell Reports. 2021 Aug 5:S2213-6711(21)00381-7. doi: 10.1016/j.stemcr.2021.07.015.


The neuroethics of disorders of consciousness: a brief history of evolving ideas.
Young MJ, Bodien YG, Giacino JT, Fins JJ, Truog RD, Hochberg LR, Edlow BL. Brain. 2021 Aug 4:awab290. doi: 10.1093/brain/awab290


Reader Response: Critical Illness-Associated Cerebral Microbleeds in COVID-19 Acute Respiratory Distress Syndrome.
Edlow BL, Conklin J, Huang SY. Neurology. 2021 Aug 3;97(5):254. doi: 10.1212/WNL.0000000000012364.


Corrigendum to "Stress, resilience, and coping strategies in a sample of community-dwelling older adults during COVID-19" [J. Psychiatr. Res. 138 (2021) 176-185].
Vannini P, Gagliardi GP, Kuppe M, Dossett ML, Donovan NJ, Gatchel JR, Quiroz YT, Premnath PY, Amariglio R, Sperling RA, Marshall GA. J Psychiatr Res. 2021 Aug 3;142:167-170. doi: 10.1016/j.jpsychires.2021.07.045.


Dopaminergic modulation of human consciousness via default mode network connectivity.
Edlow BL. Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):e2111268118. doi: 10.1073/pnas.2111268118.


Association Between Hospital Volumes and Clinical Outcomes for Patients With Nontraumatic Subarachnoid Hemorrhage.
Leifer D, Fonarow GC, Hellkamp A, Baker D, Hoh BL, Prabhakaran S, Schoeberl M, Suter R, Washington C, Williams S, Xian Y, Schwamm LH. J Am Heart Assoc. 2021 Aug 3;10(15):e018373. doi: 10.1161/JAHA.120.018373


Association of Social Support With Brain Volume and Cognition.
Salinas J, O'Donnell A, Kojis DJ, Pase MP, DeCarli C, Rentz DM, Berkman LF, Beiser A, Seshadri S. JAMA Netw Open. 2021 Aug 2;4(8):e2121122. doi: 10.1001/jamanetworkopen.2021.21122.


Microscale dynamics of electrophysiological markers of epilepsy.
Yang JC, Paulk AC, Salami P, Lee SH, Ganji M, Soper DJ, Cleary D, Simon M, Maus D, Lee JW, Nahed BV, Jones PS, Cahill DP, Cosgrove GR, Chu CJ, Williams Z, Halgren E, Dayeh S, Cash SS. Clin Neurophysiol. 2021 Aug 2:S1388-2457(21)00670-2. doi: 10.1016/j.clinph.2021.06.024.


Patient-reported safety and tolerability of the COVID-19 vaccines in persons with rare neuroimmunological diseases.
Lotan I, Romanow G, Levy M. Mult Scler Relat Disord. 2021 Aug 2;55:103189. doi: 10.1016/j.msard.2021.103189.


Radiologically isolated syndrome: A single-center, retrospective cohort study.
George IC, Rice DR, Chibnik LB, Mateen FJ. Mult Scler Relat Disord. 2021 Aug 2;55:103183. doi: 10.1016/j.msard.2021.103183.


Detection of Leptomeningeal Disease Using Cell-Free DNA From Cerebrospinal Fluid.
White MD, Klein RH, Shaw B, Kim A, Subramanian M, Mora JL, Giobbie-Hurder A, Nagabhushan D, Jain A, Singh M, Kuter BM, Nayyar N, Bertalan MS, Stocking JH, Markson SC, Lastrapes M, Alvarez-Breckenridge C, Cahill DP, Gydush G, Rhoades J, Rotem D, Adalsteinsson VA, Mahar M, Kaplan A, Oh K, Sullivan RJ, Gerstner E, Carter SL, Brastianos PK. JAMA Netw Open. 2021 Aug 2;4(8):e2120040. doi: 10.1001/jamanetworkopen.2021.20040.


A Simplified Brain Blocking Protocol Optimized for the Diagnosis of Neurodegenerative Disease Saves Time and Money While Preserving Anatomic Relationships.
Clement NF, DeWitt JC, Frosch MP, Martinez-Lage M, Samore WR, Hedley-Whyte ET. Arch Pathol Lab Med. 2021 Aug 1;145(8):960-968. doi: 10.5858/arpa.2020-0322-OA.


The Changing Face of Osmotic Demyelination Syndrome: A Retrospective, Observational Cohort Study.
Fitts W, Vogel AC, Mateen FJ. Neurol Clin Pract. 2021 Aug;11(4):304-310. doi: 10.1212/CPJ.0000000000000932.


Risk of Poor Outcomes with COVID-19 Among U.S. Detained Immigrants: A Cross-Sectional Study.
Patler C, Saadi A. J Immigr Minor Health. 2021 Aug;23(4):863-866. doi: 10.1007/s10903-021-01173-z.


Radicava/Edaravone Findings in Biomarkers From Amyotrophic Lateral Sclerosis (REFINE-ALS): Protocol and Study Design.
Berry J, Brooks B, Genge A, Heiman-Patterson T, Appel S, Benatar M, Bowser R, Cudkowicz M, Gooch C, Shefner J, Westra J, Agnese W, Merrill C, Nelson S, Apple S. Neurol Clin Pract. 2021 Aug;11(4):e472-e479. doi: 10.1212/CPJ.0000000000000968.


Telehealth Disparities: The Authors Reply.
Rodriguez JA, Bates DW, Samal L, Saadi A, Schwamm LH. Health Aff (Millwood). 2021 Aug;40(8):1340. doi: 10.1377/hlthaff.2021.01041.


Palliative Care for Polio and Postpolio Syndrome.
Rhee JY, Brizzi K. Phys Med Rehabil Clin N Am. 2021 Aug;32(3):569-579. doi: 10.1016/j.pmr.2021.02.008.


Case 292: Lyme Neuroborreliosis.
Douglas VP, Douglas KAA, Reinshagen KL, Chwalisz BK. Radiology. 2021 Aug;300(2):484-488. doi: 10.1148/radiol.2021201715.


'Drip-and-ship' intravenous thrombolysis and outcomes for large vessel occlusion thrombectomy candidates in a hub-and-spoke telestroke model.
Regenhardt RW, Rosenthal JA, Awad A, Martinez-Gutierrez JC, Nolan NM, McIntyre JA, Whitney C, Alotaibi NM, Dmytriw AA, Vranic JE, Stapleton CJ, Patel AB, Rost NS, Schwamm LH, Leslie-Mazwi TM. J Neurointerv Surg. 2021 Jul 29:neurintsurg-2021-017819. doi: 10.1136/neurintsurg-2021-017819.


Knowledge assessment and psychological impact of genetic counseling in people at risk for familial FTD.
Wong B, Lucente D, Krivensky S, Krahn E, Karlawish J, Dickerson BC. Alzheimers Dement (Amst). 2021 Jul 28;13(1):e12225. doi: 10.1002/dad2.12225.


Multimorbidity networks associated with frailty among middle aged and older people with HIV.
Lorenz DR, Mukerji SS, Misra V, Uno H, Gelman BB, Moore DJ, Singer EJ, Morgello S, Gabuzda D. AIDS. 2021 Jul 28. doi: 10.1097/QAD.0000000000003040.


Opinion & Special Articles: Preventive Neurology: An Emerging Field Toward Brain Health.
Sabayan B, Isaacson R, Rost N. Neurology. 2021 Jul 27:10.1212/WNL.0000000000012554. doi: 10.1212/WNL.0000000000012554.


COVID-19 vaccine hesitancy in multiple sclerosis: A cross-sectional survey.
Uhr L, Mateen FJ. Mult Scler. 2021 Jul 27:13524585211030647. doi: 10.1177/13524585211030647.


Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage.
Jones FJS, Sanches PR, Smith JR, Zafar SF, Blacker D, Hsu J, Schwamm LH, Newhouse JP, Westover MB, Moura LMVR. JAMA Neurol. 2021 Jul 26. doi: 10.1001/jamaneurol.2021.2249.


Free-Living Motor Activity Monitoring in Ataxia-Telangiectasia.
Khan NC, Pandey V, Gajos KZ, Gupta AS. Cerebellum. 2021 Jul 24:1-12. doi: 10.1007/s12311-021-01306-y.


Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease.
de Navas LV, Noori A, Merrill E, Das S, Hyman BT, Serrano-Pozo A. Neuropathol Appl Neurobiol. 2021 Jul 23. doi: 10.1111/nan.12753.


Treat or Retreat: Reasons for Deferral of Endovascular Therapy for Large Vessel Occlusion Stroke.
Camargo E, Jadhav AP. Stroke. 2021 Jul 22:STROKEAHA121034361. doi: 10.1161/STROKEAHA.121.034361.


Impaired Cerebrovascular Reactivity in Huntington's Disease.
Chan ST, Mercaldo ND, Kwong KK, Hersch SM, Rosas HD. Front Physiol. 2021 Jul 21;12:663898. doi: 10.3389/fphys.2021.663898.


Current advances in digital cognitive assessment for preclinical Alzheimer's disease.
Öhman F, Hassenstab J, Berron D, Schöll M, Papp KV. Alzheimers Dement (Amst). 2021 Jul 20;13(1):e12217. doi: 10.1002/dad2.12217.


Reply: Looking beyond indirect lesion network mapping of prosopagnosia: direct measures required.
Cohen AL, Fox MD. Brain. 2021 Jul 17:awab277. doi: 10.1093/brain/awab277.


Opinion & Special Articles: Maximizing Inclusiveness and Diversity Through Virtual Residency Applications and Interviews.
Budhu J, Velazquez AI, Said RR, Jordan JT. Neurology. 2021 Jul 15:10.1212/WNL.0000000000012487. doi: 10.1212/WNL.0000000000012487.


Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome.
Lai F, Mercaldo N, Wang CM, Hersch GG, Rosas HD. J Clin Med. 2021 Jul 15;10(14):3116. doi: 10.3390/jcm10143116.


FAIRSCAPE: a Framework for FAIR and Reproducible Biomedical Analytics.
Levinson MA, Niestroy J, Al Manir S, Fairchild K, Lake DE, Moorman JR, Clark T. Neuroinformatics. 2021 Jul 15. doi: 10.1007/s12021-021-09529-4.


Freedom of Speech.
Hochberg LR, Cash SS. N Engl J Med. 2021 Jul 15;385(3):278-279. doi: 10.1056/NEJMe2106392.


CLN3, at the crossroads of endocytic trafficking.
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Validation of an internationally derived patient severity phenotype to support COVID-19 analytics from electronic health record data.
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Therapies to Restore Consciousness in Patients with Severe Brain Injuries: A Gap Analysis and Future Directions.
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The Long-Term Public Health Impact of Social Distancing on Brain Health: Topical Review.
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Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss.
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Automated annotation of epileptiform burden and its association with outcomes.
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A Model of Metabolic Supply-Demand Mismatch Leading to Secondary Brain Injury.
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Mapping a memory disorder using functional network analysis.
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Enhancing Neurofibromatosis Clinical Trial Outcome Measures Through Patient Engagement: Lessons From REiNS.
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Role of Interleukin-1 Receptor-Like 1 (ST2) in Cerebrovascular Disease.
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Fenfluramine for seizures associated with Sunflower syndrome.
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Characterization of mononeuropathy of the lateral cutaneous nerve of the calf.
Oaklander AL, Van Houten T, Sabouri AS. Muscle Nerve. 2021 Jul 1. doi: 10.1002/mus.27367.


Finding a Place for Candidate Gene Studies in a Genome-Wide Association Study World.
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Helping the Public Understand Adverse Events Associated With COVID-19 Vaccinations: Lessons Learned From Functional Neurological Disorder.
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Clinical Electroencephalography Findings and Considerations in Hospitalized Patients With Coronavirus SARS-CoV-2.
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Teleneurology Comprehensive Inpatient Consultations Expedite Access to Care and Decreases Hospital Length of Stay.
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Diffuse Cerebral Edema After Moyamoya Disease-Related Intracerebral Hemorrhage: A Case Report.
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Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors.
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Solriamfetol for Excessive Daytime Sleepiness in Parkinson's Disease: Phase 2 Proof-of-Concept Trial.
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A Neural Circuit for Spirituality and Religiosity Derived From Patients With Brain Lesions.
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Clinical Reasoning: A 28-Year-Old Woman With Vision Loss and an Unusual Gait.
Dohlman JC, Chwalisz BK, Stephen CD. Neurology. 2021 Jun 29:10.1212/WNL.0000000000012446. doi: 10.1212/WNL.0000000000012446.


SNO and EANO practice guideline update: Anticonvulsant prophylaxis in patients with newly diagnosed brain tumors.
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Building clinically relevant outcomes across the Alzheimer's disease spectrum.
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Early Brain Injury and Soluble ST2 After Nontraumatic Subarachnoid Hemorrhage.
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Huntington's disease: Nearly four decades of human molecular genetics.
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Psychiatry's modern role in functional neurological disorder: join the renaissance.
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Review of Phase III Clinical Trials Outcomes in Patients with Secondary Progressive Multiple Sclerosis.
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Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults.
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Association Analysis of Chromosome X to Identify Genetic Modifiers of Huntington's Disease.
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Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation.
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Do Triphasic Waves and Nonconvulsive Status Epilepticus Arise From Similar Mechanisms? A Computational Model.
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Computational Evidence for a Competitive Thalamocortical Model of Spikes and Spindle Activity in Rolandic Epilepsy.
Li Q, Westover MB, Zhang R, Chu CJ. Front Comput Neurosci. 2021 Jun 18;15:680549. doi: 10.3389/fncom.2021.680549.


Clinical Reasoning: An 81-Year-Old Woman Who Insisted the Hospital Was Her Home.
Carlisle TC, Stanley MPH, Singhal AB, Caplan DN. Neurology. 2021 Jun 18:10.1212/WNL.0000000000012392. doi: 10.1212/WNL.0000000000012392.


Gait Difficulties and Postural Instability in Adrenoleukodystrophy.
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Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2.
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Correction to: Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder.
Zimmerman AW, Singh K, Connors SL, Liu H, Panjwani AA, Lee LC, Diggins E, Foley A, Melnyk S, Singh IN, Jill James S, Frye RE, Fahey JW. Mol Autism. 2021 Jun 16;12(1):44. doi: 10.1186/s13229-021-00451-9.


Cognitive effects of rapid-acting treatments for resistant depression: Just adverse, or contributing to clinical efficacy?
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The AAV9 variant capsid AAV-F mediates widespread transgene expression in non-human primate spinal cord after intrathecal administration.
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Anticonvulsant Primary and Secondary Prophylaxis for Acute Ischemic Stroke Patients: A Decision Analysis.
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A REDCap-based model for online interventional research: Parent sleep education in autism.
Malow BA, Galion A, Lu F, Kennedy N, Lawrence CE, Tassone A, O'Neal L, Wilson TM, Parker RA, Harris PA, Neumeyer AM. J Clin Transl Sci. 2021 Jun 14;5(1):e138. doi: 10.1017/cts.2021.798.


Patient characteristics associated with the successful transition to virtual care: Lessons learned from the first million patients.
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Unexpected Findings During Double-blind Discontinuation of Acetylcholinesterase Inhibitor Medications.
Moo LR, Martinez E, Padala K, Dunay MA, Scali RR, Chen S, Thielke SM. Clin Ther. 2021 Jun 12:S0149-2918(21)00225-3. doi: 10.1016/j.clinthera.2021.05.010.


Development and Validation of a Patient-Reported Outcome Measure of Ataxia.
Schmahmann JD, Pierce S, MacMore J, L'Italien GJ. Mov Disord. 2021 Jun 11. doi: 10.1002/mds.28670.


A deep learning approach to identify gene targets of a therapeutic for human splicing disorders.
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Skeletal Muscle and Peripheral Nerve Histopathology in COVID-19.
Suh J, Mukerji SS, Collens SI, Padera RF Jr, Pinkus GS, Amato AA, Solomon IH. Neurology. 2021 Jun 7:10.1212/WNL.0000000000012344. doi: 10.1212/WNL.0000000000012344.


Outcome after acute ischemic stroke is linked to sex-specific lesion patterns.
Bonkhoff AK, Schirmer MD, Bretzner M, Hong S, Regenhardt RW, Brudfors M, Donahue KL, Nardin MJ, Dalca AV, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh EC, Attia J, Benavente OR, Bevan S, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah CL, Rolfs A, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Söderholm M, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Zand R, McArdle PF, Worrall BB, Jern C, Lindgren AG, Maguire J, Bzdok D, Wu O; MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium, Rost NS. Nat Commun. 2021 Jun 2;12(1):3289. doi: 10.1038/s41467-021-23492-3.


Nodular Pachymeningitis Associated With Relapsing Polychondritis and Crohn Disease Responsive to Adalimumab and Prednisone.
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Outcome after acute ischemic stroke is linked to sex-specific lesion patterns.
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Effect of Long-term Continuous Cardiac Monitoring vs Usual Care on Detection of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease: The STROKE-AF Randomized Clinical Trial.
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Enhancing Aging and Ending Ageism: JAMA Network Open Call for Papers.
Inouye SK, Ganguli I, Jacobs EA. JAMA Netw Open. 2021 Jun 1;4(6):e2117621. doi: 10.1001/jamanetworkopen.2021.17621.


Dural Arteriovenous Fistula Presenting with Reversible Dementia.
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Legal Regulations and Institutional Policies Underlying Parental Leave in Graduate Medical Education.
Prasad S, Vaswani PA, Budhu JA, Conway SE, Kett LR, Eaton SHM, Bowley MP. J Grad Med Educ. 2021 Jun;13(3):349-354. doi: 10.4300/JGME-D-20-01083.1.


Assessment and Management of Cognitive Symptoms in Patients With Brain Tumors.
Parsons MW, Dietrich J. Am Soc Clin Oncol Educ Book. 2021 Jun;41:e90-e99. doi: 10.1200/EDBK_320813.


Factors Influencing Barriers and Facilitators to In-home Video Telehealth for Dementia Management.
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Expanding the therapeutic toolkit in functional neurological disorder: consensus recommendations for speech and language therapy.
Perez DL. J Neurol Neurosurg Psychiatry. 2021 Jul 1:jnnp-2021-327213. doi: 10.1136/jnnp-2021-327213.


An Update From the American Stroke Association and the Stroke Council.
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Covid-19: a call for mobilizing geriatric expertise.
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Motor tract reorganization after acute central nervous system injury: a translational perspective.
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Decreased Basal Ganglia Volume in Cerebral Amyloid Angiopathy.
Fotiadis P, Pasi M, Charidimou A, Warren AD, Schwab KM; Alzheimer’s Disease Neuroimaging Initiative, Rosand J, van der Grond J, van Buchem MA, Viswanathan A, Gurol ME, Greenberg SM. J Stroke. 2021 May;23(2):223-233. doi: 10.5853/jos.2020.04280. Epub 2021 May 31.


Sex-specific differences in presentations and determinants of outcomes after endovascular thrombectomy for large vessel occlusion stroke.
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The long-term efficacy of cannabidiol in the treatment of refractory epilepsy.
Patel S, Grinspoon R, Fleming B, Skirvin LA, Wade C, Wolper E, Bruno PL, Thiele EA. Epilepsia. 2021 May 29. doi: 10.1111/epi.16936.


A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data.
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Relapse recovery in multiple sclerosis: Effect of treatment and contribution to long-term disability.
Sotiropoulos MG, Lokhande H, Healy BC, Polgar-Turcsanyi M, Glanz BI, Bakshi R, Weiner HL, Chitnis T. Mult Scler J Exp Transl Clin. 2021 May 28;7(2):20552173211015503. doi: 10.1177/20552173211015503.


Delta power robustly predicts cognitive function in Angelman syndrome.
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Location of Subcortical Microbleeds and Recovery of Consciousness After Severe Traumatic Brain Injury.
Bianciardi M, Izzy S, Rosen B, Wald LL, Edlow BL. Neurology. 2021 May 28:10.1212/WNL.0000000000012192. doi: 10.1212/WNL.0000000000012192.


Neuromyelitis Optica Spectrum Disorder: Clinical Burden and Cost of Relapses and Disease-Related Care in US Clinical Practice.
Royston M, Kielhorn A, Weycker D, Shaff M, Houde L, Tanvir I, Bhattacharyya S, Levy M. Neurol Ther. 2021 May 27. doi: 10.1007/s40120-021-00253-4.


Cognitive Impairment and Dementia After Stroke: Design and Rationale for the DISCOVERY Study.
Rost NS, Meschia JF, Gottesman R, Wruck L, Helmer K, Greenberg SM; DISCOVERY Investigators. Stroke. 2021 May 27:STROKEAHA120031611. doi: 10.1161/STROKEAHA.120.031611.


Focal Subcortical White Matter Lesions Disrupt Resting State Cortical Interhemispheric Functional Connectivity in Mice.
Aykan SA, Xie H, Lai JH, Zheng Y, Chung DY, Kura S, Anzabi M, Sugimoto K, McAllister LM, Yaseen MA, Boas DA, Whalen MJ, Sakadzic S, Ayata C. Cereb Cortex. 2021 May 25:bhab134. doi: 10.1093/cercor/bhab134.


Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder.
Zimmerman AW, Singh K, Connors SL, Liu H, Panjwani AA, Lee LC, Diggins E, Foley A, Melnyk S, Singh IN, James SJ, Frye RE, Fahey JW. Mol Autism. 2021 May 25;12(1):38. doi: 10.1186/s13229-021-00447-5.


Targeting Protein Arginine Methylation to Death.
Miller JJ. Neuro Oncol. 2021 May 25:noab123. doi: 10.1093/neuonc/noab123.


The Woven EndoBridge device for ruptured intracranial aneurysms: international multicenter experience and updated meta-analysis.
Harker P, Regenhardt RW, Alotaibi NM, Vranic J, Robertson FC, Dmytriw AA, Ku JC, Koch M, Stapleton CJ, Leslie-Mazwi TM, Serna N, Pabon B, Mejia JA, Patel AB. Neuroradiology. 2021 May 25. doi: 10.1007/s00234-021-02727-6.


Rare Missense Functional Variants at COL4A1 and COL4A2 in Sporadic Intracerebral Hemorrhage.
Chung J, Hamilton G, Kim M, Marini S, Montgomery B, Henry J, Cho AE, Brown DL, Worrall BB, Meschia JF, Silliman SL, Selim M, Tirschwell DL, Kidwell CS, Kissela B, Greenberg SM, Viswanathan A, Goldstein JN, Langefeld CD, Rannikmae K, Sudlow CL, Samarasekera N, Rodrigues M, Al-Shahi Salman R, Prendergast JGD, Harris SE, Deary I, Woo D, Rosand J, Van Agtmael T, Anderson CD. Neurology. 2021 May 24:10.1212/WNL.0000000000012227. doi: 10.1212/WNL.0000000000012227.


Teaching NeuroImages: Notched Delta and Angelman Syndrome.
Nascimento FA, Thiele EA, Thibert RL. Neurology. 2021 May 24:10.1212/WNL.0000000000012201. doi: 10.1212/WNL.0000000000012201.


A high-content platform for physiological profiling and unbiased classification of individual neurons.
DuBreuil DM, Chiang BM, Zhu K, Lai X, Flynn P, Sapir Y, Wainger BJ. Cell Rep Methods. 2021 May 24;1(1):100004. doi: 10.1016/j.crmeth.2021.100004.


Altered maturation and atypical cortical processing of spoken sentences in autism spectrum disorder.
Alho J, Bharadwaj H, Khan S, Mamashli F, Perrachione TK, Losh A, McGuiggan N, Joseph RM, Hämäläinen MS, Kenet T. Prog Neurobiol. 2021 May 22:102077.


Development and internal validation of a predictive model of cognitive decline 36 months following elective surgery.
Jones RN, Tommet D, Steingrimsson J, Racine AM, Fong TG, Gou Y, Hshieh TT, Metzger ED, Schmitt EM, Tabloski PA, Travison TG, Vasunilashorn SM, Abdeen A, Earp B, Kunze L, Lange J, Vlassakov K, Dickerson BC, Marcantonio ER, Inouye SK. Alzheimers Dement (Amst). 2021 May 21;13(1):e12201. doi: 10.1002/dad2.12201.


Telerehabilitation for Word Retrieval Deficits in Bilinguals With Aphasia: Effectiveness and Reliability as Compared to In-person Language Therapy.
Peñaloza C, Scimeca M, Gaona A, Carpenter E, Mukadam N, Gray T, Shamapant S, Kiran S. Front Neurol. 2021 May 20;12:589330. doi: 10.3389/fneur.2021.589330.


Patient-Tailored, Home-Based Non-invasive Brain Stimulation for Memory Deficits in Dementia Due to Alzheimer's Disease.
Bréchet L, Yu W, Biagi MC, Ruffini G, Gagnon M, Manor B, Pascual-Leone A. Front Neurol. 2021 May 20;12:598135. doi: 10.3389/fneur.2021.598135.


Cerebral Amyloid Angiopathy-Related Transient Focal Neurologic Episodes.
Smith EE, Charidimou A, Ayata C, Werring DJ, Greenberg SM. Neurology. 2021 May 20:10.1212/WNL.0000000000012234. doi: 10.1212/WNL.0000000000012234.


Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease?
Rosas HD, Lewis LR, Mercaldo ND, Nasr S, Brickman AM, Siless V, Yassa M, Sathishkumar M, Lott I, Schupf N, Silverman W, Lai F; Alzheimer's Disease in Down Syndrome (ADDS) Consortium. Alzheimers Dement (Amst). 2021 May 20;13(1):e12105. doi: 10.1002/dad2.12105. eCollection 2021.


The natural history of Canavan disease: 23 new cases and comparison with patients from literature.
Bley A, Denecke J, Kohlschütter A, Schön G, Hischke S, Guder P, Bierhals T, Lau H, Hempel M, Eichler FS. Orphanet J Rare Dis. 2021 May 19;16(1):227. doi: 10.1186/s13023-020-01659-3.


Impact of revascularization therapies on outcome of posterior circulation ischemic stroke: The Indo-US stroke project.
Nair SS, Sylaja PN, Pandian J, Srivastava MVP, Khurana D, Kaul S, Arora D, Sarma PS, Khatter H, Singhal AB. J Neurol Sci. 2021 May 18;427:117499. doi: 10.1016/j.jns.2021.117499.


Predicting language treatment response in bilingual aphasia using neural network-based patient models.
Grasemann U, Peñaloza C, Dekhtyar M, Miikkulainen R, Kiran S. Sci Rep. 2021 May 18;11(1):10497.


Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes.
Bhattacharyya R, Black SE, Lotlikar MS, Fenn RH, Jorfi M, Kovacs DM, Tanzi RE. Cell Rep. 2021 May 18;35(7):109134. doi: 10.1016/j.celrep.2021.109134.


The impact of ocrelizumab on health-related quality of life in individuals with multiple sclerosis.
Glanz BI, Zurawski J, Casady EC, Shamah R, Weiner M, Chitnis T, Weiner HL, Healy BC. Mult Scler J Exp Transl Clin. 2021 May 18;7(2):20552173211007523. doi: 10.1177/20552173211007523.


Impact of Uncontrolled Hypertension at 3 Months After Intracerebral Hemorrhage.
Biffi A, Teo KC, Castello JP, Abramson JR, Leung IYH, Leung WCY, Wang Y, Kourkoulis C, Myserlis EP, Warren AD, Henry J, Chan KH, Cheung RTF, Ho SL, Anderson CD, Gurol ME, Viswanathan A, Greenberg SM, Lau KK, Rosand J. J Am Heart Assoc. 2021 May 15:e020392. doi: 10.1161/JAHA.120.020392.


Increased systemic HSP70B levels in spinal muscular atrophy infants.
Eichelberger EJ, Alves CRR, Zhang R, Petrillo M, Cullen P, Farwell W, Hurt JA, Staropoli JF, Swoboda KJ. Ann Clin Transl Neurol. 2021 May 15. doi: 10.1002/acn3.51377.


Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau.
Dickson JR, Yoon H, Frosch MP, Hyman BT. J Neuropathol Exp Neurol. 2021 May 15:nlab040. doi: 10.1093/jnen/nlab040.


Taming the Huntington's Disease Proteome: What Have We Learned?
Seeley C, Kegel-Gleason KB. J Huntingtons Dis. 2021 May 14. doi: 10.3233/JHD-200465.


Is It Time for Quotas to Achieve Racial and Ethnic Representation in Multiple Sclerosis Trials?
Mateen FJ. Front Neurol. 2021 May 13;12:680912. doi: 10.3389/fneur.2021.680912.


Effect of Patent Foramen Ovale (PFO) Closure After Stroke on Circulatory Biomarkers.
Deng W, McMullin D, Inglessis-Azuaje I, Locascio JJ, Palacios IF, Buonanno FS, Lo EH, Ning M. Neurology. 2021 May 13:10.1212/WNL.0000000000012188.


MRI Shrimp Sign in Cerebellar Progressive Multifocal Leukoencephalopathy: Description and Validation of a Novel Observation.
Adra N, Goodheart AE, Rapalino O, Caruso P, Mukerji SS, González RG, Venna N, Schmahmann JD. AJNR Am J Neuroradiol. 2021 May 13. doi: 10.3174/ajnr.A7145.


An Update From the American Stroke Association and the Stroke Council.
Schwamm LH, Panagos PD, Mohl SM. Stroke. 2021 May 13:STROKEAHA121034827. doi: 10.1161/STROKEAHA.121.034827.


Early Neurologic Recovery, Practice Pattern Variation, and the Risk of Endotracheal Intubation Following Established Status Epilepticus.
Rosenthal ES, Elm JJ, Ingles J, Rogers AJ, Terndrup TE, Holsti M, Thomas DG, Babcock L, Okada PJ, Lipsky RH, Miller JB, Hickey RW, Barra ME, Bleck TP, Cloyd JC, Silbergleit R, Lowenstein DH, Coles LD, Kapur J, Shinnar S, Chamberlain JM; Established Status Epilepticus Treatment Trial Study Group. Neurology. 2021 May 11;96(19):e2372-e2386. doi: 10.1212/WNL.0000000000011879.


Voluntary and magnetically evoked muscle contraction protocol in males with Duchenne muscular dystrophy: safety, feasibility, reliability, and validity.
Trost JP, Chen M, Stark MM, Hodges JS, Richter S, Lindsay A, Warren GL, Lowe DA, Kimberley TJ. Muscle Nerve. 2021 May 11. doi: 10.1002/mus.27323.


Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche.
Arai K, Lo EH. J Cereb Blood Flow Metab. 2021 May 9:271678X211014979. doi: 10.1177/0271678X211014979.


Progress in Elucidating Pathophysiology of Mucolipidosis IV.
Misko A, Wood L, Kiselyov K, Slaugenhaupt S, Grishchuk Y. Neurosci Lett. 2021 May 6:135944. doi: 10.1016/j.neulet.2021.135944.


Responsive neurostimulation for focal motor status epilepticus.
Yang JC, Harid NM, Nascimento FA, Kokkinos V, Shaughnessy A, Lam AD, Westover MB, Leslie-Mazwi TM, Hochberg LR, Rosenthal ES, Cole AJ, Richardson RM, Cash SS. Ann Clin Transl Neurol. 2021 May 6. doi: 10.1002/acn3.51318.


Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.
Liu G, Peng J, Liao Z, Locascio JJ, Corvol JC, Zhu F, Dong X, Maple-Grødem J, Campbell MC, Elbaz A, Lesage S, Brice A, Mangone G, Growdon JH, Hung AY, Schwarzschild MA, Hayes MT, Wills AM, Herrington TM, Ravina B, Shoulson I, Taba P, Kõks S, Beach TG, Cormier-Dequaire F, Alves G, Tysnes OB, Perlmutter JS, Heutink P, Amr SS, van Hilten JJ, Kasten M, Mollenhauer B, Trenkwalder C, Klein C, Barker RA, Williams-Gray CH, Marinus J; International Genetics of Parkinson Disease Progression (IGPP) Consortium, Scherzer CR. Nat Genet. 2021 May 6. doi: 10.1038/s41588-021-00847-6.


Telemedicine visits in myasthenia gravis: expert guidance and the myasthenia gravis core exam (MG-CE).
Guidon AC, Muppidi S, Nowak RJ, Guptill JT, Hehir MK, Ruzhansky K, Burton LB, Post D, Cutter G, Conwit R, Mejia NI, Kaminski HJ, Howard JF Jr. Muscle Nerve. 2021 May 6. doi: 10.1002/mus.27260.


Replication stress promotes cell elimination by extrusion.
Dwivedi VK, Pardo-Pastor C, Droste R, Kong JN, Tucker N, Denning DP, Rosenblatt J, Horvitz HR. Nature. 2021 May 5. doi: 10.1038/s41586-021-03526-y.


Venous Information in CT-Based Stroke Selection: The Only Way Out is Through.
Leslie-Mazwi T, Lin MP. Neurology. 2021 May 5:10.1212/WNL.0000000000012126. doi: 10.1212/WNL.0000000000012126.


Predictors of Outcomes in Patients With Mild Ischemic Stroke Symptoms: MaRISS.
Romano JG, Gardener H, Campo-Bustillo I, Khan Y, Tai S, Riley N, Smith EE, Sacco RL, Khatri P, Alger HM, Mac Grory B, Gulati D, Sangha NS, Craig JM, Olds KE, Benesch CG, Kelly AG, Brehaut SS, Kansara AC, Schwamm LH; MaRISS Investigators. Stroke. 2021 May 5:STROKEAHA120032809. doi: 10.1161/STROKEAHA.120.032809.


Clinical Reasoning: A 59-Year-Old Woman Presenting With Diplopia, Dysarthria, Right-Sided Weakness and Encephalopathy.
Manzano GS, Torre M, Luskin MR, Vaitkevicius H. Neurology. 2021 May 4:10.1212/WNL.0000000000012151. doi: 10.1212/WNL.0000000000012151.


Clinical Presentation and Management of SMART Syndrome.
Winter SF, Klein JP, Vaios EJ, Karschnia P, Lee EQ, Shih HA, Loebel F, Dietrich J. Neurology. 2021 May 4:10.1212/WNL.0000000000012150. doi: 10.1212/WNL.0000000000012150.


Expectations of Benefit in a Trial of a Candidate Disease-Modifying Treatment for Parkinson Disease.
Mestre TA, Macklin EA, Ascherio A, Ferreira JJ, Lang AE, Schwarzschild MA; Parkinson Study Group SURE-PD3 Investigators. Mov Disord. 2021 May 4. doi: 10.1002/mds.28630.


Circadian Biology and Stroke.
Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžić S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM. Stroke. 2021 May 4:STROKEAHA120031742. doi: 10.1161/STROKEAHA.120.031742.


Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium.
Chou SH, Beghi E, Helbok R, Moro E, Sampson J, Altamirano V, Mainali S, Bassetti C, Suarez JI, McNett M; GCS-NeuroCOVID Consortium and ENERGY Consortium. JAMA Netw Open. 2021 May 3;4(5):e2112131. doi: 10.1001/jamanetworkopen.2021.12131.


Editorial: Epidemiology of Atypical Demyelinating Diseases.
Rotstein D, Kim SH, Hacohen Y, Levy M. Front Neurol. 2021 May 3;12:662353. doi: 10.3389/fneur.2021.662353. eCollection 2021.


Artificial Intelligence in Clinical Neurosurgery: More than Machinery.
Tewarie IA, Hulsbergen AFC, Gormley WB, Peul WC, Broekman MLD. World Neurosurg. 2021 May;149:302-303. doi: 10.1016/j.wneu.2021.02.057.


Aneurysmal Subarachnoid Hemorrhage.
Chung DY, Abdalkader M, Nguyen TN. Neurol Clin. 2021 May;39(2):419-442. doi: 10.1016/j.ncl.2021.02.006.


A Shortage of Neurologists We Must Act Now: A Report From the AAN 2019 Transforming Leaders Program.
Majersik JJ, Ahmed A, Chen IA, Shill H, Hanes GP, Pelak VS, Hopp JL, Omuro A, Kluger B, Leslie-Mazwi T. Neurology. 2021 Apr 30:10.1212/WNL.0000000000012111. doi: 10.1212/WNL.0000000000012111.


#RadialFirst and #RadialForNeuro: A descriptive analysis of Twitter conversations regarding transradial access.
Robertson FC, Linzey JR, Alotaibi NM, Regenhardt RW, Harker P, Vranic J, Dmytriw AA, Koch MJ, Stapleton CJ, Leslie-Mazwi TM, Patel AB. Neuroradiol J. 2021 Apr 30:19714009211012363. doi: 10.1177/19714009211012363.


Local and Distant responses to single pulse electrical stimulation reflect different forms of connectivity.
Crocker B, Ostrowski L, Williams ZM, Dougherty DD, Eskandar EN, Widge AS, Chu CJ, Cash SS, Paulk AC. Neuroimage. 2021 Apr 30:118094. doi: 10.1016/j.neuroimage.2021.118094.


Correction to: Sleep Neurology's Toolkit at the Crossroads: Challenges and Opportunities in Neurotherapeutics Lost and Found in Translation.
St Louis EK, Videnovic A. Neurotherapeutics. 2021 Apr 30. doi: 10.1007/s13311-021-01059-w.


ED-DEL: Development of a change package and toolkit for delirium in the emergency department.
Kennedy M, Webb M, Gartaganis S, Hwang U, Biese K, Stuck A, Lesser A, Hshieh T, Inouye SK. J Am Coll Emerg Physicians Open. 2021 Apr 29;2(2):e12421. doi: 10.1002/emp2.12421. eCollection


Generalized periodic discharges with triphasic morphology: to treat or not to treat?
Nascimento FA, Chen PM, Cohen J, Westover BM. Epileptic Disord. 2021 Apr 29. doi: 10.1684/epd.2021.1272


Novel botanical therapeutic NB-02 effectively treats Alzheimer's neuropathophysiology in an APP/PS1 mouse model.
Lee YF, Lariviere L, Russ AN, Choi SZ, Bacskai BJ, Kastanenka KV. eNeuro. 2021 Apr 28:ENEURO.0389-20.2021. doi: 10.1523/ENEURO.0389-20.2021.


Video Telehealth Occupational Therapy Services for Older Veterans: National Survey Study.
Gately ME, Tickle-Degnen L, Voydetich DJ, Ward N, Ladin K, Moo LR. JMIR Rehabil Assist Technol. 2021 Apr 27;8(2):e24299. doi: 10.2196/24299.


Evolving Phenotypes of non-hospitalized Patients that Indicate Long Covid.
Estiri H, Strasser ZH, Brat GA, Semenov YR, Patel CJ, Murphy SN. medRxiv. 2021 Apr 27:2021.04.25.21255923. doi: 10.1101/2021.04.25.21255923.


COVID-19 in a patient treated with eculizumab for aquaporin-4 neuromyelitis optica.
Cabal-Herrera AM, Mateen FJ. J Neurol. 2021 Apr 27:1-4. doi: 10.1007/s00415-021-10578-7. 


Teaching NeuroImages: Increasing SPECTations for Ictal SPECT in Epilepsy Surgical Evaluation.
Nascimento FA, Cochran RL, Chow DZ, Scott JA, Chu CJ. Neurology. 2021 Apr 26:10.1212/WNL.0000000000012097. doi: 10.1212/WNL.0000000000012097. 


CNS demyelination with TNFα inhibitor exposure: A retrospective cohort study.
Hutto SK, Rice DR, Mateen FJ. J Neuroimmunol. 2021 Apr 26;356:577587. doi: 10.1016/j.jneuroim.2021.577587.


Risk Factors With Neurotoxicity After Chimeric Antigen Receptor T-Cell Therapy-Reply.
Rubin DB, Jacobson C, Vaitkevicius H. JAMA Neurol. 2021 Apr 26. doi: 10.1001/jamaneurol.2021.0893.


Overlapping and dissociable brain activations for fluid intelligence and executive functions.
Santarnecchi E, Momi D, Mencarelli L, Plessow F, Saxena S, Rossi S, Rossi A, Mathan S, Pascual-Leone A. Cogn Affect Behav Neurosci. 2021 Apr 26. doi: 10.3758/s13415-021-00870-4.


Identifying Medicare beneficiaries with dementia.
Moura LMVR, Festa N, Price M, Volya M, Benson NM, Zafar S, Weiss M, Blacker D, Normand SL, Newhouse JP, Hsu J. J Am Geriatr Soc. 2021 Apr 26. doi: 10.1111/jgs.17183.


Unique actions of GABA arising from cytoplasmic chloride microdomains.
Rahmati N, Normoyle KP, Glykys J, Dzhala VI, Lillis KP, Kahle KT, Raiyyani R, Jacob T, Staley KJ. J Neurosci. 2021 Apr 26:JN-RM-3175-20. doi: 10.1523/JNEUROSCI.3175-20.2021.


Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study.
Yaghi S, Henninger N, Giles JA, Leon Guerrero C, Mistry E, Liberman AL, Asad D, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Brown Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Furie KL, Keyrouz SG, Nouh A, de Havenon A, Khan M, Smith EE, Gurol ME. J Neurol Neurosurg Psychiatry. 2021 Apr 26:jnnp-2021-326166. doi: 10.1136/jnnp-2021-326166.


CNS demyelination with TNFα inhibitor exposure: A retrospective cohort study
Hutto SK, Rice DR, Mateen FJ. J. Neuroim. 2021 Apr 25. doi: 10.1016/j.jneuroim.2021.577587


Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics.
Carlyle BC, Kandigian SE, Kreuzer J, Das S, Trombetta BA, Kuo Y, Bennett DA, Schneider JA, Petyuk VA, Kitchen RR, Morris R, Nairn AC, Hyman BT, Haas W, Arnold SE. Neurobiol Aging. 2021 Apr 24;105:99-114. doi: 10.1016/j.neurobiolaging.2021.04.012.


Afferent and Efferent Neuro-Ophthalmic Complications of Coronavirus Disease 19
Tisdale AK, Dinkin M, Chwalisz BK. J Neuroophthalmol. 2021 Apr 24. doi: 10.1097/WNO.0000000000001276


Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial.
Dawson J, Liu CY, Francisco GE, Cramer SC, Wolf SL, Dixit A, Alexander J, Ali R, Brown BL, Feng W, DeMark L, Hochberg LR, Kautz SA, Majid A, O'Dell MW, Pierce D, Prudente CN, Redgrave J, Turner DL, Engineer ND, Kimberley TJ. Lancet. 2021 Apr 24;397(10284):1545-1553. doi: 10.1016/S0140-6736(21)00475-X.


Meningeal Multipotent Cells: A Hidden Target for CNS Repair?
Hayakawa K, Snyder EY, Lo EH. Neuromolecular Med. 2021 Apr 24. doi: 10.1007/s12017-021-08663-1.


Off-Label Promotion of Transcranial Magnetic Stimulation on Provider Websites.
Wexler A, Nagappan A, Kopyto D, Santarnecchi E, Pascual-Leone A. Brain Stimul. 2021 Apr 23:S1935-861X(21)00083-8. doi: 10.1016/j.brs.2021.04.013.


Covid-19: a call for mobilizing geriatric expertise.
O'Hanlon S, Dhesi J, Aronson L, Inouye SK. Eur Geriatr Med. 2021 Apr 23:1-4. doi: 10.1007/s41999-021-00500-9.


Contribution of Racial and Ethnic Differences in Cerebral Small Vessel Disease Subtype and Burden to Risk of Cerebral Hemorrhage Recurrence.
Castello JP, Pasi M, Abramson JR, Rodriguez-Torres A, Marini S, Demel S, Gilkerson L, Kubiszewski P, Charidimou A, Kourkoulis C, DiPucchio Z, Schwab K, Gurol ME, Viswanathan A, Anderson CD, Langefeld CD, Flaherty ML, Towfighi A, Greenberg SM, Woo D, Rosand J, Biffi A. Neurology. 2021 Apr 21:10.1212/WNL.0000000000011932. doi: 10.1212/WNL.0000000000011932.


Intraoperative thalamocortical tract monitoring via direct cortical recordings during craniotomy.
Simon MV, Curry WT, Jones PS, Cahill DP, Carter BS, Rapalino O, Malik AN, Nahed BV. Clin Neurophysiol. 2021 Apr 21;132(7):1416-1432. doi: 10.1016/j.clinph.2021.02.404.


Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons.
Oakley DH, Klickstein N, Commins C, Chung M, Dujardin S, Bennett RE, Hyman BT, Frosch MP. J Neurosci. 2021 Apr 20:JN-RM-2590-20. doi: 10.1523/JNEUROSCI.2590-20.2021.


Restrictive diet in a patient with irritable bowel syndrome leading to Wernicke encephalopathy.
Wang Q, Charmchi Z, George IC. BMC Gastroenterol. 2021 Apr 20;21(1):179. doi: 10.1186/s12876-021-01758-w.


To reduce the risk of dementia focus on the patient.
Pascual-Leone A. Ann Neurol. 2021 Apr 18. doi: 10.1002/ana.26086.  


A Novel Method to Measure Venular Perivascular Spaces in Patients with MS on 7T MRI.
George IC, Arrighi-Allisan A, Delman BN, Balchandani P, Horng S, Feldman R. AJNR Am J Neuroradiol. 2021 Apr 15. doi: 10.3174/ajnr.A7144.


Cognitive Demands Influence Upper Extremity Motor Performance During Recovery From Acute Stroke.
Lin DJ, Erler KS, Snider SB, Bonkhoff AK, DiCarlo JA, Lam N, Ranford J, Parlman K, Cohen A, Freeburn J, Finklestein SP, Schwamm LH, Hochberg LR, Cramer SC. Neurology. 2021 Apr 15:10.1212/WNL.0000000000011992. doi: 10.1212/WNL.0000000000011992. 


Ibudilast (MN-166) In Amyotrophic Lateral Sclerosis - an Open Label, Safety and Pharmacodynamic Trial
Babu S, Hightower BG, Chan J,  Zürcher NR,  Kivisäkk P, Tseng CJ, Sanders DL, Robichaud A,  Banno H, Evora A,  Ashokkumar A,  Pothier L,  Paganoni S,  Chew S,  Dojillo J,  Matsuda K,  Gudesblatt M, Berry JD,  Cudkowicz ME,  Hooker JM, Atassi N. NeuroImage: Clinical. 2021 April 15. doi: 10.1016/j.nicl.2021.102672


Brain insulin signaling and cerebrovascular disease in human postmortem brain.
Arvanitakis Z, Capuano AW, Wang HY, Schneider JA, Kapasi A, Bennett DA, Ahima RS, Arnold SE. Acta Neuropathol Commun. 2021 Apr 15;9(1):71. doi: 10.1186/s40478-021-01176-9.


Spreading depression as an innate antiseizure mechanism.
Tamim I, Chung DY, de Morais AL, Loonen ICM, Qin T, Misra A, Schlunk F, Endres M, Schiff SJ, Ayata C. Nat Commun. 2021 Apr 13;12(1):2206. doi: 10.1038/s41467-021-22464-x.


Confirmed disability progression provides limited predictive information regarding future disease progression in multiple sclerosis.
Healy BC, Glanz BI, Swallow E, Signorovitch J, Hagan K, Silva D, Pelletier C, Chitnis T, Weiner H. Mult Scler J Exp Transl Clin. 2021 Apr 11;7(2):2055217321999070. doi: 10.1177/2055217321999070.


Algorithm for automatic detection of self-similarity and prediction of residual central respiratory events during continuous positive airway pressure.
Oppersma E, Ganglberger W, Sun H, Thomas RJ, Westover MB. Sleep. 2021 Apr 9;44(4):zsaa215. doi: 10.1093/sleep/zsaa215.


Evidence-Based Medicine Training in US-based Physiatry Residency Programs.
Annaswamy TM, Rizzo JR, Schnappinger A, Morgenroth DC, Engkasan JP, Ilieva E, Arnold WD, Boninger M, Bean AC, Cirstea CM, Dicianno BE, Fredericson M, Jayabalan P, Raghavan P, Sawaki L, Suri P, Suskauer SJ, Wang QM, Hosseini M, Case C, Whyte J, Paganoni S. Am J Phys Med Rehabil. 2021 Apr 8. doi: 10.1097/PHM.0000000000001752.


A simple method for implanting free-floating microdevices into the nervous tissue.
Khalifa A, Eisape A, Coughlin B, Cash SS. J Neural Eng. 2021 Apr 7. doi: 10.1088/1741-2552/abf590. 


Prolonged Intubation in Patients With Prior Cerebrovascular Disease and COVID-19.
Mukerji SS, Das S, Alabsi H, Brenner LN, Jain A, Magdamo C, Collens SI, Ye E, Keller K, Boutros CL, Leone MJ, Newhouse A, Foy B, Li MD, Lang M, Anahtar MN, Shao YP, Ge W, Sun H, Triant VA, Kalpathy-Cramer J, Higgins J, Rosand J, Robbins GK, Westover MB. Front Neurol. 2021 Apr 9;12:642912. doi: 10.3389/fneur.2021.642912.


Sleep Neurology's Toolkit at the Crossroads: Challenges and Opportunities in Neurotherapeutics Lost and Found in Translation.
Louis EKS, Videnovic A. Neurotherapeutics. 2021 Apr 5:1-5. doi: 10.1007/s13311-021-01032-7.


Connecting TDP-43 Pathology with Neuropathy.
Klim JR, Pintacuda G, Nash LA, Guerra San Juan I, Eggan K. Trends Neurosci. 2021 Apr 5:S0166-2236(21)00040-0. doi: 10.1016/j.tins.2021.02.008.


MCOLN1 gene therapy corrects neurologic dysfunction in the mouse model of mucolipidosis IV.
De Rosa S, Salani M, Smith S, Sangster M, Miller-Browne V, Wassmer S, Xiao R, Vandenberghe L, Slaugenhaupt S, Misko A, Grishchuk Y. Hum Mol Genet. 2021 Apr 5:ddab093. doi: 10.1093/hmg/ddab093.


Identification of Personalized Transcranial Magnetic Stimulation Targets Based on Subgenual Cingulate Connectivity: An Independent Replication.
Siddiqi SH, Weigand A, Pascual-Leone A, Fox MD. Biol Psychiatry. 2021 Apr 2:S0006-3223(21)00119-0. doi: 10.1016/j.biopsych.2021.02.015. 


Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development.
Prokopenko D, Morgan SL, Mullin K, Hofmann O, Chapman B, Kirchner R; Alzheimer's Disease Neuroimaging Initiative (ADNI), Amberkar S, Wohlers I, Lange C, Hide W, Bertram L, Tanzi RE. Alzheimers Dement. 2021 Apr 2. doi: 10.1002/alz.12319.


Stress, resilience, and coping strategies in a sample of community-dwelling older adults during COVID-19.
Vannini P, Gagliardi GP, Kuppe M, Dossett ML, Donovan NJ, Gatchel JR, Quiroz YT, Premnath PY, Amariglio R, Sperling RA, Marshall GA. J Psychiatr Res. 2021 Apr 2;138:176-185. doi: 10.1016/j.jpsychires.2021.03.050.


Editorial: Understanding factors that, beyond plaques and tangles, contribute to the heterogeneity of Alzheimer disease and implications for the development of biomarkers and design of interventions.
Gomez-Isla T. Curr Opin Neurol. 2021 Apr 1;34(2):226-227. doi: 10.1097/WCO.0000000000000915.


Arm Motor Recovery After Ischemic Stroke: A Focus on Clinically Distinct Trajectory Groups.
Kline DK, Lin DJ, Cloutier A, Sloane K, Parlman K, Ranford J, Picard-Fraser M, Fox AB, Hochberg LR, Kimberley TJ. J Neurol Phys Ther. 2021 Apr 1;45(2):70-78. doi: 10.1097/NPT.0000000000000350.


Adult onset POLR3A leukodystrophy presenting with parkinsonism treated with pallidal deep brain stimulation.
Kyle K, Mason X, Bordelon Y, Pouratian N, Bronstein J. Parkinsonism Relat Disord. 2021 Apr;85:23-25. doi: 10.1016/j.parkreldis.2021.02.018.


Emerging Consciousness at a Clinical Crossroads.
Young MJ, Edlow BL. AJOB Neurosci. 2021 Apr-Sep;12(2-3):148-150. doi: 10.1080/21507740.2021.1904032.


Regional Changes in Patterns of Stroke Presentation During the COVID-19 Pandemic.
Etherton MR, Zachrison KS, Yan Z, Sveikata L, Bretzner M, Estrada J, Viswanathan A, Singhal AB, Schwamm LH. Stroke. 2021 Apr;52(4):1398-1406. doi: 10.1161/STROKEAHA.120.031300.


Common Data Elements for COVID-19 Neuroimaging: A GCS-NeuroCOVID Proposal.
Edlow BL, Boly M, Chou SH, Fischer D, Kondziella D, Li LM, Mac Donald CL, McNett M, Newcombe VFJ, Stevens RD, Menon DK; GCS-NeuroCOVID. Neurocrit Care. 2021 Apr;34(2):365-370. doi: 10.1007/s12028-021-01192-6.


The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches.
Tsintou M, Dalamagkas K, Moore TL, Rathi Y, Kubicki M, Rosene DL, Makris N. Neural Regen Res. 2021 Apr;16(4):605-613. doi: 10.4103/1673-5374.295269.


Promise and challenges of dystonia brain banking: establishing a human tissue repository for studies of X-Linked Dystonia-Parkinsonism.
Fernandez-Cerado C, Legarda GP, Velasco-Andrada MS, Aguil A, Ganza-Bautista NG, Lagarde JBB, Soria J, Jamora RDG, Acuña PJ, Vanderburg C, Sapp E, DiFiglia M, Murcar MG, Campion L, Ozelius LJ, Alessi AK, Singh-Bains MK, Waldvogel HJ, Faull RLM, Macalintal-Canlas R, Muñoz EL, Penney EB, Ang MA, Diesta CCE, Bragg DC, Acuña-Sunshine G. J Neural Transm (Vienna). 2021 Apr;128(4):575-587. doi: 10.1007/s00702-020-02286-9.


Cerebral microbleeds and prediction of intracranial haemorrhage.
Greenberg SM. Lancet Neurol. 2021 Apr;20(4):252-254. doi: 10.1016/S1474-4422(21)00065-X.


Associations Between Trauma, Sleep, and Cognitive Impairment Among Latino and Asian Older Adults.
Saadi A, Cruz-Gonzalez M, Hwang A, Cohen L, Alegria M. J Am Geriatr Soc. 2021 Apr;69(4):1019-1026. doi: 10.1111/jgs.16986.


Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis: a pilot study.
Barry RL, Babu S, Anteraper SA, Triantafyllou C, Keil B, Rowe OE, Rangaprakash D, Paganoni S, Lawson R, Dheel C, Cernasov PM, Rosen BR, Ratai EM, Atassi N. Neuroimage Clin. 2021 Mar 30;30:102648. doi: 10.1016/j.nicl.2021.102648.


HIV Increases Sleep-based Brain Age Despite Antiretroviral Therapy.
Leone MJ, Sun H, Boutros CL, Liu L, Ye E, Sullivan L, Thomas RJ, Robbins GK, Mukerji SS, Westover MB. Sleep. 2021 Mar 30:zsab058. doi: 10.1093/sleep/zsab058.


Home Use of a Percutaneous Wireless Intracortical Brain-Computer Interface by Individuals With Tetraplegia.
Simeral JD, Hosman T, Saab J, Flesher SN, Vilela M, Franco B, Kelemen J, Brandman DM, Ciancibello JG, Rezaii PG, Eskandar EN, Rosler DM, Shenoy KV, Henderson JM, Nurmikko AV, Hochberg LR. IEEE Trans Biomed Eng. 2021 Mar 30;PP. doi: 10.1109/TBME.2021.3069119. 


Injustice in Health: Now Is the Time to Change the Story.
Ogedegbe G, Inouye SK. Ann Intern Med. 2021 Mar 30. doi: 10.7326/M21-1279. 


Intracranial foreign body granuloma mimicking brain tumor recurrence: a case series.
Winter SF, Forst DA, Oakley DH, Batchelor TT, Dietrich J. Oncologist. 2021 Mar 29. doi: 10.1002/onco.13766. 


Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.
Ding Y, Li Y, Chhetri G, Peng X, Wu J, Wang Z, Zhao B, Zhao W, Li X. Cells. 2021 Mar 28;10(4):746. doi: 10.3390/cells10040746. 


Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.
Ding Y, Li Y, Chhetri G, Peng X, Wu J, Wang Z, Zhao B, Zhao W, Li X. Cells. 2021 Mar 28;10(4):746. doi: 10.3390/cells10040746.


The neurology of IGG4-related disease.
Saitakis G, Chwalisz BK. J Neurol Sci. 2021 Mar 27:117420. doi: 10.1016/j.jns.2021.117420.


Cerebral amyloid angiopathy and related inflammatory disorders.
Chwalisz BK. J Neurol Sci. 2021 Mar 27:117425. doi: 10.1016/j.jns.2021.117425.

Re: Predictors and outcomes of hemorrhagic stroke in reversible cerebral vasoconstriction syndrome (Garg et al., Volume 421, 117312, February 15, 2021).
Singhal AB. J Neurol Sci. 2021 Mar 27:117427. doi: 10.1016/j.jns.2021.117427.


Expectations and blind spots for structural variation detection from long-read assemblies and short-read genome sequencing technologies.
Zhao X, Collins RL, Lee WP, Weber AM, Jun Y, Zhu Q, Weisburd B, Huang Y, Audano PA, Wang H, Walker M, Lowther C, Fu J; Human Genome Structural Variation Consortium, Gerstein MB, Devine SE, Marschall T, Korbel JO, Eichler EE, Chaisson MJP, Lee C, Mills RE, Brand H, Talkowski ME. Am J Hum Genet. 2021 Mar 26:S0002-9297(21)00098-7. doi: 10.1016/j.ajhg.2021.03.014.  


Patient reported outcomes in ALS: characteristics of the self-entry ALS Functional Rating Scale-revised and the Activities-specific Balance Confidence Scale.
Chew S, Burke KM, Collins E, Church R, Paganoni S, Nicholson K, Babu S, Scalia JB, De Marchi F, Ellrodt AL, Moura LMVR, Chan J, Berry JD. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Mar 26:1-11. doi: 10.1080/21678421.2021.1900259.


Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease.
Qian J, Betensky RA, Hyman BT, Serrano-Pozo A. Neurology. 2021 Mar 26:10.1212/WNL.0000000000011883. doi: 10.1212/WNL.0000000000011883. 


A Phase 2 Proof-of-Concept, Randomized, Placebo-Controlled Trial of CX-8998 in Essential Tremor.
Papapetropoulos S, Lee MS, Versavel S, Newbold E, Jinnah HA, Pahwa R, Lyons KE, Elble R, Ondo W, Zesiewicz T, Hedera P, Handforth A, Elder J, Versavel M. Mov Disord. 2021 Mar 25. doi: 10.1002/mds.28584.


Utilization of Advanced Imaging for Acute Ischemic Stroke: The Ongoing Quest for Optimized Stroke Systems of Care.
Turner AC, Zachrison KS. Circ Cardiovasc Qual Outcomes. 2021 Mar 24:CIRCOUTCOMES121007845. doi: 10.1161/CIRCOUTCOMES.121.007845.  


Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology.
Popescu M, Feldman TB, Chitnis T. Front Pharmacol. 2021 Mar 23;12:626107. doi: 10.3389/fphar.2021.626107. eCollection 2021.


Associations between memory loss and trauma in US asylum seekers: A retrospective review of medico-legal affidavits.
Saadi A, Hampton K, de Assis MV, Mishori R, Habbach H, Haar RJ. PLoS One. 2021 Mar 23;16(3):e0247033. doi: 10.1371/journal.pone.0247033. eCollection 2021.


Microscale Physiological Events on the Human Cortical Surface.
Paulk AC, Yang JC, Cleary DR, Soper DJ, Halgren M, O'Donnell AR, Lee SH, Ganji M, Ro YG, Oh H, Hossain L, Lee J, Tchoe Y, Rogers N, Kiliç K, Ryu SB, Lee SW, Hermiz J, Gilja V, Ulbert I, Fabó D, Thesen T, Doyle WK, Devinsky O, Madsen JR, Schomer DL, Eskandar EN, Lee JW, Maus D, Devor A, Fried SI, Jones PS, Nahed BV, Ben-Haim S, Bick SK, Richardson RM, Raslan AM, Siler DA, Cahill DP, Williams ZM, Cosgrove GR, Dayeh SA, Cash SS. Cereb Cortex. 2021 Mar 22:bhab040. doi: 10.1093/cercor/bhab040.


Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection.
Roy JCL, Vitalo A, Andrew MA, Mota-Silva E, Kovalenko M, Burch Z, Nhu AM, Cohen PE, Grabczyk E, Wheeler VC, Mouro Pinto R. Nucleic Acids Res. 2021 Mar 22:gkab152. doi: 10.1093/nar/gkab152.   


Impairment of visual cortical plasticity by amyloid-beta species.
William CM, Stern MA, Pei X, Saqran L, Ramani M, Frosch MP, Hyman BT. Neurobiol Dis. 2021 Mar 22;154:105344. doi: 10.1016/j.nbd.2021.105344.  


Obesity is associated with the Optic Neuritis severity in Male patients with Multiple Sclerosis.
Chu DT, Rosso M, Gonzalez CT, Saxena S, Healy BC, Weiner HL, Chitnis T. Mult Scler Relat Disord. 2021 Mar 21;51:102910. doi: 10.1016/j.msard.2021.102910.


Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington's Disease Mouse Striatum.
Iuliano M, Seeley C, Sapp E, Jones EL, Martin C, Li X, DiFiglia M, Kegel-Gleason KB. Front Synaptic Neurosci. 2021 Mar 18;13:618391. doi: 10.3389/fnsyn.2021.618391.


Low-field portable brain MRI in CNS demyelinating disease.
Mateen FJ, Cooley CZ, Stockmann JP, Rice DR, Vogel AC, Wald LL. Mult Scler Relat Disord. 2021 Mar 18;51:102903. doi: 10.1016/j.msard.2021.102903.


Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults.
Fong TG, Vasunilashorn SM, Gou Y, Libermann TA, Dillon S, Schmitt E, Arnold SE, Kivisäkk P, Carlyle B, Oh ES, Vlassakov K, Kunze L, Hshieh T, Jones RN, Marcantonio ER, Inouye SK; RISE Study Group. Alzheimers Dement (N Y). 2021 Mar 17;7(1):e12125. doi: 10.1002/trc2.12125. eCollection 2021.  


Cerebral microbleeds and prediction of intracranial haemorrhage.
Greenberg SM. Lancet Neurol. 2021 Apr;20(4):252-254. doi: 10.1016/S1474-4422(21)00065-X. Epub 2021 Mar 17. 


Traumatic brain injury and forensic evaluations: Three case studies of U.S. asylum-seekers.
Saadi A, Anand P, Kimball SL. J Forensic Leg Med. 2021 Apr;79:102139. doi: 10.1016/j.jflm.2021.102139.


Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids.
Lathuiliere A, Hyman BT. Front Neurosci. 2021 Mar 19;15:654176. doi: 10.3389/fnins.2021.654176. eCollection 2021.


Brain-Computer Interfaces in Neurorecovery and Neurorehabilitation.
Young MJ, Lin DJ, Hochberg LR. Semin Neurol. 2021 Mar 19. doi: 10.1055/s-0041-1725137. 


Persistent repression of tau in the brain using engineered zinc finger protein transcription factors.
Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, Zhang L, Goodwin A, Ledeboer A, Lam S, Ankoudinova I, Tran H, Scarlott N, Amora R, Surosky R, Miller JC, Robbins AB, Rebar EJ, Urnov FD, Holmes MC, Pooler AM, Riley B, Zhang HS, Hyman BT. Sci Adv. 2021 Mar 19;7(12):eabe1611. doi: 10.1126/sciadv.abe1611.