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Department of Neurology Research

Explore current research projects in the Department of Neurology or search our open clinical trials and medical research studies.

Research Programs

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  • Bacskai Lab at MIND

    FLIM plaque

    Brian Bacskai's laboratory uses sophisticated optical techniques to address fundamental questions in Alzheimer's disease research.

  • BADR Lab

    brain tumor x-ray image

    The BADR lab is focused on studying the genetic drivers of malignancy and treatment resistance as well as developing targeted and experimental therapeutics for brain tumors.

  • Berezovska Lab - Presenilin Group Alzheimer Research Unit

    Oksana Berezovska FLIM shows PS1 distribution in different conformation states

    The research goal of Dr. Berezovska's lab is to study the cellular and molecular mechanisms of Alzheimer's disease pathology.

  • Biorepository for Neurological Injury

    Dr. Rosand in lab

    The Massachusetts General Hospital Biorepository for Neurological Injury advances research in brain health and recovery by providing data to help researchers understand how genes and other factors contribute to risk of brain disease, recovery from brain injuries and the maintenance of a healthy brain.

  • Bragg Laboratory -- Chemical Neurobiology of Hereditary Dystonia

    Bragg Laboratory

    The laboratory combines gene expression profiling and chemical screening of novel cellular models to understand the pathogenesis of hereditary dystonias.

  • Breakefield Laboratory: Xandra O. Breakefield, PhD

    Xandra Breakefield

    The Breakefield laboratory uses molecular genetic techniques to elucidate the etiology of inherited neurological diseases and to develop vectors which can deliver genes to the nervous system for therapeutic purposes.

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  • Delirium Lab: Eyal Y. Kimchi, MD, PhD

    Eyal Y. Kimchi, MD, PhD

    The Delirium Lab at Massachusetts General Hospital is committed to determining the causes and treatments of delirium through a combination of translational and clinical research.

  • Dickerson Lab

    Alzheimer's disease imaging signature

    Researchers in Brad Dickerson's Laboratory seek to understand the relationships between brain anatomy, physiology, and behavior in humans across the lifespan and in those with neurodegenerative diseases.

  • Difiglia Laboratory - Cellular Neurobiology

    Marian DiFiglia, PhD

    Marian M. DiFiglia, PhD, is investigating the role of the HD mutation in the molecular and cellular events leading to neurodegeneration.

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  • Eichler Lab

    Florian Eichler, MD, dorsal root ganglia

    Dr. Florian Eichler's lab studies monogenetic lipid metabolism disorders of the nervous system at the Massachusetts General Hospital and Harvard Medical School.

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  • Familial Dementia Neuroimaging Lab

    brain scan image

    The Familial Dementia Neuroimaging Lab is focused on the study of age-related cognitive and brain changes that may predispose individuals to develop dementia later in life

  • Flaherty Lab: Alice Flaherty, MD, PhD

    Functional Magnetic Resonance Image

    Alice W. Flaherty, MD, PhD, has a dual appointment as associate professor of neurology, and of psychiatry at Harvard Medical School.

  • Frosch Lab

    Matthew P. Frosch, MD, PhD

    “Understanding the pathogenesis of cerebral amyloid angiuopathy (CAA)...”

  • Functional Neurology Research Group

    Functional Neurology Research Group

    The Functional Neurology Research Group at Massachusetts General Hospital, led by David Perez, MD, aims to identify biomarkers of disease, prognosis and treatment response for Functional Neurological Disorders.

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  • Global Neurology Research Group

    Baby with cap

    The Global Neurology Research Group, part of the Department of Neurology and the Neurological Clinical Research Institute, finds innovative solutions to improve the quality of neurological care in low- and middle-income countries.

  • Glykys Lab


    Dr. Glykys studies how seizures are generated in the pediatric brain and how we can enhance the brain’s inhibition system to treat seizures.

  • Gomez-Isla Lab

    APOE and PRNP

    Dr. Gomez-Isla investigates the neurobiology of normal aging, Alzheimers, and other dementias.

  • Gomperts Lab

    Dr. Gomperts

    The Gomperts lab investigates Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease

  • Greenberg, Steven M. - Cerebral Amyloid Angiopathy Research Lab logo

    Research on the pathogenesis, diagnosis and treatment of cerebral amyloid angiopathy (CAA), a cause of cerebral hemorrhage in the elderly.

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  • Hersch Laboratory, Steven M. Hersh, MD, PhD

    Hersch Laboratory

    Led by Dr. Hersch, the Laboratory investigates Huntington’s disease using transgenic mouse models and human brain tissue. Research also includes HD clinical trials.

  • Hyman Lab

    F11 synapse rescue with treatment b a hz Courtesy of Tara Spires-Jones and Brad Hyman

    The Hyman lab focuses on research in neural system failure underlying cognitive loss in Alzheimer’s disease.

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  • Ksenia V. Kastanenka, PhD

    multiphoton image of Alzheimer’s brain

    Ksenia Kastanenka’s research interests lie in the sphere of aging with particular emphasis on Alzheimer’s disease. The laboratory is focused on studying circuitry disruption during the disease progression and mechanisms of action of Alzheimer’s therapeutics aimed at reversing the disease.

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  • Laboratory for Deep Neurophenotyping: Anoopum Gupta, MD, PhD

    Our mission is to drive the development of new mechanism-driven therapies through a richer understanding of how neurologic disease affects behavior.

  • Laboratory for NeuroImaging of Coma and Consciousness

    Institute for NeuroImaging of Coma and Consciousness

    Dr. Brian Edlow’s Laboratory for NeuroImaging of Coma and Consciousness (NICC) aims to improve acute care and long-term outcomes for patients with coma and other disorders of consciousness caused by traumatic brain injury.

  • Lagier-Tourenne Lab

    Clotilde Lagier-Tourenne

    Clotilde Lagier-Tourenne performs patient-oriented research to understand the molecular mechanisms driving neurodegeneration in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) and to develop therapeutic strategies.

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  • MassGeneral Institute for Neurodegenerative Disease (MIND)

    The MassGeneral Institute for Neurodegenerative Disease (MIND) is a research center for Alzheimer’s, ALS (Lou Gehrig’s), Huntington’s, Parkinson’s and other neurodegenerative diseases. The Institute's mission is to accelerate research discoveries that will lead to treatment and cures.

  • MIND Informatics Lab


    MIND Informatics develops and applies integrative computational methods in biomedical and brain research, working with leading clinicians and researchers to understand and cure neurological disorders.

  • MingMing Ning MD, MMSc, Clinical Proteomics Research Center

    From bench to bedside, our center works to find biomarkers from proteomics mass spect data

    The Clinical Proteomics Research Center explores neurovascular pathophysiology using a translational approach - with the goal of developing prognostic tools to guide clinical decision-making.

  • Moir Lab

    Dr. Robert Moir's research focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and aging.

  • Moura, Lidia M. V. R., MD, MPH - NeuroValue Health Services Research Lab

    Dr. Lidia Moura

    We use established health services research methods to identify and compare alternative delivery models for achieving desired outcomes. We have a particular interest in strategies for reducing costs while improving the quality of care. The ultimate mission of our group is to design and implement coordinated care models for neurological care of high value.

  • Multiple Sclerosis (MS) Imaging Laboratory

    MS Imaging Lab

    The Multiple Sclerosis (MS) Imaging Laboratory in the Department of Neurology at Massachusetts General Hospital, led by Eric Klawiter, MD, Msc, is focused on developing new imaging techniques to better understand, diagnose and treat multiple sclerosis.

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  • Neurobiology of Disease Lab: Dora M. Kovacs, PhD

    Confocal images of enriched cultures expressing Navβ2 wildtype

    Molecular research of neurodegeneration in Alzheimer’s disease (AD) focused on identifying cellular pathways regulating the generation of the toxic beta-amyloid protein (Abeta).

  • Neurogenetics: Kathryn Swoboda, MD, FACMG

    Dr. Swoboda

    Dr. Swoboda’s research and clinical activities are dedicated to the diagnosis and treatment of neurologic disorders, especially neuromuscular diseases, movement disorders, and neurodegenerative disorders with childhood-onset.

  • Neurological Clinical Research Institute

    Neurological Clinical Research Institute

    The Neurological Clinical Research Institute (NCRI) at Mass General is experienced in designing, developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.

  • Neurology of Vision Lab

    brain activity network mapping

    Drs. Vaina and Buonanno's Neurology of Vision Lab links stroke neurology to neuroscience and multimodal brain imaging, to offer diagnosis and treatment of disorders of the brain affecting visual perception and cognition.

  • NeuroNEXT Clinical Coordinating Center (CCC)

    NeuroNEXT science image

    The Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT ) consists of a Clinical Coordinating Center (CCC) at Massachusetts General Hospital, a Data Coordinating Center (DCC) at the University of Iowa, and 25 clinical sites throughout the country.

  • Neuroscience Center

    Neuroscience Center

    With faculty members from the departments of Neurology, Radiology, Pediatrics, and Anesthesia and Critical Care, the Neuroscience Center works to understand the biology of neurological disorders and develop novel methods of diagnosis and treatment.

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  • Wainger Laboratory

    Brian Wainger, MD, PhD

    The Wainger Lab at Massachusetts General Hospital focuses on how abnormalities of motor and sensory neuron physiology contribute to diseases such as ALS and chronic pain.

  • Walker Lab: James A. Walker, PhD

    The Walker Laboratory at Massachusetts General Hospital combines genetic, molecular and biochemical approaches to investigate neurofibromatosis type 1 (NF1) and schwannomatosis.

  • Wheeler Muscular Dystrophy Research Lab

    wheeler lab

    We study muscular dystrophies with the long-term goal of finding new treatments for patients.

Clinical Trials

Research Spotlights



Are Infections Causing Alzheimer’s Disease?

View a fascinating Tedx Cambridge talk by Robert Moir, PhD, Assistant Professor, about a groundbreaking discovery that suggests infection may play a role in Alzheimer’s disease and is helping point the way towards urgently needed new treatment strategies. Learn more.


Alzheimer’s and epilepsy: Intimate connection

“The parallels between epilepsy and Alzheimer’s disease are quite striking,” said Andrew J. Cole, professor of neurology at Harvard University and head of the epilepsy group at Massachusetts General Hospital. Learn more.


Science Daily quotes study co-author MGH investigator Leigh Hochberg

Clinical trial participants with paralysis chatted with family and friends, shopped online and used other tablet computer applications, all by just thinking about pointing and clicking a mouse. Learn more.


Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

Study conducted by Merit Cudkowicz, MDEric C. Klawiter, MD and the NeuroNEXT team shows promise for treating progressive multiple sclerosis. Learn more.


How an outsider in Alzheimer’s research bucked the prevailing theory

STAT news profiles MGH investigator Robert Moir (pictured right), and quotes MGH co-investigator Rudolph Tanzi (pictured left). Learn more


How does exercise keep your brain young?

Science Magazine covers promising study led by MGH investigators Se Hoon Choi, PhD (pictured left) and Rudolph Tanzi, PhD (pictured right). Learn more


Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

Study conducted by Merit Cudkowicz, MDEric C. Klawiter, MD and the NeuroNEXT team shows promise for treating progressive multiple sclerosis. Learn more.


Could There be a Link Between Herpes Virus and Alzheimer’s Disease?

A new research study lead by MGH investigators Rudolph Tanzi, PhD (pictured left), and Robert Moir, PhD (pictured right) suggests there may be. Learn more


NIH renews NeuroNEXT for neurological clinical research

We are proud to be the Clinical Coordination Center for NeuroNext, under the leadership of our Neurology Department Chief Dr. Merit Cudkowicz and Marianne Chase. Learn more.

Alex Sherman

2018 Bio-IT World Best Practices Award Winners: Personalized & Translational Medicine

Congratulations to Alex Sherman, MD, and our very own NeuroBANK team at the NCRI for receiving the award for personalized and translational medicine!
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Philanthropy Fuels Movement Disorder Breakthrough

Mass General Hospital Giving features a research breakthrough in understanding the cause of X-linked dystonia parkinsonism (XDP).
Learn more

ALS Clinical Trials

Innovations in ALS Clinical Trials at Mass General

Dr. Merit Cudkowicz, Chief of Neurology at Mass General Hospital discusses innovations in ALS clinical trials since she started in the field in 1994. Learn more.

stem cell research

CBS Boston Features MGH Stem Cell Study

New Stem Cell Treatment Could Help People Suffering From ALS featured on CBS Boston. Learn more.

Feedback loop between the lab and the clinic drives research into neurofibromatosis.

Scott Plotkin, MD, PhD, and Vijaya Ramesh, PhD, are using their respective expertise in clinical and fundamental science to investigate new treatments for neurofibromatosis and two related disorders. Learn more.

Genetic Insights, New Research Models Help to Drive New Rare Disease Research

Mass General investigators such as Florian Eichler, MD, are demonstrating how a collaborative research approach that includes patients, clinicians, scientists and members of industry could dramatically improve the treatments available for rare disease patients. Learn more.

Best of 2017

Congratulations to Brian Edlow, MD, Associate Director of our Center for Neurotechnology and Neurorecovery – his paper, “Early Detection of Consciousness in Patients with Acute Severe TBI,” was named one of the “Best of 2017” by Brain-A Journal of Neurology.

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