The Moir Lab focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease (AD) and aging. More specifically, receptor/ligand interactions and physiochemical properties that promote pathological protein behavior. Particular emphasis has been placed on the beta-amyloid peptide (A beta), amyloid precursor protein (APP), apolipoprotein E, low density lipoprotein receptor protein (LRP), alpha-2-macroblobulin and the presenilins (PS1 and PS2).