Research Investigator Profile

Alireza Atri

Alireza Atri, MD, PhD

  • Instructor in Neurology,
    Harvard Medical School
  • Assistant in Neurology,
    Massachusetts General Hospital
  • Director, Outpatient Memory Disorders
    & Dementia Units
  • Associate Director, Clinical,
    GRECC, ENRM VA Medical Center


Research Description

Dr. Atri’s MIND BrAIN Lab at MGH & Edith Nourse Rogers Memorial Veterans Hospital (ENRM VA) Bedford Medical Center focuses on translational and clinical research by combining multidisciplinary methods and the tools of cognitive neuroscience, clinical pharmacology, and computational modeling to detect and track cognitive aging, impairment and Alzheimer’s disease (AD). More specifically, the lab endeavors to:

  1. Develop quantitative methods to integrate and optimize noninvasive, sensitive and accurate pharmaco-neuroimaging biomarkers for risk-stratifying, detecting, staging, and tracking healthy cognitive aging, cognitive impairment & neurodegenerative dementias, and
  2. Construct methods and quantitative tools that allow better prediction of clinical course and treatment response, and optimization of clinical effect, efficacy and effectiveness studies in cognitive reserve and aging, cognitive impairment and AD.
Research interests Alzheimer’s disease (AD), memory, healthy cognitive aging, cognitive reserve, Mild Cognitive Impairment (MCI), Rapidly Progressive Dementias (RPDs: Prion diseases, Hashimoto’s/Steroid-Responsive Encephalopathy), cholinergic and glutaminergic neuropharmacology of memory and cognition, pro-active interference.
Research techniques Cognitive neuroscience, MRI, fMRI, sMRI, ERP, eye-tracking, pharmacology, mathematical/statistical/computational modeling.
Diseases studied Alzheimer’s disease, MCI, Cerebral Amyloid Angiopathy (CAA), Dementia with Parkinsonism, Prion diseases (CJD), Hashimoto’s Encephalopathy (Steroid Responsive Encephalopathy), Encephalopathy/Delirium.
Selected publications
  1. Atri A, O'Brien JL, Sreenivasan A, Rastegar S, Salisbury S, DeLuca AN, O'Keefe KM,
    LaViolette PS, Rentz DM, Locascio JJ, Sperling RA. FMRI Test-Retest Reliability and
    Feasibility in Alzheimer’s Disease Clinical Trials. Archives of Neurology. 2010 (in press)
  2. Putcha D, OíKeefe K, LaViolette P, OíBrien J, Greve D, Rentz D, Locascio JJ, Atri A, Sperling RA. Reliability of fMRI Associative Encoding Memory Paradigm in Non-Demented Elderly Adults. Human Brain Mapping. 2010; (in press).
  3. Atri A, Shaughnessy LW, Locascio JJ, Growdon JH. Long-term Course and Effectiveness of Combination Therapy in Alzheimer Disease. Alzheimer Dis Assoc Disord. 2008;22(3):209-21.
  4. Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. J Neurosci. 2006;26(40):10222-31.
  5. Atri A, Locascio JJ, Lin JM, Yap L, Dickerson BC, Grodstein F, Irizarry MC, Growdon JH, Greenberg SM. Prevalence and effects of lobar microhemorrhages in early-stage dementia. Neurodegener Dis. 2005;2(6):305-12.
  6. Atri A, Sherman S, Norman KA, Kirchhoff BA, Nicolas MM, Greicius MD, Cramer SC, Breiter HC, Hasselmo ME, Stern CE. Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task. Behav Neurosci. 2004;118(1):223-36.
NCBI PubMed link NCBI PubMed Publications
  • John Growdon, MD
  • Reisa Sperling, MD
  • Joseph Locascio, PhD, MMSc
  • Brad Dickerson, MD, MMSc
  • Dorene Rentz, PhD
  • Liang Yap, PhD
  • Fran Grodstein, ScD
  • Steven M. Greenberg, MD, PhD
  • Chantal Stern, D Phil
  • Michael Hasselmo, D Phil
  • Frances Yang, PhD
  • David Salat, PhD
  • Brandon Ally, PhD

E-mail address

Lab E-mail

Lab mailing address Bedford VA Hospital Center for Translational Cognitive Neuroscience GRECC, Bldg. 62, Rm B30 200 Springs Rd. Bedford, MA 01730 Phone 781-687-3360 Fax 781-687-3366
Lab website MIND BrAIN Lab
(Multimodal Imaging of Neurodegenerative Dementias & Brain Aging Integrative Neurosciences Lab
Clinical interests Healthy cognitive aging, cognitive impairment, Alzheimer’s disease, Cerebral Amyloid Angiopathy, Dementia with Parkinsonism
Clinical mailing address Massachusetts General Hospital
Memory Disorders Unit
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical website address Memory Disorders Unit



updated 11/22/2010

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