Research Investigator Profile

Paolo Ciccarese, PhD

Paolo Ciccarese, PhD

Assistant Professor of Neurology,
Harvard Medical School

Assistant in Neuroscience,
Massachusetts General Hospital



Research Description

I am interested in enabling personal and community-driven knowledge acquisition, curation and sharing. I have been working on scientific discourse representation in Alzheimer's Disease research and I am currently exploring the use of Annotation of digital resources for supporting the knowledge creation process. My goal is to limit the episodes of lost knowledge in biomedical research and help scientists capitalizing on what is already known.
Previously, I have been investigating innovative workflow- and evidence- based clinical information systems. I have been working on automation of clinical guidelines for pathologies such as heart failure, stroke and hypertension. I have also designed and developed software infrastructures for connecting health care providers focusing on rare pathologies.

Read more on my biographical site.


Research interests Biomedical informatics, software engineering, knowledge management, semantic web
Research techniques Competencies and development tools: Java, Groovy, Grails, Lucene, GWT, JavaScript, Ajax, HTML, CSS, SVN, RDF, OWL, REST, SPARQL, SpringSource Tool Suite, Annotation ontologies, Annotation Framework, Hypothesis Management for Drug Discovery
Selected publications
  1. Ciccarese P, Ocana M, Castro LJG, Das S, Clark, T.
    An Open Annotation Ontology for Science on Web 3.0.
    J Biomed Semantics 2011, 2(Suppl 2):S4 (17 May 2011) [doi:10.1186/2041-1480-2-S2-S4] (PubMed) (Open Access)
  2. Ciccarese P, Wu E, Wong G, Ocana M, Kinoshita J, Ruttenberg A, Clark T.
    The SWAN biomedical discourse ontology.
    J Biomed Inform. 2008 Oct;41(5):739-51. Epub 2008 May 4. [doi: 10.1016/j.jbi.2008.04.010] (PubMed)
  3. Quaglini S, Ciccarese P.
    Models for guideline representation.
    Neurol Sci. 2006 Jun;27 Suppl 3:S240-4. [doi: 10.1007/s10072-006-0627-6] (PubMed)
  4. Ciccarese P, Caffi E, Quaglini S, Stefanelli M.
    Architectures and tools for innovative Health Information Systems: the Guide Project.
    Int J Med Inform. 2005 Aug;74(7-8):553-62. Epub 2005 Mar 25. [doi: 10.1016/j.ijmedinf.2005.02.001] (PubMed)
  5. Ciccarese P, Caffi E, Boiocchi L, Quaglini S, Stefanelli M.
    A Guideline Management System.
NCBI PubMed link NCBI PubMed publications
Collaborators Alzheimer Research Forum
Neuroscience Information Framework
Science Commons
E-mail address

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