Research Investigator Profile

Matthew Frosch, PhD

  • Lawrence J. Henderson Associate Professor of Pathology and Health Sciences &
    Technology, Harvard Medical School
  • Director, Neuropathology Service,
    Massachusetts General Hospital
  • Core Leader, Neuropathology Core,
    Massachusetts Alzheimer's Disease Research Center

Research Description

A unifying theme in my research is the study of human tissue and animal models of neurodegenerative diseases.  My lab focuses on mouse models of cerebral amyloid angiopathy (CAA) in which Aβ (the same peptide as in plaques of Alzheimer's disease) deposits in the walls of blood vessels and is associated with risk of hemorrhage (‘lobar hemorrhages’).  We are analyzing the sequence of events leading to Aβ deposition, what determines the distribution of involvement, the consequences for the vessel wall and how CAA responds to treatments that can alter other Aβ deposits.  We have described the pattern of disease progression, measured its kinetics and characterized the patterns of growth.  We are now focusing on the mechanisms of injury to the vessel wall and on approaches to therapy.  We have demonstrated that passive immune therapy can clear CAA, which is of relevance for clinical trials of similar approaches to treating Alzheimer's disease.

Research interests Neurodegenerative disease; cerebrovascular diseases; cerebral amyloid angiopathy; experimental neuropathology
Research techniques Mouse modeling; in vivo imaing; quantitative neuropathology; laser capture microdissection
Diseases studied Alzheimer's disease; Cerebral amyloid angiopathy (CAA); Parkinson disease; other dementias
Selected publications
  1. Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of CAA in Transgenic Mouse Models of AD. Journal of Neuropathology and Experimental Neurology. 2005, 64:588-94.
  2. Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of Cerebral Amyloid Angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neuroscience. 2006, 26:365-371.
  3. Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiology of Disease. 2006. 24:516-24.
  4. Prada C, Garcia-Alloza M, Zhang-Nunes SX, Betensky RA, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of Aβ from Cerebral Amyloid Angiopathy revealed quantitative in vivo imaging. J. Neurosci. 2007, 27:1973-80.
  5. Kinnecom C, Lev MH, Wendell L, Smith EE, Rosand J, Frosch MP, Greenberg SM. Course of Cerebral Amyloid Angiopathy-Related Inflammation, Neurology, 2007, 68(17):1411-6.
NCBI PubMed link NCBI PubMed Publications
Lab mailing address MassGeneral Institute for Neurodegenerative Disease
CNY B114-2700
114 16th Street
Charlestown, MA 02129
Lab website Frosch Lab (Pathology)
Clinical interests Diagnostic neuropathology, including tumors, vascular disease, neurodegenerative diseases
Clinical mailing address C.S. Kubik Laboratory for Neuropathology
Pathology Service, Warren 3
Mass General Hospital
55 Fruit Street
Boston, MA 02114
Clinical website address

Pathology Service, Massachusetts General Hospital

Neurology Service, Massachusetts General Hospital

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