Leigh R. Hochberg, MD, PhD

Leigh R. Hochberg, MD, PhD

  • Senior Lecturer on Neurology,
    Harvard Medical School
  • Neurologist,
    Massachusetts General Hospital
  • Professor of Engineering,
    Brown University
  • Investigator,
    Rehabilitation R&D Service, Dept. VA



Research Description

The Laboratory of Restorative Neurotechnology is focused on developing and testing neural interface systems (brain-computer interfaces) for the restoration of communication, mobility, and independence for persons with paralysis or limb loss. Our principal activity is directing the pilot clinical trial (IDE) of the BrainGate2 Neural Interface System (www.braingate.org).

Our laboratory brings together leading neurologists, neuroscientists, engineers, computer scientists, neurosurgeons, mathematicians, and other researchers to comprise a multi-disciplinary, collaborative team that hopes to design and test neural interfaces that will improve the lives of people with spinal cord injury, stroke, ALS, epilepsy, and other neurologic diseases and injuries.

Research interests Brain-Computer Interfaces, Neural Interfaces, Neural Prosthetics, Stroke, Neurointensive Care, Epilepsy
Research techniques Intracortical recording
Diseases studied Locked-in Syndrome, Tetraplegia, Spinal Cord Injury, ALS, Brainstem Stroke
Selected publications
  1. Song YK, Borton DA, Park S, Patterson WR, Bull CW, Laiwalla F, Mislow J, Simeral JD, Donoghue JP, Nurmikko AV. Active microelectronic neurosensor arrays for implantable brain communication interfaces. http://www.ncbi.nlm.nih.gov/pubmed/19502132 IEEE Trans Neural Syst Rehabil Eng. 2009 Aug;17(4):339-45. Epub 2009 Jun 5.
  2. Truccolo W, Hochberg LR, Donoghue JP. Collective dynamics in human and monkey sensorimotor cortex: Predicting single neuron spikes. http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn.2455.html  Nature Neuroscience 2009 Dec 6 (Epub ahead of print).
  3. Nurmikko, A. V., Donoghue, J. P., Hochberg, L. R., Patterson, W. R., Song, Y.-K.,  Bull, C. W., Borton, D. A., Laiwalla, F., Park, S., Ming, Y., Aceros, J. (2010 Feb 25). Listening to Brain Microcircuits for Interfacing With External World—Progress in Wireless Implantable Microelectronic Neuroengineering Devices. http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=5420043&tag=1
    Proc IEEE. 98:3. 375-388.
  4. Corey J. Keller, Wilson Truccolo, John T. Gale, Emad Eskandar, Thomas Thesen, Chad Carlson, Orrin Devinsky, Ruben Kuzniecky, Werner K. Doyle, Joseph R. Madsen, Donald L. Schomer, Ashesh D. Mehta, Emery N. Brown, Leigh R. Hochberg, Istvan Ulbert, Eric Halgren, Sydney S. Cash
    Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain 2010 Apr 17 133: 1668-1681
  5. Malik, W.Q., Truccolo, W., Brown, E.N., and Hochberg, L.R. Efficient Decoding With Steady-State Kalman Filter in Neural Interface Systems http://www.ncbi.nlm.nih.gov/pubmed/21078582.  IEEE Transaction on Neural Systems and Rehabilitation Engineering. 2011 Feb; 19(1):25-34. Epub 2010 Nov 15. 
NCBI PubMed link NCBI PubMed Publications
Collaborators John P. Donoghue, PhD, Sydney S. Cash, MD, PhD, Merit Cudkowicz, MD, M.Sc., Wasim Malik, PhD, Emery Brown, MD, PhD
E-mail address lhochberg@partners.org
Lab mailing address Massachusetts General Hospital, Neurology
Suite 300
175 Cambridge Street
Boston, MA 02114
Lab website Laboratory for Restorative Neurotechnology at Brown University
Clinical interests Stroke, Neurocritical Care
Clinical address Massachusetts General Hospital, Neurology
Suite 300
175 Cambridge Street
Boston, MA 02114

Clinical website address

Stroke Service

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