Research Investigator Profile

Bradley T. Hyman, MD, PhD

Bradley T. Hyman, MD, PhD

  • John B. Penney Professor of Neurology,
    Harvard Medical School
  • Alzheimer's Unit Director,
    MassGeneral Institute for Neurodegenerative Disease
  • Director,
    Massachusetts Alzheimer's Disease Research Center

Research Description

Dr. Hyman’s research program studies the neural system failure that underlies cognitive loss in Alzheimer’s, and how genetics impacts pathophysiology. His laboratory uses transgenic mouse models of Alzheimer’s disease and in vitro systems to examine the roles of presenilin mutations and receptors in neuronal function and on Alzheimer-related processes.

Dr. Hyman’s laboratory has developed in vivo imaging with 2-photon confocal microscopy, enabling observation of neurons in the intact, functioning mouse brain, and tracking the pathological changes that occur during disease processes. His research has shown that that plaques can be reversed by therapeutic application of antibodies.

Dr. Hyman’s laboratory has been pursing the role of the protein alpha-synuclein, which is thought to be involved in the cause of Parkinson’s disease. Using sophisticated optical imaging methods and gene transfer techniques, they have found several kinds of molecules, which can change the metabolism and effects of synuclein, and which may be targets for preventative or neuroprotective treatments.

Research interests

Alpha-synuclein, genetics, presenilin mutations

Research techniques

Two-photon confocal microscopy, gene transfer

Diseases studied

Alzheimer’s disease, Parkinson’s disease

NCBI PubMed link NCBI PubMed Publications
Lab mailing address MassGeneral Institute for Neurodegenerative Disease
114 16th Street
Charlestown, MA 02129
Clinical interests

Alzheimer’s disease, Parkinson’s disease

Clinical mailing address Massachusetts General Hospital
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical website address Memory Disorders Unit


Updated 7/10/2013

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