Research Investigator Profile


Raymond J. Kelleher III, MD, PhD

  • Assistant Professor of Neurology,
    Harvard Medical School
  • Associate in Neurology ,
    Massachusetts General Hospital



Research Description

Dr. Kelleher’s laboratory studies the molecular and cellular mechanisms underlying cognition and cognitive disorders. Current research projects are directed toward defining the molecular mechanisms regulating local protein synthesis in neurons, and understanding how these translational mechanisms contribute to normal cognition and the establishment and modification of synaptic connectivity in the mammalian brain. Examination of the role of defective translational control in specific neuropsychiatric disorders is a closely related effort. In a complementary line of research, the laboratory is also investigating the molecular and cellular mechanisms responsible for neurodegenerative dementia, with a focus on Alzheimer’s disease. Due to the complexity of these problems, which span the gap from molecules to behavior, the laboratory employs a multidisciplinary approach, including conditional and inducible genetic manipulations in mice, biochemical, molecular and cell biological analysis, slice electrophysiology and mouse behavior.

Research interests

Translational regulation, synaptic plasticity and memory

Research techniques Biochemical, molecular and cell biological analysis, slice electrophysiology
Diseases studied Cognitive disorders, Alzheimer’s disease
Selected publications
  1. Kelleher, R.J., III, Govindarajan, A, Jung, H.-Y., Kang, H. and Tonegawa, S. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 2004; 116: 467-479.
  2. Kelleher, R.J. III, Govindarajan, A. and Tonegawa, S. Translational regulatory mechanisms in long-term synaptic plasticity and memory. Neuron 2004; 44:59-73.
  3. Saura , C.A. , Choi, S.Y., Beglopoulos, V., Malkani, S., Zhang, D., Rao, B.S.S, Chattarji, S., Kelleher, R.J., III, Kandel, E.R., Duff. K., Kirkwood, A. and Shen, J. Loss of Presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 2004; 42:23-36.
NCBI PubMed link NCBI PubMed publications
E-mail address
Lab mailing address Center for Human Genetic Research
Massachusetts General Hospital
Richard B. Simches Research Center
Mailcode: CPZN-6234
185 Cambridge Street
Boston, MA 02114
Clinical interests Cognitive disorders, with an emphasis on dementia and Alzheimer’s disease
Clinical mailing address Massachusetts General Hospital
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical Web site address Memory Disorders Unit




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