Research Investigator Profile

Fawn Leigh, MD

Fawn Leigh, MD

  • Instructor in Neurology,
    Harvard Medical School
  • Associate in Neurology,
    Massachusetts General Hospital




Research Description

The focus of Dr. Leigh's current research is directed at searching for modifiers of tumor development whose identification may provide potential therapeutic targets, as well as clues to better understanding the underlying mechanisms in tumor development. In Neurofibromatosis, type 1 (NF1), clinical variability is common. Prior studies of families affected by NF1 have implicated trait-specific modifier genes as important determinants of the clinical variability in NF1.

Research interests Neurofibromatosis tumor development, differentially expressed proteins in Neurofibromatosis
Research techniques Tandem mass spectrometry, two-dimensional difference in gel electrophoresis
Diseases studied Neurofibromatosis, type 1
Selected publications
  1. Waldau B, Domeshek LF, Leigh FA, Lum KC, Fuchs HE, Marcus JR, Mukundan S, Grant GA. Spontaneous resolution of a 13-mm Chiari malformation Type I in relation to differential growth of the posterior fossa volume. J Neurosurg Pediatr. 2009 Feb; 3(2):110-4.
NCBI PubMed link NCBI PubMed Publications
Lab mailing address Fawn Leigh, MD
55 Fruit Street
Boston, MA 02110
Clinical interests Clinical variability in Neurofibromatosis, identifying modifiers of tumor development as potential therapeutic targets, clinical trials
Clinical mailing address Massachusetts General Hospital
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical website address Neurofibromatosis Clinic (adult and child)

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