Research Investigator Profile

A portrait of Dr. MingMing Ning

MingMing Ning, MD, MMSc

  • Assistant Professor in Neurology,
    Harvard Medical School
  • Associate in Neurology,
    Massachusetts General Hospital
  • Director, Clinical Proteomics
    Research Center



Research Description

Sponsored by the National Institutes of Health (NINDS), the Clinical Proteomics Research Center (CPRC) explores the clinical applications of proteomic technology. The goals of the Clinical Proteomics Research Center are to explore neurovascular pathophysiology using a translational approach, to develop prognostic tools to guide clinical decision-making, and to discover new targets of therapeutic intervention at the bedside. Read more about CPRC research in the application of proteomic technology to clinical problem solving in neurovascular disease on our Research Project page.


Research interests Stroke, PFO, Clinical Proteomics, Hypothermia, Biomarkers in Thrombolysis and Stroke Therapy
Research techniques Proteomics
Diseases studied Cerebrovascular disease, Acute Stroke Therapy, Stroke and Migraine related to PFO, Stroke associated with heart disease
Selected publications
  1. Michael D, Martin KC, Seger R, Ning MM, Baston R, Kandel ER. Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia. Proc Natl Acad Sci USA. 1998;95(4):1864-9.
  2. Plotkin SR, Ning MM. Traumatic cervical spine disruption. N Engl J Med. 2001;345(15):1134-5.
  3. Kiernan TJ, Yan BP, Cubeddu RJ, Rengifo-Moreno P, Gupta V, Inglessis I, Ning MM, Demirjian ZN, Jaff MR, Buonanno FS, Schainfeld RM, Palacios IF. May-Thurner syndrome in patients with cryptogenic stroke and patent foramen ovale: an important clinical association. Stroke. 2009 Apr;40(4):1502-4.
  4. Ning MM, Sarracino DA, Buonanno F, Krastins B, Chou S, McMullin D, Wang X, Lopez M, Lo EH. Proteomic Protease Substrate Profiling of tPA Treatment in Acute Ischemic Stroke Patients: A Step Toward Individualizing Thrombolytic Therapy at the Bedside.2010;1(4): 268-275.
  5. Ning MM, Sarracino DA, Kho AT, Guo SZ, Lee SR, Krastins B, Buonanno FS, Vizcaíno, Orchard S, McMullin D, Wang X, Lo EH. Proteomic Temporal Profile of Human Brain Endothelium Post Oxidative Stress. Stroke 2011 Jan ;42:37-43.

All Selected Publications (PDF)

NCBI PubMed link NCBI PubMed Publications
E-mail address
Lab mailing address Massachusetts General Hospital
55 Fruit Street
Boston, MA 02110
Lab website MingMing Ning MD, MMSc, Clinical Proteomics Research Center (CPRC)
Clinical interests Neuro - ICU, Stroke, Cerebrovascular disorders, patent foramen ovale
Clinical address Massachusetts General Hospital
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA

Clinical website address


Cardio-Neurology Clinic

Stroke Service at Massachusetts General Hospital


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