Research Investigator Profile

Anne B. Young, MD, PhD

    Anne B. Young, MD, PhD

  • Professor of Neurology,
    Harvard Medical School
  • Founder and Scientific Director,
    MassGeneral Institute for Neurodegenerative Disease


Research Description

Dr. Young’s laboratory is examining the role of the protein alpha-synuclein, which plays a key role in the death of dopamine-producing brain cells in the Parkinson’s disease and other diseases with similar symptoms. Recently Dr. Young’s laboratory has examined the biology of synuclein in a group of Parkinson-like disorders, the Multiple Systems Atrophies. These studies suggest novel mechanisms in synuclein turnover, which may be relevant for treatments targeted at this protein.

In addition to her work in Parkinson’s disease, Dr. Young’s laboratory is attempting to elucidate cellular and systems mechanisms underlying the pathophysiology of Huntington’s disease. In an effort to help develop therapeutic targets for human movement disorders, she is conducting studies on the vulnerability of neurons to excitotoxic injury and the selective expression of glutamate receptors in these neurons.

Research interests Alpha-synuclein, genetics, expression of glutamate receptors
Research techniques Laser capture micro dissection, gene mircro arrays, protein chemistry
Diseases studied Huntington's and Parkinson's diseases
Selected publications
  1. Four decades of neurodegenerative disease research: how far we have come! Young AB. J Neurosci. 2009 Oct 14;29(41):12722-8.
  2. Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5. Orlando LR, Ayala R, Kett LR, Curley AA, Duffner J, Bragg DC, Tsai LH, Dunah AW, Young AB. J Neurochem. 2009 Jul;110(2):557-69. Epub 2009 Apr 30.
  3. Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy. Crittenden JR, Cantuti-Castelvetri I, Saka E, Keller-McGandy CE, Hernandez LF, Kett LR, Young AB, Standaert DG, Graybiel AM.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2892-6. Epub 2009 Jan 26.
  4. NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens. Chauhan VS, Sterka DG Jr, Furr SR, Young AB, Marriott I. 2009 Mar;57(4):414-23.
NCBI PubMed link NCBI PubMed Publications
NIH biosketch

Anne B. Young, MD, PhD (PDF)

Lab mailing address

MassGeneral Institute for Neurodegenerative Disease
CNY B-114, Room 2006
114 16th Street
Charlestown, MA 02129

Lab, institute or center websites MassGeneral Institute for Neurodegenerative Disease

Back to Top