Department of Medicine

COVID-19 Grand Rounds Series

The Massachusetts General Hospital's Department of Medicine presents a series of academic lectures on the impact of and response to the COVID-19 pandemic.
Image of virtual grand rounds with scans and people on video calls
Image of virtual grand rounds with scans and people on video calls

Medical Grand Rounds

Under the auspices of the department's Medical Grand Rounds, these timely and informative talks bring together the leading medical experts working to address this new global challenge.

Upcoming Grand Rounds

September 10, 2020
7:00-8:00 am

Anthony S. Fauci, MD
NIAID Director

"COVID-19: Public Health and Scientific Challenges 

Panelists for Q&A: 

Rochelle Walensky, MD, MPH 

Chief, Division of Infectious Diseases 

Massachusetts General Hospital 

 

Sharon B. Wright, MD, MPH 

Senior Medical Director, Infection Control/Hospital Epidemiology 

Beth Israel Deaconess Medical Center 

 
Michael Klompas, MD, MPH

Hospital Epidemiologist 

Brigham and Women’s Hospital 

Please use one of the following links to watch the livestream event. For optimal viewing, use Chrome or Firefox.

 LINK 1: https://partners.mediasite.com/mediasite/Play/968f633a874c4f1a80c368496f49d4661d

 LINK 2: https://partners.mediasite.com/mediasite/Play/17db07327ba3458cb647cb511c3aa2f71d


For the latest information on COVID-19, click here.

Previous Grand Rounds

July 16, 2020

COVID-19: Patient Recovery and Rehab

This Department of Medicine Grand Rounds focused on case studies and data that can inform approaches to COVID-19 patient recovery and rehab. Featured speakers included Jason H. Maley, MD, research fellow, and George A. Alba, MD, physician in the Department of Medicine, of Massachusetts General Hospital; Ginger Polich, MD, instructor of physical medicine and rehabilitation at Spaulding Rehabilitation Hospital; Zahir Kanjee, MD, MPH, Anica C. Law, MD, and Margaret Hayes, MD, of Beth Israel Deaconess Medical Center; and Kathleen J. Haley, MD, of Brigham and Women’s Hospital.

Watch the video »

July 9, 2020

COVID-19 and Health Equity: A Focus on Health System Solutions to Magnified Inequities

This Harvard Medical Grand Rounds examined ways in which the COVID-19 pandemic has revealed and exacerbated global health inequities. Featured speakers included Joseph Betancourt, MD, MPH, and Aisha James, MD, MS, of Massachusetts General Hospital; Beth Riviello, MD, MPH, and Rose L. Molina, MD, MPH, of Beth Israel Deaconess Medical Center; and Valerie Stone, MD, MPH, and Bisola Ojikutu, MD, MPH, of Brigham and Women’s Hospital.

Watch the video »

June 18, 2020

A 66-Year-Old Liver Transplant Recipient with COVID-19

This Combined Medical-Surgical Grand Rounds lecture reviewed the case of a 66-year-old liver transplant recipient with COVID-19. The panel featured Jay A. Fishman, MD, Matthew B. Roberts, MB, BS, and Eric W. Zhang, MD, of Massachusetts General Hospital; Deepali Kumar, MD, of the University of Toronto, Canada; Hans H. Hirsch, MD, MSc, of the University Hospital Basel, Switzerland; and Umberto Maggiore, MD, of the University of Parma, Italy.

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June 11, 2020

June 11th Medical Grand Rounds

The 14th lecture in the Medical Grand Rounds' COVID-19 series focused on the role of platelets and prescriptions in COVID-19. The panel included Nancy Haff, MD, primary care physician, Nino Mihatov, MD, cardiology fellow at Mass General, and other members of the Boston medical community.

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June 4, 2020

Vaccine Development for COVID-19: A Status Update on the Challenges and Prospects for Success

The 13th lecture in the Medical Grand Rounds' COVID-19 series provided an update on efforts to develop a safe, scalable vaccine for COVID-19. The panel featured Mason W. Freeman, MD, of Massachusetts General Hospital, Daniel Barouch, MD, PhD, of Beth Israel Deaconess Medical Center, and Lindsey Robert Baden, MD, of Brigham and Women’s Hospital.

Watch the video »

May 28, 2020

Impact of COVID-19 among Older Persons

The 12th lecture in the Medical Grand Rounds' COVID-19 series focused on the impact of COVID-19 in older populations. The panel included Christine Seel Ritchie, MD, MSPH, Sharon Levine, MD, and Jehan Alladina, MD, of Massachusetts General Hospital; Susan L. Mitchell, MD, MPH, and Sharon K. Inouye, MD, MPH, of Beth Israel Deaconess Medical Center; and Shalender Basin, MB, BS, Laura Nelson Frain, MD, MPH, and Shoshana Streiter, MD, of Brigham and Women’s Hospital.

Watch the video » 

May 21, 2020

COVID-19 and Acute Kidney Injury

The eleventh lecture in the Medical Grand Rounds' COVID-19 series featured Eugene Rhee, MD, Meghan Sise, MD, and Win Williams, MD, of the Nephrology Division at Massachusetts General Hospital; Peter Czarnecki, MD, David Leaf, MD, MMSc, and Danielle Saly, MD, of Brigham and Women’s Hospital; and David Friedman, MD, Samir Parikh, MD, and Martin Pollak, MD, of Beth Israel Deaconess Medical Center.

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May 14, 2020

Cardiac Manifestations of COVID-19 

The tenth lecture in the Medical Grand Rounds' COVID-19 series featured Anthony Rosenzweig, MD, Jason Wasfy, MD, MPhil, and Judy Hung, MD, of Massachusetts General Hospital; Dhruv Kazi, MD, MSc, MS, Lila Martin, MD, and Duane Pinto, MD of Beth Israel Deaconess Medical Center; and David Morrow, MD, MPH, Mandeep Mehra, MD, MSc, and Erin Bohula May, MD, DPhil, of Brigham and Women’s Hospital.

Speakers: 
00:00 - Introductions and Overview
02:18 - Jason Wasfy, MD, MPhil - Cardiac Outcomes During the COVID-19 Pandemic
09:54 - Mandeep R. Mehra, MD, MSc - Pathobiology of Cardiac Injury in COVID-19
24:05 - Lila Martin, MD, MPH - Case Presentation
26:30 - Erin Bohula May, MD, DPhil - Differential Diagnosis
32:10 - Judy Hung, MD - The Role of Cardiac Imaging in Management of COVID-19 Patients
36:43 - Duane Pinto, MD - Catheterization Laboratory Considerations
44:37 - Dhruv S. Kazi, MD, MSc, MS - Clinical, Ethical and Health Economic Considerations
54:37 - Questions and Answers

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May 7, 2020

Unraveling the Mystery of Clotting in COVID-19

Featured speakers in the ninth lecture in the Medical Grand Rounds' COVID-19 series included Pavan Bendapudi, MD, and Hanny Al-Samkari, MD, of Massachusetts General Hospital; Jason Freed, MD, Jeffrey Zwicker, MD, and Robert Flaumenhaft, MD, PhD, of Beth Israel Deaconess Medical Center; and Jean Marie Connors, MD, of Brigham and Women's Hospital.

Speakers: 
00:00 - Introductions
01:24 - Jason Freed, MD - Case Presentation: 55-year-old Woman with Four Days of Cough and Low Grade Fever
03:45 - Jeff Zwicker, MD - COVID-19 Coagulopathy: The Unfolding Story
12:52 - Robert Flaumenhaft, MD, PhD - Endothelial Mechanisms of COVID-related Thrombosis
25:12 - Pavan Bendapudi, MD - Hemorrhage and Hyperfibrinolysis  in COVID-19 Infection
35:10 - Hanny Al-Samkari, MD - COVID, Coagulation and Inflammation
42:37 - Jean M. Connors, MD - Anticoagulation in COVID-19 Patients: A Clinician's Perspective
1:01:02 - Questions and Answers

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April 30, 2020

How Diagnostic Tests for COVID-19 Got Us into, and Will Lead Us Out of, the Pandemic

Featured speakers in the eighth lecture in the Medical Grand Rounds' COVID-19 series included Galit Alter, PhD, and Wilfredo García Beltrán, MD, PhD, of the Ragon Institute of MGH, MIT and Harvard; Marc Lipsitch, DPhil, of the Harvard T.H. Chan School of Public Health; Christopher Rowley, MD, MPH, and Bess Flashner, MD, of Beth Israel Deaconess Medical Center; and Sanjat Kanjilal, MD, MPH, of Brigham and Women’s Hospital.

Speakers: 
00:00 - Katrina Armstrong, MD - Introduction
02:32 - Bess Flashner, MD - Case Presentations: Common Challenges in Treating and Testing COVID-19 Patients
09:10 - Christopher Rowley, MD, MPH - Timeline of the COVID-19 Pandemic in the U.S.
21:52 - Sanjat Kanjilal, MD, MPH - Molecular Diagnostics for SARS-CoV-2
32:20 - Galit Alter, PhD - The Wild-West of Antibody Testing...and the Basics
37:44 - Wilfredo F. García Beltrán, MD, PhD - COVID-19 Serological Testing at Mass General
49:28 - Marc Lipsitch, DPhil - Serology for Epidemiology and Public Health
01:02:57 - Questions and Answers

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April 23, 2020

A 66-year-old Man with Homelessness, with Cough and Rhinorrhea: Response to COVID-19 Among Boston’s Homeless Population

The seventh lecture in the Medical Grand Rounds' COVID-19 series focused on a case study which shed light on the challenges associated with preventing and treating COVID-19 among Boston's homeless population.

Featured speakers included David Munson, MD, instructor in medicine at Harvard Medical School and medical director of Respite Programs at Boston Health Care for the Homeless; Jessie Gaeta, MD, and Denise De Las Nueces, MD, MPH, of Boston Health Care for the Homeless and Boston University School of Medicine; and Kate Walsh, MPH, and Joshua A. Barocas, MD, MPH, of Boston Medical Center.

Speakers:
00:29 - David Dudzinksi, MD - Introduction and Overview
01:32 - Denise De Las Nueces, MD, MPH - Case History
05:53 - David Munson, MD - Respite Management
11:46 - Jessie M. Gaeta, MD - Boston Health Care for the Homeless Program Response
34:33 - Joshua A. Barocas, MD - Approach to Infection Control in an Evolving Pandemic
47:56 - Kate Walsh, MPH - Hospital Response to Persons Experiencing Homelessness During the COVID-19 Pandemic
58:25 - Jessie M. Gaeta, MD - Summary
1:01:58 - Questions and Answers

Watch video »

April 16, 2020

Publishing in a Pandemic: How Medical Journals are Responding to COVID-19

The sixth lecture in the Medical Grand Rounds' COVID-19 series focused on the role of medical journals in the development of new therapies and approaches to patient care during the COVID-19 pandemic. 

Featured speakers included: 

  • Chana A. Sacks, MD, internist at Mass General and images editor at the New England Journal of Medicine
  • Martin Hirsch, MD, senior physician in the Infectious Disease Service at Mass General and editor-in-chief of the Journal of Infectious Diseases
  • Mary Beth Hamel, MD, MPH, internist at Beth Israel Deaconess Medical Center and executive deputy editor of the New England Journal of Medicine
  • Paul Sax, MD, clinical director of the HIV Program and Division of Infectious Diseases at Brigham and Women’s Hospital
  • Howard Bauchner, MD, professor of pediatrics and community health sciences at the Boston University School of Medicine and editor-in-chief of Journal of the American Medical Association 

Speakers: 
00:26 - Eileen Reynolds, MD - Introduction
01:00 - Chana A. Sacks, MD - Overview
02:41 - Howard Bauchner, MD - Report from JAMA
08:13 - Mary Beth Hamel, MD, MPH - Report from the NEJM
13:15 - Martin Hirsch, MD - Report from the Journal of Infectious Diseases
18:53 - Chana A. Sacks, MD - Do Publishing Standards Change in a Pandemic?
31:44 - Martin Hirsch, MD - Pandemics Throughout History
41:56 - Paul Sax, MD - Reflections on Publishing in a Pandemic
45:30 - Closing Thoughts
51:05 - Questions and Answers


Watch video »

April 9, 2020

Advancing New Therapies for COVID-19: Anti-viral, Immunomodulation and Beyond

Featured speakers in the fifth lecture of the Medical Grand Rounds' COVID-19 series included Keith Flaherty, MD, Michael Mansour, MD, PhD, and Kathryn Hibbert, MD, of Massachusetts General Hospital; Kathryn Stephenson, MD, MPH, and Barbra Blair, MD, from Beth Israel Deaconess Medical Center; Richard Kaufman, MD, from Brigham and Women’s Hospital; and Scott Gottlieb, MD, former commissioner of the Food and Drug Administration and current fellow at the American Enterprise Institute.

Speakers: 
00:15 - Katrina Armstrong, MD - Overview
01:55 - Keith Flaherty, MD - COVID-19 Clinical Trial Strategy: Signal Seeking vs. Optimal Deployment
06:09 - Kathryn E. Stephenson, MD, MPH - Antiviral Therapies for COVID-19
13:43 - Richard Kaufman, MD - COVID-19 Convalescent Plasma
25:22 - Michael K. Mansour, MD, PhD - COVID Immunomodulation Group (CIG)
42:20 - Barbra M. Blair, MD - Hydroxychloroquine (HCQ) & COVID-19
50:29 - Kathryn Hibbert, MD - COVID-19 ARDS Trials
59:13 - Scott Gottlieb, MD - The Role of Regulatory Authorities in Accelerating Therapeutic Advances
1:19:25 - Questions and Answers

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April 2, 2020

Palliative Care in a Pandemic

The fourth lecture in the Medical Grand Rounds’ COVID-19 series featured Palliative Care experts and the growing role of that discipline in the response to the pandemic.

Speakers included Vicki Jackson, MDEmily Rubin, MD, Juliet Jacobsen, MD, from Mass General; Mary Buss, MD, PhD, and the Rev. Kathleen Rimer from BIDMC; and Isaac Chua, MD, from Dana-Farber and Brigham & Women's Hospital.

Speakers: 
00:46 - Vicki Jackson, MD - Overview
06:36 - Juliet Jacobsen, MD - Generalist Palliative Care and Communication
15:29 - Isaac Chua, MD, MPH - Responding to Emotion with Telehealth
21:55 - Emily Rubin, MD - Ethical Principles in the Allocation of Scarce Resources During a Public Health Emergency
30:49 - Mary K. Buss, MD, MPH - Addressing Moral Distress
45:50 - Rev. Kathleen Rimer - Maintaining Humanity and Compassion
57:38 - Questions and Answers

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March 26, 2020

Pathogenesis and Management of Respiratory Failure in COVID-19: What We Know So Far

The third lecture in the Medical Grand Rounds’ COVID-19 series focused on respiratory failure in COVID-19. Speakers included Benjamin Medoff, MD, Jehan Alladina, MD, Jayaraj Rajagopal, MD, Jason Griffith, MD, PhD, and Taylor Thompson, MD, of Mass General; Rebecca Baron, MD, of Brigham and Women’s Hospital; and Ari Moskowitz, MD, Robert Hallowell, MD, and Richard Schwartzstein, MD, of Beth Israel Deaconess Medical Center.

Speakers:
02:56 - Jehan Alladina, MD - Case Presentation
07:41 - Rebecca Baron, MD - Mechanisms Underlying ARDS (With a Focus on COVID-19)
18:45 - Ari Moskowitz, MD - Basics of Management
34:00 - Jason Griffith, MD, PhD - Aberrant Immune Responses to Respiratory Viral Infection: Lessons from Influenza
41:45 - Rob Hallowell, MD - Experimental Therapies
52:22 - Jayaraj Rajagopal, MD - The Lung Cell Atlas: COVID-19
57:18 - Taylor Thompson, MD - Hyperinflammation and Use of Steroids in ARDS
59:33 - Richard Schwartzstein, MD - Cognitive Biases in Recommendations for Treatment and Parallels to the HIV/AIDS Epidemic
1:02:42 - Questions and Answers


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March 19, 2020

COVID-19 in Low-resourced Settings: Reaching for Global Health Equity

Mass General hosted its second Medical Grand Rounds lecture related to COVID-19. Louise Ivers, MD, MPH, the executive director of the Mass General Center for Global Health, along with other members of the Greater Boston medical community, presented on the global effects of the pandemic.

Additional speakers included David Walton, MD, MPH, of Build Health International and Brigham and Women’s Hospital; Inobert Pierre, MD, of Health Equity International and St. Boniface Haiti; Quarraisha Abdool Karim, PhD, of the Centre for the Programme of AIDS Research in South Africa, Columbia University; and Paul Farmer, MD, PhD, of Partners In Health and Brigham and Women's Hospital.

Speakers: 
01:34 - Louise Ivers, MD, MPH - Overview
08:19 - David Walton, MD, MPH - Pragmatic Approaches to Cohorting Patients in Resource-limited Settings
23:44 - Inobert Pierre, MD - A View from Southern Haiti
28:44 - Quarraisha Abdool Karim - COVID-19 in South Africa
40:05 - Paul Farmer, MD, PhD - Human Responses to the COVID-19 Outbreak
1:02:17 - Questions and Answers


Watch video »

March 12, 2020

A Coordinated, Boston-wide Response to COVID-19

Bruce Walker, MD, director of the Ragon Institute and other members from Mass General and the Greater Boston medical community, came together in a Medical Grand Rounds lecture on research efforts to quickly and effectively respond to COVID-19.

The session was moderated by Katrina Armstong, MD, physician-in-chief in the Department of Medicine at Mass General, and speakers included Bruce D. Walker, MD, of the Ragon Institute at Mass General; Marc Lipsitch, DPhil, of the T.H. Chan School of Public Health; Pardis Sabeti, MD, DPhil, of Harvard University and the Broad Institute; Galit Alter, PhD, of the Ragon Institute at Mass General; Mark Namchuk, PhD, of Harvard Medical School; Dan Barouch, MD, PhD, of the Ragon Institute and Beth Israel Deaconess Medical Center; Lindsey Baden, MD, from Brigham and Women’s; and Mark Schwartz, a member of the  Mass General Board of Trustees.

Speakers: 
01:58 - Lindsey Baden, MD - Mapping the Outbreak and Clinical Management
09:24 - Marc Lipsitch, DPhil - Epidemiology of COVID-19: Flatten the Curve
19:06 - Pardis Sabeti, MD, DPhil - How SARS-CoV-2 Causes Disease
29:37 - Galit Alter, PhD - Pathogenesis
38:49 - Mark Namchuk, PhD - Prospects for Treatment of SARS-CoV-2: From the Shelf and from the Bench
47:30 - Dan Barouch, MD, PhD - COVID-19 Vaccine Development


Watch video »

Additional Resources

Responding to COVID-19

Mass General has activated its Hospital Incident Command System (HICS) in response to the ongoing Coronavirus (COVID-19) pandemic. Please find the latest news and information here.