Mass General Research Institute's latest COVID-19 research in the areas of mobilizing response, diagnostics, therapies, clinical trials and disease biology.

  • COVID-19 Urgent Resource Video Education Library Provides Resources to Clinicians and Educators Across the Globe (5/22) — One of the strategic planning goals of the Executive Committee on Teaching and Education (ECOTE) at Massachusetts General Hospital is to support broad awareness and access to key education and training materials that enhance patient care—both internally and externally. This goal has never been more important than during the COVID-19 pandemic, as Mass General clinicians and researchers are producing grand rounds videos, departmental lectures, protocols and other digital materials that are of great use to clinicians around the world. To collect and curate these digital assets, James A. Gordon, MD, MPA, chief learning officer and director of the Mass General Learning Laboratory, and Jarone Lee, MD, MPH, critical care and emergency medicine specialist in the Division of Trauma, Emergency Surgery & Surgical Critical Care and medical director of the Blake 12 ICU, worked with colleagues to create the COVID-19 Urgent Resource Video Education (CURVE) library. [All Mobilizing Response Updates]
  • Influence of COVID-19 on Delivery and Inpatient Postpartum Care (5/22) — Because data are sparse, the care of SARS-CoV-2 infected pregnant women and their newborns is predominantly guided by society recommendations and expert opinion. To summarize current practices, Anjali J. Kaimal, MD, MAS, director of the Deborah Kelly Center for Clinical Research, Ilona Goldfarb, MD, maternal-fetal medicine specialist, Lauren Hanley, MD, medical director of the Lactation Clinic in the Massachusetts General Hospital Department of Obstetrics and Gynecology, and Megan Aurora, MD, associate medical director of the Neonatal Intensive Care Unit at MassGeneral Hospital for Children, posted a fast literature update on May 16, 2020. [All Understanding the Disease Updates]
  • COVID-19 Virtual Seminar: Breakthroughs in Testing and Tracing (5/22) — As the COVID-19 curve flattens in the United States, medical experts and policymakers discuss what to expect throughout the remainder of the year and what will be necessary to resume daily life. In a Massachusetts General Hospital COVID-19 Virtual Seminar Series, a panel of experts—including Timothy Ferris, MD, MPH, chair of the board and chief executive officer, Mass General Physicians Organization; Eric Rosenberg, MD, director of Microbiology Laboratories; and Rochelle Walensky, MD, MPH, chief of the Division of Infectious Diseases—discussed breakthroughs in testing and tracing as well as implications for the future. [All Diagnostics Updates]
  • Electronic Consults Between Clinicians and Specialists Have Increased During the COVID-19 Pandemic (5/21) — New research from Massachusetts General Hospital points to the usefulness of electronic consultations, or e-consults, during the COVID-19 pandemic. Such technology allows clinicians to ask specific questions of specialists, who then provide recommendations after reviewing a patient’s electronic health record with no direct specialist-to-patient contact involved. An important part of telemedicine, e-consults—which have been used at Mass General since 2014 as a tool to improve population health—reduce unnecessary patient visits to specialists and decrease wait times for those patients who need in-person specialist visits. Neelam A. Phadke, MD, Jason Wasfy, MD, and their colleagues examined daily consultation requests from February 1, 2020 through April 1, 2020 at Mass General. Their findings are published in the Journal of General Internal Medicine[All Mobilizing Response Updates]
  • Study of Interferon + Antivirals in COVID-19 Is First Published Randomized Trial with Positive Results (5/19) — The combination of interferon beta-1b, lopinavir–ritonavir and ribavirin has become the first COVID-19 therapy to show promising results in a published randomized trial in The Lancet. Tiara Calhoun, MD, Internal Medicine and Global Medicine resident at Massachusetts General Hospital, reports and critiques the study in a fast literature update. [All Therapies Updates]
  • Helmet Ventilation May Be Considered for Selected Patients with Mild COVID-19–Associated ARDS (5/19) — In light of feared ventilator shortages, or to provide care aligned with a patient's goals and preferences, some clinicians have advocated the use of helmet ventilation in COVID-19. Camille Petri, MD, a fellow in Pulmonary and Critical Care Medicine at Massachusetts General Hospital, discussed this strategy in a fast literature update. [All Therapies Updates]
  • The Role of Imaging for COVID-19 Testing (5/18) —  Accurate and efficient testing is a powerful weapon in the fight against COVID-19, helping to direct medical resources and minimize community spread. Polymerase chain reaction (PCR) tests using a nasal/throat swab are presently the recommended method for detecting an active coronavirus infection. However, what happens when these tests are not widely available or are inconclusive? In the case of COVID-19, imaging tests, such as computerized tomography (CT) scans, have proven to be helpful tools—with a few important caveats. Brent Little, MD, a thoracic radiologist at Massachusetts General Hospital Imaging, has been doing research on the use of imaging in diagnosing the virus. [All Diagnostics Updates]
  • PatientConnect Tool Provides Compassionate Care During COVID-19 (5/18) — As in-person visitors of patients admitted to the hospital continue to be limited, a new tool is helping to unite hospitalized COVID-19 patients with their loved ones. Massachusetts General Hospital launched PatientConnect, a program that enables patients to spend time with friends and family through virtual meetings. [All Mobilizing Response Updates]
  • Ragon Institute Members Receive Funding from MassCPR for COVID-19 Projects (5/14) — As part of its COVID-19 response, the Ragon Institute of MGH, MIT and Harvard is working within the Massachusetts Consortium for Pathogen Readiness (MassCPR), a multi-institutional initiative convened by Harvard Medical School and the Ragon Institute, to combat the disease and prepare for future outbreaks. [All Mobilizing Response Updates]
  • Understanding Links Between COVID-19 and Obesity (5/12) — Obesity is not a risk factor for becoming infected with COVID-19 that we are aware of today. However, new data suggests that patients who have obesity are more likely to require intensive care for COVID-19. [All Understanding the Disease Updates]