Featured Research

From figuring out how SARS-CoV-2 is spread or infects a person, to distinguishing the antibody response to the virus, to recognizing the effects of COVID-19 on our community, Mass General researchers have ramped up collaborations to accelerate our understanding of this disease to inform new public health strategies, diagnostics, therapies and care.

Risk score predicts prognosis of outpatients with COVID-19

A new artificial intelligence–based score considers multiple factors to predict the prognosis of individual patients with COVID-19 seen at urgent care clinics or emergency departments.

Time-plus-symptoms Approach to Return to Work After COVID-19 Infection

Mass General researchers assessed test-based return to work vs. "time-and-symptoms" approaches and report that the "time-and-symptoms" approach avoids more lost worktime and is the optimal system.

Everything You Need to Know About COVID-19 Tests

Widespread testing and tracing are crucial to managing the spread of COVID-19, but there are several different kinds of tests that each have a specific use.

All Research Coverage


  • Infectious Disease Physicians Effectively Guide Evaluation of Hospitalized Patients With Suspected COVID-19 – The Infectious Diseases Society of America recommends repeating a nucleic acid test when suspicion of COVID-19 remains moderate or high after the first test. To inform physicians' decisions, Caitlin M. Dugdale, MD, and Emily P. Hyle, MD, MSc, of the Division of Infectious Diseases, and colleagues have devised an approach to reduce the need for repeat testing among low-suspicion patients and prevent inappropriate removal of precautions in patients with false-negative tests. (9/25)
  • Review: COVID-19 Diagnostics – Ralph Weissleder, MD, PhD, director of the Center for Systems Biology and attending clinician in Interventional Radiology, Hakho Lee, PhD, director of the Biomedical Engineering Program at the Center for Systems Biology, and Mikael J. Pittet, PhD, director of the Cancer Immunology Program at the Center for Systems Biology, and colleagues review challenges of current diagnostics for COVID-19 and address the need for more longitudinal testing for the virus. (6/24)
  • The Impact of Troponin Levels on the Care of COVID-19 Patients – In this Q&A, James L. Januzzi, Jr, MD, director of the Dennis and Marilyn Barry Fellowship in Cardiology Research at Massachusetts General Hospital Corrigan Minehan Heart Center, discusses cardiac injury in COVID-19 patients and what elevated troponin and other biomarker levels can tell providers about the prognosis of and care for their patients. (6/5)
  • Antibody Testing Vital to Managing the COVID-19 Pandemic — Small initial studies have demonstrated that most patients infected with SARS-CoV-2 develop antibodies against the virus. The promise and current pitfalls of antibody testing are reviewed in a fast literature update posted on May 22, 2020, by Alison Witkin, MD, associate director, Pulmonary Hypertension and Thromboendarterectomy Program with advisory review by Rod Rahimi, MD, PhD, both of the Department of Pulmonary and Critical Care Medicine at Massachusetts General Hospital. (5/29)
  • COVID-19 Virtual Seminar: Breakthroughs in Testing and Tracing — As the COVID-19 curve flattens in the United States, medical experts and policymakers discuss what to expect throughout the remainder of the year and what will be necessary to resume daily life. In a Massachusetts General Hospital COVID-19 Virtual Seminar Series, a panel of experts—including Timothy Ferris, MD, MPH, chair of the board and chief executive officer, Mass General Physicians Organization; Eric Rosenberg, MD, director of Microbiology Laboratories; and Rochelle Walensky, MD, MPH, chief of the Division of Infectious Diseases—discussed breakthroughs in testing and tracing as well as implications for the future. (5/22)
  • The Role of Imaging for COVID-19 Testing —  Accurate and efficient testing is a powerful weapon in the fight against COVID-19, helping to direct medical resources and minimize community spread. Polymerase chain reaction (PCR) tests using a nasal/throat swab are presently the recommended method for detecting an active coronavirus infection. However, what happens when these tests are not widely available or are inconclusive? In the case of COVID-19, imaging tests, such as computerized tomography (CT) scans, have proven to be helpful tools—with a few important caveats. Brent Little, MD, a thoracic radiologist at Massachusetts General Hospital Imaging, has been doing research on the use of imaging in diagnosing the virus. (5/18)
  • Meaning of Elevated Procalcitonin Unclear in COVID-19 — In isolation, elevations of procalcitonin are insufficiently specific to guide antibiotic therapy in COVID-19, according to Viral Shah, MD, PhD, a fellow in the Division of Pulmonary and Critical Care at Massachusetts General Hospital. He gives details in a fast literature update posted on April 9, 2020. (4/20) 
  • Scientists Facing Challenges to Develop Additional Methods to Detect the Novel Coronavirus — Reverse-transcriptase polymerase chain reaction (RT-PCR) is currently the method of choice to diagnose novel coronavirus, SARS-CoV-2. Physicians Laura Brenner, MD, and Vladimir Vinarsky, MD, of the Division of Pulmonary and Critical Care in the Department of Medicine at Massachusetts General Hospital, explain why—and review potential forthcoming alternatives—in a fast literature update posted on April 6, 2020. (4/15) 
  • A Team Effort to Fast Track New Testing Strategies for COVID-19 — In a recent virtual town hall, members of the MassGeneral Brigham Center for COVID Innovation outlined the parameters that new diagnostic tools will have to meet: (4/14)
  • Developing New Diagnostics for COVID-19 — David Louis, MD, pathologist-in-chief, discusses how the faculty at Mass General is collaborating with local researchers and companies to develop rapid testing for COVID-19 that can provide diagnosis at the point of care. (3/27) 


COVID-19 Updates

Learn how researchers and clinicians at Massachusetts General Hospital Research Institute are mobilizing to develop new strategies to diagnose, treat and prevent COVID-19.