Research Opportunities in the Treatment of Mitral Valve Prolapse

The article summarizes the findings of an interdisciplinary workshop hosted by the National Heart, Lung and Blood Institute (NHLBI) to discuss the current data on arrhythmic mitral valve prolapse and other aspects of this complex disease of valve and ventricle.


Tackling Prediction Uncertainty in Machine Learning for Healthcare

Unsafe prediction failure occurs when a ML system produces an erroneous prediction, and either fails to convey a lack of confidence in the prediction or deceitfully conveys a high level of confidence in the correctness of the prediction. How can we develop "zero error" ML systems that do not make these mistakes?


Predicting Health Crises From Early Warning Signs in Patient Medical Records

In this study, researchers aimed to investigate whether changes in routine population health metrics may serve as early warnings of future crises.


Identifying a Promising New Target for Immune-Oncology

The findings of a new research study by investigators from Mass General and colleagues strongly suggest that IRG1, the enzyme that makes itaconate, is a promising target for immuno-oncology.


Investigating Radation-Induced DNA Damage Using Monte Carlo Techniques

Computational simulations using well-known physics and the Monte Carlo method offer an ideal platform to study the differences in the damage induced to the DNA by different radiation types. This study provides a thorough revision of the methods employed to perform these simulations,


Neutrophils Will Overcome Their Inability to Swarm by Cooperatively Generating LTB4 Through Transcellular Biosynthesis

Researchers found that if you mix two neutrophil populations, each with a different LTB4 synthetic enzyme deleted, cells within the mixture will overcome their inability to swarm by cooperatively generating LTB4 through transcellular biosynthesis.


Investigating Radation-Induced DNA Damage Using Monte Carlo Techniques

Computational simulations using well-known physics and the Monte Carlo method offer an ideal platform to study the differences in the damage induced to the DNA by different radiation types. This study provides a thorough revision of the methods employed to perform these simulations,


Learning More About Neutrophil Involvement in Severe COVID-19

Researchers identified the relationships between neutrophil states and patient outcome, and find that specific granulocyte subsets, especially G-MDSCs, were associated with severe disease while others (e.g., neutrophil progenitors) with mild disease.


SARS-CoV-2 Placentitis and How Maternal COVID-19 Vaccination Could Prevent Stillbirth

Pregnant women with COVID-19 have an increased risk for stillbirth compared to uninfected women, and those who vaccinate can more effectively prevent adverse conditions such as SARS-CoV-2 placentitis, infant death, preterm birth, and stillbirth.


The Potential for Comorbid Autoimmune Disorders in Patients with MOGAD

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has various similarities with Aquaporine4-IgG positive Neuromyelitis Optica Spectrum Disorder (AQP4-IgG+NMOSD), in terms of clinical presentations and MRI findings. However, AQP4-IgG+NMOSD is known to coexist with various autoimmune diseases and cancers, but we do not know if the same thing is true for MOGAD.


Making the Case for Tenecteplase as a Treatment for Acute Ischemic Stroke

A growing body of literature supports the use of tenecteplase (TNK) for intravenous thrombolysis to restore perfusion for patients with acute ischemic stroke.


Comparing Proton Beam Therapy and Plaque Brachytherapy in Ocular Melanoma

Researchers found that although protons in a typical treatment could completely spare the center of the eye lens, the dose delivered at the periphery of the lens was more effectively reduced with plaques in most cases.


Coating Exogenous Mitochondria Prior to Transplantation Improves Uptake and Reduces Toxicity

The findings indicate that mitochondrial surface coating with artificial lipid membrane is feasible and may improve the therapeutic efficacy of mitochondria allograft.


Microbial Bile Acid Metabolism Regulates Gut Barrier Integrity and Liver Injury and Could Be a New Treatment Target

Researchers identified a signaling-independent, physicochemical mechanism for conjugated bile acid (BA) mediated protection of epithelial barrier function and suggests that rational manipulation of microbial BA metabolism could be leveraged to regulate gut barrier integrity.


Successful Treatment of Delayed Localized Necrotizing Inflammatory Myositis after SARS-CoV-2 mRNA-1273 (“Moderna”) Vaccine: A Case Report

Mass General clinicians describe the presentation and successful treatment of delayed localized necrotizing inflammatory myositis following the third dose of the mRNA-1273 SARS-CoV-2 vaccine (Moderna, Inc.; Spikevax®).


Riboflavin Depletion Leads to a 30% Extension in Lifespan in C. Elegans

Researchers identified a new paradigm for lifespan extension that promotes a favorable energetic state and mimics dietary restriction. This is the first work to show that active depletion rather than supplementation of vitamins provides a health benefit to the animal.


Environmental Influences Account for More Differences in Child Emotional and Behaviorial Symptoms Than Genetic Factors

The environment may play at least two key roles in children’s mental health: it affects their mental health directly and through its interplay with genetic factors.


Lower Hydroxychloroquine Dosing is Less Effective in Preventing Lupus Flares

When patients with lupus received lower dosing of hydroxychloroquine—in accordance with current ophthalmology guidelines—they had a higher risk of lupus flares than when they were taking a higher dose of the medication.


Racial and Sex Disparities in the Prevalence of Gout Among US Adults

In this nationally representative race- and sex-specific cross-sectional study of US adults, gout was more prevalent in adults self-reporting Black race during a recent 10-year period compared with their White counterparts.


Understanding Infant Mortality Rate and Risk Factors in Nigeria

An increasing rate of infant mortality in Nigeria indicates that Nigeria is not on track to achieving the Sustainable Development Goal (SDG) target of reducing child mortality by 2030.


Could a Blood Pressure Hormone Work as a Treatment for Immune Dysregulation in Sepsis?

Angiotensin-II substantially increased bacterial clearance and enhanced immune function without worsening organ injury in a mouse model of sepsis, whereas norepinephrine, the current first line treatment for septic shock, did not.


Learning More About Treatment Resistance in A Highly Fatal Form of Pancreatic Cancer

A high-resolution molecular framework sheds light on the inter- and intratumoral diversity of pancreatic cancer, spatial organization into discrete communities, treatment-associated remodeling and clinically relevant prognostication.