A selection of notable research publications from investigators at the Vincent Center for Reproductive Biology at Massachusetts General Hospital.

Bo Rueda, PhD

Al-Alem, L.F.; Baker, A.T.; Pandya, U.M.; Eisenhauer, E.L.; Rueda, B.R. Understanding and Targeting Apoptotic Pathways in Ovarian Cancer. Cancers. 2019 Oct 24; 11(11):1631. doi:10.3390/cancers11111631

Bellio, C.; DiGloria, C.; Spriggs, D.R.; Foster, R.; Growdon, W.B.; Rueda, B.R. The Metabolic Inhibitor CPI-613 Negates Treatment Enrichment of Ovarian Cancer Stem CellsCancers. 2019 Oct 29; 11(11):1678. doi:10.3390/cancers11111678

Bellio C, DiGloria C, Foster R, James K, Konstantinopoulos PA, Growdon WB, Rueda BR. PARP inhibition induces enrichment of DNA repair proficient CD133 and CD117 positive ovarian cancer stem cells. Mol Cancer Res. 2018 Nov 6. pii: molcanres.0594.2018. doi: 10.1158/1541-7786.MCR-18-0594. [Epub ahead of print] PMID:30401718.

Chiu YH, Karmon AE, Gaskins AJ, Arvizu M, Williams PL, Souter I, Rueda BR, Hauser R, Chavarro JE; Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction. EARTH Study Team. Hum Reprod. 2018 Jan 1;33(1):156-165. doi: 10.1093/humrep/dex335.PMID:29136189

Cardozo ER, Foster R, Karmon AE, Lee AE, Gatune LW, Rueda BR, Styer AK. MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma. Reprod Biol Endocrinol. 2018 May 11;16(1):46. doi: 10.1186/s12958-018-0364-8. PMID:29747655

Starbuck K, Al-Alem L, Eavarone DA, Hernandez SF, Bellio C, Prendergast JM, Stein J, Dransfield DT, Zarrella B, Growdon WB, Behrens J, Foster R, Rueda BRTreatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau. Oncotarget. 2018 May 1;9(33):23289-23305. doi: 10.18632/oncotarget.25289. eCollection 2018 May 1.PMID:29796189

Evaparone DA, Al-Alem L, Lugovskoy A, Prendergast JM, Nazer RI, Stein JN, Dransfield DT, Behrens J, Rueda BRHumanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma. PLoS One. 2018 Jul 27;13(7):e0201314. doi: 10.1371/journal.pone.0201314. eCollection 2018.PMID:30052649

Growdon WB, Amy Bregar; Amit Deshpande; Celeste DiGloria; Chris Grange; Tong Zi; Jennifer Stall; Heather Hirsch; Jason Reeves; Sriram Sathyanarayanan; Bo Rueda Characterization of immune regulatory molecules B7-H4 and PD-L1 in low and high grade endometrial tumors, 2017 March.

Bajwa P, Nielsen S, Lombard JM, Rassam L, Nahar P, Rueda BR, Wilkinson JE, Miller RA, Tanwar PS. Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice. Oncotarget. 2017 Jan 31;8(5):7265-7275. doi: 10.18632/oncotarget.13919. PMID:27980219

Garrett LA, Growdon WB, Rueda BR, Foster R. Influence of a novel histone deacetylase inhibitor panobinostat (LBH589) on the growth of ovarian cancer. J Ovarian Res. 2016 Sep 15;9(1):58. doi: 10.1186/s13048-016-0267-2

Guan Y, Guo L, Zukerberg L, Rueda BR, Styer AK. MicroRNA-15b regulates reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression in human uterine leiomyoma. Reprod Biol Endocrinol. 2016 Aug 17;14(1):45. doi: 10.1186/s12958-016-0180-y

Styer AK, Rueda BR The Epidemiology and Genetics of Uterine Leiomyoma. Best Pract Res Clin Obstet Gynaecol. 2016 Jul;34:3-12. doi: 10.1016/j.bpobgyn.2015.11.018

Hernandez SF, Chisholm S, Borger D, Foster R, Rueda BR, Growdon WB. Ridaforolimus improves the anti-tumor activity of dual HER2 blockade in uterine serous carcinoma in vivo models with HER2 gene amplification and PIK3CA mutation. Gynecol Oncol. 2016 Jun;141(3):570-9. doi: 10.1016/j.ygyno.2016.03.027.

Clark NC, Friel AM, Pru CA, Zhang L, Shioda T, Rueda BR, Peluso JJ, Pru JK. Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and growth of xenograft tumors. Cancer Biol Ther. 2016 Mar 3;17(3):262-71

Roussel-Gervais A, Couture C, Langlais D, Takayasu S, Balsalobre A, Rueda BR, Zukerberg LR, Figarella-Branger D, Brue T, Drouin J. The Cables1 gene in glucocorticoid regulation of pituitary corticotrope growth and Cushing disease. J Clin Endocrinol Metab. 2016 Feb;101(2):513-22.

Caroline Mitchell, MD, MPH

Le HG, Saeed H, Mantagos IS, Mitchell CM, Goverman J, Chodosh J. Burn unit care of Stevens Johnson syndrome/toxic epidermal necrolysis: A survey. Burns. 2016 Jan [Epub ahead of print]

Dingens A, Carlson T, Reed S, Mitchell C. Bacterial Vaginosis and Adverse Outcomes Among Full-Term Infants: A Cohort Study. BMC Pregnancy Childbirth. 2016 Sep 22;16(1):278

Herbst-Kralovetz MM, Pyles RB, Ratner AJ, Sycuro LK, Mitchell C. New Systems for Studying Intercellular Interactions in Bacterial Vaginosis. J Infect Dis. 2016 Aug 15;214 Suppl 1:S6-S13. doi: 10.1093/infdis/jiw130. PMID:27449872

Murphy K, Mitchell CM. The Interplay of Host Immunity, Environment and the Risk of Bacterial Vaginosis and Associated Reproductive Health Outcomes. J Infect Dis. 2016 Aug 15;214 Suppl 1:S29-35. doi: 10.1093/infdis/jiw140.PMID:27056955

Mark Phillippe, PhD

Foust-Wright CE, Pulliam SJ, Batalden RP, Berk TK, Weinstein MM, Wakamatsu MM, Phillippe M. Hormone Modulation of Toll-Like Receptor 5 in Cultured Human Bladder Epithelial Cells. Reprod Sci. 2016 Sep 20. pii: 1933719116667489. [Epub ahead of print]