Photo of Rakesh  Karmacharya, MD, PhD

Rakesh Karmacharya, MD, PhD

  • Director of Stem Cell Research, Center for Experimental Drugs & Diagnostics, MGH
  • Medical Director, Schizophrenia & Bipolar Disorder Research Clinic, McLean Hospital


Accepting New Patients


Dr. Karmacharya specializes in the treatment of patients with schizophrenia and bipolar disorder, with a primary focus on patients presenting with first-episode psychosis and patients with catatonia. Dr. Karmacharya's research involves work in stem cell biology aimed at studying human neurons in the laboratory.



Clinical Interests
  • First Episode and Early Psychosis
  • Schizophrenia
  • Mindfulness and meditation
  • Stem cells
  • Research
  • Psychosis
  • Psychotic Disorders
  • Bipolar disorder
  • Manic-depressive illness
  • Mood disorders
Medical Education
  • MD, PhD, Albert Einstein College of Medicine
  • Residency, Massachusetts General Hospital
Board Certifications
  • Psychiatry
Foreign Languages
  • Newari
  • Belmont: McLean Hospital
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • BMC HealthNet Mass Health MCO/ACO
  • Cigna Behavioral Health
  • Commonwealth Care Alliance
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Behavioral Health
  • United Behavioral Health - MGH
  • Well Sense Pediatrics

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Provider Gender


Dr. Rakesh Karmacharya is an Assistant Professor in Psychiatry at Harvard Medical School and the Director of Stem Cell Research of the Center for Experimental Drugs and Diagnostics. He is also a Physician-Scientist in the Chemical Biology Program at the Broad Institute of Harvard and MIT, and the Medical Director of the Schizophrenia and Bipolar Disorder Research Clinic at McLean Hospital.

Dr. Karmacharya received an A.B. in Biochemistry from Harvard University, an M.S. in Molecular Biophysics from Yale University and an MD and a PhD in Biophysics from the Albert Einstein College of Medicine in New York. His graduate studies focused on theoretical studies of the quantum mechanics of proton tunneling in condensed phase. He completed an internship in Medicine at Massachusetts General Hospital (MGH), and a residency in psychiatry at MGH and McLean Hospital. He served as the Chief Resident of the Schizophrenia and Bipolar Disorder Program. After his residency, he undertook postdoctoral studies in chemical biology under the mentorship of Prof. Stuart L. Schreiber.  

Research & Publications

Research Summary

View my most recent research

Dr. Karmacharya and his team are applying chemical biology approaches to identify "disease signatures" for schizophrenia and bipolar disorder, using neuronal cells generated from induced pluripotent stem cells (iPSCs). The goal is to find reliable and robust cellular features that segregate with disease than can serve as disease signatures. The identification of disease signatures will enable screens of small molecule libraries to delineate molecular targets that modulate these disease signatures and identify new diagnostic and therapeutic leads for schizophrenia and bipolar disorder.

View my most recent publications at PubMed


Psychiatry Associates-Inpatient Consult
55 Fruit Street
Boston, MA 02114-2696
Phone: 617-724-5600
Psychiatry-Outpatient Services
15 Parkman Street
Boston, MA 02114-3117
Phone: 617-724-5600

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