The Mass General Department of Psychiatry’s wide-ranging research portfolio spans clinical and basic research on virtually every major psychiatric disorder. These research initiatives typically began from clinical trials conducted in clinical units, and expanded to observational and mechanistic studies with notable expansions in genetics, neuroimaging, and basic neuroscience. Over the years, there has been an enormous expansion in the overall volume of research in the department and associated research funding—with more than $50 million in research programs last year alone—as well as a gradual shift in funding from pharmaceutical sponsorship to federal and foundation funding. The model of integrating clinical work and research is evident even in the name of the department’s major programs—the “Depression Clinical and Research Program,” the “Bipolar Clinic and Research Program,” the “Obsessive-Compulsive Disorder Clinic and Research Unit,” and so on. This model of cross-talk between clinical care and science has consistently borne fruit in the form of research advances.

Pre-Clinical and Translational Research

Our neuroscience, neuroimaging, and genetic research programs include clinical and translational researchers whose work is informed and motivated by the unmet needs of our patient populations. Our programs include:

Clinical Trials Network & Institute (CTNI)

At the Clinical Trials Network & Institute, we ensure that our innovative research methods are unmatched in helping sponsors meet their research goals.


Clinical Research

The model of integrating clinical work and research is evident even in the names of the department’s major programs, which include:

  • US News 2017, #2 in psychiatric care

    Ranked #2 for Psychiatric Care

    U.S. News & World Report ranks Mass General Psychiatry among the best in the nation.

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Research at Mass General

Discover the largest hospital-based research program in the U.S. and how clinicians and scientists chart new terrain in biomedical research to treat and prevent human disease and bring the latest advances to patient care.

Proto Magazine

Proto magazine stakes its ground on medicine's leading edge, reporting back from the frontiers of research and practice - exploring breakthroughs, dissecting controversies and opening a forum for informed debate.

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