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Faculty member in the Psychiatric & Neurodevelopmental Genetics Unit at Massachusetts General Hospital
Massachusetts General HospitalRichard B. Simches Research Center185 Cambridge StreetBoston, MA 02114Phone: 617-643-4371 (office), 617-724-4978 (lab)Email: firstname.lastname@example.org
Dr. Sahay is an associate professor at the Center for Regenerative Medicine and the Department of Psychiatry at Massachusetts General Hospital, Harvard Medical School. He is also principal faculty of the Harvard Stem Cell Institute of Harvard University.
The incidence and complexity of mental illnesses and cognitive impairments associated with ageing and Alzheimer’s disease underscores the need to develop novel treatments. The mission of the Sahay Lab is to generate fundamental insights into the functions of the dentate gyrus and the role of adult hippocampal neurogenesis, the process by which neural stem cells generate dentate granule neurons throughout life, in memory processing and modulation of mood. By integrating cellular, circuit, systems and behavioral level approaches, we aspire to rejuvenate and reengineer the hippocampus to optimize circuit performance and memory processing. We predict that this strategy will impact circuit-based endophenotypes shared across diseases such as PTSD, Alzheimer’s disease and age-related cognitive decline.
To address this goal, we have established a multifaceted research program that integrates inducible mouse- and viral-genetics, pharmaco- and optogenetics, synaptic tracing, in vivo awake behaving optical imaging, two photon imaging, human cellular reprogramming and behavioral analysis. Specifically, we are interested in the following questions:
Learn more about the Sahay Lab.
See a complete list of Dr. Sahay's publications
Lab manager Sally Levinson, BS (PhD program in Neuroscience at NYU) Tomer Langberg, BS
Research fellows Nannan Guo, PhD (Fudan University) Kathleen McAvoy, PhD (University of Rochester) Antoine Besnard, PhD (INSERM/CNRS/UPMC, Paris)
Graduate students Tara Raam (Program in Neuroscience) Hugo Vega-Ramirez (Program in Neuroscience)
Undergraduate students Shannen Kim (Harvard) Melissa Boldridge (Harvard) Sekinat Jumai Yusuf (Harvard)
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