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Department of Radiation Oncology
Radiation Therapy Treatment in the News: Read articles about how new technologies and discoveries are advancing how radiation therapy is useful in treating a variety of cancers.
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A study led by investigators from Massachusetts General Hospital and the University of Cyprus reveals details of a way the dangerous brain tumors called glioblastomas resist the effects of antiangiogenic drugs designed to cut off their blood supply, identifying what may be a new treatment target.
A Massachusetts General Hospital research team has found that the overgrowth of connective called fibrosis may block the effectiveness of immunotherapies against metastatic breast cancer and that treatment with plerixafor can reduce fibrosis and improve response to immunotherapy in mouse models.
A new study from a Massachusetts General Hospital research team has found that the hypertension drug losartan, which targets the angiotensin signaling pathway, may improve the effectiveness of chemotherapy agents used to treat ovarian cancer.
A Massachusetts General Hospital (MGH)-led research team has demonstrated, for the first time, how solid stress – the physical forces exerted by the solid components of a tumor – impacts the tissue surrounding brain tumors and contributes to resulting neurological dysfunction and neuronal cell death.
A study led by a team of Massachusetts General Hospital investigators has analyzed, for the first time, the mechanisms underlying the use of focused ultrasound to improve the delivery of anti-cancer drugs across the blood brain barrier into brain tumors.
A study by Massachusetts General Hospital investigators finds that, in mouse models, cancer cells from metastatic lymph nodes can escape into the circulation by invading nodal blood vessels, leading to the development of metastases in other parts of the body.
A research team led by Massachusetts General Hospital has found, for the first time, that obesity and obesity-related molecular factors appear to induce resistance to antiangiogenic therapy in breast cancer patients and in mouse models of the disease.
Adding the targeted cancer therapy drug crizotinib to radiation therapy for tumors associated with the genetic disorder neurofibromatosis 2 may reduce the hearing damage that can be exacerbated by radiotherapy.
MGH investigators describe have found in mouse models that MRSA infection impairs the ability of lymphatic vessels to pump lymphatic fluid to lymph nodes, which may contribute to the frequent recurrences of MRSA infection experienced by patients.
A Massachusetts General Hospital research team has identified a potential strategy for improving the efficacy of angiogenesis inhibitors, drugs that help fight cancer by blocking the formation of new blood vessels.
A Massachusetts General Hospital research team has identified a novel mechanism behind resistance to angiogenesis inhibitors – drugs that fight cancer by suppressing the formation of new blood vessels.
A study led by Massachusetts General Hospital investigators has found that the traditional model for the spread of carcinoma, the deadliest form of cancer – from the primary tumor, to nearby lymph nodes, to other organs – may not apply in all cases.
A Massachusetts General Hospital-based research team has identified a novel mechanism behind the resistance of brain metastases from HER2-positive breast cancer to targeted therapies and identified a potential treatment strategy.
The effects of a promising new approach to chemotherapy that involves frequent administration of dosage levels much lower than traditionally used appears to rely on the “normalization” of blood vessels within and around a tumor.
A nearly two-decades-long clinical trial has demonstrated that adding antiandrogen therapy to radiation therapy can improve the survival of prostate cancer patients who have evidence of disease recurrence after radical prostatectomy.
Massachusetts General Hospital investigators have identified a protein that may maintain a population of cells responsible for breast cancer recurrence and metastasis, as well as a compound that appears to reduce the molecule’s ability to protect these tumor-initiating cells from chemotherapy.
Massachusetts General Hospital investigators have developed new methods for mapping and measuring solid stress – the force exerted by solid and elastic components – within tumors, an accomplishment that may lead to improved understanding of those forces and their consequences and to novel treatment strategies.
Massachusetts General Hospital investigators have identified a potential mechanism behind the resistance that inevitably develops to cancer treatment with a combination of chemotherapy and antiangiogenic drugs.
Massachusetts General Hospital investigators have discovered the mechanism by which obesity increases inflammation and desmoplasia – an accumulation of connective tissue – in the most common form of pancreatic cancer. They also identify a treatment strategy that may inhibit the process, which can contribute to tumor progression and treatment resistance.
Two companion papers from Massachusetts General Hospital research teams suggest that targeting multiple angiogenesis pathways simultaneously could help overcome the resistance to anti-angiogenic treatment inevitably developed by the devastating brain tumor glioblastoma.
MGH investigators may have uncovered a novel mechanism behind the ability of obesity to promote cancer progression.
The use of proton radiotherapy to treat medulloblastoma, the most common malignant brain tumor in children, is as effective as standard radiation therapy while causing fewer long-term side effects.
MGH investigators may have uncovered a novel mechanism behind the ability of the diabetes drug metformin to inhibit the progression of pancreatic cancer.
An MGH research team, in collaboration with investigators at the Dana-Farber Cancer Institute, may have found a reason why the use of antiangiogenesis drugs – which has improved outcomes for patients with several types of cancer – fails to benefit some breast cancer patients.
An MGH Cancer Center study finds that the growth of metastases in lymph nodes – the most common site of cancer spread – does not require new blood vessels, possibly explaining why antiangiogenesis drugs fail to prevent the development of new metastases.
A new study finds that men with prostate cancer that has spread to nearby lymph nodes can benefit from the addition of radiation therapy to treatments that block the effects of testosterone.
Use of the same antiangiogenesis drugs that have improved treatment of some cancers may also help surmount persistent difficulties in treating tuberculosis, including the need for months-long treatment and the development of bacterial strains resistant to several different antibiotics.
A simple assay developed by an MGH research team can reveal the evolutionary relationships among various tumor sites within a patient, information that may someday help with treatment planning.
Advanced imaging techniques may be able to distinguish which patients' tumors will respond to treatment with anti-angiogenic drugs and which will not.
Use of existing, well-established hypertension drugs could improve the outcome of cancer chemotherapy by opening up collapsed blood vessels in solid tumors.
A new way of analyzing data acquired in MR imaging appears to be able to identify whether or not tumors are responding to anti-angiogenesis therapy, information that can help physicians determine the most appropriate treatments and discontinue ones that are ineffective.
MGH researchers have used vascular precursor cells derived from human induced pluripotent stem cells to generate, in an animal model, functional blood vessels that lasted as long as nine months.
A multi-institutional team led by MGH researchers has identified a molecular pathway that appears to be essential for the growth and spread of medulloblastoma, the most common malignant brain tumor in children.
Adding an angiogenesis inhibitor to treatment with a HER2-inhibiting drug could improve outcomes for patients with HER2-positive breast cancer who develop brain metastases.
An MGH research team has identified factors that contribute to solid stress within tumors, suggesting possible ways to alleviate it, and has developed a simple way to measure such pressures.
Massachusetts General Hospital has moved into the number one spot on the 2012-13 U.S. News & World Report’s “America’s Best Hospitals” list.
Combining two strategies designed to improve the results of cancer treatment – antiangiogenesis drugs and nanomedicines – may only be successful if the smallest nanomedicines are used.
MGH researchers have discovered the first of an entirely new class of antiangiogenesis drugs – agents that interfere with the development of blood vessels. The compound, derived from a South American tree, uses a novel mechanism to block blood vessel formation.
An MGH study has identified a new role for an important enzyme in preparing lung tissue for the development of metastases. The findings may help development of strategies to slow or halt the process.
Low doses of an inexpensive, FDA-approved hypertension medication may improve the results of nanotherapeutic approaches to cancer treatment.
Boosting the radiation dose given to prostate cancer patients to a level that cut recurrence in half did not increase the severity of side effects reported by patients up to a decade later. Patients also found the impact of continuing side effects on their quality of life to be less bothersome than would be expected, based on earlier studies.
Proton beam radiation therapy shows encouraging results for patients with locally advanced sinonasal malignancies, according to a study led by Annie Chan, MD, a radiation oncologist at Massachusetts General Hospital.
A report in Cancer Research highlights a new biomarker that may be useful in identifying patients with recurrent glioblastoma who would respond better to antiangiogenesis therapy.
The beneficial effects of anti-angiogenesis drugs in the treatment of the deadly brain tumors called glioblastomas appear to result primarily from reduction of edema – the swelling of brain tissue – and not from any direct anti-tumor effect.
A new mathematical model of the physiological regulation of body weight suggests a potential mechanism underlying the difficulty of losing weight, one that includes aspects of two competing hypotheses of weight regulation.
An introduction to the Department of Radiation Oncology at Massachusetts General Hospital. An overview of the different processes and procedures to expect in the course of your treatment program. Learn about what radiation is and the different types of radiation used to treat cancer.
Watch Tommy McGraw's story, who was treated with Proton Therapy here at Mass General.
Learn about traditional radiation therapy and treatment procedures at the Department of Radiation Oncology at Massachusetts General Hospital.
Introduction to Department of Radiation Oncology at the Massachusetts General Hospital Cancer Center
Important information about types of cancer treatment at Mass General.
Learn what expect and how to prepare for your radiation appointment with a CT simulation.
Meet the different members of your care team, including your radiation oncologist, registered nurse, radiation therapist, and more.
Tandem and ovoid treatment is a type of radiation used to treat different cancers that affect the female reproductive system. Learn how to prepare and what to expect before, during and after treatment.
There are many people on your care team who provide your different treatments. Meet the members of your care team, including your radiation oncologist, radiation therapist and registered nurse.
There are lots of people on the Proton Therapy team who will care for your child. Meet the members of the care team, including the radiation oncologist, social workers, nurses and child life specialist.
MGH Radiation Oncology Female Sexual Health Clinic
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