Mass General Hospital

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Title: Galloway Lab

Short description: Our laboratory is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.

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Overview:

Injuries to tendons and ligaments result in a slow and imperfect regenerative response. In most cases, the original biomechanical properties of the tissue are never restored, resulting in scarring and limited mobility. Research in our laboratory uses a multidisciplinary approach, combining genetic and chemical screening with different model systems such as zebrafish and stem cells, to identify essential regulators of tendon and ligament biology.

One major area of research in the laboratory aims to identify the cues that direct progenitor cells to become mature tendons and ligaments. During embryogenesis, progenitor cell populations will form the tendon or cartilage tissues in our limbs, head and spine. We are interested in elucidating the factors that regulate this fate decision, expand tendon and ligament populations and promote more faithful differentiation into these lineages.

We are also focused on understanding the critical factors that coordinate the attachments between muscle, tendon, and bone. By combining live-imaging and high-throughput screening approaches, our goal is to identify the molecules and cellular behaviors governing these processes. In the long term, my laboratory aims to transform these discoveries into regenerative biology solutions to better heal and repair tendon and ligament injuries.

 

Group member:

Galloway Lab Members

Research Fellows
Erin Betters, Ph.D.
Rishita Shah, Ph.D.

Lab Manager
Matthew King

Graduate Student
Jessica Chen, BBS

 

Research projects:

Research opportunities:

For research positions, please contact jenna_galloway@hms.harvard.edu

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Publications:

Publications

Fujimori S, Novak H, Weissenböck M, Jussila M, Gonçalves A, Zeller R, Galloway J, Thesleff I, and Hartmann C. (2010) Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol, 348 (1):97-106.

Galloway JL*, Delgado I*, Ros MA, and Tabin CJ. (2009) A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning. Nature, 460(7253):400-4.

Burns CE*, Galloway JL*, Smith AC, Keefe MD, Cashman TJ, Paik EJ, Mayhall EA, Amsterdam AH, Zon LI. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood, 113(23):5776-82.

Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R, and Zelzer E. (2009) Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell, 17(6):861-73.

Galloway JL, Wingert RA, Thisse C, Thisse B, Zon LI. (2008) Combinatorial regulation of novel erythroid gene expression in zebrafish. Exp Hematol, 36(4):424-32.

Wingert, R.A., Galloway, J.L., Barut, B., Foott, H., Fraenkel, P., Axe, J., Dooley, K., Davidson, A.J., Weber, G., Paw, B., Shaw, G., Kingsley, P., Palis, J., Schubert, H., Chen, O., Kaplan, J., Tübingen 2000 Screen Consortium, and Zon, L.I. Deficiency of glutaredoxin 5 reveals Fe/S clusters are required for vertebrate haem synthesis. Nature, 436, 1035-1039.

Galloway, J.L., Wingert, R.A., Thisse, C., Thisse, B., and Zon, L.I. 2005. Loss of Gata1 but not Gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev. Cell, 8(1), 109-116.

Wingert, R.A., Brownlie, A., Galloway, J.L., Dooley, K., Fraenkel, P., Axe, J., Barut, B., Davidson, A.J., Noriega, L., Sheng, X., Zhou, Y., Tübingen 2000 Screen Consortium, and Zon, L.I. 2004. The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1. Development, 131(24), 6225-6235.

Rodriguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, Ayala R, Stewart AF, Dymecki SM. 2000. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet, 25(2), 139-40.

Review Articles:

Galloway JL and Tabin CJ. (2008) Classic limb patterning models and the work of Dennis Summerbell. Development, 135(16):2683-7.

Galloway, J.L. and Zon, L.I. 2003. Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo. Curr Top Dev Biol, 53,139-58.

Contact:

Department: Department of Medicine - 1005

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Multidisciplinary care center:

Research center: Center for Regenerative Medicine - 1018

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