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Research at Mass General
Research news and stories from Massachusetts General Hospital, home to the largest hospital-based biomedical research program in the United States.
Mass General-led study may reveal how chronic stress in early life increases vulnerability to PTSD
A collaboration between investigators at Massachusetts General Hospital and Khyber Medical University in Pakistan may have discovered how chronic stress experienced early in life increases vulnerability to post-traumatic stress disorder later in life.
Featuring Ki Goosens, PhD, of the MassGeneral Institute for Neurodegenerative Disease.
RB1 gene mutations underlie clinical resistance to CDK 4/6 inhibitor therapy for breast cancer
Featuring Aditya Bardia, MD, of the Mass General Cancer Center
A multi-institutional research team led by a Massachusetts General Hospital investigator has identified what may be a novel mechanism underlying acquired resistance to CDK 4/6 inhibitor treatment for breast cancer.
Relaxation response therapy may reduce blood pressure by altering expression of a distinct set of genes
Featuring Randall Zusman, MD, Director of the Division of Hypertension at the Mass General Corrigan Minehan Heart Center
A new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC), Massachusetts General Hospital (MGH), and the Benson-Henry Institute for Mind Body Medicine at MGH identified genes associated with the body’s response to relaxation techniques and sheds light on the molecular mechanisms by which these interventions may work to lower blood pressure. The findings were published today in the Journal of Alternative and Complementary Medicine.
Combination immunotherapy improves survival in mouse models of mesothelioma
Featuring Mark Poznansky, MD, PhD, Steve and Deborah Gorlin MGH Research Scholar and Director of the Vaccine and Immunotherapy Center at Mass General
Massachusetts General Hospital investigator have found that combined treatment with two cancer immunotherapy drugs significantly prolonged survival in mouse models of the aggressive cancer malignant mesothelioma.
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A new initiative from the Department of Medicine, the Pathways Service provides a way for medical residents to discuss unusual patient cases and initiate new research projects based on the questions the cases raise.
Scott Plotkin, MD, PhD, and Vijaya Ramesh, PhD, are using their respective expertise in clinical and fundamental science to investigate new treatments for neurofibromatosis and two related disorders.
Like a pebble thrown into a still body of water, a new study from the Mass General Center for Systems Biology has found that white blood cells called macrophages create a ripple effect in the heart that can lead to development of a condition known as heart failure with preserved ejection fraction, or HFpEF.
While it may not have been called rare disease research by name, Massachusetts General Hospital has been identifying and tracking rare diseases for more than a century, says Florian Eichler, MD, Director of the Center for Rare Neurological Diseases in the Department of Neurology. By combining new genetic insights with new models of collaborative research, Eichler and other clinician-investigators at Mass General are working to develop much needed new treatments for rare disease patients.
Mass General researcher Bryan Hurley, PhD, is exploring how controlling the infection and inflammation associated with cystic fibrosis could be the key to developing improved therapies for patients.
Jacqueline Lane, PhD, a postdoctoral researcher at Massachusetts General Hospital, is studying genetic factors that impact our sleep.
Joel Salinas, MD, is using data from long-term research studies to gain insights into how strong social networks help to promote brain health in individuals as they age.
Caroline Mitchell, MD, MPH, a researcher at the Vincent Center for Reproductive Biology at Massachusetts General Hospital, is studying how microbial changes in the female reproductive tract impact health outcomes across the lifecycle of women.
The leaders of the Community Research Program at MGH Chelsea discuss the role that research can play in improving the health outcomes of the residents in their community.
Martinos Center researchers Nouchine Hadjikhani, MD, PhD and Daphne Holt, MD, PhD, are using brain imaging technology to learn more about how individuals with autism and schizophrenia view the world through different lenses.
Elsie Taveras, MD, MPH, uses a combination of clinical and community-based research approaches to address the causes of childhood health problems and reduce health disparities.
Massachusetts General Hospital researcher Jennifer Gatchel, MD, PhD, is using brain imaging technology to learn more about the connections between mental illness and cognitive decline in aging populations.
Massachusetts General Hospital researcher Casey Maguire, PhD, is developing new strategies to shield virus-based gene therapy treatments from the immune system to help patients with genetic disorders.
Kamryn Eddy, PhD, is part of a research team that recently published the results of a long-term study analyzing the recovery rates of patients with eating disorders. What the team found provides new reasons for hope for individuals with bulimia and anorexia.
Basak Uygun, PhD, a researcher at the Center of Engineering in Medicine at Massachusetts General Hospital, is working on ways to create bioengineered livers in the lab that could one day be used in patients with liver failure.
Peter Moschovis, MD, MPH, is helping to develop new digital technology that could provide an efficient and cost effective way to diagnose childhood respiratory illnesses across the globe.
Researchers identify the role of immune cells in a life threatening heart condition, plus genetic clues reveal a key contributor to hereditary aortic aneurysms.
Mass General researchers uncover gender differences that impact the risk of developing heart disease. Plus, could strenuous exercise be bad for your heart?
Researchers investigate how thyroid levels affect a woman's fertility, what age is best to screen for HIV, and how patients with malignant brain tumors utilize hospice services.
Researchers harness the power of artificial intelligence to develop a new screening method for high risk breast lesions. Plus, a team from the Mass General Cancer Center provides data to show how a diagnostic tool can identify early signs of cancer treatment resistance.
Investigators have developed a new food allergen detector small enough to fit on a keychain, and a team from Mass General and MIT has devised a new system for measuring sleep that is wireless, portable and powered by artificial intelligence.
Could laws restricting use of off-road-vehicles by young drivers have an impact on injury rates? Plus, researchers study how the brains of patients with fibromyalgia process pain.
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A spotlight on nursing research at Massachusetts General Hospital.
Massachusetts General Hospital is home to a vibrant community of postdoctoral researchers. Here are some of their stories.
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