Press Releases

APRIL 2018

Mass General-led study may reveal how chronic stress in early life increases vulnerability to PTSD

A collaboration between investigators at Massachusetts General Hospital and Khyber Medical University in Pakistan may have discovered how chronic stress experienced early in life increases vulnerability to post-traumatic stress disorder later in life.

Featuring Ki Goosens, PhD, of the MassGeneral Institute for Neurodegenerative Disease.

RB1 gene mutations underlie clinical resistance to CDK 4/6 inhibitor therapy for breast cancer

Featuring Aditya Bardia, MD, of the Mass General Cancer Center

A multi-institutional research team led by a Massachusetts General Hospital investigator has identified what may be a novel mechanism underlying acquired resistance to CDK 4/6 inhibitor treatment for breast cancer.

Relaxation response therapy may reduce blood pressure by altering expression of a distinct set of genes

Featuring Randall Zusman, MD, Director of the Division of Hypertension at the Mass General Corrigan Minehan Heart Center

A new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC), Massachusetts General Hospital (MGH), and the Benson-Henry Institute for Mind Body Medicine at MGH identified genes associated with the body’s response to relaxation techniques and sheds light on the molecular mechanisms by which these interventions may work to lower blood pressure. The findings were published today in the Journal of Alternative and Complementary Medicine.

Combination immunotherapy improves survival in mouse models of mesothelioma

Featuring Mark Poznansky, MD, PhD, Steve and Deborah Gorlin MGH Research Scholar and Director of the Vaccine and Immunotherapy Center at Mass General

Massachusetts General Hospital investigator have found that combined treatment with two cancer immunotherapy drugs significantly prolonged survival in mouse models of the aggressive cancer malignant mesothelioma.


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Research Stories

Pathways service turns puzzling patient cases into new avenues of research

A new initiative from the Department of Medicine, the Pathways Service provides a way for medical residents to discuss unusual patient cases and initiate new research projects based on the questions the cases raise.

Feedback loop between lab and clinic helps to drive research into neurofibromatosis

Scott Plotkin, MD, PhD, and Vijaya Ramesh, PhD, are using their respective expertise in clinical and fundamental science to investigate new treatments for neurofibromatosis and two related disorders.

Macrophages found to be the source of a ripple effect in the development of a life-threatening heart condition

Like a pebble thrown into a still body of water, a new study from the Mass General Center for Systems Biology has found that white blood cells called macrophages create a ripple effect in the heart that can lead to development of a condition known as heart failure with preserved ejection fraction, or HFpEF.

Genetic insights, new partnership models help to drive rare disease research

While it may not have been called rare disease research by name, Massachusetts General Hospital has been identifying and tracking rare diseases for more than a century, says Florian Eichler, MD, Director of the Center for Rare Neurological Diseases in the Department of Neurology. By combining new genetic insights with new models of collaborative research, Eichler and other clinician-investigators at Mass General are working to develop much needed new treatments for rare disease patients.

Hurley searches for cystic fibrosis treatments by developing a model of the respiratory tract

Mass General researcher Bryan Hurley, PhD, is exploring how controlling the infection and inflammation associated with cystic fibrosis could be the key to developing improved therapies for patients.

Could the secret to a good night’s sleep be found in our genes?

Jacqueline Lane, PhD, a postdoctoral researcher at Massachusetts General Hospital, is studying genetic factors that impact our sleep.

How the quality and quantity of your social connections can impact your brain health as you age

Joel Salinas, MD, is using data from long-term research studies to gain insights into how strong social networks help to promote brain health in individuals as they age.

Mitchell studies bacterial changes in the female reproductive tract to improve health outcomes for women

Caroline Mitchell, MD, MPH, a researcher at the Vincent Center for Reproductive Biology at Massachusetts General Hospital, is studying how microbial changes in the female reproductive tract impact health outcomes across the lifecycle of women.

Spotlight on Community Research: Q&A with the Chelsea Research Program Leadership Team

The leaders of the Community Research Program at MGH Chelsea discuss the role that research can play in improving the health outcomes of the residents in their community.

Brain imaging studies provide new insights into biological basis of behaviors in schizophrenia and autism

Martinos Center researchers Nouchine Hadjikhani, MD, PhD and Daphne Holt, MD, PhD, are using brain imaging technology to learn more about how individuals with autism and schizophrenia view the world through different lenses.

Taveras engages communities to make a lasting impact on child health

Elsie Taveras, MD, MPH, uses a combination of clinical and community-based research approaches to address the causes of childhood health problems and reduce health disparities.

Gatchel works to untangle the connections between mental health issues and cognitive decline in aging adults

Massachusetts General Hospital researcher Jennifer Gatchel, MD, PhD, is using brain imaging technology to learn more about the connections between mental illness and cognitive decline in aging populations.

Maguire hopes to improve gene therapy treatments by hiding viruses from the immune system

Massachusetts General Hospital researcher Casey Maguire, PhD, is developing new strategies to shield virus-based gene therapy treatments from the immune system to help patients with genetic disorders.

Eddy's research offers hope for long-term recovery from eating disorders

Kamryn Eddy, PhD, is part of a research team that recently published the results of a long-term study analyzing the recovery rates of patients with eating disorders. What the team found provides new reasons for hope for individuals with bulimia and anorexia.

Uygun is putting the pieces together in quest to create new livers in the lab

Basak Uygun, PhD, a researcher at the Center of Engineering in Medicine at Massachusetts General Hospital, is working on ways to create bioengineered livers in the lab that could one day be used in patients with liver failure.

Meet the researcher who wants to diagnose respiratory illness with a Smartphone

Peter Moschovis, MD, MPH, is helping to develop new digital technology that could provide an efficient and cost effective way to diagnose childhood respiratory illnesses across the globe.

Research Roundup

March 2018

Researchers identify the role of immune cells in a life threatening heart condition, plus genetic clues reveal a key contributor to hereditary aortic aneurysms.

February 2018

Mass General researchers uncover gender differences that impact the risk of developing heart disease. Plus, could strenuous exercise be bad for your heart?

January 2018

Researchers investigate how thyroid levels affect a woman's fertility, what age is best to screen for HIV, and how patients with malignant brain tumors utilize hospice services.

December 2017

Researchers harness the power of artificial intelligence to develop a new screening method for high risk breast lesions. Plus, a team from the Mass General Cancer Center provides data to show how a diagnostic tool can identify early signs of cancer treatment resistance.

November 2017

Investigators have developed a new food allergen detector small enough to fit on a keychain, and a team from Mass General and MIT has devised a new system for measuring sleep that is wireless, portable and powered by artificial intelligence.

October 2017

Could laws restricting use of off-road-vehicles by young drivers have an impact on injury rates? Plus, researchers study how the brains of patients with fibromyalgia process pain.

See all Research Roundup columns

Special Features

Nursing Research

A spotlight on nursing research at Massachusetts General Hospital.

Postdoc Profiles

Massachusetts General Hospital is home to a vibrant community of postdoctoral researchers. Here are some of their stories.

Social Media

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