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Research at Mass General
Our goal is to conduct research that will ultimately improve clinical care for patients with neuroendocrine disorders.
Research at the Neuroendocrine and Pituitary Tumor Clinical Center at Massachusetts General Hospital is divided into four major areas including:
Our clinical mission is to advance the diagnosis and treatment of patients with pituitary and neuroendocrine disorders. The Neuroendocrine Unit is an internationally recognized research center in neuroendocrinology, body composition, and pituitary disease. Investigators in the Center have been awarded 14 NIH and federal research grants. In addition, funding from industry and private foundation support for investigator initiated research.
Research in the Neuroendocrine Unit incorporates both clinical and translational laboratory investigations in neuroendocrinology. In vitro and in vivo investigations have allowed basic studies of pituitary tumor pathogenesis and regulation to be brought directly into the clinical research arena.
Investigators in the Neuroendocrine Unit have played key leadership roles in the establishment and implementation of nationally recognized research programs in neuroendocrine disorders and have pioneered novel therapies for patients with secretory pituitary tumors, including the use of GH receptor antagonists and somatostatin receptor subtype specific analogues.
Another major focus of research is the relationship between the neuroendocrine axis and body composition. In recent collaborative work with the bioimaging groups in Psychiatry and Radiology, we are investigating the impact of psychiatric disorders and associated hormone disorders on specific brain regions, and the use of novel imaging modalities to investigate the effects of hormone deficiency states on body composition. In collaboration with Neuropathology, we are investigating the role of novel tumor suppressors in pituitary tumor development. In collaboration with the Department of Radiology, we are using novel imaging techniques to assess body composition and metabolism. In our collaborations with the Departments of Neurosurgery and Radiation Oncology, we have improved patient care for patients following cranial irradiation and have and completed investigations and have published work regarding the effects of surgery and radiotherapy on hypothalamic/pituitary function. The creation and expansion of the Neuroendocrine Center has provided a patient base for obtaining tumor tissue for in vitro experiments, conducting clinical studies, as well as providing continued care to these patients.
Learn more about Pediatric Endocrine/Neuroendocrine/Sports Endocrine Research.
Research projects and highlights include:
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