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Research at Mass General
The major focus of the Laboratory of Gastrointestinal Epithelial Biology is to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia. The small intestine is lined by a simple columnar epithelium in which pluripotent, proliferating crypt cells (stem cells) give rise to four distinct lineages of differentiated cells, including enterocytes (95%), goblet, and enteroendocrine cells on the villi, and paneth cells at the crypt base.
Our various ongoing projects relate to understanding the differentiation process in the contexts of:
Dr. Hodin has a highly specialized practice focused on (1) Colorectal Surgery, particularly patients with Crohns Disease and Ulcerative Colitis, and (2) Endocrine Surgery which involves surgery on the Thyroid, Parathyroid, and Adrenal glands.
Hometown: Tabriz, IranEducation: MD and MPH, Tehran University of Medical SciencesProfessional interests: Academic GI surgery, Burn-induced gut hyperpermeability and how intestinal alkaline phosphatase helps to improve gut barrier function in this context, How IAP as a regulator of the gut barrier and anti-inflammatory can extend lifespan in different speciesPersonal Interests: Basketball and dancing
Hometown: Zhengzhou, ChinaEducation: MD and PhD, Zhengzhou UniversityProfessional Interests: GI Surgery, gastrointestinal disease, especially inflammatory bowel disease, intestinal cancer, trauma, obstruction, perforation and bleedingPersonal Interests: Movies, music and sports
Hometown: Xi’an, ChinaEducation: MD, Xi’an Jiaotong UniversityProfessional interests: GI Surgery, gut-liver axis and alcoholic liver diseasePersonal Interests: Basketball, soccer and travel
Hometown: Ahvaz, IranEducation: MD, Shahid Beheshti University of Medical SciencesProfessional interests: Gut microbiome, systemic inflammation and gut inflammationPersonal interests: Soccer, travel and psychology
Hometown: Doncaster, South Yorkshire, United KingdomEducation: MBBS (Lond.) BSc. (Hons), University College London Medical SchoolProfessional Interests: General Surgery, Cardiothoracic Surgery, The role of intestinal alkaline phosphatase in inflammatory and metabolic diseasePersonal Interests: Tennis, table tennis, chess, running, keeping fit, reading, exploring and enjoying the many great restaurants in Boston, and supporting the Celtics
Hometown: Rye, NY, USAEducation: Harvard University undergraduate, concentrating on Human Evolutionary BiologyProfessional Interests: The effects of exercise on mouse models of colitisPersonal Interests: Harvard football, research, music, cinema and Ukelele
Presently, we are focused on defining the mechanisms that govern gut mucosal defense and the interplay between the host and the intestinal microflora.
We are employing IAP knockout and IAP transgenic mice in order to examine the role of this protein in regard to the gut barrier, and to lay the groundwork for IAP-based therapies that could be used clinically to help patients in the settings of severe trauma, sepsis, critical illness, and in the context of a variety of gut diseases such as IBD.
View a list of publications by researchers at the Laboratory of Gastrointestinal Epithelial Biology
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