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Research at Mass General
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My primary interest focuses on the anatomical substrates of cognition and emotion. In my Laboratory for Neuroanatomy and Cerebellar Neurobiology we use the methods of systems neuroscience, and we uphold the mission of the Massachusetts General Hospital by incorporating patient care and teaching into our research program.
My work pioneered the role of the cerebellum in cognition and emotion, and together with my collaborators I continue to evaluate the clinical features and neuroanatomical and functional substrates of the cerebellar cognitive affective syndrome. Our methods include tract tracing studies in animals of pathways that link cerebellum with the cerebral cortex; neurological and neuropsychological studies of cognition and emotion in patients with cerebellar diseases; and structural (MRI) and functional imaging (PET and fMRI) of the cerebellum to better understand the organization of the human cerebellum and the consequences of cerebellar damage on higher order behaviors.
In addition to cerebellar connections with cerebral cortex, we are interested in the connections of different cortical association areas with each other, with subcortical structures such as thalamus and basal ganglia, and the organization of the white matter tracts that link different brain regions. Our tract tracing studies in animals provided new insights into cerebral white matter pathways, and we are using new MRI approaches (diffusion spectrum imaging – DSI) to study these pathways and connections in the whole brain – in animals and humans. This work has potential to shed new light on cerebral and cerebellar systems affected by many diseases, from the ataxias to autism, schizophrenia and depression. We complement these anatomical investigations by studying patients with lesions in these areas (thalamus, pons, and cerebral white matter, as well as cerebellum) to better understand these presentations, and to facilitate improved diagnosis, management, and counseling.
The Massachusetts General Hospital Ataxia Unit is the clinical arm of the Laboratory for Neuroanatomy and Cerebellar Neurobiology. It is widely recognized as a premier center in the country for the evaluation and management of patients with cerebellar disorders, including spinocerebellar ataxias, Friedreich’s ataxia, multiple system atrophy - cerebellar type, sporadic ataxia, and cerebellar malformations resulting in motor and cognitive developmental delay. Clinical and translational research programs are directed at better diagnosing, understanding, and treating patients with cerebellar disorders, and collaborations with local and national investigators help advance these goals.
Our collaborators play an essential role in fulfilling our mission. At the Massachusetts General Hospital these include investigators and clinicians in the following areas:
We also collaborate closely with neuroscientists in the Boston University Laboratory for Anatomy and Neurobiology, the New England Regional Primate Center, the Beth Israel Deaconess Medical Center for Non-Invasive Brain Stimulation, the University of Lausanne, Switzerland, and previously with the McConnell Brain Imaging Center at the Montreal Neurological Institute and the Laboratory for Neuroimaging at UCLA.
Education is central to our mission. The clinical insights and results of our research efforts are shared in teaching sessions with medical students who rotate through Mass General wards on the neurology clerkships, as well as with undergraduate and graduate students locally and nationally.
Patient out-reach is a central part of our clinical mission, and a driving force in our research efforts. Dr. Schmahmann is a member of the Medical Advisory Board of the National Ataxia Foundation, and the Medical Advisor to its New England Ataxia Support Group.
The Laboratory has been funded by the National Institutes of Health for the development of the MRI Cerebellar Atlas, anatomical studies of the corticopontine projections in animals, and studies of motor and cognitive effects of cerebellar strokes in patients; by the McDonnell-Pew Foundations for behavioral and anatomical studies in animals; the Birmingham Foundation; the Massachusetts General Hospital Executive Committee on Research for anatomical as well as clinical studies; and philanthropic gifts from patients and their families.
Jeremy D. Schmahmann, MDDirector, Laboratory for Neuroanatomy and Cerebellar Neurobiology
Other core members of the Laboratory for Neuroanatomy and Cerebellar Neurobiology at the Massachusetts General Hospital are:
The ongoing research projects and publications of this laboratory are the result of the collaborative efforts of a large number of individuals, some of whom are listed below.
Massachusetts General Hospital
Massachusetts General Hospital Center for Morphometric Analysis
Athinoula Martinos Center for Biomedical Imaging
Beth Israel Deaconess Medical Center
University of Lausanne
We are not presently hiring, but we welcome enquiries from students who are interested in volunteering in the laboratory and/or clinic on selected projects.
Selected PublicationsThe selected publications below provide an overview of the work in our lab. Please see my full curriculum vitae for further details and links to the published work.
Composite color-coded summary diagram
Composite color-coded summary diagram illustrating the distribution within the basilar pons of the research animal of projections derived from associative cortices in the prefrontal (purple), posterior parietal (blue), temporal (red), and parastriate and parahippocampal regions (orange), and from motor, premotor and supplementary motor areas (green). The medial (A), lateral (B) and ventral (C) surfaces of the cerebral hemisphere are shown at upper left.
The plane of section through the basilar pons is at lower left, and the rostrocaudal levels of the pons I through IX are shown on the right. Cerebral areas that have been shown to project to the pons by other investigators using either anterograde or retrograde tracers are depicted in white; those areas studied with both anterograde and retrograde studies and found to have no pontine projections are shown on the hemispheres in yellow; and those with no pontine projections according to retrograde studies by other investigators are shaded in gray.
The dashed lines in the hemisphere diagrams represent the sulcal cortices. In the pons diagrams the dashed lines represent the pontine nuclei, and the solid lines depict the traversing corticofugal fibers. The associative corticopontine projections are substantial. There is a complex mosaic of terminations in the pons, and each cerebral cortical region has preferential sites of pontine terminations. There is considerable interdigitation of the terminations from some of the different cortical sites, but almost no overlap.
Neuroanatomy and Cerebellar Neurobiology
Jeremy D. Schmahmann, MDCharles River PlazaSouth Building, Suite 340175 Cambridge StreetBoston, MA 02114
For information on research at the Laboratory for Neuroanatomy and Cerebellar Neurobiology, contact Jason MacMore at 617-726-5060 or email email@example.com.
Phone: 617-726-3216Fax: 617-724-7836
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