Rajagopal Lab

The Rajagopal Lab at Massachusetts General Hospital focuses on lung regeneration and the application of developmental biology to human lung disease.

Overview

Jayaraj Rajagopal, MD
Principal Investigator, Center for Regenerative Medicine, Massachusetts General Hospital
HHMI Faculty Scholar
Maroni MGH Research Scholar
Professor in Medicine, Harvard Medical School

Please visit our lab website for further information.


The lung is a vertebrate invention that allowed the early tetrapods to leave the water and colonize the land. Oxygen is the essential actor in aerobic metabolism and the lung’s cardinal function is to mediate the efficient transfer of oxygen from theatmosphere to the circulatory system. Given the lung’s essential function, diseases of the lung are often life-threatening or incapacitating.

The Rajagopal Lab's interest in regeneration is focused on an attempt to understand how cells in a tissue act in concert, as an ensemble, to respond to injury and restore normal tissue form and function. Recently, we’ve been interested in topics like plasticity, intercellular signaling circuits operant between different subpopulation of epithelial cells, injury sensing, how tissues form and physiologic function are related and cellular heterogeneity. But we are open to any and all new avenues that give us insight into how cells act, not as individuals, but as components of a broader cellular tapestry, within the lung, with immune cells and across organ domains. And we are interested in how all this relates to human lung disease.

Please visit our lab website

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