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The Center for Quantitative Health (CQH) in the Division of Clinical Research at Massachusetts General Hospital focuses on utilizing large data sets to develop strategies for probabilistic medicine and quantitative health.
We believe that despite the incredible hype associated with big data, there is an opportunity to better serve our patients by developing tools for making clinically actionable predictions.
By facilitating the interaction of clinical and basic scientists at Mass General and the broader community, and providing tools to do challenging but essential studies, CQH is intended to bridge the gap between large data sets and clinical application. It works closely with the Mass General clinical and research programs, with the Clinical Trials Network and Institute (CTNI), and with translational programs such as the Psychiatric and Neurodevelopmental Genetics Unit (PNGU) and the Center for Genomic Medicine (CGM).
Roy H. Perlis, MD, MScDirector, Center for Quantitative Health, Massachusetts General HospitalProfessor of Psychiatry, Harvard Medical School
Dr. Perlis is the director of the Center for Quantitative Health in the Department of Psychiatry at Massachusetts General Hospital, the Associate Director of the Psychiatric Genetics Program in Mood and Anxiety Disorders, and Professor of Psychiatry at Harvard Medical School. He also serves as consultant to the American Psychiatric Association's bipolar treatment guidelines workgroup.
A graduate of Brown University, Harvard Medical School and Harvard School of Public Health, he completed his residency, chief residency, and clinical/research fellowship at Mass General before joining the faculty.
Dr. Perlis' clinical work and research is focused on difficult-to-treat or treatment resistant mood disorders, including major depressive disorder and bipolar disorder. He has authored more than 125 articles reporting original research, as well as numerous book chapters and reviews.
Current research efforts include identifying genetic variations which might predict treatment response, creating neuronal models of disease, and identifying and studying novel treatments for mood disorders.
His research has been supported by awards from NARSAD, NIMH, NSF, the American Philosophical Society, the Bowman Family Foundation, and the Stanley Center for Psychiatric Research, among others. In 2010 Dr. Perlis was awarded the Depression and Bipolar Support Alliance's Klerman Young Investigator Award.
Thomas H. McCoy Jr, MD Director of Research, Center for Quantitative Health
Dr. McCoy attended Dartmouth College and Cornell Medical School before completing the MGH/McLean Psychiatry residency and an informatics fellowship in the Center for Experimental Drugs and Diagnostics. Dr. McCoy served as MGH Consult Psychiatry Chief Resident.
Kamber L. HartClinical Research Coordinator, Center for Quantitative Health
Kamber graduated from Princeton University in 2016 with a AB in psychology. Her thesis focused on linguistic patterns of depression, specifically the use of metaphors in literature and personal accounts to describe the depressed state. Her goals are to apply to medical school and continue studying the intersection of language and mental health.
Amelia M. PellegriniClinical Research Coordinator, Center for Quantitative Health
Amelia graduated from Tufts University with a BA in Clinical Psychology and Spanish. She is from Bangor, Maine and is looking forward to spending the next few years in Boston before pursuing a Ph.D. in Clinical Psychology. She is particularly interested in investigating neuropsychological abnormalities in schizophrenia and other psychotic disorders.
Undergraduate Research Interns:
Cristina Cusin, MD Staff Psychiatrist, Depression Clinical and Research Program, Massachusetts General Hospital Assistant Professor of Psychiatry, Harvard Medical School
Maurizio Fava, MD Executive Vice Chair, Department of Psychiatry, Massachusetts General Hospital Director, Division of Clinical Research, Mass General Research Institute Executive Director, Clinical Trials Network and Institute (CTNI) Associate Dean for Clinical and Translational Research, Slater Family Professor of Psychiatry, Harvard Medical School
Steve Haggarty, PhD Associate Investigator, Center for Genomic Medicine, Massachusetts General Hospital Associate Professor of Neurology, Harvard Medical School
Tracey Petryshen, PhD Center for Genomic Medicine, Massachusetts General Hospital Associate Professor of Psychology, Harvard Medical School Associate Member, Broad Institute Director, Harvard Catalyst ‘Omics Education Program
Joshua L. Roffman, MD, MMSc Co-Director for Psychiatric Neuroimaging, Massachusetts General Hospital Director of Research, Mass General Schizophrenia Clinical and Research Program Associate Professor of Psychiatry, Harvard Medical School
Jordan Smoller, MD, ScD Director, Psychiatric and Neurodevelopment Genetics Unit, Massachusetts General Hospital Co-Director, Genetics and Genomics Unit, Division of Clinical Research, Mass General Research Institute Professor of Psychiatry, Harvard Medical School
Hannah E. Brown, MDFaculty Psychiatrist, Massachusetts General Hospital
Victor M. Castro, MSData Scientist, Partners HealthCare
Center for Experimental Drugs and Diagnostics
Steven D. Sheridan, PhDSr. Research InvestigatorDirector, Platform for Cellular Modeling of Neuropsychiatric Disease (cMiND)
Dr. Sheridan has more than 15 years of experience in both academia and industry deriving, expanding, differentiating, and characterizing pluripotent and multipotent stem cells and their progeny for the purposes of disease modeling, genetic engineering, cell therapy, tissue engineering, and drug discovery. Currently a Senior Research Investigator and Director of the Platform for Cellular Modeling of Neuropsychiatric Disease in the Center for Genomic Medicine (CGM) at Massachusetts General Hospital, he has also served as a Principal Scientist in biotech leading cross-functional teams in stem cell technology development.
Most recently, his research at the Center for Quantitative Health involves the generation and characterization of human induced pluripotent stem cells (iPSCs), neural stem cells, and neurons directly from patients of various neurodevelopmental and neuropsychiatric disease backgrounds (such as Fragile X syndrome, Rett Syndrome, CDKL5, Pitt-Hopkins Syndrome, schizophrenia, and bipolar disorder) in order to facilitate the development of novel cell-based assays of disease mechanism.
Dr. Sheridan received his PhD in Molecular Genetics at the University of California, Irvine and followed-up with post-doctoral training in genetic engineering at Harvard University.
Jennifer Wang, PhDSr. Research Investigator
Jen has BA in Mathematics and a BS in Physics from the University of California, San Diego. She earned her PhD in Neuroscience from the Massachusetts Institute of Technology where she studied neural circuits in-vitro using electrophysiology and optogenetics. She did a fellowship at MGH reprogramming patient cell models to identify psychiatric disease phenotypes. She continues this work as a senior research scientist where she develops new assays and tools for psychiatric disease models.
Smita Jagtap, PhDPost-doctoral Fellow
Dr. Jagtap earned her PhD in Cell and Molecular Biology at the University of Cologne, Germany. During her PhD, she worked with hESC and hiPSC to develop toxicity assays and understand the molecular mechanisms of developmental toxicants such as retinoic acid, cytarabine, and thalidomide. She worked on various differentiation protocols (neuronal, cardiomyocytes, and hepatocyte-like cells) using hESC and hiPSC.
Smita is interested in the study of a rare X-linked genetic disorder CDKL5 (cyclin-dependent kinase-like 5) that results in early onset, difficult to control seizures, and severe neurodevelopmental impairment, with the goal of understanding the mechanisms and identifying novel targets. In particular, she would like to develop treatments selectively targeting diseased neurons by exploiting changes in neuronal metabolic potential during the course of the disorder.
When not at work, Smita enjoys music, sketching, and painting with urban sketchers.
Ting FuSenior Research Technologist
Ting is a senior research technologist with more than 14 years of experience in a variety of biomedical research areas, including rabbit monoclonal antibody development, therapeutic drugs discovery targeting EGFR family receptor, and the generation of iPSC-derived neurons. Since she joined MGH in 2012, she has successfully generated more than one hundred iPSCs, NPCs, and neurons from patients of various neurodevelopmental disorders and neuropsychiatric diseases, such as Pitt-Hopkins Syndrome. By using state-of-the-art iPSC technologies, she hopes we can one day discover the pathogenesis of these diseases and eventually find a cure for these neuronal disorders.
Jessica M. ThanosResearch Technologist
Jessica graduated with a BS in Biology from Emmanuel College. Prior to joining the Perlis lab, she studied mood and autism spectrum disorders using animal models. In the long-term, she hopes to pursue a graduate degree and study the neurodevelopmental basis for mental illness. Her hobbies include scuba diving, manual photography, and playing with her two dogs.
Former CEDD Members:
Marion “Joe” Riggs
If you are interested in applying for a position in this lab, please ask us about our favorite place to get donuts!
We are currently recruiting patients diagnosed with a variety of neuropsychiatric disorders, including depression, bipolar disorder, and schizophrenia.
Please call the research coordinator at 617-643-6310 or contact us by email to see if you might be eligible to participate in a study.
The Use of Human Skin in the Creation of Cellular Models of Neuropsychiatric Disorders
The purpose of this research study is to collect, process and store samples to do research on neuropsychiatric disorders. This research study looks at changes in the human body associated with neuropsychiatric disorders. Part of this study involves the collection of skin and blood samples that will be stored in a tissue bank for later use. Research using these samples will attempt to identify causes and what helps prevent, treat, or cure neuropsychiatric disorders. In addition, the samples collected for this study will be used for genetic research on these diseases.
Using Mobile Phones for Social and Behavioral Sensing of Mood Disorder Patients
In this research study, a smartphone app collects data over an 8-week period of time. We are interested in recruiting people who have had a wide range of mood symptoms or psychiatric symptoms, as well as people who have never experienced those kinds of symptoms. It is our hope that by collecting this information, we can better understand how people’s mood changes over time and how these changes may be correlated to phone usage (e.g., texting and calling patterns), which could ultimately lead to better management of symptoms.
Current and past CQH studies are supported by funding from NIMH, NARSAD, the National Science Foundation, AHRQ, the Stanley Center for Psychiatric Research at the Broad Institute, the American Philosophical Society, the Bowman Family Foundation, and the Sidney J. Baer, Jr. Foundation, as well as by industry partners including Proteus Biomedical.
For a PubMed listing of Dr. Perlis' articles, please click here.
Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J Clin Invest. 2018 Dec 10. [Epub ahead of print]
Perlis RH, Fava M, McCoy TH Jr. Can Electronic Health Records Revive Central Nervous System Clinical Trials? Mol Psychiatry. 2018 Nov 14. [Epub ahead of print]
McCoy TH Jr, Pellegrini AM, Perlis RH. Assessment of Time-Series Machine Learning Methods for Forecasting Hospital Discharge Volume. JAMA Netw Open. 2018 Nov 2;1(7):e184087.
Gordon DD, Patel I, Pellegrini AM, Perlis RH. Prevalence and Nature of Financial Discussions Documented in Narrative Clinical Records in Intensive Care Units: A Machine Learning Assessment of the MIMIC-III Cohort. JAMA Netw Open. 2018 Nov 2;1(7):e184178.
Snapper LA, Hart KL, Venkatesh KK, Kaimal AJ, Perlis RH. Cohort study of the relationship between individual psychotherapy and pregnancy outcomes. J Affect Disord. 2018 Oct 15;239:253-257.
Perlis RH, Mehta R, Edwards AM, Tiwari A, Imbens GW. Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study. Depress Anxiety. 2018 Oct;35(10):946-952.
McCoy TH Jr, Perlis RH. Temporal trends and characteristics of reportable health data breaches, 2010-2017. JAMA. 2018 Sep 25;320(12):1282-1284.
McCoy TH Jr, Hart K, Pellegrini A, Perlis RH. Genome-wide association identifies a novel locus for delirium risk. Neurobiol Aging. 2018 Aug;68:160.e9-160.e14.
Hart KL, Brown HE, Roffman JL, Perlis RH. Risk tolerance measured by probability discounting among individuals with primary mood and psychotic disorders. Neuropsychology. 2018 Aug. [Epub ahead of print]
Freedman R, Brown AS, Cannon TD, Druss BG, Earls FJ, Escobar J, Hurd YL, Lewis DA, López-Jaramillo C, Luby J, Mayberg HS, Moffitt TE, Oquendo M, Perlis RH, Pine DS, Rush AJ, Tamminga CA, Tohen M, Vieta E, Wisner KL, Xin Y. Can a Framework Be Established for the Safe Use of Ketamine? Am J Psychiatry. 2018 Jul 1;175(7):587-589.
McCoy TH Jr, Yu S, Hart KL, Castro VM, Brown HE, Rosenquist JN, Doyle AE, Vuijk PJ, Cai T, Perlis RH. High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records. Biol Psychiatry. 2018 Jun 15;83(12):997-1004.
McCoy TH Jr, Castro VM, Hart KL, Pellegrini AM, Yu S, Cai T, Perlis RH. Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records. Biol Psychiatry. 2018 Jun 15;83(12):1005-1011.
Fabbri C, Lewis CM, Perlis RH, Uher R. No Association Between Antidepressant Efficacy and rs28365143 in Corticotropin-Releasing Hormone Binding Protein in a Large Meta-Analysis. Am J Psychiatry. 2018 Jun 1;175(6):575-576.
Perlis RH. Anxiety About Antidepressants. Am J Psychiatry. 2018 Jun 1;175(6):500-501.
McCoy TH Jr, Fragomen AT, Hart KL, Pellegrini AM, Raskin KA, Perlis RH. Genomewide Association Study of Fracture Nonunion Using Electronic Health Records. JBMR Plus. 2018 May 29.
Brown HE, Hart KL, Snapper LA, Roffman JL, Perlis RH. Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders. NPJ Schizophr. 2018 May 28;4(1):9.
Chen CY, Lee PH, Castro VM, Minnier J, Charney AW, Stahl EA, Ruderfer DM, Murphy SN, Gainer V, Cai T, Jones I, Pato CN, Pato MT, Landén M, Sklar P, Perlis RH, Smoller JW. Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records. Transl Psychiatry. 2018 Apr 18;8(1):86.
McCoy TH, Castro VM, Cagan A, Snapper L, Roberson A, Perlis RH. Cytochrome P450 interactions are common and consequential in Massachusetts hospital discharges. Pharmacogenomics J. 2018 Apr;18(2):347-350.
Sagers JE, Brown AS, Vasilijic S, M Lewis R, Sahin MI, Landegger LD, Perlis RH, Kohane IS, Welling DB, Patel CJ, Stankovic KM. Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. Sci Rep. 2018 Apr 3;8(1):5437.
Ravichandran C, Shinn AK, Öngür D, Perlis RH, Cohen B. Frequency of non-right-handedness in bipolar disorder and schizophrenia. Psychiatry Res. 2017 Jul;253:267-269.
Venkatesh KK, Castro VM, Perlis RH, Kaimal AJ. Impact of antidepressant treatment during pregnancy on obstetric outcomes among women previously treated for depression: an observational cohort study. J Perinatol. 2017 Jul 6.
McCoy TH, Hart KL, Perlis RH. Characterizing and predicting rates of delirium across general hospital settings. Gen Hosp Psychiatry. 2017 May;46:1-6.
Venkatesh KK, Kaimal AJ, Castro VM, Perlis RH.Improving discrimination in antepartum depression screening using the Edinburgh Postnatal Depression Scale.J Affect Discord. 2017 May;214:1-7.
Pavlova B, Perlis RH, Mantere O, Sellgren CM, Isometsä E, Mitchell PB, Alda M, Uher R. Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis. Psychol Med. 2017 Apr;47(6):1107-1115.
García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, Farmer A, Aitchison KJ, Craig I, McGuffin P, Giupponi M, Perroud N, Bondolfi G, Evans D, O'Donovan M, Peters TJ, Wendland JR, Lewis G, Kapur S, Perlis R, Arolt V, Domschke K; Major Depressive Disorder Working Group of the Psychiatric Genomic Consortium, Breen G, Curtis C, Sang-Hyuk L, Kan C, Newhouse S, Patel H, Baune BT, Uher R, Lewis CM, Fabbri C. Pharmacogenetics of antidepressant response: A polygenic approach. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:128-134.
McCoy TH Jr, Chaukos DC, Snapper LA, Hart KL, Stern TA, Perlis RH. Enhancing Delirium Case Definitions in Electronic Health Records Using Clinical Free Text. Psychosomatics. 2017 Mar - Apr;58(2):113-120.
Bigdeli TB, Ripke S, Peterson RE, Trzaskowski M, Bacanu SA, Abdellaoui A, Andlauer TF, Beekman AT, Berger K, Blackwood DH, Boomsma DI, Breen G, Buttenschøn HN, Byrne EM, Cichon S, Clarke TK, Couvy-Duchesne B, Craddock N, de Geus EJ, Degenhardt F, Dunn EC, Edwards AC, Fanous AH, Forstner AJ, Frank J, Gill M, Gordon SD, Grabe HJ, Hamilton SP, Hardiman O, Hayward C, Heath AC, Henders AK, Herms S, Hickie IB, Hoffmann P, Homuth G, Hottenga JJ, Ising M, Jansen R, Kloiber S, Knowles JA, Lang M, Li QS, Lucae S, MacIntyre DJ, Madden PA, Martin NG, McGrath PJ, McGuffin P, McIntosh AM, Medland SE, Mehta D, Middeldorp CM, Milaneschi Y, Montgomery GW, Mors O, Müller-Myhsok B, Nauck M, Nyholt DR, Nöthen MM, Owen MJ, Penninx BW, Pergadia ML, Perlis RH, Peyrot WJ, Porteous DJ, Potash JB, Rice JP, Rietschel M, Riley BP, Rivera M, Schoevers R, Schulze TG, Shi J, Shyn SI, Smit JH, Smoller JW, Streit F, Strohmaier J, Teumer A, Treutlein J, Van der Auwera S, van Grootheest G, van Hemert AM, Völzke H, Webb BT, Weissman MM, Wellmann J, Willemsen G, Witt SH, Levinson DF, Lewis CM, Wray NR, Flint J, Sullivan PF, Kendler KS. Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry. 2017 Mar 28;7(3):e1074.
Harper DG, Jensen JE, Ravichandran C, Perlis RH, Fava M, Renshaw PF, Iosifescu DV. Tissue Type-Specific Bioenergetic Abnormalities in Adults with Major Depression. Neuropsychopharmacology. 2017 Mar;42(4):876-885.
Sellgren CM, Sheridan SD, Gracias J, Xuan D, Fu T, Perlis RH. Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors. Mol Psychiatry. 2017 Feb; 22(2): 170–177.
McCoy TH, Castro V, Cagan A, Roberson AM, Perlis RH. Validation of a risk stratification tool for fall-related injury in a state-wide cohort. Brit Med J Open. 2017 Feb 6;7(2):e012189.
Barak-Corren Y, Castro VM, Javitt S, Hoffnagle AG, Dai Y, Perlis RH, Nock MK, Smoller JW, Reis BY. Predicting Suicidal Behavior From Longitudinal Electronic Health Records. Am J Psychiatry. 2017 Feb 1;174(2):154-162.
Charney AW, Ruderfer DM, Stahl EA, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Di Florio A, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Green EK, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Roussos P, Knowles JA, Jones I, Jones LA, Hultman CM, Perlis RH, Purcell SM, McCarroll SA, Pato CN, Pato MT, Craddock N, Landén M, Smoller JW, Sklar P. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Transl Psychiatry. 2017 Jan 10;7(1):e993.
Direk N, Williams S, Smith JA, Ripke S, Air T, Amare AT, Amin N, Baune BT, Bennett DA, Blackwood DH, Boomsma D, Breen G, Buttenschøn HN, Byrne EM, Børglum AD, Castelao E, Cichon S, Clarke TK, Cornelis MC, Dannlowski U, De Jager PL, Demirkan A, Domenici E, van Duijn CM, Dunn EC, Eriksson JG, Esko T, Faul JD, Ferrucci L, Fornage M, de Geus E, Gill M, Gordon SD, Grabe HJ, van Grootheest G, Hamilton SP, Hartman CA, Heath AC, Hek K, Hofman A, Homuth G, Horn C, Jan Hottenga J, Kardia SL, Kloiber S, Koenen K, Kutalik Z, Ladwig KH, Lahti J, Levinson DF, Lewis CM, Lewis G, Li QS, Llewellyn DJ, Lucae S, Lunetta KL, MacIntyre DJ, Madden P, Martin NG, McIntosh AM, Metspalu A, Milaneschi Y, Montgomery GW, Mors O, Mosley TH Jr, Murabito JM, Müller-Myhsok B, Nöthen MM, Nyholt DR, O'Donovan MC, Penninx BW, Pergadia ML, Perlis R, Potash JB, Preisig M, Purcell SM, Quiroz JA, Räikkönen K, Rice JP, Rietschel M, Rivera M, Schulze TG, Shi J, Shyn S, Sinnamon GC, Smit JH, Smoller JW, Snieder H, Tanaka T, Tansey KE, Teumer A, Uher R, Umbricht D, Van der Auwera S, Ware EB, Weir DR, Weissman MM, Willemsen G, Yang J, Zhao W, Tiemeier H, Sullivan PF. An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biol Psychiatry. 2016 Dec 8; S0006-3223(16)33068-2.
Bernhard RM, Chaponis J, Siburian R, Gallagher P, Ransohoff K, Wikler D, Perlis RH, Greene JD. Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment. Soc Cogn Affect Neurosci. 2016 Dec; 11(12):1872-1881.
Rumshisky A, Ghassemi M, Naumann T, Szolovits P, Castro VM, McCoy TH, Perlis RH. Predicting early psychiatric readmission with natural language processing of narrative discharge summaries. Transl Psychiatry. 2016 Oct 18;6(10):e921.
Perlis RH. Abandoning personalization to get to precision in the pharmacotherapy of depression. World Psychiatry. 2016 Oct; 15(3):228-235.
McCoy TH Jr, Castro VM, Roberson AM, Snapper LA, Perlis RH. Improving Prediction of Suicide and Accidental Death After Discharge From General Hospitals With Natural Language Processing. JAMA Psychiatry. 2016 Oct 1; 73(10):1064-1071.
McCoy TH Jr, Snapper L, Stern TA, Perlis RH. Underreporting of Delirium in Statewide Claims Data: Implications for Clinical Care and Predictive Modeling. Psychosomatics. 2016 Sep-Oct; 57(5):480-8.
Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR, Tung JY, Hinds DA, Perlis RH, Winslow AR. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat Genet. 2016 Sep; 48(9):1031-6.
Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA; Members of the International Cohort Collection for Bipolar Disorder (ICCBD), Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M, Smoller JW, Perlis RH, Lee PH, Castro VM, Hoffnagle AG, Sklar P, Stahl EA, Purcell SM, Ruderfer DM, Charney AW, Roussos P, Michele Pato CP, Medeiros H, Sobel J, Craddock N, Jones I, Forty L, Florio AD, Green E, Jones L, Gordon-Smith K, Landen M, Hultman C, Jureus A, Bergen S, McCarroll S, Moran J, Smoller JW, Chambert K, Belliveau RA. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2016 Sep;21(9):1290-7.
Liang SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P, Plummer MS, Para KS, Conn EL, Lopresti-Morrow L, Lanyon LF, Cook JM, Richter KE, Nolan CE, Schachter JB, Janat F, Che Y, Shanmugasundaram V, Lefker BA, Enerson BE, Livni E, Wang L, Guehl NJ, Patnaik D, Wagner FF, Perlis R, Holson EB, Haggarty SJ, El Fakhri G, Kurumbail RG, Vasdev N. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016 Aug 8; 55(33):9601-5.
Perlis RH. Autism and antidepressant use in pregnancy. J Pediatr. 2016 Jul; 174:278.
Haggarty SJ, Silva MC, Cross A, Brandon NJ, Perlis RH. Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models. Mol Cell Neurosci. 2016 Jun;73:104-15.
Corral-Frías NS, Pizzagalli DA, Carré JM, Michalski LJ, Nikolova YS, Perlis RH, Fagerness J, Lee MR, Conley ED, Lancaster TM, Haddad S, Wolf A, Smoller JW, Hariri AR, Bogdan R. COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.Genes Brain Behav. 2016 Jun;15(5):503-13.
Balekian DS, Linnemann RW, Castro VM, Perlis R, Thadhani R, Camargo CA Jr. Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy. Pediatr Allergy Immunol. 2016 Jun; 27(4):413-8.
Perlis RH, Perlis CS. Physician Payments from Industry Are Associated with Greater Medicare Part D Prescribing Costs. PLoS One. 2016 May 16; 11(5):e0155474.
Venkatesh KK, Riley L, Castro VM, Perlis RH, Kaimal AJ. Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth. Obstet Gynecol. 2016 May; 127(5):926-33.
McGrath LM, Braaten EB, Doty ND, Willoughby BL, Wilson HK, O'Donnell EH, Colvin MK, Ditmars HL, Blais JE, Hill EN, Metzger A, Perlis RH, Willcutt EG, Smoller JW, Waldman ID, Faraone SV, Seidman LJ, Doyle AE. Extending the 'cross-disorder' relevance of executive functions to dimensional neuropsychiatric traits in youth. J Child Psychol Psychiatry. 2016 Apr;57(4):462-71.
Sylvia LG, Gold AK, Stange JP, Peckham AD, Deckersbach T, Calabrese JR, Weiss RD, Perlis RH, Nierenberg AA, Ostacher MJ. A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder.Am J Addict. 2016 Mar; 25(2):94-8.
Vöhringer PA, Perlis RH. Discriminating Between Bipolar Disorder and Major Depressive Disorder. Psychiatr Clin North Am. 2016 Mar; 39(1):1-10.
Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CE, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.Lancet. 2016 Mar 12; 387(10023):1085-93.
Roberson AM, Castro VM, Cagan A, Perlis RH. Antidepressant nonadherence in routine clinical settings determined from discarded blood samples. J Clin Psychiatry. 2016 Mar;77(3):359-62.
Castro VM, Roberson AM, McCoy TH, Wiste A, Cagan A, Smoller JW, Rosenbaum JF, Ostacher M, Perlis RH. Stratifying Risk for Renal Insufficiency Among Lithium-Treated Patients: An Electronic Health Record Study. Neuropsychopharmacology. 2016 Mar;41(4):1138-43.
Castro VM, Kong SW, Clements CC, Brady R, Kaimal AJ, Doyle AE, Robinson EB, Churchill SE, Kohane IS, Perlis RH. Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study.Transl Psychiatry. 2016 Jan 5;6:e708.
Perlis RH. Getting Past Proof of Concept For New Treatments. Am J Psychiatry. 2015 Oct;172(10):937-8.
McCoy TH, Castro VM, Cagan A, Roberson AM, Kohane IS, Perlis RH. Sentiment Measured in Hospital Discharge Notes Is Associated with Readmission and Mortality Risk: An Electronic Health Record Study. PLoS One. 2015 Aug 24; 10(8):e0136341.
Pavlova B, Perlis RH, Alda M, Uher R. Lifetime prevalence of anxiety disorders in people with bipolar disorder: a systematic review and meta-analysis.Lancet Psychiatry. 2015 Aug;2(8):710-7.
Uchida M, Spencer AE, Biederman J, Castro VM, Kenworthy T, Chan J, Rosales AM, Newton-Cheh C, Perlis RH. A Systematic Evaluation of the QTc Interval and Antidepressants in Youth: An Electronic Health Record Study. J Dev Behav Pediatr. 2015 Jul-Aug;36(6):434-9.
Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron. 2015 Jun 3;86(5):1189-202.
Ostacher MJ, Perlis RH, Geddes J. Monotherapy Antidepressant Treatment is Not Associated With Mania in Bipolar I Disorder. Am J Psychiatry. 2015 Jun;172(6):586.
Ramos EM, Gillis T, Mysore JS, Lee JM, Alonso I, Gusella JF, Smoller JW, Sklar P, MacDonald ME, Perlis RH. Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder.Bipolar Disord. 2015 Jun;17(4):403-8.
Rotstein BH, Liang SH, Belov VV, Livni E, Levine DB, Bonab AA, Papisov MI, Perlis RH, Vasdev N. Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist. Molecules. 2015 May 26;20(6):9550-9.
Brennan FX, Gardner KR, Lombard J, Perlis RH, Fava M, Harris HW, Scott R. A Naturalistic Study of the Effectiveness of Pharmacogenetic Testing to Guide Treatment in Psychiatric Patients With Mood and Anxiety Disorders. Prim Care Companion CNS Discord. 2015 Apr 16; 17(2).
Uher R, Ripke S, Müller-Myhsok B, Lewis CM, Perlis RH. Association of a brain methylation site with clinical outcomes in depression does not replicate across populations.Am J Psychiatry. 2015 Apr;172(4):395-7.
Castro VM, Minnier J, Murphy SN, Kohane I, Churchill SE, Gainer V, Cai T, Hoffnagle AG, Dai Y, Block S, Weill SR, Nadal-Vicens M, Pollastri AR, Rosenquist JN, Goryachev S, Ongur D, Sklar P, Perlis RH, Smoller JW; International Cohort Collection for Bipolar Disorder Consortium. Validation of electronic health record phenotyping of bipolar disorder cases and controls. Am J Psychiatry. 2015 Apr;172(4):363-72.
McCoy TH, Castro VM, Rosenfield HR, Cagan A, Kohane IS, Perlis RH. A clinical perspective on the relevance of research domain criteria in electronic health records. Am J Psychiatry. 2015 Apr;172(4):316-20.
McCoy TH Jr, Perlis RH. A tool to utilize adverse effect profiles to identify brain-active medications for repurposing. Int J Neuropsychopharmacol. 2015 Feb 11;18(3).
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