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Research at Mass General
Amar Sahay, PhD, Principal InvestigatorAssociate Professor, Department of Psychiatry and Center for Regenerative Medicine, Massachusetts General HospitalPrincipal Faculty, Harvard Stem Cell Institute Associate Member, Broad Institute of MIT and Harvard
The incidence and complexity of mental illnesses and cognitive impairments associated with ageing and Alzheimer’s disease underscores the need to develop novel treatments. Our mission is to generate fundamental insights into the functions of the dentate gyrus and the role of adult hippocampal neurogenesis, the process by which neural stem cells generate dentate granule neurons throughout life, in memory processing and modulation of mood. By integrating cellular, circuit, systems and behavioral level approaches, we aspire to rejuvenate and reengineer the hippocampus to optimize circuit performance and memory processing. We predict that this strategy will impact circuit-based endophenotypes shared across diseases such as PTSD, Alzheimer’s disease and age-related cognitive decline.
To address this goal, we have established a multifaceted research program that integrates inducible mouse- and viral-genetics, pharmaco- and optogenetics, synaptic tracing, in vivo awake behaving optical imaging, 2 photon imaging, human cellular reprogramming and behavioral analysis.
Specifically, we are interested in the following questions.
Amar Sahay, PhD, Principal Investigator Associate Professor, Department of Psychiatry and Center for Regenerative Medicine, Mass GeneralPrincipal Faculty, Harvard Stem Cell Institute Associate Member, BROAD Institute of Harvard and MIT
Antoine Besnard, PhD, Postdoctoral fellow, NARSAD YI Awardee
Nannan Guo, PhD, Postdoctoral fellow
Kathleen McAvoy, PhD, Postdoctoral fellow
Cinzia Vicidomini, PhD, Postdoctoral fellow, NARSAD YI Awardee
Hannah Twarkowski, PhD, Postdoctoral Fellow
Tara Raam, BS, Graduate Student (Neuroscience)
Hugo Vega-Ramirez, BS, Graduate Student (Neuroscience, HHMI Gilliam Fellow)
Michael Kim, BS, Lab tech/Manager
See Team Bios and Alumni
For research opportunities please contact Dr. Amar Sahay.
See the full list of Laboratory publications
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