Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation.
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J Cereb Blood Flow Metab. 2014 Feb 19. doi: 10.1038/jcbfm.2014.31.
Response to laskowitz and dawson.
Mannix R, Meehan WP, Feany M, Grant PE, Mandeville J, Kaplan DL, Whalen M.
Ann Neurol. 2013 Nov 16. doi: 10.1002/ana.24056.
Akt and mTOR mediate programmed necrosis in neurons.
Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ.
Cell Death Dis. 2014 Feb 27;5:e1084. doi: 10.1038/cddis.2014.69.
Beneficial effect of amyloid beta after controlled cortical impact.
Mannix RC, Zhang J, Berglass J, Qui J, Whalen MJ.
Brain Inj. 2013 Jun;27(6):743-8. doi: 10.3109/02699052.2013.771797.
Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice.
Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ.
J Neurotrauma. 2013 Mar 1;30(5):382-91. doi: 10.1089/neu.2012.2536.
Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
Walker KR, Kang EL, Whalen MJ, Shen Y, Tesco G.
J Neurosci. 2012 Jul 25;32(30):10423-37. doi: 10.1523/JNEUROSCI.5491-11.2012.
Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury.
Lok J, Zhao S, Leung W, Seo JH, Navaratna D, Wang X, Whalen MJ, Lo EH.
Transl Stroke Res. 2012 Jul;3 Suppl 1:S119-24. doi: 10.1007/s12975-012-0157-x.
Increasing recovery time between injuries improves cognitive outcome after repetitive mild concussive brain injuries in mice.
Meehan WP 3rd, Zhang J, Mannix R, Whalen MJ.
Neurosurgery. 2012 Oct;71(4):885-91.
Neuroglobin-overexpression reduces traumatic brain lesion size in mice.
Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X.
BMC Neurosci. 2012 Jun 15;13:67. doi: 10.1186/1471-2202-13-67.
Traumatic brain injury, microglia, and Beta amyloid.
Mannix RC, Whalen MJ.
Int J Alzheimers Dis. 2012;2012:608732. doi: 10.1155/2012/608732. Epub 2012 May 14.
Neurovascular matrix metalloproteinases and the blood-brain barrier.
Seo JH, Guo S, Lok J, Navaratna D, Whalen MJ, Kim KW, Lo EH.
Curr Pharm Des. 2012;18(25):3645-8. Review.
Low-level laser therapy for closed-head traumatic brain injury in mice: effect of different wavelengths.
Wu Q, Xuan W, Ando T, Xu T, Huang L, Huang YY, Dai T, Dhital S, Sharma SK, Whalen MJ, Hamblin MR.
Lasers Surg Med. 2012 Mar;44(3):218-26. doi: 10.1002/lsm.22003. Epub 2012 Jan 24.
Traumatic brain injury during warfarin anticoagulation: an experimental study in mice.
Foerch C, You Z, Wang H, Lo EH, Whalen MJ.
J Neurotrauma. 2012 Apr 10;29(6):1150-5. doi: 10.1089/neu.2011.2104.
Kollidon VA64, a membrane-resealing agent, reduces histopathology and improves functional outcome after controlled cortical impact in mice.
Mbye LH, Keles E, Tao L, Zhang J, Chung J, Larvie M, Koppula R, Lo EH, Whalen MJ.
J Cereb Blood Flow Metab. 2012 Mar;32(3):515-24. doi: 10.1038/jcbfm.2011.158.
Plasmalemma permeability and necrotic cell death phenotypes after intracerebral hemorrhage in mice.
Zhu X, Tao L, Tejima-Mandeville E, Qiu J, Park J, Garber K, Ericsson M, Lo EH, Whalen MJ.
Stroke. 2012 Feb;43(2):524-31. doi: 10.1161/STROKEAHA.111.635672.
Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice.
Ando T, Xuan W, Xu T, Dai T, Sharma SK, Kharkwal GB, Huang YY, Wu Q, Whalen MJ, Sato S, Obara M, Hamblin MR.
PLoS One. 2011;6(10):e26212. doi: 10.1371/journal.pone.0026212.
Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.
Krajewska M, You Z, Rong J, Kress C, Huang X, Yang J, Kyoda T, Leyva R, Banares S, Hu Y, Sze CH, Whalen MJ, Salmena L, Hakem R, Head BP, Reed JC, Krajewski S.
PLoS One. 2011;6(9):e24341. doi: 10.1371/journal.pone.0024341.
Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice.
Park J, Zhang J, Qiu J, Zhu X, Degterev A, Lo EH, Whalen MJ.
J Cereb Blood Flow Metab. 2012 Feb;32(2):330-40. doi: 10.1038/jcbfm.2011.131.
Low-level laser light therapy improves cognitive deficits and inhibits microglial activation after controlled cortical impact in mice.
Khuman J, Zhang J, Park J, Carroll JD, Donahue C, Whalen MJ.
J Neurotrauma. 2012 Jan 20;29(2):408-17. doi: 10.1089/neu.2010.1745.
Detrimental effect of genetic inhibition of B-site APP-cleaving enzyme 1 on functional outcome after controlled cortical impact in young adult mice.
Mannix RC, Zhang J, Park J, Lee C, Whalen MJ.
J Neurotrauma. 2011 Sep;28(9):1855-61. doi: 10.1089/neu.2011.1759.
Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice.
Khuman J, Meehan WP 3rd, Zhu X, Qiu J, Hoffmann U, Zhang J, Giovannone E, Lo EH, Whalen MJ.
J Cereb Blood Flow Metab. 2011 Feb;31(2):778-89. doi: 10.1038/jcbfm.2010.172. Epub 2010 Oct 13.
Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice.
Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ.
J Cereb Blood Flow Metab. 2011 Jan;31(1):351-61. doi: 10.1038/jcbfm.2010.99. Epub 2010 Jun 30.
Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice.
Yang J, You Z, Kim HH, Hwang SK, Khuman J, Guo S, Lo EH, Whalen MJ.
J Neurotrauma. 2010 Jun;27(6):1037-46. doi: 10.1089/neu.2009.1229.
Diffusion-weighted magnetic resonance imaging reversal by gene knockdown of matrix metalloproteinase-9 activities in live animal brains.
Liu CH, You Z, Liu CM, Kim YR, Whalen MJ, Rosen BR, Liu PK.
J Neurosci. 2009 Mar 18;29(11):3508-17. doi: 10.1523/JNEUROSCI.5332-08.2009.