Gomez-Isla Lab

Dr. Gomez-Isla investigates the neurobiology of normal aging, Alzheimers, and other dementias.

Lab Phone: 617-643-5562

MassGeneral Institute for Neurodegenerative Disease (MIND)

Neurology Access Center: 1-855-644-6387


The Gomez-Isla lab focuses on the development and characterization of transgenic mouse models of Alzheimer's disease and on testing novel therapeutic strategies. Research is also conducted with human brain tissue from individuals who suffered Alzheimer's disease while alive.

Dr. Gomez-Isla’s clinical research focuses on cognitively intact individuals across the age spectrum in order to search for molecular mechanisms responsible for individual vulnerability or resilience to this type of dementia.








Group Members

Teresa Gomez-Isla

Principal Investigator

Teresa Gomez-Isla, MD

  • Associate Professor,
    Harvard Medical School
  • Neurologist,
    Massachusetts General Hospital



 Research Lab Members

  • Beatriz Perez-Nievas Gomez, PhD
  • Marta Marquire Sayagues, MD
  • Isabel Barroeta, MD
  • Elena Galea, PhD


Updated 7/12/2013

Research Projects

Genetic cross-interaction between APOE and PRNP 

figure showing age dependent risks for sCJD and AD

In this work, we investigated for the first time, APOE and PRNP genotypes simultaneously in 474 AD and 175 sporadic CJD (sCJD) patients compared to a common control population of 335 subjects. Differences in genotype distribution between patients and control subjects were studied by logistic regression analysis using age and gender as covariates.








Updated 7/11/2012

Research Positions

Request a list of currently open positions at mghneurologyjobs@partners.org.

Read about and apply for residency, fellowship and observership programs at http://www.massgeneral.org/neurology/education/.

All applicants should register with the Mass General Careers Web site at http://www.massgeneral.org/careers/viewall.aspx.


  1. Rapidly Progressive Dementia: Experience in a Tertiary Care Medical Center. Sala I, Marquié M, Sánchez-Saudinós MB, Sánchez-Valle R, Alcolea D, Gómez-Ansón B, Gómez-Isla T, Blesa R, Lleó A. Alzheimer Dis Assoc Disord. 2011 Oct 13. [Epub ahead of print]
  2. Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease. DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, Rodríguez M, Sánchez MB, Hyman BT, Gómez-Isla T. Neurobiol Dis. 2012 Jan;45(1):425-37. Epub 2011 Sep 13.
  3. Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases. Calero O, Bullido MJ, Clarimón J, Frank-García A, Martínez-Martín P, Lleó A, Rey MJ, Rábano A, Blesa R, Gómez-Isla T, Valdivieso F, de Pedro-Cuesta J, Ferrer I, Calero M. PLoS One. 2011;6(7):e22090. Epub 2011 Jul 20.
  4. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease. Serrano-Pozo A, Mielke ML, Gómez-Isla T, Betensky RA, Growdon JH, Frosch MP, Hyman BT. Am J Pathol. 2011 Sep;179(3):1373-84. Epub 2011 Jul 21.
  5. Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T. J Neuropathol Exp Neurol. 2011 May;70(5):360-76.


Updated 7/11/2012


Contact Us

MassGeneral Institute for Neurodegenerative Disease

Building 114, Charlestown Navy Yard

114 16th Street, Room 2003Mailcode: CNY B114-2-2003 Charlestown, MA 02129
  • Near Public Transit
  • Accessible
  • Phone: 617-726-2000
  • Fax: 617-724-1480

How to Apply for Positions

How to apply for jobs: Send an e-mail to mghneurologyjobs@partners.org to receive an automated e-mail with full instructions for all types of positions.

Fundraising Contact

Contact Krista McCabe in the Mass General Development office at 617-726-1392 or KMCCABE@PARTNERS.ORG.


Anne B. Young, MD, PhD
Director, Massgeneral Institute for Neurodegenerative Disease 
Professor of Neurology, Harvard Medical School

Clinical Appointments, Consultations & Clinical Trials

Please visit the main Neurology Service Contact page for all other contact information.

Lab Phone: 617-643-5562

MassGeneral Institute for Neurodegenerative Disease (MIND)

Neurology Access Center: 1-855-644-6387

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